The research in my laboratory bridges genetics, cancer biology and developmental biology. Using the genetically tractable Drosophila model, we seek to understand how cell growth, proliferation and polarity are regulated during development, and how their deregulation may result in uncontrolled growth, loss of tissue integrity, and neoplastic tumor transformation. Currently, we focus on the following research projects: I. Characterization of “tumor hotspots”, the tissue microenvironment for tumorigenesis. II. A transition zone model for oncogenic Notch induced neoplastic-tumorigenesis. III. Drosophila model for pediatric malignant rhabdoid tumors. IV. Tissue homeostasis through cell competition and compensatory cellular hypertrophy.
For those who are interested in joining the Deng Lab for postdoctoral, graduate and undergraduate research, please contact Dr. Deng at email@example.com.