THRCE News

World Kidney Day 2023

In honor of the 2023 World Kidney Day (WKD), THRCE hosted two events.  The events were scheduled at the following times:

  • 9:00 AM – 12:00 PM: TULANE WKD HEALTH SCREENING
    A health screening was conducted in the second-floor lobby of Tulane University Hospital and Clinics. This event was co-sponsored by the THRCE and the National Kidney Foundation of Louisiana (NKFLA). The goal of the Health Screening fair was to screen participants for blood pressure and the risk for developing kidney disease.
    Six Tulane Medical students volunteered their valuable time and services at the Health Fair. Their names were: Dora Dujmic, Arman Raz, Nadia Salib, Leilani Gammada, and Eva Kruger.  Also at the event, Community Development and Programs Manager at the NKFLA, Ms. Tracey Eldridge, spoke to participants and provided brochures informing them of the various risk for developing kidney disease.  The event was a success where over 100 participants had their blood pressure checked and were provided brochures and information about kidney diseases.
  • 12:00 PM – 1:00 PM: SPECIAL WKD SEMINAR
    A Special WKD Seminar was set-up that was presented by the distinguished, Dr. L. Gabriel Navar.  This was a hybrid presentation that was accessible via zoom. The CEO of the NKFLA, Torie Kranz, gave a brief talk before Dr. Navar's presentation.   You may access the presentation via the following link: 2023 WKD Presentation

Below are some pictures taken of the various 2023 WKD activities organized by THRCE.

Meetings & Conferences

Past Meetings
Investigators affiliated with THRCE have participated at the 2022 AHA Hypertension Scientific Sessions Meeting between Sep 07 - 10, 2022 at Hilton San Diego Bayfront, in San Diego, California. The meeting is organized by American Heart Association (AHA) and is one of premier conferences in the fields of hypertension and its connection to kidney disease and cardiac and stroke, obesity and genetics. Participants from all around the globe meet at this conference to share and exchange latest ideas and information in the hypertension.
The following are presentation were made at the 2022 AHA Meeting by THRCE affiliated investigators:

  1. Ana Paula Oliveira Leite, Xiao C Li, Rumana Hassan and Jia L Zhuo. Abstract P111: Deletion Of Na+/H+ Exchanger 3 Selectively In The Proximal Tubules Doesn’T Prevent The Development Of Doca-salt Hypertension In Pt-Nhe3-/- Mice. HypertensionVolume 79, Issue Suppl_11 September 2022 - Poster
  2. Xiao C Li, Rumana Hassan, Ana Leite and Jia L Zhuo. Abstract 098: Double Deletion Of At1a Receptors And Na+/h+ Exchanger 3 In The Proximal Tubules Attenuates Angiotensin Ii-induced And 2k1c Goldblatt Hypertension In Proximal Tubule-specific Pt-Agtr1a-/-/Nhe3-/- Mice. HypertensionVolume 79, Issue Suppl_11 September 2022 - Oral
  3. Chandramohan Ramasamy, Umadevi Subramanian and Kailash N Pandey. Abstract 068: Genetic Mechanisms Of Cardiac Hypertrophy And Fibrosis In Global Npr1 Gene-ablated Male And Female Mice. HypertensionVolume 79, Issue Suppl_11 September 2022 - Oral
  4. Ryousuke Satou, Dien Ye, Hong S Lu, Akemi Katsurada, Courtney M Dugas, Alan Daugherty, Shahriar Motazedian and L G Navar. Abstract 044: Stimulation Of Intrarenal Angiotensinogen Expression And The Development Of Hypertension And Kidney Injury In Angiotensin II-infused Hepatic Angiotensinogen Knockout Mice. HypertensionVolume 79, Issue Suppl_11 September 2022 - Oral
  5. Rodrigo Yokota, Ana Paula de Oliveira Leite, Vitor Marcel Faça and Dulce Elena Casarini. Abstract P117: MECHANISMS OF SIGNALING PATHWAYS TRIGGERED BY ANGIOTENSIN I CONVERTING ENZYME IN CHO ECA CELLS TREATED WITH CAPTOPRIL. HypertensionVolume 79, Issue Suppl_11 September 2022 - Poster
     

Awards & Recognition

Dr. Zhuo served as a mentor for the NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program. This mentored career development program aims to recruit a critical mass of diverse early career faculty to the university with a focus on inclusive excellence.

