Faculty Publications

Section of Pulmonary Diseases, Critical Care and Environmental Medicine
Faculty Publications: July 1, 2023 –  June 30, 2024

JOSEPH LASKY, MD
Sydney B. Montesi, Dana Ball, Bill Schmidt, Michael Beers, Robert Brown, Ishanu Chattopadhyay, Cory Hogaboam, Kevin Flaherty, Christine Garcia, Brigitte Gomperts, Lida Hariri, Naftali Kaminski, Grace Kim, Melanie Koenigshoff, Martin Kolb, Darrell Kotton, Jonathan Kropski, Joseph Lasky, Chelsea Magin, Toby Maher, Mark McCormick, Bethany Moore, Justin Oldham, Anna Podolanczuk, Ganesh Raghu, Ivan Rosas, Steven Rowe, David Schwartz, Jessica Shore, Cathie Spino, Matthew Craig, Fernando J. Martinez. Pulmonary Fibrosis Stakeholder Summit: A Joint National Heart, Lung, and Blood Institute, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report, Am J Respir Crit Care Med. 2023 Dec 19. 

Ganesh Raghu, Marya Ghazipura, Thomas R Fleming, Kerri I Aronson, Jürgen Behr, Kevin, K Brown, Kevin R Flaherty, Ella A Kazerooni, Toby M Maher, Luca Richeldi, Joseph A Lasky, Jeffrey J Swigris, Robert Busc, Lili Garrard 14, Dong-Hyun Ahn, Ji Li, Khalid, Puthawala, Gabriela Rodal, Sally Seymour, Nargues Weir, Sonye K Danoff, Neil, Ettinger, Jonathan Goldin, Marilyn K Glassberg, Leticia Kawano, Nasreen Khalil, Lisa, Lancaster, David A Lynch, Yolanda Mageto, Imre Noth, Jessica E Shore, Marlies, Wijsenbeek, Robert Brown, Daniel Grogan, Dot Ivey, Patrycja Golinska, Banu Karimi-Shah, and Fernando Martinez. Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Prioritizing Feels, Functions, Survives, Am J Respir Crit Care Med. 2024 Jan 4.

Christopher S. King, MD; Rosalinda V. Ignacio, MS; Vikramjit Khangoora, MD; Alan Nyquist, MD; Anju Singhal, MD; Christopher Thomas, MD; Onix Fonseca Cantres, MD; Shambhu Aryal, MD; Oksana A. Shlobin, MD; Kevin Flaherty, MD; Joseph Lasky, MD; MD; Steven D. Nathan, MD. Hospitalization Rates in Interstitial Lung Disease: An Analysis of the Pulmonary Fibrosis Foundation Registry, Am J Respir Crit Care Med. 2024 Jan 18.

Fayez Kheir, Ramsy Abdelghani, Diana Espinoza, Regina Villalobos, David Becnel, Rachel Herr, Alejandro Aragaki, Joseph A. Lasky. Impact of the Envisia Genomic Classifier in Patients with Undiagnosed Interstitial Lung Disease, in press, Chest.

Francesco Lombardi , Iain Stewart , Laura Fabbri , Wendy Adams , Leticia Kawano-Dourado, Christopher J Ryerson, Gisli Jenkins ; REMAP-ILD Consortium (Lasky JA). Mycophenolate and azathioprine efficacy in interstitial lung disease: a systematic review and meta-analysis. BMJ Open Respir Res, 2024 Feb 27;11(1).

Kawano-Dourado L, Kulkarni T, Ryerson CJ, Rivera-Ortega P, Baldi BG, Chaudhuri N, Funke-Chambour M, Hoffmann-Vold AM, Johannson KA, Khor YH, Montesi SB, Piccari L, Prosch H, Molina-Molina M, Sellares Torres J, Bauer-Ventura I, Rajan S, Jacob J, Richards D, Spencer LG, Wendelberger B, Jensen T, Quintana M, Kreuter M, Gordon AC, Martinez FJ, Kaminski N, Cornelius V, Lewis R, Adams W, Jenkins G; REMAP-ILD consortium (Lasky JA). Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung disease. Thorax. 2024 Mar 6:thorax-2023-221148.

JAY KOLLS, MD
Clark RDE, Rabito F, Munyonho FT, Remcho TP, Kolls JK. Evaluation of anti- vector immune responses to adenovirus-mediated lung gene therapy and modulation by αCD20. Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101286. doi: 10.1016/j.omtm.2024.101286. PMID: 39070292; PMCID: PMC11283059.

Currey J, Ellsworth C, Khatun MS, Wang C, Chen Z, Liu S, Midkiff C, Xiao M, Ren M, Liu F, Elgazzaz M, Fox S, Maness NJ, Rappaport J, Lazartigues E, Blair R, Kolls JK, Mauvais-Jarvis F, Qin X. Upregulation of inflammatory genes and pathways links obesity to severe COVID-19. Biochim Biophys Acta Mol Basis Dis. 2024 Jun 26;1870(7):167322. doi: 10.1016/j.bbadis.2024.167322. Epub ahead of print. PMID: 38942338.

Castro-Pando S, Howell RM, Li L, Mascaro M, Faraoni EY, Le Roux O, Romanin D, Tahan V, Riquelme E, Zhang Y, Kolls JK, Allison JP, Lozano G, Moghaddam SJ, McAllister F. Pancreatic epithelial IL-17/IL-17RA signaling drives B7-H4 expression to promote tumorigenesis. Cancer Immunol Res. 2024 Jun 6. doi: 10.1158/2326-6066.CIR-23-0527. Epub ahead of print. PMID: 38842383.

Ellsworth CR, Wang C, Katz AR, Chen Z, Islamuddin M, Yang H, Scheuermann SE, Goff KA, Maness NJ, Blair RV, Kolls JK, Qin X. Natural Killer Cells Do Not Attenuate a Mouse-Adapted SARS-CoV-2-Induced Disease in Rag2-/- Mice. Viruses. 2024 Apr 15;16(4):611. doi: 10.3390/v16040611. PMID: 38675952; PMCID: PMC11054502.

Qadir MMF, Elgamal RM, Song K, Kudtarkar P, Sakamuri SSVP, Katakam PV, El- Dahr S, Kolls J, Gaulton KJ, Mauvais-Jarvis F. Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes. bioRxiv [Preprint]. 2024 Jun 11:2024.04.11.589096. doi: 10.1101/2024.04.11.589096. PMID: 38645001; PMCID: PMC11030320.

Hoffmann JP, Srivastava A, Yang H, Iwanaga N, Remcho TP, Hewes JL, Sharoff R, Song K, Norton EB, Kolls JK, McCombs JE. Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunity. Commun Biol. 2024 Apr 9;7(1):433. doi: 10.1038/s42003-024-06138-0. PMID: 38594380; PMCID: PMC11003962.

Tong S, Scott JC, Eyoh E, Werthmann DW, Stone AE, Murrell AE, Sabino-Santos G, Trinh IV, Chandra S, Elliott DH, Smira AR, Velazquez JV, Schieffelin J, Ning B, Hu T, Kolls JK, Landry SJ, Zwezdaryk KJ, Robinson JE, Gunn BM, Rabito FA, Norton EB. Altered COVID-19 immunity in children with asthma by atopic status. J Allergy Clin Immunol Glob. 2024 Feb 29;3(2):100236. doi: 10.1016/j.jacig.2024.100236. PMID: 38590754; PMCID: PMC11000189.

Yang H, Iwanaga N, Katz AR, Ridley AR, Miller HD, Allen MJ, Pociask D, Kolls JK. Embigin Is Highly Expressed on CD4+ and CD8+ T Cells but Is Dispensable for Several T Cell Effector Responses. Immunohorizons. 2024 Mar 1;8(3):242-253. doi: 10.4049/immunohorizons.2300083. PMID: 38446446; PMCID: PMC10985056.

Taghavi S, Engelhardt D, Campbell A, Goldvarg-Abud I, Duchesne J, Shaheen F, Pociask D, Kolls J, Jackson-Weaver O. Dimethyl sulfoxide as a novel therapy in a murine model of acute lung injury. J Trauma Acute Care Surg. 2024 Jul 1;97(1):32-38. doi: 10.1097/TA.0000000000004293. Epub 2024 Mar 6. PMID: 38444065.

Abdulnour-Nakhoul SM, Kolls JK, Flemington EK, Ungerleider NA, Nakhoul HN, Song K, Nakhoul NL. Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G438-G459. doi: 10.1152/ajpgi.00066.2023. Epub 2024 Jan 9. PMID: 38193195; PMCID: PMC11213479.

Harrison MAA, Morris SL, Rudman GA, Rittenhouse DJ, Monk CH, Sakamuri SSVP, Mehedi Hasan M, Shamima Khatun M, Wang H, Garfinkel LP, Norton EB, Kim S, Kolls JK, Jazwinski SM, Mostany R, Katakam PVG, Engler-Chiurazzi EB, Zwezdaryk KJ. Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice. Brain Behav Immun. 2024 Mar;117:36-50. doi: 10.1016/j.bbi.2023.12.033. Epub 2024 Jan 3. PMID: 38182037.

Huckestein BR, Zeng K, Westcott R, Alder JK, Antos D, Kolls JK, Alcorn JF. Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection. Am J Pathol. 2024 Mar;194(3):384-401. doi: 10.1016/j.ajpath.2023.11.017. Epub 2023 Dec 28. PMID: 38159723; PMCID: PMC10913760.

Chandra V, Li L, Le Roux O, Zhang Y, Howell RM, Rupani DN, Baydogan S, Miller HD, Riquelme E, Petrosino J, Kim MP, Bhat KPL, White JR, Kolls JK, Pylayeva-Gupta Y, McAllister F. Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. Cancer Cell. 2024 Jan 8;42(1):85-100.e6. doi: 10.1016/j.ccell.2023.12.006. Epub 2023 Dec 28. PMID: 38157865; PMCID: PMC11238637.

Munyonho FT, Clark RDE, Lin D, Khatun MS, Pungan D, Dai G, Kolls JK. Precision-cut lung slices as an ex vivo model to study Pneumocystis murina survival and antimicrobial susceptibility. mBio. 2024 Jan 16;15(1):e0146423. doi: 10.1128/mbio.01464-23. Epub 2023 Dec 20. PMID: 38117035; PMCID: PMC10790776.

Wang C, Khatun MS, Zhang Z, Allen MJ, Chen Z, Ellsworth CR, Currey JM, Dai G, Tian D, Bach K, Yin XM, Traina-Dorge V, Rappaport J, Maness NJ, Blair RV, Kolls JK, Pociask DA, Qin X. COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes. Commun Biol. 2023 Dec 13;6(1):1265. doi: 10.1038/s42003-023-05626-z. PMID: 38092883; PMCID: PMC10719262.

Melton A, Rowe LA, Penney T, Krzykwa C, Goff K, Scheuermann S, Melton HJ, Williams K, Golden N, Green KM, Smith B, Russell-Lodrigue K, Dufour JP, Doyle- Meyers LA, Schiro F, Aye PP, Lifson JD, Beddingfield BJ, Blair RV, Bohm RP, Kolls JK, Rappaport J, Hoxie JA, Maness NJ. The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection. bioRxiv [Preprint]. 2023 Nov 16:2023.11.15.567132. doi: 10.1101/2023.11.15.567132. Update in: Viruses. 2024 Jul 21;16(7):1173. doi: 10.3390/v16071173. PMID: 38014096; PMCID: PMC10680717.

Hu Y, Bojanowski CM, Britto CJ, Wellems D, Song K, Scull C, Jennings S, Li J, Kolls JK, Wang G. Aberrant immune programming in neutrophils in cystic fibrosis. J Leukoc Biol. 2024 Feb 23;115(3):420-434. doi: 10.1093/jleuko/qiad139. PMID: 37939820.

Taghavi S, Campbell A, Engelhardt D, Duchesne J, Shaheen F, Pociask D, Kolls J, Jackson-Weaver O. Dimethyl malonate protects the lung in a murine model of acute respiratory distress syndrome. J Trauma Acute Care Surg. 2024 Mar 1;96(3):386-393. doi: 10.1097/TA.0000000000004184. Epub 2023 Nov 8. PMID: 37934622; PMCID: PMC10922501.
Lu S, Chen K, Song K, Pilewski JM, Gunn BM, Poch KR, Rysavy NM, Vestal BE, Saavedra MT, Kolls JK. Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function. Cell Rep Med. 2023 Oct 17;4(10):101210. doi: 10.1016/j.xcrm.2023.101210. PMID: 37852181; PMCID: PMC10591031.

Khatun MS, Remcho TP, Qin X, Kolls JK. Cell-intrinsic and -extrinsic effects of SARS-CoV-2 RNA on pathogenesis: single-cell meta-analysis. mSphere. 2023 Oct 24;8(5):e0037523. doi: 10.1128/msphere.00375-23. Epub 2023 Sep 22. PMID: 37737611; PMCID: PMC10597400.

