Representatives from the Ladies Leukemia League – (back row, from the left) Carolyn Escher, past president; Rosalie Edwards, grant administrator; and Anita Hymel, current president – recently awarded Tulane Cancer Center researchers – (front row, from the left) Hua Lu, MD, PhD; Matthew Burow, PhD; and Zhen Lin, MD, PhD – with $35,000 grants to help support their leukemia/lymphoma research projects.
Three Tulane Cancer Center researchers – Hua Lu, MD, PhD; Matthew Burow, PhD; and Zhen Lin MD, PhD – were each recently awarded $35,000 Ladies Leukemia League (LLL) grants to help support their leukemia and lymphoma research projects.
Founded in 1969, the LLL is a volunteer organization of 225 women who have dedicated themselves to raising funds for leukemia and lymphoma research in Louisiana, Mississippi and Texas. Since their founding, they have raised over $4.1 million, which they have distributed as "pilot" or "seed" money to research scientists working in leukemia and lymphoma research, or related fields.
The LLL issues a call for grant applications each fall and then utilizes a panel of medical advisors to evaluate proposals and make recommendations for funding. They cap awards at $35,000 per investigator in order to provide support for as many worthy projects as possible.
Tulane's current grant recipients were recognized and awarded with the first half of their grants at the organization's annual grant recipient luncheon, which took place in April. The balance of their awards will be distributed at the halfway point in the grant period, during the organization's annual Fête de Noël Luncheon in December.
LLL's Fête de Noël Luncheon and Fashion Show is their major annual fundraiser and a premiere benefit of the Holiday Season in New Orleans. It is scheduled to take place on Tuesday, December 13, this year. For more information, please visit: https://ladiesleukemialeague.org/index.htm
Below is a synopsis of Tulane's currently funded projects:
Matthew Burow, PhD
Associate Professor of Medicine
Utilization of the Kinase Chemo-Genomic Set to Identify Targets of Therapeutic Opportunity in MCL
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin lymphoma with a median survival time of 3-4 years and a 10-year survival rate of 5-10%. Despite initial positive responses to existing therapeutic strategies (chemotherapy, immunotherapy, and targeted therapy), MCL inevitably relapses as a treatment-resistant disease. Therefore, there is a critical need to identify novel, druggable targets for MCL. Human cells contain many different kinases – enzymes that help control important functions, such as cell signaling, metabolism, division, and survival. Kinase inhibitors block the action of kinases. The Burow lab previously utilized the Kinase Chemogenomic Set (KCGS) – a collection of 187 understudied kinase inhibitors assembled by the Structural Genomics Consortium at the University of North Carolina Chapel Hill -- to identify NEK5 as a novel kinase of importance in triple-negative breast cancer, a treatment-resistant and malignant disease with outcomes similar to MCL. The current project proposes to use the KCGS to screen for novel kinase targets in MCL.
Hua Lu, MD, PhD
Professor & Chair of Biochemistry and Molecular Biology
Developing Nano-Encapsulated INZ-C as a Potential and Novel Leukemia/Lymphoma Therapeutic Agent
Previous studies by the Lu Lab identified Inauhzin-C (INZ-C) as a non-genotoxic small molecule that suppresses cancer cell growth by promoting the functions of a well-recognized tumor suppressor protein called p53. Through projects previously funded by LLL, the Lu lab also demonstrated that INZ-C suppresses the function of an oncoprotein called c-Myc in lymphoma cells, repressing the growth of these cells. In order to improve its anti-cancer potency and bioavailability in animals, the Lu Lab has also generated nanoparticles for encapsulating INZ-C. The nanoparticles-encapsulated INZ-C – called “n-INZ-C” – is more metabolically stable and more potent in activating p53. Also, the lab demonstrated that n-INZ-C can more effectively suppress the growth of mouse xenograft tumors derived from colorectal cancer cells. This LLL-funded project will support the Lu Lab’s study of n-INZ-C and its development into a novel cancer cell-specific molecule-targeted therapy for leukemia and lymphoma.