Recent Publications by Center Affiliated Investigators

Publications listed below include those published between January 2021 through December 2022. These publications acknowledges either funding awards affiliated to the center, the THRCE center itself, or one of the center’s CORE facilities.

  1. Bautista-Pérez R, Pérez-Méndez O, Cano-Martínez A, Pacheco U, Santamaría J, Rodríguez-Iturbe FRB, Navar LG, Franco M. The Role of P2X7 Purinergic Receptors in the Renal Inflammation Associated with Angiotensin II-induced Hypertension. Int J Mol Sci. 2020 Jun 5;21(11):4041. doi: 10.3390/ijms21114041. PMID: 32516946, PMCID: PMC7312644.
  2. Castorena-Gonzalez JA. Lymphatic Valve Dysfunction in Western Diet-Fed Mice: New Insights Into Obesity-Induced Lymphedema. Front Pharmacol. 2022 Mar 4;13:823266. doi: 10.3389/fphar.2022.823266. eCollection 2022. PMID: 35308249 PMCID: PMC8931217.
  3. Chies AB, Spadella MA, de Oliveira PR, Domeniconi RF, de Mello Santos T, Moreira RP, Rosales CB, Casarini DE, Navar LG. Exercise-Induced Modulation of Angiotensin II Responses in Femoral Veins From 2-Kidney-1-Clip Hypertensive Rats. Front Physiol. 2021 Apr 7;12:620438. doi: 10.3389/fphys.2021.620438. eCollection 2021. PMID: 33897446. PMCID: PMC8058411.
  4. Eguchi S, Sparks MA, Sawada H, Lu HS, Daugherty A, Zhuo JL. Recent Advances in Understanding the Molecular Pathophysiology of Angiotensin II Receptors; Lessons from Cell-Selective Receptor Deletion in Mice. Can J Cardiol. 2023 Jun 30:S0828-282X(23)01451-4. doi: 10.1016/j.cjca.2023.06.421. Online ahead of print. PMID: 37394059.
  5. Fernandes FB, Fernandes AB, Febba ACS, Leite APO, Leite CA, Vitalle MSS, Jung FF, Casarini DE. Association of Ang-(1-7) and des-Arg 9 BK as new biomarkers of obesity and cardiometabolic risk factors in adolescents. Hypertens Res. 2021 Aug;44(8):969-977. doi: 10.1038/s41440-021-00618-0. PMID: 33568792.
  6. Gogulamudi VR, Arita DY, Bourgeois CRT, Jorgensen J, He J, Wimley WC, Satou R, Gonzalez AA, Prieto MC. High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct. Sci Rep. 2021 Jul 5;11(1):13815. doi: 10.1038/s41598-021-93296-4. PMID: 34226610. PMCID: PMC8257763.
  7. Gonzalez AA, Olsen EL, Killeen SZ, Blair RV, Seshan SV, Jaimes EA, Roy CJ, Prieto MC. Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model. J Med Primatol. 2023 Apr;52(2):131-134. doi: 10.1111/jmp.12626. Epub 2022 Nov 15. PMID: 36377612, PMCID: PMC10023264.
  8. Guerrero A, Visniauskas B, Cárdenas P, Figueroa SM, Vivanco J, Salinas-Parra N, Araos P, Nguyen QM, Kassan M, Amador CA, Prieto MC, Gonzalez AA. α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions. Front Cardiovasc Med. 2021 Jun 4;8:644797. doi: 10.3389/fcvm.2021.644797. eCollection 2021. PMID: 34179130. PMCID: PMC8220822.
  9. Gurrala R, Kilanowski-Doroh IM, Hutson DD, Ogola BO, Zimmerman MA, Katakam PVG, Satou R, Mostany R, Lindsey SH. Alterations in the estrogen receptor profile of cardiovascular tissues during aging. Geroscience. 2021 Feb;43(1):433-442. doi: 10.1007/s11357-021-00331-3. PMID: 33558965. PMCID: PMC8050209.