Beppu AK, Zhao J, Yao C, Carraro G, Israely E, Coelho AL, Drake K, Hogaboam CM, Parks WC, Kolls JK, Stripp BR. Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection. Nat Commun. 2023 Sep 19;14(1):5814. doi: 10.1038/s41467-023-41387-3. PMID: 37726288; PMCID: PMC10509177.
Alam MA, Caocci M, Ren M, Chen Z, Liu F, Khatun MS, Kolls JK, Qin X, Burdo TH. Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice. Int J Mol Sci. 2023 Aug 17;24(16):12871. doi: 10.3390/ijms241612871. PMID: 37629052; PMCID: PMC10454548.

Landry SJ, Mettu RR, Kolls JK, Aberle JH, Norton E, Zwezdaryk K, Robinson J. Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins. Biochemistry. 2023 Sep 5;62(17):2517-2529. doi: 10.1021/acs.biochem.3c00335. Epub 2023 Aug 9. PMID: 37554055; PMCID: PMC10483696.

Ponde NO, Shoger KE, Khatun MS, Sarkar MK, Dey I, Taylor TC, Cisney RN, Arunkumar SP, Gudjonsson JE, Kolls JK, Gottschalk RA, Gaffen SL. SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor. J Immunol. 2023 Jul 15;211(2):252-260. doi: 10.4049/jimmunol.2300110. PMID: 37265402; PMCID: PMC10330444.

Taghavi S, Abdullah S, Shaheen F, Packer J, Duchesne J, Braun SE, Steele C, Pociask D, Kolls JK, Jackson-Weaver O. EXOSOMES AND MICROVESICLES FROM ADIPOSE- DERIVED MESENCHYMAL STEM CELLS PROTECTS THE ENDOTHELIAL GLYCOCALYX FROM LPS INJURY. Shock. 2023 Jul 1;60(1):56-63. doi: 10.1097/SHK.0000000000002133. Epub 2023 Apr 22. PMID: 37086080.

DAVID JANZ, MD
Noninvasive Ventilation for Preoxygenation during Emergency Intubation.  
Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, Resnick-Ault D, White HD, Gandotra S, Doerschug KC, Mohamed A, Prekker ME, Khan A, Gaillard JP, Andrea L, Aggarwal NR, Brainard JC, Barnett LH, Halliday SJ, Blinder V, Dagan A, Whitson MR, Schauer SG, Walker JE Jr, Barker AB, Palakshappa JA, Muhs A, Wozniak JM, Kramer PJ, Withers C, Ghamande SA, Russell DW, Schwartz A, Moskowitz A, Hansen SJ, Allada G, Goranson JK, Fein DG, Sottile PD, Kelly N, Alwood SM, Long MT, Malhotra R, Shapiro NI, Page DB, Long BJ, Thomas CB, Trent SA, Janz DR, Rice TW, Self WH, Bebarta VS, Lloyd BD, Rhoads J, Womack K, Imhoff B, Ginde AA, Casey JD; PREOXI Investigators and the Pragmatic Critical Care Research Group. N Engl J Med. 2024 Jun 20;390(23):2165-2177. doi: 10.1056/NEJMoa2313680. Epub 2024 Jun 13. PMID: 38869091 Clinical Trial.

Validation of a Novel, Rapid Sepsis Diagnostic for Emergency Department Use.  
O'Neal HR Jr, Sheybani R, Janz DR, Scoggins R, Jagneaux T, Walker JE, Henning DJ, Rosenman E, Mahler SA, Regunath H, Sampson CS, Files DC, Fremont RD, Noto MJ, Schneider EE, Shealey WR, Berlinger MS, Carver TC, Walker MK, Ledeboer NA, Shah AM, Tse HTK, DiCarlo D, Rice TW, Thomas CB. Crit Care Explor. 2024 Feb 7;6(2):e1026. doi: 10.1097/CCE.0000000000001026. eCollection 2024 Feb. PMID: 38333076 Free PMC article.

Prophylactic Administration of Vasopressors Prior to Emergency Intubation in Critically Ill Patients: A Secondary Analysis of Two Multicenter Clinical Trials. Fuchita M, Pattee J, Russell DW, Driver BE, Prekker ME, Barnes CR, Brewer JM, Doerschug KC, Gaillard JP, Gandotra S, Ghamande S, Gibbs KW, Hughes CG, Janz DR, Khan A, Mitchell SH, Page DB, Rice TW, Self WH, Smith LM, Stempek SB, Trent SA, Vonderhaar DJ, West JR, Whitson MR, Williamson K, Semler MW, Casey JD, Ginde AA. Crit Care Explor. 2023 Jul 12;5(7):e0946. doi: 10.1097/CCE.0000000000000946. eCollection 2023 Jul.PMID: 37457916 Free PMC article.

Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults.  
Prekker ME, Driver BE, Trent SA, Resnick-Ault D, Seitz KP, Russell DW, Gaillard JP, Latimer AJ, Ghamande SA, Gibbs KW, Vonderhaar DJ, Whitson MR, Barnes CR, Walco JP, Douglas IS, Krishnamoorthy V, Dagan A, Bastman JJ, Lloyd BD, Gandotra S, Goranson JK, Mitchell SH, White HD, Palakshappa JA, Espinera A, Page DB, Joffe A, Hansen SJ, Hughes CG, George T, Herbert JT, Shapiro NI, Schauer SG, Long BJ, Imhoff B, Wang L, Rhoads JP, Womack KN, Janz DR, Self WH, Rice TW, Ginde AA, Casey JD, Semler MW; DEVICE Investigators and the Pragmatic Critical Care Research Group. N Engl J Med. 2023 Aug 3;389(5):418-429. doi: 10.1056/NEJMoa2301601. Epub 2023 Jun 16.PMID: 37326325 Free PMC article. Clinical Trial.

Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients. Fox TH, Mazalewski WR, Tran HS, Lindsey T, Krishnan A, Kantrow SP, Happel KI, Janz DR, deBoisblanc BP, Lammi MR. J Intensive Care Med. 2023 Dec;38(12):1151-1157. doi: 10.1177/08850666231186947. Epub 2023 Jul 7. PMID: 37415515 Free PMC article.

Defining Successful Intubation on the First Attempt Using Both Laryngoscope and Endotracheal Tube Insertions: A Secondary Analysis of Clinical Trial Data. Trent SA, Driver BE, Prekker ME, Barnes CR, Brewer JM, Doerschug KC, Gaillard JP, Gibbs KW, Ghamande S, Hughes CG, Janz DR, Khan A, Mitchell SH, Page DB, Rice TW, Russell DW, Self WH, Smith LM, Stempek S, Vonderhaar DJ, West JR, Whitson MR, Ginde AA, Casey JD, Semler MW.
Ann Emerg Med. 2023 Oct;82(4):432-437. doi: 10.1016/j.annemergmed.2023.03.021. Epub 2023 Apr 18. PMID: 37074254 Free PMC article.

Laryngoscopy and Tracheal Intubation: Does Use of a Video Laryngoscope Facilitate Both Steps of the Procedure? 
Prekker ME, Trent SA, Lofrano A, Russell DW, Barnes CR, Brewer JM, Doerschug KC, Gaillard JP, Gandotra S, Ginde AA, Ghamande S, Gibbs KW, Hughes CG, Janz DR, Khan A, Mitchell SH, Page DB, Rice TW, Self WH, Smith LM, Stempek SB, Vonderhaar DJ, West JR, Whitson MR, Casey JD, Semler MW, Driver BE.
Ann Emerg Med. 2023 Oct;82(4):425-431. doi: 10.1016/j.annemergmed.2023.02.016. Epub 2023 Apr 5. PMID: 37028995 Free PMC article.

ANIL MISHRA, Ph.D.

Kandikattu, H. K., Venkateshaiah, S. U., Kumar, S., Yadavalli, C. S., & Mishra, A. (2023). IL-18-mediated neutrophil recruitment promotes acute lung injury in inflammation-mediated chronic pancreatitis. Molecular immunology, 155, 100-109

Yadavalli, C. S., Upparahalli Venkateshaiah, S., Kumar, S., Kandikattu, H. K., Oruganti, L., Kathera, C. S., & Mishra, A. (2023). Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis. Communications Biology, 6(1), 763.

Kandikattu, H. K., Venkateshaiah, S. U., Yadavalli, C. S., Oruganti, L., & Mishra, A. (2023). Development and Characterization of Novel Chronic Eosinophilic Inflammation-Mediated Murine Model of Malignant Pancreatitis. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 23(10), 1303-1317.

Yadavalli, C. S., Upparahalli Venkateshaiah, S., Verma, A. K., Kathera, C., Duncan, P. S., Vaezi, M., ... & Mishra, A. (2024). Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis. Cells, 13(4), 295.

BRIAN DESKIN, Ph.D.

Rehan M, Deskin B, Kurundkar AR, Yadav S, Matsunaga Y, Manges J, Smith N, Dsouza KG, Burow ME, Thannickal VJ. Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance. J Biol Chem. 2023 Aug;299(8):105027. doi: 10.1016/j.jbc.2023.105027. Epub 2023 Jul 7. PMID: 37423298; PMCID: PMC10413354.

YONG ZHOU, Ph.D.

Zhou Y*, Thannickal VJ. Demystifying the Enigmatic Fibroblast in Pulmonary Fibrosis.  Am J Respir Cell Mol Biol. 2023 Jul;69(1):1-2

Hu Q, Saleem K, Pandey J, Charania A, Zhou Y, He C. Cell Adhesion Molecules in Fibrotic Diseases. Biomedicines 2023 Jul 14;11(7):1995. doi: 10.3390/biomedicines11071995.

Shan D, Hu Q, He C, Zhou Y. Editorial: Targeting immune cell metabolism in tissue fibrosis. Frontiers in Pharmacology 2024 Apr 5;15:1400858. doi: 10.3389/fphar.2024.1400858.

Zheng Z, Peng F, Zhou Y. Biomarkers in Idiopathic Pulmonary Fibrosis: Current Insights and Future Directions. Chin Med J Pulm Crit Care Med (invited review). 2024 Jun;2(2):72-79.

ZHEN ZHENG, Ph.D.
Zheng Z, Peng F, Zhou Y. Biomarkers in idiopathic pulmonary fibrosis: Current insight and future direction. Chin Med J Pulm Crit Care Med. 2024 Jun;2(2):72-79. doi: 10.1016/j.pccm.2024.04.003. Epub 2024 Jun 14. PMID: 38962100; PMCID: PMC11221783.

Zheng Z, Peng F, Zhou Y. Pulmonary fibrosis: A short- or long-term sequelae of severe COVID-19? Chin Med J Pulm Crit Care Med. 2023 Jun;1(2):77-83. doi: 10.1016/j.pccm.2022.12.002. Epub 2023 Jan 23. PMID: 37388822 Free PMC article.

DEEPAK TRIPATHI, Ph.D.
Yang B, Mukherjee T, Radhakrishnan R, Paidipally P, Ansari D, John S, Vankayalapati R, Tripathi D*, Yi G. HIV-Differentiated Metabolite N-Acetyl-L-Alanine Dysregulates Human Natural Killer Cell Responses to Mycobacterium tuberculosis Infection. Int J Mol Sci. 2023 Apr 14;24(8):7267. doi: 10.3390/ijms24087267. PMID: 37108430; PMCID: PMC10138430. *Co-corresponding author.

CHAD ROY, Ph.D.
Current vaccine strategies and novel approaches to combatting Francisella infection. Harrell JE, Roy CJ, Gunn JS, McLachlan JB. Vaccine. 2024 Apr 2;42(9):2171-2180. doi: 10.1016/j.vaccine.2024.02.086. Epub 2024 Mar 8. PMID: 38461051 
MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques. Beddingfield BJ, Plante KS, Plante JA, Weaver SC, Bose S, Krzykwa C, Chirichella N, Redmann RK, Seiler SZ, Dufour J, Blair RV, Endt K, Volkmann A, Maness NJ, Roy CJ.NPJ Vaccines. 2024 Feb 27;9(1):47. doi: 10.1038/s41541-024-00842-y. PMID: 38413593

DEREK POCIASK, Ph.D.
IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury. Zhang Z, Chakawa MB, Galeas-Pena M, Frydman JA, Allen MJ, Jones M, Pociask D. Am J Pathol. 2024 Mar;194(3):338-352. doi: 10.1016/j.ajpath.2023.11.011. Epub 2023 Dec 14. PMID: 38101567
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes. Wang C, Khatun MS, Zhang Z, Allen MJ, Chen Z, Ellsworth CR, Currey JM, Dai G, Tian D, Bach K, Yin XM, Traina-Dorge V, Rappaport J, Maness NJ, Blair RV, Kolls JK, Pociask DA, Qin X. Commun Biol. 2023 Dec 13;6(1):1265. doi: 10.1038/s42003-023-05626-z. PMID: 38092883
Dimethyl malonate protects the lung in a murine model of acute respiratory distress syndrome. Taghavi S, Campbell A, Engelhardt D, Duchesne J, Shaheen F, Pociask D, Kolls J, Jackson-Weaver O. J Trauma Acute Care Surg. 2024 Mar 1;96(3):386-393. doi: 10.1097/TA.0000000000004184. Epub 2023 Nov 8. PMID: 37934622

ROSS KLINGSBERG, MD

Safety and efficacy of vanzacaftor-tezacaftor-deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials. Uluer AZ, MacGregor G, Azevedo P, Indihar V, Keating C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Rubenstein RC, Taylor-Cousar JL, Tullis E, Yonker LM, Chu C, Lam AP, Nair N, Sosnay PR, Tian S, Van Goor F, Viswanathan L, Waltz D, Wang LT, Xi Y, Billings J, Horsley A; VX18-121-101; VX18-561-101 Study Groups. Lancet Respir Med. 2023 Jun;11(6):550-562. doi: 10.1016/S2213-2600(22)00504-5. Epub 2023 Feb 23. PMID: 36842446

CHRISTINE BOJANOWSKI, MD

Sweeney PL, Morrison DG, Bojanowski CM. Staphylococcus aureus Induced Purpura Fulminans. Am J Med Sci. 2024 Jan 13: S0002-9629 (24) 00007-7. Online ahead of print. PMID: 38219983

Hu Y, Bojanowski CM, Britto CJ, Wellems D, Song K, Scull C, Jennings S, Li J, Kolls JK, Wang G. Aberrant Immune Programming in Neutrophils in Cystic Fibrosis. J Leukoc Biol. 2023 Nov 6:qiad139. Online ahead of print. PMID: 37939820.

