Publications

 

Total Citations as of May 2021: Google Scholar, > 2,520 citations, h-index: 25

https://scholar.google.com/citations?user=jFGkkLgAAAAJ&hl=en&oi=ao

Peer-Reviewed Journals
  1. Asuka Nanbo, Wakako Furuyama, Zhen Lin. RNA virus-encoded miRNAs: Current insights and future challenges. Frontiers in Microbiology. 2021. In press.
     
  2. Becnel D, Abdelghani R, Nanbo A, Avilala J, Kahn J, Li L, Lin Z*. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses. 2021 May. 13(5), 877 (*Corresponding author, impact factor 3.816)
     
  3. Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z*. Role of virally encoded circular RNAs in the pathogenicity of human oncogenic viruses. Frontiers in Microbiology. 2021 April;12(668). doi: 10.3389/fmicb.2021.657036.(*Corresponding author, impact factor 4.235)
     
  4. Del Valle L, Dai L, Lin HY, Lin Z, Chen J, Post SR, Qin Z. Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. J Cell Mol Med. 2021 Feb 4. doi: 10.1111/jcmm.16307. (impact factor 4.438)
     
  5. Ning B, Yu T, Zhang S, Huang Z, Tian D, Lin Z, Niu A, Golden N, Hensley K, Threeton B, Lyon CJ, Yin XM, Roy CJ, Saba NS, Rappaport J, Wei Q, Hu TY. A smartphone-read ultrasensitive and quantitative saliva test for COVID-19. Science Advances. 2021 Jan 8; 7(2):eabe3703. doi: 10.1126/sciadv.abe3703. (impact factor 13.116)
     
  6. Chen J*, Goyal N*, Dai L*, Lin Z*,Del Valle L, Zabaleta J, Liu J, Post S, Foroozesh M, Qin Z. Developing new ceramide analogs and identifying novel sphingolipid controlled genes against a virus-associated lymphoma. Blood. 2020 Nov:136(19):2175-2187. doi: 10.1182/blood.2020005569.  (*Co-first author, impact factor 17.543).
     
  7. Zhao M, Nanbo A, Becnel D, Qin Z, Morris GF, Li L, Lin Z*. Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta. J Virol. 2020 Oct:JVI.01298-20. doi: 10.1128/JVI.01298-20. PMID: 32847852. (*Corresponding author, impact factor 4.501)
     
  8. Thompson JW Jr, Mikolajewski AJ, Kissinger P, McCrossen P, Smither A, Chamarthi GD, Lin Z, Tian D. An Epidemiologic Study of COVID-19 Patients in a State Psychiatric Hospital: High Penetrance With Early CDC Guidelines. Psychiatr Serv. 2020 Oct 6:appips202000270. doi: 10.1176/appi.ps.202000270. PMID: 33019856.
     
  9. Huang Z, Tian D, Liu Y, Lin Z, Lyon CJ, Lai W, Fusco D, Drouin A, Yin X, Hu T, Ning B. Ultra-sensitive and high-throughput CRISPR-powered COVID-19 diagnosis. Biosens Bioelectron. 2020 Sep 15;164:112316. doi: 10.1016/j.bios.2020.112316. (impact factor 10.257)
     
  10. Chen J, Lin Z, Barrett L, Dai L, Qin Z. Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). Bioorg Chem. 2020 Jun;99:103847. doi: 10.1016/j.bioorg.2020.103847
     
  11. Dai L*, Chen J*, Lin Z*, Wang Z, Mu S, Qin Z. Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). J Cancer. 2020 May 22;11(16):4683-4691. (*Co-first author, impact factor 3.565).
     
  12. Zhang Y, Nguyen A, Chun M, Lin Z, Ross J, Sun L. Ninety Days in: A comprehensive Review of the Ongoing COVID-19 Outbreak. Health Sci J. 2020; Vol.14. No. 2:706
     
  13. Zhang Y, Yuan F, Liu L, Chen Z, Ma X, Lin Z*, Zou J*. The Role of the miR-21/SPRY2 Axis in Modulating Proangiogenic Factors, Epithelial Phenotypes, and Wound Healing in Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3854-3862. (*Corresponding author, impact factor 3.470).
     
  14. Kheir F, Zhao M, Strong MJ, Yu Y, Nanbo A, Flemington EK, Morris GF, Reiss K, Li L, Lin Z*. Detection of Epstein-Barr Virus Infection in Non-Small Cell Lung Cancer. Cancers (Basel). 2019;11(6). (*Corresponding author, impact factor 6.126).
     