Zhen Lin, MD, PhD
Associate Professor of Pathology
Developing a Novel Targeted Oncolytic Therapy for Epstein-Barr Virus (EBV)-Associated Lymphoma
Epstein-Barr virus (EBV) is a human oncogenic virus etiologically related to a group of hematologic cancers known as EBV-associated lymphoma (EBVaL). Patients with EBVaL usually have co-morbidities, cannot adequately tolerate conventional intensive chemotherapy, and have worse prognoses. Thus, there is an urgent need to improve the current therapeutic regimen. Given the nearly universal presence of EBV in tumor cells, targeting the viral infection cycle and avoiding toxic chemotherapeutics would likely benefit patients. In this LLL-funded project, Dr. Lin will evaluate a novel EBV-targeting strategy that simultaneously induces a latent form of the virus and then exposes it to an anti-viral drug to eliminate EBVaL in both cell and animal models. If successful, the findings will provide important preclinical insight into the implementation of this novel therapeutic strategy and its possible benefits for patients suffering from this deadly disease.
After a two-year COVID hiatus, NOLA Bluedoo is back, and we're so ready to celebrate! The Seventh Annual NOLA Bluedoo rocks Tulane’s Uptown Campus once again on Saturday, September 17, 2022, at 4 PM!
Bluedoo Fest combines funky New Orleans‐style music, food and drinks, as well as costuming, a kids' tent, a two‐mile walk/run and other entertainment in celebration of prostate cancer survivorship and in support of the research efforts of Dr. Oliver Sartor, head of Tulane's Prostate Cancer Research Program.
Dr. Sartor leads an internationally renowned research and treatment program here in New Orleans. His is one of the larger programs in the U.S. – 1,300 patients from 26 states and 7 foreign countries. Dr. Sartor and his team have helped to drive great progress over the past few years in the development and approval of new drugs for prostate cancer. In fact, a unique new cancer treatment that uses engineered radioactive molecules to target prostate cancer cells recently received FDA approval. This practice-changing therapy inhibits tumor growth and in clinical trials extended survival for patients with advanced prostate cancer and very few alternative treatment options. Dr. Sartor was co-principal investigator on this international trial.
Of course, none of this would be possible without the research funding necessary to blaze new trails in the search for cures. That's why this event and the support it generates are so very important. You can help! Please click here to learn more about making a donation, sponsoring the event, or helping to raise awareness of prostate cancer, a disease that impacts one in eight of our men. ALL NOLA Bluedoo donations are put to immediate use — right here in our New Orleans laboratories — in the search for cures.
Although this year's event will be similar to Bluedoos past, there are a couple of changes planned:
Your support of NOLA Bluedoo helps to save lives. Get Your Blue On and join us September 17!
Krewe de Pink's Annual Pink Bra Run – which benefits Tulane Cancer Center's Breast Cancer Research Program – made a live comeback on Saturday, May 7, just in time for Mother's Day.
This quirky event attracted walkers, runners and partiers of all ages, many of whom completed a picturesque 5K course atop the Mississippi River levee, starting and ending at the Thomas Jefferson Memorial in Old Gretna.
A festival-style party – including music, food, drinks, face painting, and the highly anticipated and entertaining "Best Decorated Bra" contest – followed the walk/run. Entrants cheekily strutted their stuff for the judges, showing off their fantastic and whimsical creations. First-, second-, and third-place prizes were awarded, but more importantly, fun was had by all.
"After the COVID hiatus, it was so fulfilling to finally come together again to laugh, dance and have a great time raising funds for a great cause," said Greg Cantrell, Krewe de Pink president. "We all know someone who has battled or is battling this disease, and it's our mission to do something about it. Research is the key, and we are proud to help fund Tulane's search for a cure."
Funds raised through Krewe de Pink's annual events – the Pink Bra Run; Death by Chocolate, NOT Breast Cancer; and the Pink Prom – support the work of Drs. Matthew Burow and Bridgette Collins-Burow and their team, whose joint laboratories investigate novel therapeutic targets for triple negative breast cancer, the mechanisms of LKB1 kinase signaling in breast cancer tumorigenesis and metastasis, and the effects of activated foods and extracts on human health using in vitro cancer cell models, among other projects.