Okoli S, Jenkins K, Bojanowski CM. Current Intensive Care Management of Thrombotic Thrombocytopenic Purpura: A Case Report and Updated Literature Review. J Intensive Care Medicine. 2023 Jul; 38 (7):592-597. Doi: 10.1177/08850666231171907. Epub 2023 Jun 18. PMID: 37331965

Cited As An Investigator: 
Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial. O'Halloran JA, Ko ER, Anstrom KJ, Kedar E, McCarthy MW, Panettieri RA Jr, Maillo M, Nunez PS, Lachiewicz AM, Gonzalez C, Smith PB, de Tai SM, Khan A, Lora AJM, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Wen J, Silverstein A, O'Brien SM, Al-Khalidi HR, Maldonado MA, Melsheimer R, Ferguson WG, McNulty SE, Zakroysky P, Halabi S, Benjamin DK Jr, Butler S, Atkinson JC, Adam SJ, Chang S, LaVange L, Proschan M, Bozzette SA, Powderly WG; ACTIV-1 IM Study Group Members.JAMA. 2023 Jul 25;330(4):328-339. doi: 10.1001/jama.2023.11043.PMID: 37428480 Free PMC article.
Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19: A Secondary Analysis of the ACTIV-1 IM Randomized Clinical Trial. Balevic SJ, Benjamin DK Jr, Powderly WG, Smith PB, Gonzalez D, McCarthy MW, Shaw LK, Lindsell CJ, Bozzette S, Williams D, Linas BP, Blamoun J, Javeri H, Hornik CP; ACTIV-1 IM Study Group.JAMA Netw Open. 2024 Apr 1;7(4):e247615. doi: 10.1001/jamanetworkopen.2024.7615.PMID: 38662372 Free PMC article. Clinical Trial.

HIMMAT GREWAL, MD
Asymptomatic Metastatic Pleural Calcifications from End-Stage Renal Disease. Lee NM, Ferrell S, Grewal H. R I Med J (2013). 2023 Jul 5;106(6):21-22. PMID: 37368829
The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials. Tea K, Zu Y, Chung CH, Pagliaro J, Espinoza-Barrera D, Mehta P, Grewal H, Douglas IS, Khan YA, Shaffer JG, Denson JL. Crit Care Med. 2024 Mar 1;52(3):407-419. doi: 10.1097/CCM.0000000000006092. Epub 2023 Nov 1. PMID: 37909824
From detection to disappearance: A tale of a nodule. Herr R, Grewal H, Abdelghani R. Respir Med Case Rep. 2024 Jun 5;50:102059. doi: 10.1016/j.rmcr.2024.102059. eCollection 2024. PMID: 39021870

JERRY ZIFODYA, MD
HIV and diabetes impair M. tuberculosis-specific interferon-gamma responses on QuantiFERON-TB Gold Plus testing. J S Zifodya  1 , J S Kreniske  2 , T M Temu  3 , S J Masyuko  3 , E F Attia  3   4 , J N Mogaka  5 , D Onyango  6 , S T Page  7 , K Crothers  4   8 , J Kinuthia  9 , C Farquhar  3   10   11 , S M LaCourse  3   10   11 Affiliations. PMID: 39022782 PMCID: PMC11249601 DOI: 10.5588/ijtldopen.24.0011

JOSHUA DENSON, MD
Financial Education in U.S. Pulmonary and Critical Care Medicine Fellowship Programs. Krutsinger DC, Adamson R, Olson EM, Denson JL, Kelm DJ, Chu DC, Stewart NH. ATS Sch. 2023 Sep 29;4(3):302-306. doi: 10.34197/ats-scholar.2023-0005BR. eCollection 2023 Sep. PMID: 37795115
Association Between Hypertension and Diabetes Control and COVID-19 Severity: National Patient-Centered Clinical Research Network, United States, March 2020 to February 2022. Jackson SL, Woodruff RC, Nagavedu K, Fearrington J, Rolka DB, Twentyman E, Carton TW, Puro J, Denson JL, Kappelman MD, Paranjape A, Thacker D, Weiner MG, Goodman AB, Lekiachvili A, Boehmer TK, Block JP; PCORnet Collaboration Authors *. J Am Heart Assoc. 2023 Nov 7;12(21):e030240. doi: 10.1161/JAHA.122.030240. Epub 2023 Oct 18. PMID: 37850404 
The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials. Tea K, Zu Y, Chung CH, Pagliaro J, Espinoza-Barrera D, Mehta P, Grewal H, Douglas IS, Khan YA, Shaffer JG, Denson JL. Crit Care Med. 2024 Mar 1;52(3):407-419. doi: 10.1097/CCM.0000000000006092. Epub 2023 Nov 1. PMID: 37909824
Systematic review of the effect of metabolic syndrome on outcomes due to acute respiratory distress syndrome: a protocol.  Stone G, Sisk A, Brown M, Corder A, Tea K, Zu Y, Shaffer J, Kashyap R, Qadir N, Denson JL. BMJ Open. 2023 Nov 10;13(11):e076036. doi: 10.1136/bmjopen-2023-076036. PMID: 37949623 
The Association of Asthma and Metabolic Dysfunction With Outcomes of Hospitalized Patients With COVID-19. Vukoja M, Tekin A, Parada NA, Gray JC, Mallouhi A, Roddy T, Cartin-Ceba R, Perkins NE, Belden KA, Cheruku S, Kaufman M, Lee Armaignac D, Christie AB, Lal A, Zu Y, Kumar V, Walkey A, Gajic O, Kashyap R, Denson JL; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. J Allergy Clin Immunol Pract. 2024 May 23:S2213-2198(24)00539-7. doi: 10.1016/j.jaip.2024.05.025. Online ahead of print. PMID: 38796103

NEREIDA PARADA, MD
Biologic outcomes in US Hispanic and Black patients with severe asthma. Trevor J, Moore WC, Lugogo N, Ledford DK, Mackie A, Carstens D, Parada NA, Ambrose CS. J Allergy Clin Immunol Pract. 2024 Jun 18:S2213-2198(24)00643-3. doi: 10.1016/j.jaip.2024.06.020. Online ahead of print. PMID: 38901615
The Association of Asthma and Metabolic Dysfunction With Outcomes of Hospitalized Patients With COVID-19. Vukoja M, Tekin A, Parada NA, Gray JC, Mallouhi A, Roddy T, Cartin-Ceba R, Perkins NE, Belden KA, Cheruku S, Kaufman M, Lee Armaignac D, Christie AB, Lal A, Zu Y, Kumar V, Walkey A, Gajic O, Kashyap R, Denson JL; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. J Allergy Clin Immunol Pract. 2024 May 23:S2213-2198(24)00539-7. doi: 10.1016/j.jaip.2024.05.025. Online ahead of print. PMID: 38796103

RAMSY ABDELGHANI, MD
Imaging modalities during navigational bronchoscopy.  Abdelghani R, Omballi M, Abia-Trujillo D, Casillas E Jr, Villalobos R, Badar F, Bansal S, Kheir F. Expert Rev Respir Med. 2024 Mar-Apr;18(3-4):175-188. doi: 10.1080/17476348.2024.2359601. Epub 2024 May 29. PMID: 3879491
From detection to disappearance: A tale of a nodule. Herr R, Grewal H, Abdelghani R. Respir Med Case Rep. 2024 Jun 5;50:102059. doi: 10.1016/j.rmcr.2024.102059. eCollection 2024. PMID: 39021870

SHIGEKI SAITO, MD
STOP-Bang for OSA screening in patients with pulmonary hypertension. Fox TH, LaNasa M, Saketkoo LA, Saito S, deBoisblanc BP, Lammi MR. Respir Med. 2023 Oct;217:107339. doi: 10.1016/j.rmed.2023.107339. Epub 2023 Jul 5. PMID: 37419376

VICTOR THANNICKAL, MD
Demystifying the Enigmatic Fibroblast in Pulmonary Fibrosis. 
Zhou Y, Thannickal VJ. Am J Respir Cell Mol Biol. 2023 Jul;69(1):1-2. doi: 10.1165/rcmb.2023-0090ED. PMID: 37040483

Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance. 
Rehan M, Deskin B, Kurundkar AR, Yadav S, Matsunaga Y, Manges J, Smith N, Dsouza KG, Burow ME, Thannickal VJ. J Biol Chem. 2023 Aug;299(8):105027. doi: 10.1016/j.jbc.2023.105027. Epub 2023 Jul 7. PMID: 37423298

The lung mesenchyme in development, regeneration, and fibrosis. 
El Agha E, Thannickal VJ. J Clin Invest. 2023 Jul 17;133(14):e170498. doi: 10.1172/JCI170498. PMID: 37463440

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma. Hough KP, Trevor JL, Chacko BK, Strenkowski JG, Wang Y, Goliwas KF, Bone NB, Kim YI, Holmes R, Vang S, Pritchard A, Chin J, Bodduluri S, Antony VB, Tousif S, Athar M, Chanda D, Mitra K, Zmijewski J, Zhang J, Duncan SR, Thannickal VJ, Gabrielsson S, Darley-Usmar VM, Deshane JS. bioRxiv [Preprint]. 2024 May 3:2024.04.30.589227. doi: 10.1101/2024.04.30.589227. PMID: 38746361

YASIN KHAN, MD
Retraction Note: The COVID-19 pandemic and its impact on environment: the case of the major cities in Pakistan. Khan YA. Environ Sci Pollut Res Int. 2024 Mar;31(15):23288. doi: 10.1007/s11356-024-32886-x. PMID: 38472592

The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials. Tea K, Zu Y, Chung CH, Pagliaro J, Espinoza-Barrera D, Mehta P, Grewal H, Douglas IS, Khan YA, Shaffer JG, Denson JL. Crit Care Med. 2024 Mar 1;52(3):407-419. doi: 10.1097/CCM.0000000000006092. Epub 2023 Nov 1. PMID: 37909824 