  15. Lei J, Sun L, Li P, Zhu C, Lin Z, Mackey V, Coy D, He Q. The Wound Dressings and Their Applications in Wound Healing and Management. Health Sci J. 2019; Vol.13 (4), 1-8
     
  16. Nakhoul H, Lin Z, Wang X, Roberts C, Dong Y, Flemington E. High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments. mSphere. 2019 Jul 10;4(4). 
     
  17. Zhao M, Nanbo A, Sun L, Lin Z*. Extracellular Vesicles in Epstein-Barr Virus' Life Cycle and Pathogenesis. Microorganisms. 2019 Feb 11;7(2). (*Corresponding author, impact factor 4.152).
     
  18. He JQ, Sun L, He J, Zhu C, Li P, Lei J, He Q, Mackey V, Lin Z, Cheng P, Coy D.  The Pathogenesis and Therapeutics of Nasopharyngeal Carcinoma. Health Sci J. 2019; Vol.13. No. 2:642
     
  19. Mills KL, Gomes AM, Standlee CR, Rojo MD, Carmeliet P, Lin Z, Machado HL. Gas6 is dispensable for pubertal mammary gland development. PLoS One. 2018 Dec 11;13(12):e0208550.
     
  20. Dai L, Zhao M, Jiang W, Lin Z, Del Valle L, Qin Z. KSHV co-infection, a new co-factor for HPV-related cervical carcinogenesis? Am J Cancer Res. 2018 Nov 1;8(11):2176-2184.
     
  21. Ungerleider N, Concha M, Lin Z, Roberts C, Wang X, Cao S, Baddoo M, Moss WN, Yu Y, Seddon M, Lehman T, Tibbetts S, Renne R, Dong Y, Flemington EK. The Epstein Barr virus circRNAome. PLoS Pathog. 2018 Aug 6;14(8):e1007206
     
  22. Lin Z*, Nguyen C, Xu B, Flemington EK, Morris GF. Interleukin-17A in the Pathogenesis of Lung Adenocarcinoma. Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S125. (*First author, impact factor 4.836)
     
  23. Lam BQ, Dai L, Li L, Qiao J, Lin Z*, Qin Z*. Molecular mechanisms of activating c-MET in KSHV+ primary effusion lymphoma. Oncotarget. 2017 Mar 14;8(11):18373-18380. doi: 10.18632/oncotarget.15444. PubMed PMID: 28407694; PubMed Central PMCID: PMC5392335. (*Corresponding authors).
     
  24. Li M, Li X, Zhuang Y, Flemington EK, Lin Z, Shan B. Induction of a novel isoform of the lncRNA HOTAIR in Claudin-low breast cancer cells attached to extracellular matrix. Mol Oncol. 2017 Aug 28. doi: 10.1002/1878-0261.12133. PubMed PMID: 28846832.
     
  25. Dai L, Lin Z, Jiang W, Flemington E, Qin Z. Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis. Virol Sin. 2017 Oct;32(5):369-375.
     
  26. Dai L, Lin Z, Cao Y, Chen Y, Xu Z, Qin Z. Targeting EIF4F complex in non-small cell lung cancer cells. Oncotarget. 2017 Jun 8;8(33):55731-55735.
     
  27. Dai L, Lin Z, Qiao J, Chen Y, Flemington EK, Qin Z. Ribonucleotide reductase represents a novel therapeutic target in primary effusion lymphoma. Oncogene. 2017 Aug 31;36(35):5068-5074. doi: 10.1038/onc.2017.122. PubMed  PMID: 28459467.
     
  28. Zhu B, Chen S, Hu X, Jin X, Le Y, Cao L, Yuan Z, Lin Z, Jiang S, Sun L, Yu L. Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma. Neoplasia. 2017 Jul;19(7):583-593. doi: 10.1016/j.neo.2017.02.007. PubMed PMID: 28628795; PubMed Central PMCID: PMC5476975.
     
  29. Zhang R, Strong MJ, Baddoo M, Lin Z, Wang YP, Flemington EK, Liu YZ. Interaction of Epstein-Barr virus genes with human gastric carcinoma transcriptome. Oncotarget. 2017 Jun 13;8(24):38399-38412. doi:10.18632/oncotarget.16417. PubMed PMID: 28415594; PubMed Central PMCID: PMC5503541.
     
