Ihor V. Yosypiv, MD

Our research investigates the mechanisms by which the Renin-Angiotensin System (RAS), cardinal regulator of the blood pressure and fluid/electrolyte homeostasis, controls normal embryonic kidney development and how aberrations in RAS signaling result in congenital anomalies of the kidney and urinary tract (CAKUT), the leading cause of end-stage kidney disease (ESKD) in children. The goal of our integrated basic science and translational research is to identify the types of molecular processes that can be targeted for clinical intervention. Together with our trans-disciplinary collaborators, we expect that enhanced understanding of how specific RAS gene mutations linked to CAKUT and associated cardiovascular co-morbidities will lead to novel intervention and preventive strategies that improve child health throughout life.