Section of Pulmonary Diseases, Critical Care and Environmental Medicine

July 1, 2022 - June 30, 2023

ILD/PULMONARY FIBROSIS

• Saito S, Chung CHH, Jacob A, Nuradin N, Meyer AE, Yang H, Kolls JK, Thannickal VJ, Lasky JA, Saito T, Liu YZ. The potential utility of megakaryocyte/platelet-based biomarkers in idiopathic pulmonary fibrosis (IPF): gene signatures and mean platelet volume (MPV), Am J Respir Crit Care Med. 2022 Jul 19.
• Saito S, Deskin B, Rehan M, Yadav S, Matsunaga Y, Lasky JA, Thannickal VJ. Novel mediators of idiopathic pulmonary fibrosis. Clin Sci (Lond). 2022 Aug 31;136(16):1229-1240.
• Solomon JJ, Danoff SK, Woodhead FA, Hurwitz S, Maurer R, Glaspole I, Dellaripa PF, Gooptu B, Vassallo R, Cox PG, Flaherty KR, Adamali HI, Gibbons MA, Troy L, Forrest IA, Lasky JA, Spencer LG, Golden J, Scholand MB, Chaudhuri N, Perrella MA, Lynch DA, Chambers DC, Kolb M, Spino C, Raghu G, Goldberg HJ, Rosas IO; TRAIL1 Network Investigators. A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease. Lancet Respir Med. 2022 Sep 2:S2213-2600(22)00260-0.
• Lasky JA, Thannickal VJ. Notch-ing up surface tension in the fibrotic lung. Am J Respir Crit Care Med. 2022 Nov 9.
• Anna J. Podolanczuk, John S. Kim, Christopher B. Cooper, Joseph A. Lasky, Susan Murray, Justin M. Oldham, Ganesh Raghu, Kevin R. Flaherty, Catherine A. Spino, Imre Noth, Fernando J. Martinez for the PRECISIONS Study Team. Design and Rationale for the Prospective Treatment Efficacy in IPF Using Genotype for NAC Selection (PRECISIONS) Clinical Trial, BMC Pulm Med. 2022 Dec 13;22(1):475.
• Sachin Chaudhary; S. Sam Weigt; Manuel Riberio Neto; Bryan Benn; Janelle Vu Pugashetti; Rebecca Keith; Arista Chand; Scott Oh; Fayez Kheir; Vijaya Ramalingam; Joshua Solomon; Richart Harper; Joseph A. Lasky; Justin M. Oldham. Interstitial Lung Disease Progression after Genomic Usual Interstitial Pneumonia Testing. Eur Respir J. 2022 Dec 22:2201245.
• Qinyan Yin, Gilbert F. Morris, Shigeki Saito, Yan Zhuang, Chunmin Dong, Michal S Jazwinski, Joseph A. Lasky. The function of a novel lamin A/C splice variant in the pathogenesis of IPF, Am J Respir Cell Mol Biol. 2023 Feb 27.
• Maher TM, Ford P, Brown KK, Costabel U, Cottin V, Danoff SK, Groenveld I, Helmer E, Jenkins RG, Milner J, Molenberghs G, Penninckx B, Randall MJ, Van Den Blink B, Fieuw A, Vandenrijn C, Rocak S, Seghers I, Shao L, Taneja A, Jentsch G, Watkins TR, Wuyts WA, Kreuter M, Verbruggen N, Prasad N, Wijsenbeek MS; ISABELA 1 and 2 Investigators (Lasky). Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis: The ISABELA 1 and 2 Randomized Clinical Trials.
• El Agha E, Thannickal VJ. The lung mesenchyme in development, regeneration, and fibrosis. J Clin Invest. 2023 Jul 17;133(14): e170498. doi: 10.1172/JCI170498.PMID: 37463440 Free PMC article. Review.
• Rehan M, Deskin B, Kurundkar AR, Yadav S, Matsunaga Y, Manges J, Smith N, Dsouza KG, Burow ME, Thannickal VJ. Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance. J Biol Chem. 2023 Jul 7;299(8):105027. doi: 10.1016/j.jbc.2023.105027. Online ahead of print.PMID: 37423298 Free PMC article.
• Zhou Y, Thannickal VJ. Demystifying the Enigmatic Fibroblast in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2023 Jul;69(1):1-2. doi: 10.1165/rcmb.2023-0090ED.PMID: 37040483 Free PMC article. No abstract available.
• Yin Q, Morris GF, Saito S, Zhuang Y, Thannickal VJ, Jazwinski SM, Lasky JA. Enhanced Expression of a Novel Lamin A/C Splice Variant in Idiopathic Pulmonary Fibrosis Lung. Am J Respir Cell Mol Biol. 2023 Jun;68(6):625-637. doi: 10.1165/rcmb.2022-0222OC.PMID: 36848480
• Thannickal VJ, Jandeleit-Dahm K, Szyndralewiez C, Török NJ. Pre-clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis. J Cell Mol Med. 2023 Feb;27(4):471-481. doi: 10.1111/jcmm.17649. Epub 2023 Jan 19. PMID: 36658776 Free PMC article. Review.
• Zmijewski JW, Thannickal VJ. Autophagy in Idiopathic Pulmonary Fibrosis: Predisposition of the Aging Lung to Fibrosis? Am J Respir Cell Mol Biol. 2023 Jan;68(1):3-4. doi: 10.1165/rcmb.2022-0379ED.PMID: 36201669 No abstract available.
• Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis.
• Aging Cell. 2022 Sep;21(9):e13674. doi: 10.1111/acel.13674. Epub 2022 Aug 7.PMID: 35934931 Free PMC article.
• Yadav S, Sampath SS, Deskin BJ, Thannickal VJ. H 2 O 2 Release Assay. Bio Protoc. 2022 Jun 5;12(11):e4429. doi: 10.21769/BioProtoc.4429. eCollection 2022 Jun 5.PMID: 35799911 Free PMC article.
   
• Ikonomou L, Magnusson M, Dries R, Herzog EL, Hynds RE, Borok Z, Park JA, Skolasinski S, Burgess JK, Turner L, Mojarad SM, Mahoney JE, Lynch T, Lehmann M, Thannickal VJ, Hook JL, Vaughan AE, Hoffman ET, Weiss DJ, Ryan AL. Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L341-L354. doi: 10.1152/ajplung.00113.2022. Epub 2022 Jun 28.PMID: 35762622 Free PMC article. Review.
   
• Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. Am J Respir Crit Care Med. 2022 Aug 15;206(4):459-475. doi: 10.1164/rccm.202109-2151OC.PMID: 35687485
   

INTERVENTIONAL PULMONARY

• Lee NM, Bojanowski CM, Abdelghani RA. Arid Airways: Airway Mucosal Injury with Nonhumidified Invasive Ventilation. Am J Respir Crit Care Med. 2022 Jul 15;206(2):217-218. doi: 10.1164/rccm.202110-2313IM. PubMed
   

CYSTIC FIBROSIS

• Hu Y, Bojanowski CM, Britto CJ, Wellems D, Song K, Scull C, Jennings S, Li J, Kolls JK, Wang G. ABERRANT IMMUNE PROGRAMMING IN NEUTROPHILS IN CYSTIC FIBROSIS. medRxiv. 2023 Jan 25;. doi: 10.1101/2023.01.22.23284619. PubMed PMID: 36747678; PubMed Central
• Bojanowski CM, Bitoun JP, Kolls JK. An ALARMINg Type 2 Response in Cystic Fibrosis-The Key to Understanding ABPA?. Am J Respir Crit Care Med. 2023 Jun 1;207(11):1418-1419. doi: 10.1164/rccm.202303-0580ED. PubMed
• Shiping Lu , Jay K Kolls. Multi-omic comparisons between CFBE41o- cells stably expressing wild-type CFTR and F508del-mutant CFTR. J Cyst Fibros.2023 Jan;22(1):146-155.doi: 10.1016/j.jcf.2022.06.010.
   

INFECTIOUS DISEASE

• Zheng W, LaCourse SM, Song B, Singh DK, Khanna M, Olivo J, Stern J, Escudero JN, Vergara C, Zhang F, Li S, Wang S, Cranmer LM, Huang Z, Bojanowski CM, Bao D, Njuguna I, Xiao Y, Wamalwa DC, Nguyen DT, Yang L, Maleche-Obimbo E, Nguyen N, Zhang L, Phan H, Fan J, Ning B, Li C, Lyon CJ, Graviss EA, John-Stewart G, Mitchell CD, Ramsay AJ, Kaushal D, Liang R, Pérez-Then E, Hu TY. Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples. Nat Biomed Eng. 2022 Aug;6(8):979-991. doi: 10.1038/s41551-022-00922-1. Epub 2022 Aug 19.
   
• Temu TM, Polyak SJ, Wanjalla CN, Mandela NA, Dabee S, Mogaka JN, Masyuko S, Longernecker C, Shakil S, Chohan B, Page ST, Lacourse SM, Gitura B, Crothers K, Oyugi J, Jaspan H, Farquhar C, Zifodya JS. Latent tuberculosis is associated with heightened levels of pro-and anti-inflammatory cytokines among Kenyan men and women living with HIV on long-term antiretroviral therapy. AIDS. 2023 Jun 1;37(7):1065-1075. doi: 10.1097/QAD.0000000000003523. Epub 2023 Mar 3. PubMed PMID: 36928263; PubMed Central PMCID: PMC10155699.
• Farrant MT, Masyuko SJ, Kinuthia J, Osoti AO, Mogaka JN, Temu TM, Zifodya JS, Nakanjako D, Ameda F, Farquhar C, Page ST. Association of HIV, cardiovascular risk factors, and carotid intimal media thickness: A cross-sectional study in Western Kenya. Medicine (Baltimore). 2022 Nov 25;101(47):e31366. doi: 10.1097/MD.0000000000031366. PubMed PMID: 36451447; PubMed Central PMCID: PMC9704953.
   
• A systematic review to assess the relationship between disseminated cerebral aspergillosis, leukemias and lymphomas, and their respective therapeutics. Sullivan, B.N., M.A. Baggett, S.S. O’Connell, K.M. Pickett and C. Steele. Journal of Fungi (Basel) 8:722 (2022) PMID: 35887477
   
• Neuroimmune mechanisms in a new experimental animal model of cerebral aspergillosis. Sullivan B.S., M.A. Baggett, C. Guillory, M. Jones and C. Steele. mBio 13:e0225422 (2022) PMID: 36040029
• Glycocalyx degradation and the endotheliopathy of viral infection. Taghavi S, Abdullah S, Shaheen F, Mueller L, Gagen B, Duchesne J, Steele C, Pociask D, Kolls J, Jackson-Weaver O. PLoS One. 2022 Oct 19;17(10):e0276232 PMID: 36260622
   
• Exosomes and microvesicles from adipose-derived mesenchymal stem cells protects the endothelial glycocalyx from LPS injury. Taghavi S, Abdullah S, Shaheen F, Packer J, Duchesne J, Braun SE, Steele C, Pociask D, Kolls J, Jackson-Weaver O. Shock. 2023 Apr 24. doi: 10.1097/SHK.0000000000002133. PMID: 37086080
   
• Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma Makullah, M., D. Ellis, M. Jones and C. Steele. American Journal of Physiology Lung Cellular and Molecular Physiology 2023 May 30. doi: 10.1152/ajplung.00090.2023. PMID: 37253655
   
• Beddingfield BJ, Maness NJ, Spencer S, Rappaport J, Aye PP, Russell-Lodrigue K, Doyle-Meyers LA, Blair RV, Gao H, Montefiori D, Roy CJ. Mid-titer human convalescent plasma administration results in suboptimal prophylaxis against SARS-CoV-2 infection in rhesus macaques. Front Immunol. 2023 Feb 10;14:1085883.doi: 10.3389/fimmu.2023.1085883. PMID: 36845143; PMCID: PMC9950397.
   
• Noell K, Dai G, Pungan D, Ebacher A, McCombs JE, Landry SJ, Kolls JK. Germline IgM predicts T cell immunity to Pneumocystis. JCI Insight. 2022 Sep 8;7(17):e161450. doi: 10.1172/jci.insight.161450
   
• Pungan D, Eddens T, Song K, Lakey MA, Crovetto NS, Arora SK, Husain S, Kolls JK. Targeted NGS-Based Analysis of Pneumocystis jirovecii Reveals Novel Genotypes. J Fungi (Basel). 2022 Aug 17;8(8):863. doi: 10.3390/jof8080863.
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• Walker EM, Merino KM, Slisarenko N, Grasperge BF, Mehra S, Roy CJ, Kaushal D,Rout N. Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques. Front Immunol. 2023 Jan 16;13:1085786. doi: 10.3389/fimmu.2022.1085786. PMID: 36726992; PMCID: PMC9885173.
   