  30. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. PubMed PMID: 28617871; PubMed Central PMCID: PMC5487075.
     
  31. Cao Y, Qiao J, Lin Z, Zabaleta J, Dai L, Qin Z. Up-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma. Oncotarget. 2017 Feb 28;8(9):15220-15229. doi: 10.18632/oncotarget.14838. PubMed PMID: 28146424; PubMed Central PMCID: PMC5362481.
     
  32. Strong MJ, Blanchard E 4th, Lin Z, Morris CA, Baddoo M, Taylor CM, Ware ML, Flemington EK. A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus - tumor association. Acta Neuropathol Commun. 2016 Jul 11;4(1):71. doi: 10.1186/s40478-016-0338-z. PubMed PMID: 27402152; PubMed Central PMCID: PMC4940872.
     
  33. Dai L, Bai L, Lin Z, Qiao J, Yang L, Flemington EK, Zabaleta J, Qin Z. Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget. 2016 Jul  26;7(30):47052-47060. doi: 10.18632/oncotarget.9720. PubMed PMID: 27363016; PubMed Central PMCID: PMC5216923.
     
  34. Lin Z*, Swan K, Zhang X, Cao S, Brett Z, Drury S, Strong MJ, Fewell C, Puetter A, Wang X, Ferris M, Sullivan DE, Li L, Flemington EK. Secreted Oral Epithelial Cell Membrane Vesicles Induce Epstein-Barr Virus Reactivation in Latently Infected B Cells. J Virol. 2016 Jan 13;90(7):3469-79. doi: 10.1128/JVI.02830-15. (*First author, impact factor 4.501)
     
  35. Strong MJ, Laskow T, Nakhoul H, Blanchard E, Liu Y, Wang X, Baddoo M, Lin Z, Yin Q, Flemington EK. Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas. J Virol. 2015 Oct;89(19):10110-4.
     
  36. Cao S, Moss W, O'Grady T, Concha M, Strong MJ, Wang X, Yu Y, Baddoo M, Zhang K, Fewell C, Lin Z, Dong Y, Flemington EK. New Noncoding Lytic Transcripts Derived from the Epstein-Barr Virus Latency Origin of Replication, oriP, Are Hyperedited, Bind the Paraspeckle Protein, NONO/p54nrb, and Support Viral Lytic Transcription. J Virol. 2015 Jul 15;89(14):7120-32.
     
  37. Cao S, Strong MJ, Wang X, Moss WN, Concha M, Lin Z, O'Grady T, Baddoo M,Fewell C, Renne R, Flemington EK. High-Throughput RNA sequencing based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project. J Virol. 2015 Jan;89(1):713-29.
     
  38. Strong MJ, Xu G, Morici L, Splinter Bon-Durant S, Baddoo M, Lin Z, Fewell C,Taylor CM, Flemington EK. Microbial contamination in next generation sequencing: implications for sequence-based analysis of clinical samples. PLoS Pathog. 2014 Nov 20;10(11):e1004437.
     
  39. Strong MJ, Lin Z, Flemington EK. Expanding the conversation on high-throughput virome sequencing standards to include consideration of microbial contamination sources. MBio. 2014 Oct 28;5(6).
     
  40. Strong MJ, Baddoo M, Nanbo A, Xu M, Puetter A, Lin Z*. Comprehensive RNA-seq analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes. J Virol. 2014 Sep; 88(18):10696-704. (*Corresponding author, impact factor 4.501).
     
  41. O'Grady T, Cao S, Strong MJ, Concha M, Wang X, Splinter Bondurant S, Adams M, Baddoo M, Srivastav SK, Lin Z, Fewell C, Yin Q, Flemington EK. Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol. 2014 Feb;88(3):1604-16.
     
  42. Strong MJ, O'Grady T, Lin Z, Xu G, Baddoo M, Parsons C, Zhang K, Taylor CM, Flemington EK. Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing. J Virol. 2013 Dec;87(23):13059-62.
     
  43. Sides MD, Sosulski ML, Luo F, Lin Z, Flemington EK, Lasky JA. Co-treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of nasopharyngeal carcinoma. Virol J. 2013 May 16;10:152. doi: 10.1186/1743-422X-10-152.
     
