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Molecularly Targeted Radiation Trials
AAA
Phase 1/2 Open-Label, Multi-Center, Dose-Escalation Study of Safety, Tolerability, Pharmacokinetics, Dosimetry, and Response to Repeat Dosing of 177Lu-PSMA-R2 Radio-Ligand Therapy in Patients with Prostate Specific Membrane Antigen (PSMA) Positive (68Ga-PSMA-R2) Progressive Metastatic Castration-Resistant Prostate Cancer, Following Previous Systemic Treatment
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ARROW
A multicenter, Randomized, controlled phase 2 study: Efficacy and safety of I-131-1095 Radiotherapy in combination with enzalutamide in metastatic castration-resistant prOstate cancer (mCRPC) patients Who are 18F-DCFPyL prostate-specific membrane antigen (PSMA)-avid, chemotherapy-naïve, and progressed on abiraterone
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BED IIT-382
Changes in 18F-fluciclovine Positron Emission Tomography (PET) in Patients with Metastatic Castration Resistant Prostate Cancer Treated with Abiraterone Acetate: A Pilot Study
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ESCALATE
A Phase III Randomized Study Comparing Enzalutamide or Darolutamide with Radium-223 vs Enzalutamide or Darolutamide with Placebo and the Effect upon Symptomatic Skeletal Event-Free Survival for mCRPC Patients
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69086420PCR1001
A Phase 1 Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer
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BAY16996
A Phase 4 Long-Term Follow-Up Study to Define the Safety Profile of Radium-223 Dichloride
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FIREFLY
68Ga-PSMA-11 Patients with Newly Diagnosed and Recurrent Prostate Cancer
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JNJ-69086420
A Phase I Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer
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NiraRad
Phase 1B Trial of Radium-223 and Niraparib in Patients With Castrate Resistant Prostate Cancer (NiraRad)
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PSMAfore
A Phase III, Open-Label, Multi-Center, Randomized Study Comparing 177Lu-PSMA-617 vs. a Change of Androgen Receptor-Directed Therapy in the Treatment of Taxane Naive Men with Progressive Metastatic Castrate Resistant Prostate Cancer
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SPLASH
STudy Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-Line Hormonal Treatment
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Other Prostate Cancer Trials
NU 17U19
Cognitive Effects of Androgen Receptor (AR) Directed Therapies for Advanced Prostate Cancer
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TUHC 07/25/13 - Genetics of Prostate Cancer
IRONMAN
Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men With Advanced Prostate Cancer (IRONMAN)
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Merck 641
A Phase 3, Randomized, Double-Blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)
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C17-191
A Phase II Study of Carboplatin, Cabazitaxel and Abiraterone in Metastatic Castration Sensitive Prostate Cancer with and without DNA Repair Mutations. (CASCARA: Castration Sensitive Carboplatin, Cabazitaxel and Abiraterone.)
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AMGEN 509
A Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 509 in Subjects With Metastatic Castration-Resistant Prostate Cancer
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AMGEN 160
A Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Prostate Specific Membrane Antigen Half-Life Extended Bispecific T-Cell Engager AMG 160 in Subjects with Metastatic Castration-Resistant Prostate Cancer
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ARV-110-mCRPC-101
A Phase 1/2, open-label, dose escalation, and cohort expansion clinical trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ARV-110 in patients with metastatic castration resistant prostate cancer
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PLANETTE
A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations) in Patients With Advanced Cancer Whose Tumours Contain Molecular Alterations
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AR-V7
Prevalence of AR-V7 in African American Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated with Novel Hormonal Agents
NRG GU008
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
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PANTHER
Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer
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PROMISE
PROstate Cancer Precision Medicine Multi-Institutional Collaborative Effort: The PROMISE Study