• Fears AC, Walker EM, Chirichella N, Slisarenko N, Merino KM, Golden N, Picou B, Spencer S, Russell Lodrigue KE, Doyle-Meyers LA, Blair RV, Beddingfield BJ, Maness NJ, Roy CJ, Rout N. The dynamics of γδ T cell responses in nonhuman primates during SARS-CoV-2 infection. Commun Biol. 2022 Dec 16;5(1):1380. doi:10.1038/s42003-022-04310-y. PMID: 36526890; PMCID: PMC9756695.
• Roy CJ, Ehrbar D, Van Slyke G, Doering J, Didier PJ, Doyle-Meyers L, Donini O, Vitetta ES, Mantis NJ. Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques. NPJ. Vaccines. 2022 Dec 16;7(1):164. doi: 10.1038/s41541-022-00582-x. PMID: 36526642;PMCID: PMC9755799.
• Gonzalez AA, Olsen EL, Killeen SZ, Blair RV, Seshan SV, Jaimes EA, Roy CJ, Prieto MC. Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model. JMed Primatol. 2023 Apr;52(2):131-134. doi: 10.1111/jmp.12626. Epub 2022 Nov 15.PMID: 36377612; PMCID: PMC10023264.
• Yang L, Liang T, Pierson LM, Wang H, Fletcher JK, Wang S, Bao D, Zhang L,Huang Z, Zheng W, Zhang X, Park H, Li Y, Robinson JE, Feehan AK, Lyon CJ, Cao J, Morici LA, Li C, Roy CJ, Yu X, Hu T. SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites. Research (Wash D C). 2022 Jul 9;2022:9769803. doi: 10.34133/2022/9769803. PMID: 35928300; PMCID: PMC9297724.
• Fears AC, Beddingfield BJ, Chirichella NR, Slisarenko N, Killeen SZ, Redmann RK, Goff K, Spencer S, Picou B, Golden N, Midkiff CC, Bush DJ, Branco LM, Boisen ML, Gao H, Montefiori DC, Blair RV, Doyle-Meyers LA, Russell-Lodrigue K, Maness. NJ, Roy CJ. Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species. PLoS Pathog. 2022 Jul 5;18(7):e1010618. doi: 10.1371/journal.ppat.1010618. PMID: 35789343; PMCID: PMC9286241.
• Beddingfield BJ, Rowe LA, Russell-Lodrigue KE, Doyle-Meyers LA, Golden N, Spencer S, Chirichella N, Blair RV, Maness NJ, Roy CJ. Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody Prophylaxis. J Infect Dis. 2022 Nov 1;226(9):1588-1592. doi:10.1093/infdis/jiac134. PMID: 35429402; PMCID: PMC9213849.
• Bucşan AN, Veatch A, Singh DK, Akter S, Golden NA, Kirkpatrick M, Threeton B, Moodley C, Ahmed M, Doyle LA, Russell-Lodrigue K, Norton EB, Didier PJ, Roy CJ, Abramovitch RB, Mehra S, Khader SA, Kaushal D. Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts <i>Mycobacterium tuberculosis</i> Pathogenicity. Am J Respir Crit Care Med. 2022 Jul 1;206(1):94-104. doi: 10.1164/rccm.202112-2747OC. Erratum in: Am J Respir Crit Care Med. 2022 Dec 1;206(11):1434. PMID: 35412961; PMCID: PMC9718519.
• Huang Z, Zhang L, Lyon CJ, Ning B, Youngquist BM, Niu A, Beddingfield BJ, Maness NJ, Saba NS, Li CZ, Roy CJ, Hu TY. CRISPR-based assay reveals SARS-CoV-2 RNA dynamic changes and redistribution patterns in non-human primate model. Emerg Microbes Infect. 2022 Dec;11(1):629-638. doi: 10.1080/22221751.2022.2038020. PMID: 35108153; PMCID: PMC8865122.
• Brosseau LM, Escandón K, Ulrich AK, Rasmussen AL, Roy CJ, Bix GJ, Popescu SV, Moore KA, Osterholm MT. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Dose, Infection, and Disease Outcomes for Coronavirus Disease 2019. (COVID-19): A Review. Clin Infect Dis. 2022 Aug 24;75(1):e1195-e1201. doi:10.1093/cid/ciab903. PMID: 34651164; PMCID: PMC8524637.
• Mackin, R.; Edwards, J. V.; Atuk, E. B.; Beltrami, N.; Condon, B. D.; Jayawickramarajah, J.; French, A. D. Structure/function analysis of truncated amino-terminal ACE2 peptide analogs that bind to SARS-Cov-2 spike glycoprotein. Molecules 2022, 27 (7), 2070. DOI:10.3390/molecules27072070
   
• Khatun MS, Qin X, Pociask DA, Kolls JK. SARS-CoV2 Endotheliopathy: Insights from Single Cell RNAseq. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1178-1179. doi: 10.1164/rccm.202206-1105LE.
   
• Taghavi S, Abdullah S, Shaheen F, Mueller L, Gagen B, Duchesne J, Steele C, Pociask D, Kolls J, Jackson-Weaver O. Glycocalyx degradation and the endotheliopathy of viral infection. PLoS One. 2022 Oct 19;17(10):e0276232. doi: 10.1371/journal.pone.0276232. eCollection 2022.
   
• Chen D, Srivastava AK, Dubrochowska J, Liu L, Li T, Hoffmann JP, Kolls JK, Boons GJ. A Bioactive Synthetic Outer-Core Oligosaccharide Derived from a Klebsiella pneumonia Lipopolysaccharide for Bacteria Recognition. Chemistry. 2023 May 2;29(25):e202203408. doi: 10.1002/chem.202203408. Epub 2023 Mar 23.
   
• Izadpanah A, Mudd JC, Garcia JGN, Srivastav S, Abdel-Mohsen M, Palmer C, Goldman AR, Kolls JK, Qin X, Rappaport J. SARS-CoV-2 infection dysregulates NAD metabolism. Front Immunol. 2023 Jun 29;14:1158455. doi: 10.3389/fimmu.2023.1158455. eCollection 2023

INFLAMMATION

• Kandikattu HK, Venkateshaiah SU, Kumar S, Yadavalli CS, Mishra A. IL-18-mediated neutrophil recruitment promotes acute lung injury in inflammation-mediated chronic pancreatitis. Molecular Immunology. 2023 Mar 1;155:100-9. (PMID: 36758469)
• Kandikattu HK, Venkateshaiah SU, Yadavalli CS, Oruganti L, Mishra A. Development and Characterization of Novel Chronic Eosinophilic Inflammation-Mediated Murine Model of Malignant Pancreatitis. Endocrine, Metabolic & Immune Disorders Drug Targets. 2022 Aug 4. (PMID: 3604373
• Upparahalli Venkateshaiah S, Yadavalli CS, Kandikattu HK, Kumar S, Oruganti L, Mishra A. Molecules involved in the development of Barrett’s esophagus phenotype in chronic eosinophilic esophagitis. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2022 Jul 1;323(1):G31-43. (PMID: 35437997)
• Yadavalli CS, Mishra A. IL-5 overexpression induced blood eosinophilia associated progression of cardiac abnormalities. International journal of basic and clinical immunology. 2022 Sep 3;5(3-4):1. (PMID: 36704611)

MEDICAL EDUCATION

• Kelm DJ, Neumeier A, Hinkle LJ, Adamson R, Heath JK, Stewart NH, Nirola A, Chiarchiaro J, Denson JL, Holden VK, Soffler M, Carlos WG. Build It and They Shall Come: Medical Education Communities of Practice. ATS Scholar (Received in original form November 13, 2022; accepted in final form March 22, 2023). ats-scholar.2022-0124IN.
• Camac E, Stewart N, Santhosh L, Carlos WG, Denson JL, Heath J. Best Practices for Remediation in Pulmonary and Critical Care Medicine Fellowship Training. ATS Sch. 2022 Aug 31;3(3):485-500. doi: 10.34197/ats-scholar.2022-0007RE. PMID: 36312805; PMCID: PMC9590524.

CRITICAL CARE/COVID

• Pham TT, Zu Y, Ghamsari F, Oh J, Mauvais-Jarvis F, Zheng H, Filbin M, Denson JL. Association Between Metabolic Syndrome Inflammatory Biomarkers and COVID-19 Severity. J Endocr Soc. 2023 Feb 23;7(5):bvad029. doi: 10.1210/jendso/bvad029. PMID: 36911320; PMCID: PMC9999108.
• Boehmer TK, Koumans EH, Skillen EL, Kappelman MD, Carton TW, Patel A, August EM, Bernstein R, Denson JL, Draper C, Gundlapalli AV, Paranjape A, Puro J, Rao P, Siegel DA, Trick WE, Walker CL, Block JP. Racial and Ethnic Disparities in Outpatient Treatment of COVID-19 - United States, January-July 2022. MMWR Morb Mortal Wkly Rep. 2022 Oct 28;71(43):1359-1365. doi: 10.15585/mmwr.mm7143a2. PMID: 36301738; PMCID: PMC9620572.
• Burns KEA, Moss M, Lorens E, Jose EKA, Martin CM, Viglianti EM, Fox-Robichaud A, Mathews KS, Akgun K, Jain S, Gershengorn H, Mehta S, Han JE, Martin GS, Liebler JM, Stapleton RD, Trachuk P, Vranas KC, Chua A, Herridge MS, Tsang JLY, Biehl M, Burnham EL, Chen JT, Attia EF, Mohamed A, Harkins MS, Soriano SM, Maddux A, West JC, Badke AR, Bagshaw SM, Binnie A, Carlos WG, Çoruh B, Crothers K, D'Aragon F, Denson JL, Drover JW, Eschun G, Geagea A, Griesdale D, Hadler R, Hancock J, Hasmatali J, Kaul B, Kerlin MP, Kohn R, Kutsogiannis DJ, Matson SM, Morris PE, Paunovic B, Peltan ID, Piquette D, Pirzadeh M, Pulchan K, Schnapp LM, Sessler CN, Smith H, Sy E, Thirugnanam S, McDonald RK, McPherson KA, Kraft M, Spiegel M, Dodek PM; Diversity-Related Research Committee of the Women in Critical Care (WICC) Interest Group of the American Thoracic Society. Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey. Crit Care Med. 2022 Oct 27. doi: 10.1097/CCM.0000000000005674. Epub ahead of print. PMID: 36300945.
• Agarwal A, Chen JT, Coopersmith CM, Denson JL, Dickert NW, Ferrante LE, Gershengorn HB, Gosine AD, Hayward BJ, Kaur N, Khan A, Lamberton C, Landsittel D, Lyons PG, Mikkelsen ME, Nadig NR, Pietropaoli AP, Poole BR, Viglianti EM, Sevransky JE. SWEAT ICU-An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs. Crit Care Explor. 2022 Oct 13;4(10):e0774. doi: 10.1097/CCE.0000000000000774. PMID: 36259061; PMCID: PMC9575792.
• Yoshida Y, Chu S, Fox S, Zu Y, Lovre D, Denson JL, Miele L, Mauvais-Jarvis F. Sex differences in determinants of COVID-19 severe outcomes - findings from the National COVID Cohort Collaborative (N3C). BMC Infect Dis. 2022 Oct 12;22(1):784. doi: 10.1186/s12879-022-07776-7. PMID: 36224551; PMCID: PMC9555705
• Lal A, Garces JPD, Bansal V, Tekin A, Zec S, Khanna AK, Warner MA, Christie AB, Cartin-Ceba R, Banner-Goodspeed VM, Armaignac DL, Cheruku SR, Raju U, Tarabichi Y, Denson JL, Kumar V, Walkey A, Boman K, Deo N, Kashyap R, Gajic O; from the Society of Critical Care Medicine Discovery Viral Infection, Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pre-hospital Aspirin Use and Patient Outcomes in COVID-19: Results from the International Viral Infection and Respiratory Illness Universal Study (VIRUS). Arch Bronconeumol. 2022 Sep 8:S0300-2896(22)00510-5. doi: 10.1016/j.arbres.2022.07.017. Epub ahead of print. PMID: 36153214; PMCID: PMC9451929.
• Tekin A, Qamar S, Bansal V, Surani S, Singh R, Sharma M, LeMahieu AM, Hanson AC, Schulte PJ, Bogojevic M, Deo N, Sanghavi DK, Cartin-Ceba R, Jain NK, Christie AB, Sili U, Anderson HL, Denson JL, Khanna AK, Zabolotskikh IB, La Nou AT, Akhter M, Mohan SK, Dodd KW, Retford L, Boman K, Kumar VK, Walkey AJ, Gajic O, Domecq JP, Kashyap R. The Association of Latitude and Altitude with COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis. Open Respir Med J. 2022 Aug 31;16:e187430642207130. doi: 10.2174/18743064-v16-e2207130. PMID: 37273949; PMCID: PMC10156053.
• Gupta N, Settle L, Brown BR, Armaignac DL, Baram M, Perkins NE, Kaufman M, Melamed RR, Christie AB, Danesh VC, Denson JL, Cheruku SR, Boman K, Bansal V, Kumar VK, Walkey AJ, Domecq JP, Kashyap R, Aston CE; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19. Crit Care Med. 2022 Jul 27. doi: 10.1097/CCM.0000000000005627. Epub ahead of print. PMID: 35894609.
• Jackson SL, Block JP, Rolka DB, Pavkov ME, Chevinsky JR, Lekiachvili A, Carton TW, Thacker D, Denson JL, Paranjape A, Kappelman MD, Boehmer TK, Twentyman E. COVID-19 Outcomes Stratified by Control Status of Hypertension and Diabetes: Preliminary Findings From PCORnet, U.S. AJPM Focus. 2022 Sep;1(1):100012. doi: 10.1016/j.focus.2022.100012. Epub 2022 Jul 10. PMID: 36942020; PMCID: PMC9271352.
• Impact of early pericardial fluid chymase activation after cardiac surgery. Butts B, Goeddel LA, Zheng J, Pat B, Powell P, Mobley J, Ahmad S, Steele C, McGiffin D, Davies JE, George JF, Melby SJ, Ferrario CM, Dell'Italia LJ. Frontiers in Cardiovascular Medicine 2023 Apr 12;10:1132786. PMID: 37265571
• Feasibility study of intraoperative pericardial fluid biomarkers and length of stay after cardiac surgery. Goeddel LA, Zaky A, Aban I, Steele C, George JF, Melby SJ, Dell'Italia LJ. JTCVS Tech 2023 Apr 14;19:86-92. PMID: 373243.
• Finn A, Selvaraj V, Peterson E, Banerjee D, Lal A, Grewal H, Martin E, Dapaah-Afriyie K. Management of the Patient with Chronic Critical Illness - Part 1: This is part one of a two part series. Part two will be published in September. J Community Hosp Intern Med Perspect. 2022 Jul 4;12(4):28-33. doi: 10.55729/2000-9666.1065. eCollection 2022.
• Finn A, Selvaraj V, Peterson E, Banerjee D, Lal A, Grewal H, Martin E, Dapaah-Afriyie K. Management of the Patient with Chronic Critical Illness - Part 2.  J Community Hosp Intern Med Perspect. 2022 Sep 9;12(5):6-10. doi: 10.55729/2000-9666.1066. eCollection 2022.
• McCormack E, Aysenne A, Cardona JJ, Chaiyamoon A, Bui CJ, Dumont A, Tubbs S. Effects of Intubation Technique on Intracranial Pressure: A Cadaveric Study. Neurosurg Rev. 2023 Apr 17;46(1):88. Doi: 10.1007/s10143-023-01996-4.