  10. Hansen-Estruch C, Bikhet MH, Javed M, Katsurada A, Satou R, Shao W, Ayares D, Venkataramanan R, Cooper DKC, Judd E, Navar LG. Renin-angiotensin-aldosterone system function in the pig-to-baboon kidney xenotransplantation model. Am J Transplant. 2023 Mar;23(3):353-365. doi: 10.1016/j.ajt.2022.11.022. Epub 2023 Jan 5. PMID: 36695679.
  11. Kulthinee S, Shao W, Franco M, Navar LG. Purinergic P2X1 receptor, purinergic P2X7 receptor, and angiotensin II type 1 receptor interactions in the regulation of renal afferent arterioles in angiotensin II-dependent hypertension. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1400-F1408. doi: 10.1152/ajprenal.00602.2019. Epub 2020 Apr 20. PMID: 32308022, PMCID: PMC7311710.
  12. Lara SL, Gonzalez AA, Hennrikus MT, Prieto MC. Hormone-dependent regulation of renin and effects on prorenin receptor signaling in the collecting duct. Curr Hypertens Rev (2022) Feb 16. doi:10.2174/1573402118666220216105357. PMID: 35170417
  13. Leite APO, Li XC, Hassan R, Zheng X, Alexander BT, Casarini DE, Zhuo JL. Sex Differences in Angiotensin II-Induced Hypertension and Kidney Injury: Role of AT1a Receptors in The Proximal Tubule of The Kidney. Clin Sci (Lond). 2021 Jul 20;CS20201574. doi: 10.1042/CS20201574. PMID: 34282828, PMCID: PMC8969897.
  14. Leite APO. Angiotensin II and NHE3 in the proximal tubules of the kidney are two key players in blood pressure control and hypertension. EARLY CAREER RESEARCHERS - ISH Hypertension News - April 2022. DOI: 10.30824/2204-15.
  15. Leite APO, Li XC, Nwia SM, Hassan R, Zhuo JL. Angiotensin II and AT1a Receptors in the Proximal Tubules of the Kidney: New Roles in Blood Pressure Control and Hypertension. Int J Mol Sci. 2022 Feb 22;23(5):2402. doi: 10.3390/ijms23052402. PMID: 35269547 PMCID: PMC8910592.
  16. Li XC, Leite APO, Zheng X, Zhao C, Chen X, Zhang L, Zhou X, Rubera I, Tauc M, Zhuo JL. Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT-Agtr1a-/- Mice. Hypertension. 2021 Apr;77(4):1285-1298. doi: 10.1161/HYPERTENSIONAHA.120.16336. PMID: 33641366, PMCID: PMC7946728
  17. Li XC, Zhou X, Zhuo JL. Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules: Novel Roles of Mitochondrial Ang II/AT1a/O2- and Ang II/AT2/NO Signaling. Hypertension, 2020 Jul;76(1):121-132. doi: 10.1161/HYPERTENSIONAHA.119.13942. PMID: 32475319, PMCID: PMC7299167
  18. Li XC, Wang C-H, Leite APO, Zhuo JL. Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays A Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury. Front Physiol. 2021 Aug 2;12:702797. doi: 10.3389/fphys.2021.702797. eCollection 2021. PMID: 34408663. PMCID: PMC8364949.
  19. Li XC, Hassan R, Leite APO, Katsurada A, Dugas C, Sato R, Zhuo JL. Genetic Deletion of AT1a Receptor or Na+/H+ Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice. Int J Mol Sci. 2022 Dec 13;23(24):15798. doi: 10.3390/ijms232415798. PMID: 36555438, PMCID: PMC9779213.
