Dr. Mauvais-Jarvis is a physician-scientist with clinical training in Medicine and Endocrinology from the University of Paris V School of Medicine in France. He also holds a PhD in Biochemistry and Molecular Biology from the University of Paris XI School of Medicine. Dr. Mauvais-Jarvis studied the mechanisms of insulin resistance as a Post-Doctoral Fellow in the laboratory of Dr. C. Ronald Kahn at the Joslin Diabetes Center and Harvard Medical School. He was respectively Assistant Professor of Medicine in the Division of Endocrinology at Baylor College of Medicine in Houston and Associate Professor of Medicine in the Division of Endocrinology and Molecular Medicine at Northwestern University, Feinberg School of Medicine in Chicago. In 2013, he joined Tulane University School of Medicine where he holds the Price-Goldsmith Professorship and is Professor of Medicine in the Department of Medicine, Section of Endocrinology and Metabolism. He is also Staff Physician in the Endocrine service at the Southeastern Louisiana Veterans Affairs Medical Center.
Dr. Mauvais-Jarvis is the Director of the Diabetes Discovery Research and Gender Medicine Laboratory. Dr. Mauvais-Jarvis’ research program focuses on translational approaches in cells, rodents, primates and humans to modulate estrogens and androgens actions with the goal of developing gender-specific therapies to delay diabetes. He has authored over 150 publications on diabetes and obesity and the role of sex hormones in journals including Diabetes, Proceedings of the National Academy of Sciences of the United States of America, Nature Medicine, Journal of Clinical Investigation, Cell Metabolism, and the Lancet. He is the Editor of the book Sex and gender factors affecting metabolic homeostasis, diabetes and obesity. He also serves as Editorial Board member of Diabetes and Molecular Metabolism, and as Associate Editor of the Journal of Diabetes Complications. He is the Principal Investigator of research grants from the National Institutes of Health and the Veterans Health Administration and has received awards from organizations including the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, the March of Dimes Research Foundation and the French Diabetes Association. In 2010, he was elected to the American Society for Clinical Investigation.
Ongoing research projects related to sex differences in diabetes and obesity
Virtually every advance in medical science in the 20th century, from antibiotics and vaccines to drugs against common diseases and organ transplants, has been achieved through the use of animals in laboratory experiments. Our Laboratory focuses on identifying the cellular and molecular mechanisms by which estrogens and androgens influence the risks of diabetes, obesity and metabolic syndrome using rodent models. We use genetic, molecular, pharmacological and physiological tools to study mice with conditional knockouts of the estrogen and/or androgen receptors as well as rodent and human cell culture models in highly controlled environments. Students and fellows are trained to gain a full understanding of the sex-specific biological processes at the root of obesity and diabetes and the ability to demonstrate that modulating sex steroid actions can have a sex-specific therapeutic impact on metabolic dysfunction.
Dragana Lovre, MD, Assistant Professor
Chandra Tate, MS, Medical Research Specialist and Lab Manager
Camille Allard, PhD, Post-Doctoral Research Fellow
Taylor Fuselier, PhD, Post-Doctoral Research Fellow
Weiwei Xu, Graduate Student, BMS
Jamie Morford, Graduate Student, Neuroscience Program
To learn more about Dr. Mauvais-Jarvis' research, visit his lab's website