MISCELLANEOUS

• Yousefi, H.; Khosla, M.; Lauterboeck, L.; Okpechi, S. C.; Worthylake, D.; Garai, J.; Zabaleta, J.; Guidry, J.; Zarandi, A. M.; Wyczechowska, D.; Jayawickramarajah, J.; Yang, Q.; Kissil, J.; Alahari, S. K. A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming. Oncogene, 2022, Ahead of Print. DOI: 10.1038/s41388-022-02497-2.
• Kankanamalage, D. V. D. W.; Tran, J. H. T.; Beltrami, N.; Meng, K.; Zhou, X.; Pathak, P.; Isaacs, L,; Burin, A. L.; Ali, M. F.; Jayawickramarajah, J. DNA strand displacement driven by host-guest interactions. J. Am. Chem. Soc. 2022. DOI:10.1021/jacs.2c05726.
• Remcho TP, Kolls JK. Gene Therapy for Occupational Lung Disease: Steering Macrophages in the Right Direction?  Am J Respir Cell Mol Biol. 2023 Feb;68(2):129-130. doi: 10.1165/rcmb.2022-0408ED.
• Sukhanov S, Higashi Y, Yoshida T, Danchuk S, Alfortish M, Goodchild T, Scarborough A, Sharp T, Jenkins JS, Garcia D, Ivey J, Tharp DL, Schumacher J, Rozenbaum Z, Kolls JK, Bowles D, Lefer D, Delafontaine P. Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia. JCI Insight. 2023 Feb 22;8(4):e165713. doi: 10.1172/jci.insight.165713.

CASE REPORTS

• Okoli S, Jenkins KA, Bojanowski CM. Current Intensive Care Management of Thrombotic Thrombocytopenic Purpura: A Case Report and Updated Literature Review. J Intensive Care Med. 2023 Jul;38(7):592-597. doi: 10.1177/08850666231171907. Epub 2023 Jun 18. Review. PubMed

Section of Pulmonary Diseases, Critical Care
and Environmental Medicine
 July 1, 2021 - June 30, 2022

RAMSY ABDELGHANI, MD

1. A Meyer, N Lee, D Thompson, R Abdelghani. Multifactorial, Delayed-Onset Euglycemic Diabetic Ketoacidosis. American Thoracic Society. Pages. A1582-A1582. Publication date May 2022.
2. Norman M Lee, Christine M Bojanowski, Ramsy A Abdelghani. Arid Airways: Airway Mucosal Injury with Non-humidified Invasive Ventilation. American Journal of Respiratory and Critical Care Medicine. Issue. Ja. May 2022. PMID:35570574

DAVID BECNEL, MD

1. Pathogenic Role of Epstein–Barr Virus in Lung Cancers. D Becnel, R Abdelghani, A Nanbo, J Avilala, J Kahn, L Li, Z Lin. Viruses 13 (5), 877. https://doi.org/10.3390/v13050877
2. Michael A. Jantz, Mohamed Omballi, , Bashar N. Alzghoul, Sebastian Fernandez Bussy, David Becnel, Adnan Majid, and Hiren J. Mehta. Utility of bronchoscopic intra-tumoral alcohol injection to restore airway patency. J Thorac Dis. 2021 Aug; 13(8): 4956–4964. PMID: 34527334

CHRISTINE BOJANOWSKI, MD

1. Lee N, Bojanowski CM, Abdelghani R. Arid Airways: Airway Mucosal Injury with Non-humidified Invasive Ventilation. AJRCCM. Accepted and In Press
2. Zheng W, LaCourse S, Song B, Singh DK, Khanna M, Olivo J, Stern J, Escudero J, Vergara C, Zhang F, Li S, Wang S, Crammer L, Huang Z, Bojanowski CM, Bao D, Njuguna I, Ziao Y, Warnalwa D, Nguyen D, Yang K, Maleche-Obimbo E, Nguyen N, Zhang L, Phan H, Fan J, Ning B, Li C, Lyon CJ, Gravies EA, John-Steward G, Mitchell CD, Ramsay AJ, Kaushal D, Lianbg R, Perez-Then E, Hu TY. Detection of M. tuberculosis-specific extracellular vesicles in peripheral blood for pediatric TB diagnosis. Nat Biomed Eng. Accepted and In Press
3. Liao X, Bojanowski CM, Yen A, Kerr KM, Dumouchel J, Auger WR, Madani MM, Pretorius V, Wang H-Y, Yi ES, Lin GY. Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases. Pulmonary Circulation. 2022; 12:e12004. https://doi.org/10.1002/pul2.12004
4. Bojanowski CM, Lu S, Kolls JK.  Mucosal Immunity in Cystic Fibrosis. J Immunol. 2021. 207: 2901-2912; doi: 10.4049/jimmunol.2100424. Invited
5. Sayed I, Masso-Silva J, Mittal A, Patel A, Lin E, Moshensky A, Shin J, Bojanowski C, Das S, Akuthota P, Crotty Alexander L. Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study. AJP-Lung Cell Mol Physiol. 2021 Oct 27. Doi:10.1152/ajplung.00363.2021. Online ahead of print. PMID: 34704852
6. Mankowski N, Al-Qurayshi Z, Souza S, Campbell B, Beighley A, Denson J, Mauldin B, Bojanowski C, Friedlander, Zifodya Z. The effect of race, socioeconomic status, and combordity on patients afflicted with COVID-19: A Local Perspective. Ann Epidemiol. 2021 Sep 22; 64: 83-7. Online ahead of print. PMID 34562588
7. Ning B, Xiao Y, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin X, Cao J, Lyon CJ, Li C, Roy CJ, Hu TY. Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Nat Nanotechnol. 2021 Jul 22. Online ahead of print. PMID: 34294909
8. Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowski CM, Jain M, Christiani DC, and Crotty Alexander LE.  Vaping induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex.  ERJ Open Res. 2021 Jul; 7 (3). Doi: 10.1183/23120541.00229-2021. eCollection 2021. PMID: 34262972
9. Weinrich DM, Sivapalasignam S, Norton T, et al. on behalf of the Trial Team. REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19. N Eng J Med. 2021. 385 (23): e81. PMID: 34587383
10. O’Brien MP, Forleo-Neto E, Musser BJ, et al. on behalf of the Covid-19 Phase 3 Prevention Trial Team. Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med. 2021 Sept 23; 385 (13): 1184-1195. PMID 34347950

Clinical Studies:
Role as PI (Bojanowski):

1. Randomized Master Protocol for Immune Modulators for Treating COVID-19 (ACTIV-1 IM)
2. A Prospective Study Evaluating Maternal and Fetal Outcomes in the Era of ModulatorS (MAYFLOWERS
3. International Prospective Registry for the Diagnosis and Management of Sepsis-Associated Disseminated Intravascular Coagulation
4. Biospecimen Banking for Future Research in Lung Inflammation and Infection
5. Impact of Handheld Home Spirometry on Health-Related Anxiety and Health Literacy in Patients with Cystic Fibrosis
6. Role as Co-I (Bojanowski):
7. Collection of SARS CoV-2 Secretions and Serum for Countermeasure Development
8. Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired (REMAP-CAP) Core protocol for COVID-19 patients (REMAP-CAP: covid, REMAP-COVID)
9. VX-20-121-1102 A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
10. Role as Sub-I (Bojanowski):
11. A Phase3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation
12. CFF Patient Registry
13. Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens (PICKUP)
14. A Phase 2/3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of mavrilimumab (KPL-301) treatment in adult subjects hospitalized with severe COVID-19 pneumonia and hyper-inflammation
15. A master protocol to test the impact of discontinuing chronic therapies in people with cystic fibrosis on highly effective CFTR modulator therapy (SIMPLIFY)
16. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis – The ASPEN Study
17. A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous for F508del or Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation Vertex Study Number: VX20-121-103
18. Human Eosinophilic Disorders in Health and Disease
19. Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections - CLAM320B2002M

JOSHUA DENSON, MD

1. Cervantes-Arslanian AM, Venkata C, Anand P, Burns JD, Ong CJ, LeMahieu AM, Schulte PJ, Singh TD, Rabinstein AA, Deo N, Bansal V, Boman K, Domecq Garces JP, Lee Armaignac D, Christie AB, Melamed RR, Tarabichi Y, Cheruku SR, Khanna AK, Denson JL, Banner-Goodspeed VM, Anderson HL 3rd, Gajic O, Kumar VK, Walkey A, Kashyap R. Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic. Crit Care Explor. 2022 Apr 25;4(4):e0686. doi: 10.1097/CCE.0000000000000686. PMID: 35492258; PMCID: PMC9042584.
2. Bogojevic M, Bansal V, Pattan V, Singh R, Tekin A, Sharma M, La Nou AT, LeMahieu AM, Hanson AC, Schulte PJ, Deo N, Qamar S, Zec S, Valencia Morales DJ, Perkins N, Kaufman M, Denson JL, Melamed R, Banner-Goodspeed VM, Christie AB, Tarabichi Y, Heavner S, Kumar VK, Walkey AJ, Gajic O, Bhagra S, Rahul Kashyap, Amos Lal, Domecq JP; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of Hypothyroidism with Outcomes in Hospitalized Adults with COVID-19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry. Clin Endocrinol (Oxf). 2022 Feb 18. doi: 10.1111/cen.14699. Epub ahead of print. PMID: 35180316.
3. Bjornstad EC, Cutter G, Guru P, Menon S, Aldana I, House S, M Tofil N, St Hill CA, Tarabichi Y, Banner-Goodspeed VM, Christie AB, Mohan SK, Sanghavi D, Mosier JM, Vadgaonkar G, Walkey AJ, Kashyap R, Kumar VK, Bansal V, Boman K, Sharma M, Bogojevic M, Deo N, Retford L, Gajic O, Gist KM; SCCM Discovery VIRUS Investigators Group. SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution. BMC Nephrol. 2022 Feb 11;23(1):63. doi: 10.1186/s12882-022-02681-2. PMID: 35144572; PMCID: PMC8831033. (*member of the investigative team cited in the appendix of the manuscript).
4. Wiltz JL, Feehan AK, Molinari NM, Ladva CN, Truman BI, Hall J, Block JP, Rasmussen SA, Denson JL, Trick WE, Weiner MG, Koumans E, Gundlapalli A, Carton TW, Boehmer TK. Racial and Ethnic Disparities in Receipt of Medications for Treatment of COVID-19 - United States, March 2020-August 2021. MMWR Morb Mortal Wkly Rep. 2022 Jan 21;71(3):96-102. doi: 10.15585/mmwr.mm7103e1. PMID: 35051133.
5. O'Brien MP, Forleo-Neto E, Sarkar N, Isa F, Hou P, Chan KC, Musser BJ, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Brown ER, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Geba GP, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; COVID-19 Phase 3 Prevention Trial Team. Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial. JAMA. 2022 Jan 14. doi: 10.1001/jama.2021.24939. Epub ahead of print. PMID: 35029629. (*member of the investigative team cited in the appendix of the manuscript).
6. Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Netw Open. 2021 Dec 1;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568. PMID: 34935924.
7. Soegaard Ballester JM, Bass GD, Urbani R, Fala G, Patel R, Leri D, Steinkamp JM, Denson JL, Rosin R, Adusumalli S, Hanson CW, Koppel R, Airan-Javia S. A Mobile, Electronic Health Record-Connected Application for Managing Team Workflows in Inpatient Care. Appl Clin Inform. 2021 Oct;12(5):1120-1134. doi: 10.1055/s-0041-1740256. Epub 2021 Dec 22. PMID: 34937103.
8. Cheruku SR, Barina A, Kershaw CD, Goff K, Reisch J, Hynan LS, Ahmed F, Armaignac DL, Patel L, Belden KA, Kaufman M, Christie AB, Deo N, Bansal V, Boman K, Kumar VK, Walkey A, Kashyap R, Gajic O, Fox AA; Society of Critical Care Medicine Discovery Viral Infection, Respiratory Illness Universal Study VIRUS: COVID-19 Registry Investigator Group. Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients. Resuscitation. 2021 Dec 14;170:230-237. doi: 10.1016/j.resuscitation.2021.12.011. Epub ahead of print. PMID: 34920014; PMCID: PMC8669976. (*member of the investigative team cited in the appendix of the manuscript).
9. Amer M, Kamel AM, Bawazeer M, Maghrabi K, Butt A, Dahhan T, Kseibi E, Khurshid SM, Abujazar M, Alghunaim R, Rabee M, Abualkhair M, Al-Janoubi A, AlFirm AT, Gajic O, Walkey AJ, Mosier JM, Zabolotskikh IB, Gavidia OY, Teruel SY, Bernstein MA, Boman K, Kumar VK, Bansal V, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry. Eur J Med Res. 2021 Oct 2;26(1):117. doi: 10.1186/s40001-021-00591-x. PMID: 34600589; PMCID: PMC8487342. (*member of the investigative team cited in the appendix of the manuscript).
10. Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, Xiao J, Hooper AT, Hamilton JD, Musser BJ, Rofail D, Hussein M, Im J, Atmodjo DY, Perry C, Pan C, Mahmood A, Hosain R, Davis JD, Turner KC, Baum A, Kyratsous CA, Kim Y, Cook A, Kampman W, Roque-Guerrero L, Acloque G, Aazami H, Cannon K, Simón-Campos JA, Bocchini JA, Kowal B, DiCioccio AT, Soo Y, Geba GP, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD; Trial Investigators. REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19. N Engl J Med. 2021 Sep 29. doi: 10.1056/NEJMoa2108163. Epub ahead of print. PMID: 34587383. (*member of the investigative team cited in the appendix of the manuscript).
11. Mankowski N, Al-Qurayshi Z, Souza S, Campbell B, Beighley A, Denson J, Mauldin B, Bojanowski C, Friedlander P, Zifodya J. The Effect of Race, Socioeconomic Status, and Comorbidity on Patients Afflicted with COVID 19: A Local Perspective. Ann Epidemiol. 2021 Sep 22:S1047-2797(21)00305-7. doi: 10.1016/j.annepidem.2021.09.013. Epub ahead of print. PMID: 34562588; PMCID: PMC8457904.
12. O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Hou P, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; Covid-19 Phase 3 Prevention Trial Team. Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med. 2021 Sep 23;385(13):1184-1195. doi: 10.1056/NEJMoa2109682. Epub 2021 Aug 4. PMID: 34347950; PMCID: PMC8362593. (*member of the investigative team cited in the appendix of the manuscript).
13. Hardeman A, Wong T, Denson JL, Postelnicu R, Rojas JC. Evaluation of Health Equity in COVID-19 Vaccine Distribution Plans in the United States. JAMA Netw Open. 2021 Jul 1;4(7):e2115653. doi: 10.1001/jamanetworkopen.2021.15653. PMID: 34213561.