"Krewe de Pink is a perfect example of how our community partnerships both impact and direct our research initiatives," said Prescott Deininger, PhD, Tulane Cancer Center director (and honorary judge of the 2022 Best Decorated Bra contest!). "Their passion for this cause is what generates the unrestricted funds that allow our researchers to pursue theories and projects they might not have been able to otherwise. We can only capitalize on these unique opportunities because of the support of community advocates like Krewe de Pink, and we are extremely grateful. Simply put, we can't do all that we want to without them."
Krewe de Pink's next event – Death by Chocolate, NOT Breast Cancer – takes place on Saturday, July 9, at Schoen Mansion on Canal St. For more information, visit www.KrewedePink.org.
Researcher Awarded $2 Million NIGMS Grant to Study Biology of "Jumping Genes"
Tulane and New Orleans VA Researcher Receives Funding for Prostate Cancer Breakthrough
The Pink Bra Run is Back! Join The Fun – In Person or Virtually
One Man Shoot Raises $130K for Prostate Cancer Research
FDA Approves Pluvicto™ for Eligible Patients with Metastatic Castration-Resistant Prostate Cancer
New Findings May Lead to Personalized Treatments for Non-Clear Cell Renal Cell Carcinoma
"One Man Can Make a Difference" at the One Man Shoot Sporting Clays Event
March is Colorectal Cancer Awareness Month
Gunning for a Cure Sets Record - $340K Raised for Prostate Cancer Research
Exploring the Role of "Activated" Foods in Human Health / Cancer Prevention
AACR Releases Report Outlining Impact of COVID-19 Pandemic on Cancer Research and Patient Care
Annual Gunning for a Cure Sporting Clays Event to Benefit Prostate Cancer Research
February is National Cancer Prevention Month: The ACS Reminds You to "Get Your Tests"
Annual "Pink Games" Surpass $250K Mark in Funds Raised for Patient Relief
Study Links Louisiana's Severe Air Pollution to Dozens of Cancer Cases Each Year
Tulane Professor Elected to National Academy of Inventors
Krewe de Pink Donates $27.5K to Tulane's Breast Cancer Research Program
$3.1 Million NCI Grant Supports Development of Potential Blood Test for Pancreatic Cancer
Looking Back and Looking Forward: Our Year in Review
Tulane University Study Uses Artificial Intelligence to Detect Colorectal Cancer
November is Lung Cancer Awareness Month: Tulane's Low-Dose CT Lung Screening Saves Lives
Let the "Great American Smokeout" Be Day One of Your Tobacco-Free Life
Blue Ribbon Soirée Celebrates 10th Year, Raising $155K for Prostate Cancer Research
Honoring Breast Cancer Survivorship
Researcher Receives $1.7 Million Grant to Study Faulty DNA Repair & Cancer Risk
Tulane Urology Acquires First Single-Port Da Vinci Surgical Robot in the Gulf South
The Department of Surgery Welcomes David Pointer, MD
Cancer Crusaders Postpones 20th Annual Celebration of Life Luncheon
Tulane Cancer Center Faculty Honored as "Top Doctors" in Their Fields
Join Us! Community Webinar on Prostate Cancer
Shedding Light on Light: Can Daytime Indoor Lighting Impact Your Health / Cancer Risk?
