Graduated, B.S. and M.S. in Biochemistry (Honors School, Chardigarh, India)
Doctoral degree in Pharmacology from Post-Graduate Institute of Medical Education and Research, Chandigarh, India-1978
Post Doctoral Fellowships at All India Institute of Medical Sciences (AIIMS), New Delhi, India (1978-1979) and University of Southern California (USC), Los Angeles, California, 1979-1982
- Director, Urology Research and Andrology Clinic and Research Laboratories.
- Director of Urology Research Laboratory and Assistant Professor at Harbor - UCLA Medical Center, Los Angeles, California, 1982 - 1988.
- Full-time faculty in Urology at Tulane University since December 1988.
- Adjunct Professor in Departments of Pharmacology and Biochemistry at Tulane University
- Faculty member of Molecular and Cellular Biology (MCB); Human Genetics, Tulane Cancer Center and Tulane School of Medicine, Xavier Center of Bioenvironmental Research Graduate Program.
- Board Certification, HCLD (Andrology) by American Board of Bioanalysis; and Certification of Clinical Laboratory Scientist-Specialist, Louisiana State Board of Medical Examiners - 1995. •Directs CLIA/HCFA certified Andrology laboratory at Tulane University Health Sciences Center.
- Study section reviewer for EPA and other agencies in the area of reproductive toxicology.
- Faculty of sperm morphology workshops at ASA since 2007.
- Expertise in Clinical Diagnosis of Vascular Impotence using Doppler Ultrasound; manual and CASA semen analysis; assisted reproductive techniques in Andrology/Fertility.
- Expert Panel Member on Standardization of Penile Doppler Ultrasound Technology.
- Wrote SOP and panel member at SMSNA special session at the AUA Annual Meeting in San Francisco, 2010.
- Directs basic research projects focused on oxidative stress response elements and signal transduction mechanisms related to Andrological issues in males especially related to bioenvironmental toxicology, infertility, aging, sexual dysfunction and prostate tumorgenesis employing specific in-vivo and in-vitro models.
- Published over 140 peer-reviewed manuscripts, 8 book chapters and more than 280 abstract and special lecture presentations at both the National and International level.
- Involved in teaching/training of Urology residents, medical students, and research fellows.
- Reviewer of manuscripts submitted to more than 10 journals.
- Past editorial board member of Journal of Andrology, Journal of Sexual Medicine, and Frontiers of Bioscience.
- Mentor to graduate students, A.F.U.D. scholars, summer students, and other research fellows for the past 30 years.
- In 1999 set up a unique state-of-the-art standardized semen analysis training program and quality control management in the Tulane Department of Urology that caters to the needs of many pharmaceutical companies for their multicenter clinical trials on drug safety evaluation targeting reproductive toxicology as mandated by the FDA. Dr. Sikka has also set up a Central Reader facility for sperm morphology evaluation for such multicenter studies.
- Certified technical personnel throughout the US, Canada, Germany, and South Africa for standardized S/A as required by many major Pharmaceutical companies for drug safety studies.
Dr. Sikka received his Ph.D. from the Department of Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, in 1978. He did his post-doctoral fellowship from 1979-1982 in the Department of Biochemistry at the University of Southern California (USC), Los Angeles where he obtained training in the field of protein-lipid interactions in cell membranes, protein purification, and functional incorporation into liposomes. In 1982 Dr. Sikka moved to the Urology section of the Department of Surgery at Harbor-UCLA Medical Center, University of California Los Angeles (UCLA), as Urology Laboratory Research Director. Dr. Sikka joined the Tulane faculty in 1989 as Assistant Professor of Urology and Andrology Laboratory Director. He was responsible for setting up a CLIA-approved Andrology Clinical and Research Laboratory at Tulane Medical Center, catering to the needs of many infertility and sexual dysfunction patients. Dr. Sikka's current research focus is oxidative stress-related signal transduction pathways and gene expression involved in prostate tumorigenesis (BPH and cancer) and drug targeting. The Urology department has recently procured a Laser Capture Microscope (LCM) to microdissect specific and selective biological cells from various clinical samples. LEQSF has also recently funded the Department to acquire the latest DNA - microarray system for expression of specific genes (genomics), and their translational products (proteonomics). The lab routinely employs molecular biology, differential gene expression, suppressive subtractive hybridization, other cell biology, biochemical, and chemiluminescence techniques as well as xenograft and transgenic models of disease and in situ studies on human tissues approaches to address many questions as they relate to prostate tumorigenesis. Using a super-repressor I kappa B adenoviral delivery approach, the lab plans to evaluate the role of inhibiting the activation of the nuclear factor NF-kappa B in enhancing radio/chemosensitization and apoptosis of prostate tumor cells. Analysis of the expression and function of these genes should allow for a more in depth understanding of the processes controlling prostate tumor growth, invasion and metastasis. The ultimate aim is on developing new diagnostic tools and potential therapeutic applications using a gene therapy approach (pharmacogenomics).
Molecular biology, differential gene expression, suppressive subtractive hybridization, other cell biology, biochemical, and chemiluminescence techniques
Sikka SC. (2001) Relative Impact of Oxidative Stress on Male Reproductive Function. Current Medicinal Chem 1: 851-862. Rajasekaran M, Hellstrom WJG, Sikka SC. (2001) Nitric oxide induces oxidative stress and mediates cytotoxicity to human cavernosal cells in culture. J Androl 22: 34-39.
Sikka SC, Champion H, Bivalacqua TJ, Estrada L, Wang R, Rajasekaran M, Aggarwal B, Hellstrom WJG. (2001) Role of genitourinary inflammation of infertility: detrimental effect of lipopolysaccharide (LPS) and nterferon-gamma on human spermatozoa. Int J Androl (in press).
Nguyen A, Jing S, Mahoney S, Davis R, Sikka SC, Agrawal KC, Abdel-Mageed AB. (2000) In vivo gene expression profile analysis of metallothionein in renal cell carcinoma. Cancer Letters 160: 133-140.
Bivalacqua TJ, Champion HC, Mehta YS, Abdel-Mageed AB, Sikka SC, Ignarro LJ, Kadowitz PJ, Hellstrom WJG. (2000) Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. Int J Impotence Res 12: 8-17.
Armstrong JS, Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJG, Sikka SC. (1999) Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radical Biol Med 26(7/8): 869-80.
To view more of Dr. Sikka's publications, see PubMed