SANDY DITTA, RN

1. An open-label extension trial to assess the long term safety of nintedanib in patients with Systemic Sclerosis associated Interstitial Lung Disease
2. A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of GKT137831 in Patients with Idiopathic Pulmonary Fibrosis
3. Analysis of Peptide Splicing Variants as a Biomarker for Progression of Pulmonary Fibrosis
4. A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis
5. Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype Prospective Outcomes (ILD-PRO) Registry
6. Pulmonary Fibrosis Foundation Patient Registry Protocol
7. Randomized double blinded, placebo-controlled trials to investigate the safety and efficacy of two doses of BI 1015550 PDE4 inhibitor-oral dose twice daily inpatients (1305-0014 for IPF), (1305-0023 for Non-IPF, PF-ILD patients)
8. A PHASE III RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF PRM-151 IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS

HIMMAT GREWAL, MD

1. Yuan Zhang, Housne A. Begum, Himmat Grewal, Itziar Etxeandia-Ikobaltzeta, Gian Paolo Morgano, Rasha Khatib, Robby Nieuwlaat, Chengyi Ding, Wojtek Wiercioch, Reem A. Mustafa, Wendy Lim, and Holger J. Sch€unemann. Blood Advances 2021; ‘Cost-effectiveness of diagnostic strategies for venous thromboembolism: Systematic Review’; 19 January 2022.
2. VIJAIRAM SELVARAJ, MD, MPH; KWAME DAPAAH-AFRIYIE, MD; HIMMAT GREWAL, MD. Cryptic Presentation of Disseminated Cryptococcosis; December 2021.
3. VIJAIRAM SELVARAJ, MD, MPH; KWAME DAPAAH-AFRIYIE, MD; DENISE FERNANDES, MD; HIMMAT GREWAL, MD. Acute Nephrotic Syndrome and Otosyphilis; February 2022.

CHRISTINE GLYNN, RN

1. Prospective Treatment Efficacy in IPF Using Genotype for NAC Selection (PRECISIONS) Trial
2. A Clinical Evaluation of the RheOx Bronchial Rheoplasty System for the Treatment of the Symptoms of Chronic Bronchitis in Adult Patients with COPD
3. CTBM100C2407 [A prospective observational study in cystic fibrosis patients with chronic respiratory Pseudomonas aeruginosa infection treated with TOBI® Podhaler™ (tobramycin inhalation powder) or other FDA approved inhaled antipseudomonal antibacterial drugs]
4. A Phase3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation
5. A Phase 3, Randomized, Double-Blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who are Homozygous for F508del, Heterozygous for F08del and a Gating (F/G) or Residual Function (F/RF) Mutation, or have At Least 1 Other Triple Combination Responsive CFTR Mutation and No F508del Mutation
6. A Prospective Study Evaluating maternal and Fetal Outcomes in the Era of Modulators (MAYFLOWERS)

KARIN HALVORSON, MD

1. Timothy Amass, MD, ScM1,2; Lauren Jodi Van Scoy, MD3; May Hua, MD, MS4,5; et al. Stress-Related Disorders of Family Members of Patients Admitted to the Intensive Care Unit With COVID-19. JAMA Intern Med. 2022;182(6):624-633. doi:10.1001/jamainternmed.2022.1118. April 15,2022.

ROSS KLINGSBERG, MD

Peer-reviewed publications:

1. Bojanowski CM, Wilson SM, Klingsberg RC. CFTR modulator therapy improves cystic fibrosis-related diabetes. But how? J Diabetes Complications. 2021 Feb 25.
    

Book Chapters:

1. Bojanowski CM, Landry M and Klingsberg RC. Care of the Adult with Cystic Fibrosis in Care of the Adult with a Chronic Childhood Condition: A Practical Guide. Pilapil M, DeLaet D, Kuo A, Peacock C and Sharma N (Editors) Springer Publishing. 2022
   
   Clinical Trials:
2. A Phase3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation
3. Cystic Fibrosis Foundation Patient Registry
4. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis – The ASPEN Study
5. VX-20-121-102 A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
6. A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous for F508del or Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation Vertex Study Number: VX20-121-103
7. Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections - CLAM320B2002M
8. Observational Study of Pulmonary Nontuberculous Mycobacterial Disease

JAY KOLLS, MD

1. Serum Anti-p Jiroveci Glucanase Responses in a Pediatric Cohort
   D Pungan, J Fan, K Zwezdaryk, M Dietrich, J Robinson, G Dai, JK Kolls
   C61. BREAKING THE MOLD, A5752-A5752
2. IL-22 Binding Protein (IL-22RA2) Is Associated with Chronic Sinopulmonary Infections in Cystic Fibrosis
   CM Bojanowski, K Choi, J Bodnar, S Lee, G Trevejo-Nunez, G Kurland,..
   A62. CYSTIC FIBROSIS AND NON-CF BRONCHIECTASIS: MECHANISTIC INSIGHTS, A1991 …
3. Identifying Monoclonal Antibodies for Development of Klebsiella Pneumoniae Therapies
   JE Mccombs, JP Hoffmann, JK Kolls
   B31. IMMUNE CELLS AND INFLAMMATORY PATHWAYS DRIVING LUNG INJURY AND …
4. Single-Cell RNA-seq Revealed T Cell Metabolism as a Target to Tissue-Resident Memory T Cell Contractio, H Yang, JK Kolls
   B31. IMMUNE CELLS AND INFLAMMATORY PATHWAYS DRIVING LUNG INJURY AND …
5. Vaccine Mediated Lung Tissue Resident Memory T Cells Require IL-1 and CCR2 Signaling to Protect Against K. Pneumoniae Challenge
   JP Hoffmann, N Iwanaga, H Yang, EB Norton, JE Mccombs, JK Kolls
   A101. DEFINING CELLULAR AND MOLECULAR IMMUNE MECHANISMS IN LUNG INFECTIONS …
6. Interferon-γ promotes monocyte-mediated lung injury during influenza infection
   T Schmit, K Guo, JK Tripathi, Z Wang, B McGregor, M Klomp, ...
   Cell Reports 38 (9), 110456
7. IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
   X Lin, SJ Gaudino, KK Jang, T Bahadur, A Singh, A Banerjee, M Beaupre, ...
   Immunity 55 (2), 237-253. e8
8. ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2
   N Iwanaga, L Cooper, L Rong, NJ Maness, B Beddingfield, Z Qin, ...
   Iscience 25 (1), 103670
9. Antibody Responses In Non-Severe SARS-CoV-2 Infections Are Driven By CD4+ T cells and Age.
   AE Murrell, E Eyoh, JG Shaffer, ML Dietrich, IV Trinh, S Bai, CY Zheng, ...medRxiv
10. Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis (IPF)
    S Saito, CHH Chung, A Jacob, N Nuradin, AE Meyer, T Saito, H Yang, ...medRxiv
11. Role of the T cell vitamin D receptor in severe COVID-19
    JK Kolls, RF Garr Nature Immunology 23 (1), 5-6
12. Mucosal Immunity in Cystic Fibrosis
    CM Bojanowski, S Lu, JK Kolls
    The Journal of Immunology 207 (12), 2901-2912
13. HIV, Pulmonary Infections, and Risk of Chronic Lung Disease among Kenyan Adults
    JS Zifodya, TM Temu, SJ Masyuko, G Nyale, J Kinuthia, ST Page, ...
    Annals of the American Thoracic Society 18 (12), 2090-2093
14. Surgical stabilization of traumatic rib fractures is associated with reduced readmissions and increased survival
    EA Green, C Guidry, C Harris, P McGrew, R Schroll, M Hussein, E Toraih, ...
    Surgery 170 (6), 1838-1848
15. Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences
    N Priedigkeit, K Ding, W Horne, JK Kolls, T Du, PC Lucas, JU Blohmer, ...
    Breast Cancer Research 23 (1), 1-14
16. Exosomes and Microvesicles from Adipose-derived Mesenchymal Stem Cells Protects the Endothelial Glycocalyx From Lipopolysaccharide Injury
    S Taghavi, S Abdullah, F Shaheen, JC Duchesne, S Braun, C Steele, ...
    Journal of the American College of Surgeons 233 (5), e205

JOSEPH LASKY, MD

1. Joseph A. Lasky, Amy Case, Avraham Unterman, Michael Kreuter, Mary Beth Scholand, Sachin Chaudhary, Lori R. Lofaro, Marla Johnson, Jing Huang, Sangeeta M. Bhorade, Giulia C. Kennedy. The impact of the Envisia Genomic Classifier in the diagnosis and management of patients with idiopathic pulmonary fibrosis. Ann Am Thorac Soc. 2021 Dec 10.  
2. Jamie L Todd, Megan L Neely, Robert Overton, Hillary Mulder, Jesse Roman, Joseph A Lasky, Joao de Andrade, Mridu Gulati, Howard Huang, Thomas B Leonard, Christian Hesslinger, Imre Noth, John A Belperio, Kevin R Flaherty, Scott M Palmer, on behalf of the IPF-PRO Registry investigators. Association of circulating proteins with death or lung transplant in the IPF-PRO Registry cohort. Lung. 2022, Jan. 23.
3. Kim HJ, Snyder LD, Adegunsoye A, Neely ML, Bender S, White ES, Conoscenti CS, Strek ME; IPF-PRO Registry Investigators. Hospitalizations in patients with idiopathic pulmonary fibrosis. Respir Res. 2021 Sep 30;22(1):257. doi: 10.1186/s12931-021-01851-4.
4. de Andrade JA, Kulkarni T, Neely ML, Hellkamp AS, Case AH, Culver DA, Guntupalli K, Bender S, Conoscenti CS, Snyder LD; IPF-PRO Registry Investigators. Associations between resources and practices of ILD centers and outcomes in patients with idiopathic pulmonary fibrosis: data from the IPF-PRO Registry. Respir Res. 2022 Jan 7;23 (1):3.  
5. Lee J, White E, Freiheit E, Scholand MB, Strek ME, Podolanczuk AJ, Patel NM; Pulmonary Fibrosis Foundation. Cough-Specific Quality of Life Predicts Disease Progression Among Patients with Interstitial Lung Disease: Data From the Pulmonary Fibrosis Foundation Patient Registry. Chest. 2022 Mar 23: S0012-3692(22)00545-1.
6. Swaminathan AC, Hellkamp AS, Neely ML, Bender S, Paoletti L, White ES, Palmer SM, Whelan TPM, Dilling DF; Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry investigators. Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry. Ann Am Thorac Soc. 2022 Jun;19(6):981-990

• Site Director
  • A phase III randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of PRM-151 in patients with idiopathic pulmonary fibrosis. F. Hoffmann-La-Roche Ltd
  • Site Director
• A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis. United Therapeutics
• o    Present    Site Director and Chair Performance Committee
• PRECISIONS (Prospective treatment EffiCacy in IPF using genotype for Nac Selection) study.  This study also aims to distinguish IPF from non-IPF interstitial lung diseases using unbiased combinations of blood transcriptomics, large-scale molecular analysis of blood samples, and proteomics.
• Site Director
• A Phase 3, randomized, double-blind, parallel-group, placebo-controlled multi-center study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis.
• o    Site Director
• TRAIL1: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
• o    A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of GKT137831 in Patients with Idiopathic Pulmonary Fibrosis

ANIL MISHA, PhD., SATHISHA UPPARAHALLI VENKATESHAIAH, Ph.D., CHANDRA SEKHAR YADAVALLI, Ph.D, HEMANTH KUMAR KANDIKATTU, Ph.D.

