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Awards & Recognition

Dr. Zhuo served as a mentor for the NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program. This mentored career development program aims to recruit a critical mass of diverse early career faculty to the university with a focus on inclusive excellence.


The following investigators presented at the APS/Physiology Section of the 2022 Experimental Biology Meeting held in Philadelphia in April 2022. The 2022 EB Meeting was the first face-to-face EB Event since the COVID pandemic began. The 2020 EB Meeting was canceled due to the pandemic and the 2021 EB Meeting was held as a virtual event. Postdoctorial fellow, Dr. Ana Paul Leite, was invited to give an oral presentation at the 2022 EB. Other presentations by THRCE affiliated investigators:

Ana Paula Leite, Xiao Li, Rumana Hassan, Jia Zhuo: Angiotensin Ii-induced Hypertension and Glomerular and Tubulointerstitial Injury in Mutant Mice With Kidney Proximal Tubule-selective Deletion of Mitochondrial Nad+-dependent Deacetylase Sirtuin 3: Focus on Sex Differences. (856.13).

Chih-Hong Wang, Xiao Li, Rumana Hassan, Akemi Sato, Courtney Dugas, Ana Leite, Ryosuke Sato, Jia Zhuo: Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors Augments Natriuretic Response to Atrial Natriuretic Peptide via NPRA/cGMP/NO Signaling Pathways in the Kidney. (724.1).

Xiao Li, Rumana Hassan, Ana Leite, Courtney Dugas, Ryosuke Sato, Akemi Sato, Jia Zhuo: Genetic Evidence for A Critical Role of Intratubular Angiotensin II AT1a Receptors in The Proximal Tubules of The Kidney in Two-Kidney, One-Clip Goldblatt Hypertension in PT-Agtr1a-/- Mice. (715.19).

Dewan Majid, Alexander Castillo: Increase in Salt Concentration in the Culture Media Enhances Protein Expression of Tumor Necrosis Factor-Alpha Receptor Type 1 in Cultured Renal Cortical Collecting Duct Cells But Not in Proximal Tubular Cells. (963.3).

L. Navar, Christophe Hansen-Estruch, Mohamed Bikhet, Mariyam Javed, Akemi Katsurada, Ryousuke Satou, Weijian Shao, David Ayares, David Cooper, Eric Judd: The Renin-Angiotensin System after Pig Kidney Transplantation in Baboons. (963.8).


Three abstracts, one oral and two posters, were presented at 2021 AHA Hypertension Council Meeting. The event was Virtual Meeting held between September 27 to 29, 2021.

Oral Presentation: Xiao C Li; Ana Leite; Rumana Hassan; Akemi Sato; Courtney Dugas; Chih-Hong Wang; Ryosuke Sato; Jia L Zhuo. Genetic Deletion Of Angiotensin Ii AT1a Receptors Selectively In The Proximal Tubules Of The Kidney Attenuates Two-kidney, One-clip Goldblatt Hypertension In Pt-Agtr1a-/- Mice.

Poster Presentation: Ana Paula O. Leite; Xiao C Li; Rumana Hassan; Jian-xiong X Chen; Akemi Sato; Courtney M. Dugas; Ryosuke Sato; Jia L Zhuo. Sex Differences In Angiotensin Ii-induced Hypertension In Mice With Proximal Tubule-specific Deletion Of Mitochondrial Protein Sirtuin 3 In The Kidney.

Poster Presentation: Chih-hong Wang, Jia L. Zhuo, Xiao Li. A Significant Anemic Phenotype In Ren1c-/- Mice Due To Impaired Erythropoiesis And Epo Production.


Recent Publications by Center Affiliated Investigators

  1. Nwia SM, Li XC, Leite APO, Hassan R, Zhuo JL. The Na+/H+ Exchanger 3 in The Intestines and The Proximal Tubules of The Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension. Front. Physiol., 19 April 2022 | https://doi.org/10.3389/fphys.2022.86165.

  2. Li XC, Wang CH, Leite APO, Zhuo JL. Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT 1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury. Front Physiol. 2021 Aug 2;12:702797. doi: 10.3389/fphys.2021.702797. eCollection 2021. PMID: 34408663 PMCID: PMC8364949.

  3. Chies AB, Spadella MA, de Oliveira PR, Domeniconi RF, de Mello Santos T, Moreira RP, Rosales CB, Casarini DE, Navar LG. Exercise-Induced Modulation of Angiotensin II Responses in Femoral Veins From 2-Kidney-1-Clip Hypertensive Rats. Front Physiol. 2021 Apr 7;12:620438. doi: 10.3389/fphys.2021.620438. eCollection 2021. PMID: 33897446.

