The Department of Biochemistry and Molecular Biology is honored to present the 17th Annual George Adrouny Memorial Lectureship on Thursday, April 19th, 2018, at 10:00am in the 1st Floor Auditorium of the Tulane University School of Medicine, 1430 Tulane Avenue.
This year's featured speaker is James L. Manley, PhD, Julian Clarence Levi Professor of Life Sciences at Columbia University, New York. Dr. Manley received a BS from Columbia University, his PhD from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995-2001 and Julian Clarence Levi Professor of Life Sciences since 1995. Read More
His research interests center on understanding the mechanisms and regulation of gene expression in mammalian cells. His work has been supported by many grants, including an NIH MERIT Award. He has authored or coauthored over 330 research articles and reviews on these topics, and is an ISI Highly Cited Researcher. Manley is or has been an Editor of three journals and has served on numerous editorial boards and review panels. He is a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.
Dr. Manley's laboratory studies gene expression in mammalian cells. Manley and his colleagues identified and characterized the key factors responsible for polyadenylation of mRNA precursors, and elucidated how this remarkably complex machinery functions in gene regulation, for example during cell growth and differentiation. He has also studied the mechanism and regulation of the process by which introns are removed from mRNA precursors, mRNA splicing. Manley and his coworkers co-discovered the first alternative splicing factor (SR protein), characterized how this and other splicing regulatory proteins function and are themselves regulated, showed how alternative splicing can become deregulated in disease, and with respect to mechanism demonstrated that two spliceosomal small nuclear RNAs by themselves have catalytic activity. Finally, he elucidated unexpected links between these mRNA processing reactions and transcription, DNA damage signaling and maintenance of genomic stability. His work has thus provided considerable insight into the complex mechanisms that are essential for the regulated production of mRNAs in mammalian cells.
As a memorial to their late father, the distinguished former Professor of Biochemistry, George A. Adrouny, a memorial lectureship was established in 2000 by his children and family to honor his memory. The Department of Biochemistry, Tulane University Health Sciences Center, School of Medicine, is proud to host this annual event.
George A. Adrouny was born of Armenian parents in Turkey on April 2, 1912. He received his B.A. in chemistry in 1934, and a degree in pharmaceutical chemistry in 1940, both from the American University of Beirut. While working as a freelance pharmacist, he also taught chemistry and biology at Aleppo College in Aleppo, Syria. In 1951, a Smith-Mundt Fellowship permitted him to begin graduate studies at Emery University where he earned a Ph.D. in Biochemistry in 1954. After two years as a Research Associate in Biochemistry at Emory, he was recruited to the Tulane University School of Medicine, Department of Biochemistry, where he ultimately rose to the rank of full professor.
Dr. Adrouny’s research interests were diverse. His identification and characterization of the fire ant venom was published in 1959 in Science magazine. He also published papers in the areas of cardiac glycogen metabolism, intestinal dextran-hydrolyzing enzymes, biochemical effects of growth hormone and the phylogenic and evolutionary importance of hickory nut and pecan oils.
He headed the Foreign Fellows Program, specifically created for foreign graduate students studying at Tulane. He also was placed in charge of the Medical Biochemistry course, a post that he enjoyed until his retirement in 1981. In recognition of his devotion to the organization and teaching of this course, the Owl Club gave him a certificate of recognition in 1981. He was named Professor Emeritus following his retirement from the Medical School.
Dr. Adrouny was a member of the Society of Sigma Xi, the New York Academy of Sciences, the American Chemical Society and he was a Fellow of the American Association for the Advancement of Sciences. He was listed in the Who’s Who of American Education in 1967-68.
In 1987, a few years after the death of Alice K. Adrouny, his wife of 38 years, Dr. Adrouny moved to Maryland to be near family where he lived until his death on November 24, 1999.
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