Fly Bayou: The Tiny Fruit Fly Helps Researchers in the Fight Against Cancer
NCI's Annual Report to Nation: Overall Cancer Death Rates Continue to Decline
Liquid Biopsy Analysis Reveals Genetic Differences in Advanced Prostate Tumors
USPSTF Lowers Recommended Age to Begin Colon Cancer Screenings
Chancellor Donald, MD, Honored as a "Health Care Hero"
Researcher Awarded $1.74 Million to Study Role of Virus in HIV-Associated Lung Cancer
Molecularly Targeted Radiation Therapy Extends Survival for Patients with Advanced Prostate Cancer
Head & Neck Cancer Surgical Clinic Opens on the Northshore
Cancer Crusaders Raise $81K for Research Despite Challenges of COVID-19
"Chocolate Extravaganza" to Benefit Breast Cancer Research
Tulane World Leader in Molecularly Targeted Radiation Trials for Prostate Cancer
New Lung Cancer Screening Guidelines Include Broader Patient Population
Calling All Chocoholics! Indulge Those Cravings And Make a Difference
Join Our 1st Interdisciplinary Urothelial Carcinoma Workshop
Researcher Investigates Possible Link Between Obesity and Colon Cancer
New Faculty Member Broadens Tulane's Fruit Fly Research Program
$50K ACS Award to Assist Patients in Getting to Treatment Appointments
Pink Bra Run Goes VIRTUAL This Year!
Department of Urology Launches Men's Health Webinar Series
Tulane Cancer Center First in Region to Offer MRI-Guided Perineal Prostate Biopsy
Doctors Should Address Reduced Sense of Taste and Smell in Cancer Patients, Tulane Study Says
Tulane Cancer Center Receives American Cancer Society Lodging Funds
Annual Sporting Clays Event Raises $180K for Prostate Cancer Research
Department of Urology Launches Men's Health Webinar Series
Want a Rapid Second Opinion? Tulane Cancer Center Doctors Are Standing By
Krewe de Pink Donates $25K to Breast Cancer Research Program
Annual Pink Games Surpass $200K in Funds Raised for Patient Relief
Department of Urology Launches Men's Health Webinar Series
Progress in a Year of Unprecedented Challenge
Tulane Cancer Center Welcomes New Office of Clinical Research Director
Cancer Crusaders Raise $131K for Cancer Research at Tulane/LSU
New Thoracic Oncologist Spearheads Development of Lung Cancer Program
Researchers Identify Marker That May Predict Whether Lung Cancer Likely to Spread
Tulane / ACCC Host Urothelial Carcinoma Workshop for Healthcare Professionals
VIRTUAL Krewe de Pink Prom Benefits Breast Cancer Research Program
Kidney Cancer Association Hosts First Annual Virtual Patient Symposium
Tulane / ACCC Host Urothelial Carcinoma Workshop for Healthcare Professionals
Liver Cancer Treatment Showing Positive Results, Tulane Study Says
Community Webinar on Prostate Cancer Posted to YouTube
Many Thanks to Our 2020 NOLA Bluedoo Donors
Join Our Community Webinar on Prostate Cancer
Patient Stories - Cyril Harvey, Jr.
NOLA Bluedoo is Canceled, BUT Prostate Cancer Research Support is Still Needed!
Clinical Trial to Test Effectiveness of Drug in Treating Cancer Patients with Severe COVID-19
Join Us for our Virtual Community Seminar on Prostate Cancer
Gynecologic Oncology: Diverse Team of "Women Caring for Women"
$792K ACS Grant to Help Metastatic Cancer Patients Understand/Access Palliative Care
Tulane Scientists Find a Switch to Flip and Turn off Breast Cancer Growth and Metastasis
$100K Kay Yow Cancer Fund Grant to Raise Clinical Trial Awareness In Minority Patients
Fruit Flies Help Shed Light on Tumor Formation, Migration and Growth
Tulane Seeks Recovered COVID-19 Patients to Volunteer as Plasma Donors for Clinical Trial
A Ray of Hope in the Crisis, Dr. Kendra Harris Shines Light on Needs of Healthcare Providers
ACS Grant to Help Cancer Patients Overcome Transportation Barriers Especially Critical Now
