Dr. Mohan is a tenured Associate Professor in the Department of Microbiology, Tulane University School of Medicine.
MicroRNA’s, epigenetics, cannabinoids, and SIV pathogenesis: The focus of his laboratory is to investigate epigenetic mechanisms and the role of microRNAs (miRNAs) in the molecular pathogenesis of HIV/SIV infection. He currently has two NIH funded grants, an R01 grant to study the role of microRNAs in B-cell dysfunction, respectively and a recently funded R56 grant to study the molecular mechanisms underlying HIV/SIV induced oral mucosal dysfunction. In the R01 entitled “Role of microRNAs in B-cell dysfunction in HIV/SIV infection” (awarded March 2016) he and his team will determine the combinatorial effect of suppressing viral replication and gastrointestinal inflammation using cannabinoids on T and B-cell function and disease progression. He is currently extending the cannabinoid studies to other chronic inflammatory diseases of the gastrointestinal tract such as Celiac disease using the unique rhesus macaque model of Gluten sensitive enteropathy. His previous NIH funding included an R01 grant to study the role of microRNAs in HIV/SIV induced intestinal dysfunction and a subcontract through a collaborative R01 with LSUHSC to examine the epigenomic effects underlying the anti-inflammatory effects of cannabinoids [delta-9-Tetrahydrocannabinol (D9-THC)] in HIV/SIV infection. He has a broad background in veterinary medicine, pathology and molecular biology, with specific training and expertise in key research areas pertaining to nonhuman primate immunology. He contributes to the mission of the TNPRC by being involved in education and training activities with graduate students and postdoctoral fellows. He also collaborates/advises many investigators at the TNPRC and has contributed to the development of core services at the TNRPC including the molecular pathology and pathogen detection cores.