  20. Lin H, Geurts F, Hassler L, Batlle D, Mirabito Colafella KM, Denton KM, Zhuo JL, Li XC, Ramkumar N, Koizumi M, Matsusaka T, Nishiyama A, Hoogduijn MJ, Hoorn EJ, Danser AHJ. Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting. Pharmacol Rev. 2022 Jul;74(3):462-505. doi: 10.1124/pharmrev.120.000236. PMID: 35710133, PMCID: PMC9553117.
  21. Liu H. The roles of histone deacetylases in kidney development and disease. Clin Exp Nephrol. 2021 Mar;25(3):215-223. doi: 10.1007/s10157-020-01995-5. PMID: 33398599, PMCID: PMC7925501.
  22. Majid DSA, Castillo A. Angiotensin II-induced natriuresis is attenuated in knockout mice lacking the receptors for tumor necrosis factor-α. Physiol Rep. 2021 Aug;9(15):e14942. doi: 10.14814/phy2.14942. PMID: 34337896, PMCID: PMC8326895.
  23. Majid DSA, Mahaffey E, Castillo A, Prieto MC, Navar LG. Angiotensin II induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-α type-1 receptor. Physiol Rep. 2021 Aug;9(16):e14990. doi: 10.14814/phy2.14990. PMID: 34427402, PMCID: PMC8383705.
  24. Majid DSA. Inflammation induced hyponatremia: Evidence for tumor necrosis factor-alpha (TNFα) receptor type 1 (TNFR1) as a therapeutic target in its’ management. BMANA Scientific Journal (BSJ) 1: 38- 43.
  25. Majid DSA, Castillo A, Prieto MC, Navar LG. High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney. Exploration of Medicine, 3(2), 205-218. doi:10.37349/emed.2022.00086.
  26. Nwia SM, Leite APO, Li XC, Zhuo JL. Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases. Front Cardiovasc Med. 2023 Jun 19;10:1198090. doi: 10.3389/fcvm.2023.1198090. eCollection 2023. PMID: 37404743, PMCID: PMC10315499.
  27. Nwia SM, Li XC, Leite APO, Hassan R, Zhuo JL. The Na+/H+ Exchanger 3 in The Intestines and The Proximal Tubules of The Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension. Front Physiol. 2022 Apr 19;13:861659. doi: 10.3389/fphys.2022.861659. PMID: 35514347, PMCID: PMC9062697
  28. Patel NR, K C R, Blanks A, Li Y, Prieto MC, Meadows SM. Endothelial cell polarity and extracellular matrix composition require functional ATP6AP2 during developmental and pathological angiogenesis. JCI Insight. 2022 Oct 10;7(19):e154379. doi: 10.1172/jci.insight.154379. PMID: 35998033, PMCID: PMC9675464.
  29. Prieto MC, Gonzalez AA, Visniauskas B, Navar LG. The evolving complexity of the collecting duct renin-angiotensin system in hypertension. Nat Rev Nephrol. 2021 Jul;17(7):481-492. doi: 10.1038/s41581-021-00414-6. PMID: 33824491, PMCID: PMC8443079.
  30. Reina-Couto M, Afonso J, Carvalho J, Morgado L, Ronchi FA, de Oliveira Leite AP, Dias CC, Casarini DE, Bettencourt P, Albino-Teixeira A, Morato M, Sousa T. Interrelationship between renin-angiotensin-aldosterone system and oxidative stress in chronic heart failure patients with or without renal impairment. Biomed Pharmacother. 2021 Jan;133:110938. doi: 10.1016/j.biopha.2020.110938. PMID: 33171402.
