My research interests are mainly focused on identifying and characterizing genetic and epigenetic variation that affects susceptibility to complex human disorders, such as osteoporosis and sarcopenia. Toward these ends, we are integrating multidisciplinary approaches including genetic epidemiology, functional genomics, epigenomics, proteomics, bioinformatics, and molecular biology. We recently performed an epidgenome-wide MeDIP sequencing (MeDIP-Seq) study to identify differentially methylated regions associated with osteoporosis. We also performed several pioneering sequencing-based projects, including a whole genome sequencing study and an exome sequencing project for osteoporosis in different ethnic groups, using the next-generation sequencing technologies. The successful identification and characterization of genetic and epigenetic variations underlying osteoporosis and sarcopenia will markedly increasing our understanding of disease pathophysiology and may lead to novel and individualized treatment.