PhD: University of Delhi South Campus, New Delhi, India
MSC: University of Delhi South Campus, New Delhi, India
BSC: University of Delhi South Campus, New Delhi, India
I am the Director of the Director, Tulane Center for TB Research and Professor of Microbiology & Immunology. I lead the TB research program at the Tulane National Primate Research Center (TNPRC) and at the Tulane University. My research focuses on several different aspects of M. tuberculosis (Mtb) infections. Several of these areas utilize the nonhuman primate model of TB and TB/AIDS, based on the natural route of Mtb infection, which we have optimized to: (i) Understanding the response of Mtb to in vivo stress, (ii) Understanding the role of inducible bronchus associated lymphoid tissue in mediating granuloma level protection from TB, (iii) Identifying classically activated T cell based antigen-specific responses associated with protection vs. disease, (iv) CD4 T cell independent mechanisms of protection from TB and HIV-induced reactivation of TB, (v) Identification of biomarkers of the various stages of disease and infection, (vi) Host-directed approaches to better treat TB. We are testing several host-directed approaches, and (vii) Development of attenuated vaccines against TB. We are focused on the development of an extremely safe vaccine based on stress-response attenuation.