  4. Fernandes FB, Fernandes AB, Febba ACS, Leite APO, Leite CA, Vitalle MSS, Jung FF, Casarini DE. Association of Ang-(1-7) and des-Arg 9 BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents. Hypertens Res. 2021 Aug;44(8):969-977. doi: 10.1038/s41440-021-00618-0. PMID: 33568792.

  5. Gogulamudi VR, Arita DY, Bourgeois CRT, Jorgensen J, He J, Wimley WC, Satou R, Gonzalez AA, Prieto MC. High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct. Sci Rep. 2021 Jul 5;11(1):13815. doi: 10.1038/s41598-021-93296-4. PMID: 34226610. PMCID: PMC8257763.

  6. Gurrala R, Kilanowski-Doroh IM, Hutson DD, Ogola BO, Zimmerman MA, Katakam PVG, Satou R, Mostany R, Lindsey SH. Alterations in the estrogen receptor profile of cardiovascular tissues during aging. Geroscience. 2021 Feb;43(1):433-442. doi: 10.1007/s11357-021-00331-3. PMID: 33558965.

  7. Leite APO, Li XC, Hassan R, Zheng X, Alexander BT, Casarini DE, Zhuo JL. Sex Differences in Angiotensin II-Induced Hypertension and Kidney Injury: Role of AT1a Receptors in The Proximal Tubule of The Kidney. Clin Sci (Lond). 2021 Jul 20;CS20201574. doi: 10.1042/CS20201574. PMID: 34282828.

  8. Majid DSA, Castillo A. Angiotensin II-induced natriuresis is attenuated in knockout mice lacking the receptors for tumor necrosis factor-α. Physiol Rep. 2021 Aug;9(15):e14942. doi: 10.14814/phy2.14942. PMID: 34337896. PMCID: PMC8326895.

  9. Majid DSA, Mahaffey E, Castillo A, Prieto MC, Navar LG. Angiotensin II induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-α type-1 receptor. Physiol Rep. 2021 Aug;9(16):e14990. doi: 10.14814/phy2.14990. PMID: 34427402.PMCID: PMC8383705.

  10. Ogola BO, Clark GL, Abshire CM, Harris NR, Gentry KL, Gunda SS, Kilanowski-Doroh I, Wong TJ, Visniauskas B, Lawrence DJ, Zimmerman MA, Bayer CL, Groban L, Miller KS, Lindsey SH. Sex and the G Protein-Coupled Estrogen Receptor Impact Vascular Stiffness. Hypertension. 2021 Jul;78(1):e1-e14. doi: 10.1161/HYPERTENSIONAHA.120.16915. PMID: 34024124. PMCID: PMC8192475.

  11. Prieto MC, Gonzalez AA, Visniauskas B, Navar LG. The evolving complexity of the collecting duct renin-angiotensin system in hypertension. Nat Rev Nephrol. 2021 Jul;17(7):481-492. doi: 10.1038/s41581-021-00414-6. PMID: 33824491.

  12. Richfield O, Cortez R, Navar LG. Simulations of increased glomerular capillary wall strain in the 5/6-nephrectomized rat. Microcirculation. 2021 Oct;28(7):e12721. doi: 10.1111/micc.12721. PMID: 34192389.

  13. Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345. doi: 10.1097/TA.0000000000003019. PMID: 33502147.

  14. Torres H, Huesing C, Burk DH, Molinas AJ, Neuhuber W, Berthoud HR, Munzberg H, Derbenev AV, Zsombok A. Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia. Am J Physiol Regul Integr Comp Physiol. 2021 Jul 7. doi: 10.1152/ajpregu.00079.2021. PMID: 34231420.

  15. Yanofsky SM, Dugas CM, Katsurada A, Liu J, Saifudeen Z, El-Dahr SS, Satou R. Angiotensin II biphasically regulates cell differentiation in human iPSC-derived kidney organoids. Am J Physiol Renal Physiol. 2021 Nov 1;321(5):F559-F571. doi: 10.1152/ajprenal.00134.2021. Epub 2021 Aug 27. PMID: 34448643.

  16. Yosypiv IV. Renin-angiotensin system in mammalian kidney development. Pediatr. Nephrol. 2021 Mar;36(3):479-489. doi: 10.1007/s00467-020-04496-5. Epub 2020 Feb 18. PMID: 32072306

  17. Li XC, Leite APO, Zheng X, Zhao C, Chen X, Zhang L, Zhou X, Rubera I, Tauc M, Zhuo JL. Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT-Agtr1a-/- Mice. Hypertension. 2021 Apr;77(4):1285-1298. doi: 10.1161/HYPERTENSIONAHA.120.16336. Epub 2021 Mar 1. PMID: 33641366, PMCID: PMC7946728