Tulane Center for Eosinophilia Disorders under the leadership of Dr. Anil Mishra, PhD, is a first center in the southern region of USA. The center will provide an opportunity to the researchers, patients and their families to understand the disease and consult for the better treatment of the eosinophil associated disorders. The center will also provide an opportunity to the basic research scientist to directly translate their experimental findings to the human disease with the help of clinicians. The center will be involved in basic, clinical and translational studies to determine the mechanistic aspects of eosinophilic disorders in the lung, skin and multiple gastrointestinal segments. Read More
The center's aim is to develop a diagnostic and therapeutic interventions for eosinophil associated multiple diseases. Eosinophilic disorders occur when eosinophils, white blood cells with a bilobed nucleus with multiple toxic granules white blood cell, are found in above-normal amounts in various parts of the body. At healthy state the eosinophil reside in the gastrointestinal tract; however, during allergic (food or aeroallergen) responses, a large number of eosinophils are generated from their precursors in response to the stimulus and move into the sites (responsive organ of the body) and release a variety of toxins that can cause chronic inflammation, resulting in tissue damage and repair.
The Center and other investigators found that eosinophils have a major role in promoting asthma, dermatitis and a number of gastrointestinal symptoms and tissue remodeling (fibrosis). Because of the growing knowledge and a better diagnostic technology, we now have a better understanding of a number of allergic diseases. We are currently studying multiple compounds that might block eosinophil production and their recruitment into the tissues. Our research work indicated that in the future we could provide the best treatment for eosinophil-associated multiple medical disorders such as asthma, eosinophilic dermatitis, eosinophil associated gastrointestinal disorders and tissue remodeling (fibrosis).
Dr. Mishra's general research is aimed at deciphering mechanisms of inflammation, primarily based on discoveries concerning innate immunity. In particular, gene-environment interactions in the elicitation of inflammatory states in the respiratory and gastrointestinal tracts are under investigation.Read More
Environmental triggers (such as aeroallergens and food allergens) are studied in the context of specific genetic variants (e.g. IL-15 and IL-18 signaling) using population studies (cross sectional and longitudinal prospective cohorts) and mechanism-driven studies. The biological properties of innate inflammatory cells (eosinophil, mast cells, NKT cells, epithelial cells) and the cytokines (especially chemokines) that mediate their function are under investigation. The contribution of these basic processes to diverse human inflammatory conditions (e.g. asthma, eosinophil associated gastrointestinal disorders) is pursued by translational studies often involving unique clinical resources (e.g. patient samples and databanks) and clinical intervention studies (e.g. anti-cytokine therapeutics). ). We showed an important protective role of IL-15 in allergen or cytokine induced airway obstruction and bronchial fibrosis (JACI 2017 and AJRCMB 2019)
Most Importantly, we first time implicated the role of IL-18 in eosinophils biology including maturing the naïve eosinophils into the CD101/CD274 double positive pathogenic eosinophils (JACI 2018). We also shown a critical role of eosinophils in promoting chronic pancreatitis and first time report a chemical-induced mouse model of pancreatic cancer.
Anil Mishra, PhD
Endowed Schlieder Chair and Professor of Medicine, Pulmonary Diseases
Director, Tulane Eosinophilic Disorder Center, Tulane Medical Center, New Orleans, LA 70112
Eosinophilic gastrointestinal Disorders:
Eosinophilic esophagitis, characterized by elevated levels of eosinophil in the esophagus.
Eosinophilic gastritis, characterized by elevated eosinophil in the stomach.
Eosinophilic enteritis, characterized by elevated eosinophil in the intestine.
Eosinophilic colitis, characterized by excessive eosinophil in the colon.
Eosinophilic Pancreatitis, accumulation of eosinophils in the pancreas
Cregory Gaspard, MD (Gastroentrology and Hepatology, Tulane Medical Center, New Orleans, LA)
Mansour A. Parsi, MD (Gastroentrology and Hepatology Section, Tulane Medical center, New Orleans, LA)
Asthma, is a chronic inflammatory disease of the airways caused by a combination of genetic and environmental factors and characterized by airflow obstruction, and bronchospasm. Common symptoms include wheezing, coughing, chest tightness, and shortness of breath.
Dr. Nereida Parada, MD (Associate Professor, Pulmonary Medicine. Tulane Medical Center, New Orleans, LA)
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This can be a reactive, benign, or pathological state.
Dr. Joseph Lasky, MD (Professor and Director, Pulmonary Medicine. Tulane Medical Center, New Orleans, LA)
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:
Jane M. El-Dhar, MD (Professor of Clinical Pediatrics and Clinical Professor of Medicine, Head, Section of Pediatric Allergy/Immunology/Rheumatology
Dr. Laurianne Wild, MD (Professor and Director, Clinical Immunology, Tulane Medical Center, New Orleans, LA
Dr. John Affornti, MD, Professor of Medicine Interim Chief Division of Gastroenterology & Hepatology
Sandeep K. Gupta, MD, Professor of Clinical Pediatrics & Clinical Medicine Director, Pediatric Over Weight Education and Research Program, Riley Hospital for Children, Indianapolis, IN. email: firstname.lastname@example.org
Future clinical trials
Patients and Family
Patients and families are encouraged to contact our center for the information needed to understand disease pathogenesis or treatment procedure for eosinophil related disorders.
Tulane Eosinophilic Disorder Center
Principal Investigator: Anil Mishra, PhD
Funds needed for diagnostic and therapeutic Interventions.
Currently, we have very limited support from NIH and our research is very limited. We are in a need of funds to support of research program to find a permanent cure for eosinophil related lung skin and gastrointestinal disorders. We appeal to the common people and private funding agencies to provide the donations for our research programs.
The following high school/graduate students were introduced to medical research in summer (June-August) of all years and trained in my laboratory.