Study Targeting Tumor Genetic Mutations Yields ‘Practice Changing’ Results for Prostate Cancer Treatment
Gunning for a Cure 2020 Raises $220K for Prostate Cancer Research
Spike in U.S. Colorectal Cancer Rates From Age 49 to 50 Suggests Many Cases Likely Undiagnosed Before Screenings
Gunning for a Cure: Making a "Tremendous Difference" to Prostate Cancer Research
Radiation Oncologist Audrey Dang Returns to NOLA / Joins Tulane's Team
Death by Chocolate: A Sweet (and Savory!) Success
Pink Games Initiative Sets New Record in Effort to Assist Local Cancer Patients
Radiation Oncology to Unveil New Linear Accelerator / Patient Care Area
Krewe de Pink Presents Death by Chocolate
Tulane Health First in Region to Offer Focal Therapy for Prostate Cancer
Our Year in Review
Kidney Cancer Day: Connecting Patients to Care Teams
Tulane Researcher is Editor of Journal Issue Honoring 40th Anniversary of Key Cancer Discovery
Pickup Truck for the Cure Raffle Extended - Winner to be Pulled June 1, 2020
Tulane Study Reveals Dim Light at Night May Promote Breast Cancer Metastasis to Bone
Cancer Cells Turn to Cannibalism to Survive Chemotherapy
Tulane School of Medicine Welcomes Neuro-Oncologist Christopher Trevino, MD
Sixth Annual NOLA Bluedoo Raises $143K for Prostate Cancer Research
Cancer Crusaders Support Research/Celebrate Life at Annual Luncheon
Blue Ribbon Soiree Closing in on $1 Million Raised for Prostate Cancer Initiatives
Krewe de Pink Continues Their Support of Breast Cancer Research with $35K Gift
Tulane Lakeside Hospital Now Offering 3D Breast Biopsy
16 Tulane Cancer Center Faculty Named "Top Docs" by New Orleans Magazine
Flemington Team Awarded $2.3 Million For Virus-Related Malignancies Research
Our Summer Drive is ON!
Bryan Subaru / LLS Distribute Blankets, Art Kits & Messages of Hope to Cancer Patients
Win a Truck & Help Cure Prostate Cancer
Researcher's Publication Honored as "Top 100" by Scientific Reports
New Multidisciplinary Prostate Cancer Clinic Enhances Care / Convenience
In the Pink: 4th Annual Pink Bra Run Raises Spirits/Funds for Breast Cancer Research
Cancer Crusaders Raise $171K for Tulane/LSU Cancer Research Programs
Researcher Awarded $1.8 Million NCI Grant to Study New Targets for Rare Pediatric Cancer
Meet Us at the Levee: Pink Bra Run to Benefit Breast Cancer Research!
2019 One Man Shoot Continues the Mission - Making a Difference in Fighting Prostate Cancer
Exploring "Dark Matter of Genomes" Could Shed Light on Cancer Risk
Joe W. & Dorothy Dorsett Brown Foundation Grant Supports Training of Aspiring Female Scientists
Colorectal Cancer Awareness Month Q & A - "Screening Saves Lives"
Improving Access to Care Top Priority for New Genitourinary Cancers Expert
Study Finds Genetic Risks Associated With Prostate Cancer are Underestimated
Greenberg Family Endowment Boosts Fight Against Prostate Cancer
8th Annual One Man Shoot: Proving "One Man Can Make a Difference"
Gunning for a Cure Sets New Record, Raising $220K for Prostate Cancer Research
Tulane Medical Students Raise Money for Pediatric Cancer Research
New Gynecologic Oncologist Aims to Reduce Cervical Cancer Rates in NOLA
Tulane Study Finds Potential Role for Personality Psychology in Cancer Care
Sixth Annual Gunning for a Cure Benefits Prostate Cancer Research
Student Athletes Provide Much-Needed Financial Assistance to Cancer Patients
Improving Early Prostate Cancer Detection: Latest Technology Combines Imaging/Biopsy Tools to Improve Accuracy of Diagnosis
Advanced Cancer Patients Can Live Longer with Palliative Care, Tulane Study Says
Serve and Assist: Student Athletes Raise Funds for Patient Relief
Prostate Cancer Patients Target of New $1.6M Tulane Study
Tulane Opens Novocure Trial for Patients with Stage 4 Non-Small Cell Lung Cancer
The Great American Smokeout ® - Quitting Starts Here!
