Dr. Mauvais-Jarvis is a physician scientist who received his medical degree from the University of Paris V School of Medicine in Paris, France and holds a PhD in Biochemistry and Molecular Biology from the University of Paris XII. Following completion of his residency in medicine and a clinical fellowship in endocrinology in teaching hospitals of Paris in 1996, he joined the laboratory of Dr. Ronald Kahn at the Joslin Diabetes Center and Harvard Medical School to study the mechanisms of insulin resistance as a post-doctoral fellow. In 1999, he was recruited as Junior Faculty at the Lariboisiere & St Louis Medical Center and University of Paris VII in Paris, France where he specialized in diabetes care in indigent minority populations and characterized an emerging form of type 2 diabetes, ketosis-prone diabetes. In 2003, Dr. Mauvais-Jarvis was recruited as an Assistant Professor in the Department of Medicine, Division of Endocrinology at Baylor College of Medicine in Houston and served as attending physician in Endocrinology at Ben Taub General Hospital. Between 2006 and 2013 he was Associate Professor in the Division of Endocrinology, Metabolism and Molecular Medicine in the Department of Medicine and Research Director of the Comprehensive Center on Obesity at Northwestern University Feinberg School of Medicine in Chicago. In 2013, he was recruited at Tulane University School of Medicine where he holds the Price-Goldsmith Professorship and is Professor of Medicine in the Department of Medicine, Section of Endocrinology and Metabolism. He is an elected member of the American Society for Clinical Investigation.
Dr. Mauvais-Jarvis has been the Director of a Diabetes Research Laboratory since 2003 and has authored over 90 publications and book chapters dealing with novel mechanisms and/or therapeutic perspectives for diabetes and obesity and the role estrogen and androgen in the development/prevention of these diseases. He is internationally recognized for the discovery of estrogen receptors activation in protecting insulin-producing pancreatic beta-cells in type 1 and type 2 diabetes. Dr. Mauvais-Jarvis is the principal investigator of federal research grants from the National Institutes of Health and has received national and international awards from organizations including the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, the March of Dimes and Birth Defects Foundation and the French Diabetes Association.
Ongoing research projects related to diabetes and obesity
Virtually every advance in medical science in the 20th century, from antibiotics and vaccines to drugs against common diseases and organ transplants, has been achieved through the use of animals in laboratory experiments. Our Laboratory focuses on identifying the cellular and molecular mechanisms by which estrogens and androgens influence the risks of diabetes, obesity and metabolic syndrome using rodent models. We use genetic, molecular, pharmacological and physiological tools to study mice with conditional knockouts of the estrogen or/and androgen receptors as well as rodent and human cell culture models in highly controlled environments. Students and fellows are trained to gain a full understanding of the biological processes at the root of obesity and diabetes and the ability to demonstrate that modulating sex steroid actions can have a therapeutic impact on metabolic dysfunction.
Ongoing projects include
- Targeted estrogen delivery using novel GLP1-estrogen fusion peptides in improving human pancreatic islet transplantation in diabetic rodent models
- Novel actions of the selective estrogen receptor modulator bazedoxifene in insulin sensitivity and diabetes prevention in post-menopausal mouse models
- Novel effects of estrogens in islet alpha-cells and preventing hyperglucagonemia.
- Role of the androgen receptor in pancreatic beta-cell function and insulin secretion in males. Implications for diabetes in aging
- Role of androgen excess in predisposing to type 2 diabetes in females via central nervous system and peripheral actions.
Chandra Tate, MS, Medical Research Specialist and Lab manager
Camille Allard, PhD, Post-Doctoral Research Fellow
Beibei Xu, PhD, Post-Doctoral Research Fellow
Weiwei Xu, Graduate Student, BMS
Publications & Presentations
Nohara K, Liu S, Meyers MS, Waget A, Ferron M, Karsenty G, Burcelin R, Mauvais-Jarvis F. Developmental androgen excess disrupts reproduction and energy
homeostasis in adult male mice. J Endocrinol. 2013 Oct 1. PubMed PMID: 24084835.
Nohara K, Waraich RS, Liu S, Ferron M, Waget A, Meyers MS, Karsenty G,Burcelin R, Mauvais-Jarvis F. Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice. Am J Physiol Endocrinol Metab. 2013 Apr 23. [Epub ahead of print] PubMed PMID: 23612996.
Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev. 2013 Jun;34(3):309-38. Epub 2013 Mar 4. PubMed PMID: 23460719.
Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W,Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Targeted estrogendelivery reverses the metabolic syndrome. Nat Med. 2012 Dec;18(12):1847-56. Epub 2012 Nov 11. PubMed PMID: 23142820.
Liu S, Kilic G, Meyers MS, Navarro G, Wang Y, Oberholzer J, Mauvais-Jarvis F. Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia. 2013 Feb;56(2):370-81. Epub 2012 Nov 7. PubMed PMID: 23132340.
Mauvais-Jarvis F. Estrogen sulfotransferase: intracrinology meets metabolic diseases. Diabetes. 2012 Jun;61(6):1353-4. PubMed PMID:22618773.
Tiano JP, Mauvais-Jarvis F. Molecular mechanisms of estrogen receptors'suppression of lipogenesis in pancreatic β-cells. Endocrinology. 2012Jul;153(7):2997-3005. Epub 2012 May 7. PubMed PMID:22564979.
Tiano JP, Mauvais-Jarvis F. Importance of oestrogen receptors to preserve functional β-cell mass in diabetes. Nat Rev Endocrinol. 2012 Feb 14;8(6):342-51. Review. PubMed PMID: 22330739.
Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Kaw MK, Khuder SS, Latour MG, Bhatt SA, Korach KS, Najjar SM, Prentki M, Mauvais-Jarvis F. Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest. 2011 Aug;121(8):3331-42. Epub 2011 Jul 11. PubMed PMID:21747171.
Nohara K, Zhang Y, Waraich RS, Laque A, Tiano JP, Tong J, Münzberg H,Mauvais-Jarvis F. Early-life exposure to testosterone programs the hypothalamic melanocortin system. Endocrinology. 2011 Apr;152(4):1661-9. Epub 2011 Feb 8. PubMed PMID: 21303958.
Mauvais-Jarvis F. Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends Endocrinol Metab. 2011 Jan;22(1):24-33. Epub 2010 Nov 5.Review. PubMed PMID: 21109497.
Wong WP, Tiano JP, Liu S, Hewitt SC, Le May C, Dalle S,Katzenellenbogen JA, Katzenellenbogen BS, Korach KS, Mauvais-Jarvis F. Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13057-62. Epub 2010 Jun 29. PubMed PMID: 20616010.
Liu S, Navarro G, Mauvais-Jarvis F. Androgen excess produces systemic oxidative stress and predisposes to beta-cell failure in female mice. PLoS One. 2010 Jun 24;5(6):e11302.PubMed PMID:20585581.
Liu S, Mauvais-Jarvis F. Minireview: Estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology.2010 Mar;151(3):859-64. Epub 2009 Dec 4. Review. PubMed PMID: 19966178.
Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F. Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009 Oct;58(10):2292-302. Epub 2009 Jul 8. PubMed PMID:19587358.
Le May C, Chu K, Hu M, Ortega CS, Simpson ER, Korach KS, Tsai MJ, Mauvais-Jarvis F. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9232-7. Epub 2006 Jun 5. PubMed PMID: 16754860.
Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S,Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. J Clin Endocrinol Metab. 2005 Aug;90(8):4446-51. Epub 2005 May 24. PubMed PMID: 15914531.
Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M,Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet. 2004 Dec15;13(24):3151-9. Epub 2004 Oct 27. PubMed PMID: 15509590.
Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes. 2004 Mar;53(3):645-53. PubMed PMID: 14988248.
Cariou B, Postic C, Boudou P, Burcelin R, Kahn CR, Girard J, Burnol AF,Mauvais-Jarvis F. Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology. 2004 Apr;145(4):1926-32.Epub 2003 Dec 18. PubMed PMID: 14684612.
Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ,Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest. 2002 Jan;109(1):141-9. PubMed PMID:11781359.
Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.Diabetes. 2000Dec;49(12):2126-34. PubMed PMID: 11118016.
Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT,Kahn CR, Cantley LC. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet. 2000 Nov;26(3):379-82. PubMed PMID: 11062485.