  31. Reverte V, Gogulamudi VR, Rosales CB, Musial DC, Gonsalez SR, Parra-Vitela AJ, Galeas-Pena M, Sure VN, Visniauskas B, Lindsey SH, Katakam PVG, Prieto MC. Urinary angiotensinogen increases in the absence of overt renal injury in high fat diet-induced type 2 diabetic mice. J Diabetes Complications. 2020 Feb;34(2):107448. doi: 10.1016/j.jdiacomp.2019.107448. PMID: 31761419, PMCID: PMC6981045.
  32. Satou R, Franco M, Dugas CM, Katsurada A, Navar LG. Immunosuppression by Mycophenolate Mofetil Mitigates Intrarenal Angiotensinogen Augmentation in Angiotensin II-Dependent Hypertension. Int J Mol Sci. 2022 Jul 12;23(14):7680. doi: 10.3390/ijms23147680. PMID: 35887028 PMCID: PMC9319385.
  33. Shaikh G. B, Hippargi S, Majid D.S.A., Das K.K. Protective Actions of Cilnidipine:Dual L/N-Type Calcium Channel Blocker Against hypertension Renal Injury in Rats. Biomed Pharmacol J 2021;14(4). DOI : https://dx.doi.org/10.13005/bpj/2287.
  34. Singh P, Stephenson R, Castillo A, Majid DSA. High-salt intake reduces renal tissue levels of inflammatory cytokines in mice. Physiol Rep. 2021 Jan;8(24):e14621. doi: 10.14814/phy2.14621. PMID: 33345460. PMCID: PMC7750173.
  35. Taghavi S, Abdullah S, Toraih E, Packer J, Drury RH, Aras OAZ, Kosowski EM, Cotton-Betteridge A, Karim M, Bitonti N, Shaheen F, Duchesne J, Jackson-Weaver O. Dimethyl Malonate Slows Succinate Accumulation and Preserves Cardiac Function in a Swine Model of Hemorrhagic Shock. J Trauma Acute Care Surg. 2022 Mar 2. Doi. 10.107/TA.0000000000003593. Online. PMID:35234713.
  36. Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345. doi: 10.1097/TA.0000000000003019. PMID: 33502147.
  37. Visniauskas B, Reverte V, Abshire CM, Ogola BO, Rosales CB, Galeas-Pena M, Sure VN, Sakamuri SSVP, Harris NR, Kilanowski-Doroh I, McNally AB, Horton AC, Zimmerman M, Katakam PVG, Lindsey SH, Prieto MC. High plasma soluble prorenin receptor (sPRR) is associated with vascular damage in male but not female mice fed a high fat diet. Am J Physiol Heart Circ Physiol. 2023 Mar 17. doi: 10.1152/ajpheart.00638.2022. PMID: 36930656.
  38. Visniauskas B, Arita DY, Rosales CB, Feroz MA, Luffman C, Accavitti MJ, Dawkins G, Hong J, Curnow AC, Thethi TK, Lefante JJ, Jaimes EA, Mauvais-Jarvis F, Fonseca VA, Prieto MC. Sex differences in soluble prorenin receptor in patients with type 2 diabetes. Biol Sex Differ. 2021 May 1;12(1):33. PMID: 33933156, PMCID: PMC8088668.
  39. Yanofsky SM, Dugas CM, Katsurada A, Liu J, Saifudeen Z, El-Dahr SS, Satou R. Angiotensin II biphasically regulates cell differentiation in human iPSC-derived kidney organoids. Am J Physiol Renal Physiol. 2021 Nov 1;321(5):F559-F571. doi: 10.1152/ajprenal.00134.2021. PMID: 34448643, PMCID: PMC8616599.
  40. Yosypiv IV. Renin-angiotensin system in mammalian kidney development. Pediatr. Nephrol. 2021 Mar;36(3):479-489. doi: 10.1007/s00467-020-04496-5. PMID: 32072306.
  41. Zhuo JL, Soleimani M, Li XC. New Insights into the Critical Importance of Intratubular Na +/H + Exchanger 3 and Its Potential Therapeutic Implications in Hypertension. Review Curr Hypertens Rep. 2021 Jun 10;23(6):34. doi: 10.1007/s11906-021-01152-7. PMID: 34110521, PMCID: PMC8314783.