  44. Strong MJ, Xu G, Coco J, Baribault C, Vinay DS, Lacey MR, Strong AL, Lehman TA, Seddon MB, Lin Z, Concha M, Baddoo M, Ferris M, Swan KF, Sullivan DE, Burow ME, Taylor CM, Flemington EK. Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog. 2013;9(5):e1003341.
     
  45. Lin Z*, Wang X, Strong MJ, Concha M, Baddoo M, Xu G, Baribault C, Fewell C, Hulme W, Hedges D, Taylor CM, Flemington EK. Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol. 2013 Jan;87(2):1172-82. (*First author, impact factor 4.501)
     
  46. Li C, Nguyen HT, Zhuang Y, Lin Z, Flemington EK, Zhuo Y, Kantrow SP, Morris GF, Sullivan DE, Shan B. Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene. 2012 Dec 15;511(2):143-50.
     
  47. Lin, Z.*, Puetter, A., Coco, J., Xu, G., Strong, M.J., Wang, X., Fewell, C., Baddoo, M., Taylor, C., and Flemington, E.K. Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES. J Virol. 2012 86 (6), 2970-2977. (*First author, impact factor 4.501)
     
  48. Nguyen HT, Li C, Lin Z, Zhuang Y, Flemington EK, Burow ME, Lin Y, Shan B. The microRNA expression associated with morphogenesis of breast cancer cells in three-dimensional organotypic culture. Oncol Rep. 2012 Jul;28(1):117-26.
     
  49. Concha M, Wang X, Cao S, Baddoo M, Fewell C, Lin Z, Hulme W, Hedges D, McBride J, Flemington EK. Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-seq. J Virol. 2012 86(3): 1458-1467.
     
  50. Lin, Z.*, and E. K. Flemington. 2011. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Lett 305:186-99.  (*First author, impact factor 7.360)
     
  51. Sides MD, Block GJ, Shan B, Esteves KC, Lin Z, Flemington EK, Lasky JA. Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology. 2011 Jul 20;416(1-2):86-97.
     
  52. Sides MD, Klingsberg RC, Shan B, Gordon KA, Nguyen HT, Lin Z, Takahashi T, Flemington EK, Lasky JA. The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells. Am J Respir Cell Mol Biol. 2011 Jun;44(6):852-62.
     
  53. Lin, Z.*, X. Wang, C. Fewell, J. Cameron, Q. Yin, and E. K. Flemington. 2010. Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429. J Virol 84:7892-7.  (*First author, impact factor 4.501)
     
  54. Lin, Z.*, G. Xu, N. Deng, C. Taylor, D. Zhu, and E. K. Flemington. 2010. Quantitative and qualitative RNA-Seq-based evaluation of Epstein-Barr virus transcription in type I latency Burkitt's lymphoma cells. J Virol 84:13053-8. (*First author, impact factor 4.501)
     
  55. Yin Q, Wang X, Fewell C, Cameron J, Zhu H, Baddoo M, Lin Z, Flemington EK. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP mediated Epstein-Barr virus reactivation. J Virol. 2010 Jul;84(13):6318-27.
     
  56. Xu G, Fewell C, Taylor C, Deng N, Hedges D, Wang X, Zhang K, Lacey M, Zhang H, Yin Q, Cameron J, Lin Z, Zhu D, Flemington EK. Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA. 2010 Aug;16(8):1610-22.
     
  57. Cameron JE, Fewell C, Yin Q, McBride J, Wang X, Lin Z, Flemington EK. Epstein-Barr virus growth/latency III program alters cellular microRNA expression. Virology. 2008 Dec 20;382(2):257-66.
     
  58. Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z, Cameron J, Flemington EK. MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus regulated gene expression pathways. J Virol. 2008 Jun;82(11):5295-306.
     
  59. Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol. 2008 Feb;82(4):1946-58.
     
  60. Lin Z*, Yin Q, Flemington E. Identification of a negative regulatory element in the Epstein-Barr virus Zta transactivation domain that is regulated by the cell cycle control factors c-Myc and E2F1. J Virol. 2004 Nov;78(21):11962-71. (*First author, impact factor 4.501)

 

Book Chapters
  1. Zhen Lin and Erik K. Flemington, Regulation of EBV latency by viral lytic proteins. In: Erle S. Robertson, Editor, Epstein-Barr virus: latency and transformation, Caister Academic Press, London, England. (2010): 167-192.