The aims of this project are to understand mechanisms by which CD4+ T-cells provide host defense against Pneumocystis infection.
The Aims of this project are to understand the role of Th17 cytokines in mucosal immunity against K. pneumoniae and S. aureus in the lung.
Cystic Fibrosis is the most common lethal genetic disease in the US and is characterized by chronic infection inflammation in the airway. We have identified an important role of the immune system in controlling the infection in these patients and this proposal will try to develop novel therapies for lung infections based on these observations.
This project will identify novel targets to improve treatment outcomes as well as improve diagnostics for this pneumonia in patients lacking CD4+ T-cell immunity such as advanced AIDS.
The goal of this project is to develop point of care non-invasive diagnostics for pneumonia in HIV infected children