8th Annual Blue Ribbon Soiree Sets Record, Raising $130K for Prostate Cancer Research
Krewe de Pink Celebrates New Orleans-Style, Donating $35K to Breast Cancer Research!
Researcher Examines Role of DNA-Damaging Elements in Aging/Age-Related Diseases
Lynch Syndrome Can Lead to Cancer — Why Physicians Don't Test For It
Fifth NOLA Bluedoo a Record-Setting Success - Raises $193K for Prostate Cancer Research
Tulane Cancer Center to Host Free Prostate Cancer Seminar
Fifth Annual NOLA Bluedoo Celebrates Prostate Cancer Survivorship New Orleans-Style
Tulane Doctor Elected to Elite Surgery College
Tulane Welcomes Kendra Harris, MD, MSc - New Interim Chair of Radiation Oncology
Nakhle Saba Receives Ladies Leukemia League Grant to Study New Target for ALL
Bryan Subaru & LLS Bring Comfort to Patients Through Subaru Loves to Care Initiative
Repurposed Drug Approach May Halt Spread of Cancer Cells
Tulane Head and Neck Experts Lead Call for HPV Vaccines
American Cancer Society Updates Colorectal Cancer Screening Guidelines
Tulane Cancer Center Now Offering Imaging Tool to Detect Recurring Prostate Cancer
Grant Supports Smoking Cessation Education for Outpatient Mental Health Facilities
It's All About the Pink - Third Annual Pink Bra Run Supports Breast Cancer Research
Cancer Crusaders Donate $169,000 to Tulane/LSU Cancer Research Programs
Grant Supports Smoking Cessation Program for Newly Diagnosed Cancer Patients
Med Student Takes Top Honors at Recent Meeting
State Rep. Julie Stokes to Lead 3rd Annual Pink Bra 5K Fun Run
7th Annual One Man Shoot Raises $130,000 for Prostate Cancer Research
Grant Supports Smoking Cessation Program For Newly Diagnosed Cancer Patients
Researcher Explores Unique Genetic Mutation Associated with Liver Cancer
Healing Hands Across the Divide: Evolving to Address Cancer Disparities
Gunning for a Cure Raises $192K for Prostate Cancer Research
Tulane Oncologist Outlines Prostate Cancer Treatment Advances in New England Journal of Medicine
Pink Games raise money — and hope — for patients fighting cancer
May 25, 2017
Prostate Cancer Immunotherapy Works Better for African-American Men
Cancer Crusaders Present Check for $210K
Free Skin Cancer Screenings Offered at Downtown Dermatology Clinic
National Cancer Survivor's Day
Second Annual Pink Bra Run -
Great Fun for a Great Cause
April 25, 2017
"Scarless Thyroid Surgery" on Agenda at Thyroid/Parathyroid & Skin Malignancies Symposia
Free Skin Cancer Screenings Offered at Covington Clinic
Second Annual Pink Bra Run Scheduled for Mother's Day Weekend
April 11, 2017
Tulane Researcher Shows Education Can Ease Fear in Cancer Patients
Thanks A Million!
March 10, 2017
Komen Grant Supports Study of Ductal Carcinoma In Situ
One Man Can Make a Difference: 6th Annual One Man Shoot Takes Aim at Prostate Cancer
2017 Gunning for a Cure Fundraiser Exceeds $500,000 Goal!
February 16, 2017
Leading Study Backs Hormone Therapy With Radiation for Recurrent Prostate Cancer
Victory Bell: Donation Helps Cancer Patients Celebrate Survivorship
February 3, 2017
Genetic Counselors Help Patients Better Understand Inherited Cancer Risk
Perez Family Targets Prostate Cancer Through Sporting Clays Event
January 26, 2017
Tulane Researchers Find Tumor-Suppressing Protein Actually Promotes Cancer
Tickled Pink: Local Student Athletes Assist Breast Cancer Patients