1. Anil Mishra, Dewan Majid, Hemanth Kumar Kandikattu, Yadavalli CS, Sathisha Upparahalli Venkateshaiah. Role of IL-18 transformed CD274-expressing eosinophils in promoting airway obstruction in experimental asthma. Allergy journal, Nov, 2021. PMID: 34800294
2. Sathisha Upparahalli Venkateshaiah, Hemanth Kumar Kandikattu, Yadavalli CS, Anil Mishra. Eosinophils and T cell surface molecule transcript levels in the blood differentiate eosinophilic esophagitis (EoE) from GERD. Int J Basic Clin Immunol. 2021;4(1-2):1-8. PMID: 34557864
3. Hemanth Kumar Kandikattu, Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Anil Mishra. Vaccine efficacy in mutant SARS-CoV-2 variants. Int J Cell Biol Physiol. 2021; 4(1-2): 1–12. PMID: 34790972
4. Sathisha U Venkateshaiah, et al., Blood mRNA levels of T cells and IgE receptors are novel non-invasive biomarkers for eosinophilic esophagitis (EoE), Clin Immunol. 2021;227:108752. PMID: 33945873
5. Hemanth Kumar Kandikattu, Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, & Anil Mishra. Vaccine efficacy in mutant SARS-CoV-2 variants. Int J Cell Biol Physiol . 2021;4(1-2):1-12. PMID: 34790972
6. Murli Manohar, Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli & Anil Mishra. Eosinophils in the pathogenesis of pancreatic disorders. Seminars in Semin Immunopathol, 1-12, (2021). PMID: 33783592
7. Anil Mishra, Hemanth Kumar Kandikattu, Sandeep Kumar, Sathisha Upparahalli Venkateshaiah. An update on available traditional and convalescent plasma (CP) therapies for COVID-19. Int J. Pub. Health Awa. 2021: 4 (1-2) 1-6.
8. Chandrasekhar Yadavalli, Anil Mishra. Review of: "Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals”. https://doi.org/10.32388/56KNC7.
9. Hemanth Kumar Kandikattu, Sathisha U Venkateshaiah, et al., Tacrolimus (FK506) treatment protects allergen‐, IL‐5‐ and IL‐13‐induced mucosal eosinophilia. Immunology. 2021;163:220-235. PMID: 33512727
10. Hemanth K Kandikattu, Murli Manohar, Sathisha U Venkateshaiah et al, Chronic inflammation promotes epithelial-mesenchymal transition-mediated malignant phenotypes and lung injury in experimentally-induced pancreatitis. Life Sci. 2021;278:119640. PMID: 34048812
11. Sathisha Upparahalli Venkateshaiah, Murali Manohar, Hemanth Kumar Kandikattu, Anil Mishra. Experimental Modeling of Eosinophil-Associated Diseases. Eosinophils (Book Chapter), Methods Mol Biol. 2021;2241:275-291. PMID: 33486743

JAIME PALOMINO, MD

1. Applicability of the USPSTF Lung Cancer Screening Guidelines in a Predominantly Black Veteran Population. Thomas N. Rusher, MD; Lekha Deere, MD; Albert Jang, MD; Rahul Kamat, MD; and Jaime Palomino, MD. Fed Pract. 2022;39(suppl 2). doi:10.12788/fp.0269

NEREIDA A. PARADA, MD

Clinical trial

1. CHRONICLE- Astra Zeneca, a longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States, 234262 AstraZeneca D3250R00023

DEREK POCIASK, Ph.D.

1. Fatal enhanced respiratory syncytial virus disease in toddlers. Polack FP, Alvarez-Paggi D, Libster R, Caballero MT, Blair RV, Hijano DR, de la Iglesia Niveyro PX, Menendez DR, Gladwell W, Avendano LM, Velozo L, Wanek A, Bergel E, Prince GA, Kleeberger SR, Johnson J, Pociask D, Kolls JK.Sci Transl Med. 2021 Oct 20;13(616):eabj7843. doi: 10.1126/scitranslmed.abj7843. Epub 2021 Oct 20.PMID: 34669442
2. Interleukin-22 mitigates acute respiratory distress syndrome (ARDS). Taghavi S, Jackson-Weaver O, Abdullah S, Wanek A, Drury R, Packer J, Cotton-Betteridge A, Duchesne J, Pociask D, Kolls J.PLoS One. 2021 Oct 1;16(10):e0254985. doi: 10.1371/journal.pone.0254985. eCollection 2021.PMID: 34597299

CAROL ROCKWELL, RN

1. Observational Nontuberculous Mycobacteria Clinical Study
2. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis – The ASPEN Study
3. Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections - CLAM320B2002M
4. Vertex A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)

SHIGEKI SAITO, MD
Publications:

1. Samant S, Tran HV, Uddo RB, deBoisblanc BP, Saketkoo LA, Saito S, Helmcke FR, Lammi MR. Use of Handheld Ultrasound to Estimate Right Atrial Pressure in a Pulmonary Hypertension Clinic. Ann Am Thorac Soc. 2021 Jul 2. doi: 10.1513/AnnalsATS.202101-092OC. Online ahead of print. PMID: 34214012.
2. Lammi MR, Samant S, Tran H, Uddo R, Saketkoo LA, Saito S, Helmcke FR, deBoisblanc BP. Jugular venous pressure measured by handheld ultrasound is independently associated with worsening events in pulmonary hypertension patients. Eur Respir J. 2021 Dec 9:2102591. doi: 10.1183/13993003.02591-2021. Online ahead of print. PMID: 34887321
3. Provisionally accepted- Saito S, Rehan M, Yadav S, Deskin B, Matsunaga Y, Lasky JA, Thannickal VJ. Novel Mediators of Lung Fibrosis Clinical Science 2022.
4. Preprint - Saito S, Chung CH, Jacob A, Nuradin N, Meyer AE, Saito T, Yang H, Kolls JK, Thannickal VJ, Liu YZ, Lasky JA. Hematopoietic and Lung Platelet Biogenesis as a Prognostic Indicator in Idiopathic Pulmonary Fibrosis (IPF) https://www.medrxiv.org/content/10.1101/2022.04.04.22273424v1

Clinical Studies (Ongoing)
o    An open-label extension trial to assess the long term safety of nintedanib in patients with Systemic Sclerosis associated Interstitial Lung Disease.
o    Sponsor: Boehringer Ingelheim
o    Role: Local Principal Investigator
o    Pulmonary Hypertension Association Registry (PHAR)
o    Sponsor: Pulmonary Hypertension Association
o    Role: Sub-investigator
o    OPsumit USers (OPUS) Registry
o    Sponsor: Actelion
o    Role: Sub-investigator
o    Selexipag for pulmonary hypertension associated with sarcoidosis
o    Sponsor: Actelion
o    Role: Sub-investigator
o    A Phase 3, Prospective, Multicenter, Double-blind, Double-dummy, Randomized, Activecontrolled, Parallel-group, Group-sequential, Adaptive, Event-driven Study to Compare Efficacy, Safety, and Tolerability of Macitentan 75 mg Versus Macitentan 10 mg in Patients with Pulmonary Arterial Hypertension, Followed by an Open-label Treatment

o    Period With Macitentan 75 mg: UNISUS (outcome study assessing a 75 mg dose of macitentan In patients with pulmonary arterial hypertension) trial Sponsor: Actelion
Role: Sub-investigator
o    A Phase 2a, Double-Blind, Placebo-Controlled Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of RVT-1201 in Patients with Pulmonary Arterial Hypertension
o    Sponsor: Altavant Sciences
o    Role: Sub-investigator

VICTOR THANNICKAL, MD

1. Qu J, Yang SZ, Zhu Y, Guo T, Thannickal VJ, Zhou Y. Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice. J Exp Med 2021; 218:e20202033.
2. Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 2021; 13:eaba2927
3. Jiang C, Liu G, Cai L, Deshane J, Antony V, Thannickal VJ, Liu RM. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. Am J Pathol 2021; 191:1227-1239.
4. Goliwas KF, Ashraf HM, Wood AM, Wang Y, Hough KP, Bodduluri S, Athar M, Berry JL, Ponnazhagan S, Thannickal VJ, Deshane JS. Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model. Front Oncol 2021; 11:654922.
5. Bone NB, Becker EJ Jr, Husain M, Jiang S, Zmijewska AA, Park DW, Chacko B, Darley-Usmar V, Grégoire M, Tadie JM, Thannickal VJ, Zmijewski JW. AMPK Activates Parkin Independent Autophagy and Improves Post-Sepsis Immune Defense Against Secondary Bacterial Lung Infections. Sci Rep 2021; 11:12387.
6. Rehan M, Kurundkar D, Kurundkar AR, Logsdon NJ, Smith SR, Chanda D, Bernard K, Sanders YY, Deshane JS, Dsouza KG, Rangarajan S, Zmijewski JW, Thannickal VJ. Restoration of SIRT3 Gene Expression by Airway Delivery Resolves Age-Associated Persistent Lung Fibrosis in Mice. Nature Aging 2021; 1:205-217.
7. Chanda D, Rehan M, Smith SR, Dsouza KG, Wang Y, Bernard K, Kurundkar D, Memula V, Kojima K, Mobley JA, Benavides GA, Darley-Usmar V, Kim YI, Zmijewski JW, Deshane JS, De Langhe S, Thannickal VJ. Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells. Elife 2021; 10:e68049.
8. Tousif S, Wang Y, Jackson J, Hough KP, Strenkowski JG, Athar M, Thannickal VJ, McCusker RH, Ponnazhagan S, Deshane JS. Indoleamine 2, 3-Dioxygenase Promotes Aryl Hydrocarbon Receptor-Dependent Differentiation of Regulatory B Cells in Lung Cancer. Front Immunol 2021; 12:747780.
9. Zhang X, Liu H, Zhou JQ, Krick S, Barnes JW, Thannickal VJ, Sanders YY. Modulation of H4K16Ac Levels Reduces Pro-fibrotic Gene Expression and Mitigates Lung Fibrosis in Aged Mice. Theranostics 2022; 12:530-541.
10. Wilson AC, Chiles J, Ashish S, Chanda D, Kumar PL, Mobley JA, Neptune ER, Thannickal VJ, McDonald MN. Integrated Bioinformatics Analysis Identifies Established and Novel TGFβ1-Regulated Genes Modulated by Anti-fibrotic Drugs. Sci Rep 2022; 12:3080.
11. Thannickal VJ. “Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction” in Myofibroblasts: Methods and Protocols, Boris Hinz and David Lagares, eds., Methods Mol Biol 2021; 2299:9-15.

JERRY ZIFODYA, MD

1. Zifodya JS, Temu TM, Masyuko S, Nyale G, Nyabiage JM, Nyale G, Kinuthia J, Page S, LaCourse S, Kolls J, Farquhar C, Crothers K, HIV, Pulmonary Infections, and Risk of Chronic Lung Disease among Kenyan Adults, Annals of the American Thoracic Society, 2021; 18(12): 2090-2093. [Original work] PMID: 34237231
2. Zifodya JS, Triplette M, Shahrir S, Attia EF, Akgun KM, Soo Hoo GW, Wongtrakool C, Rodriguez-Barradas MC, Tate JP, Crothers K, A cross-sectional analysis of diagnosis and management of chronic obstructive pulmonary disease in people living with HIV: Opportunities for improvement, Medicine (Baltimore), 2021; 17, 100(37): e27124 [Original work] PMID: 34664836
3. Mankowski N, Al-Qurayshi Z, Souza S, Campbell B, Beighley A, Denson J, Mauldin B, Bojanowski C, Friedlander P, Zifodya J, The Effect of Race, Socioeconomic Status, and Comorbidity on Patients Afflicted with COVID 19: A Local Perspective, Ann Epidemiol, 2021; 64: 83-87. [Original work] PMID: 34562588
4. Mogaka JN, Sharma M, Temu T, Masyuko S, Kinuthia J, Osoti A, Zifodya J, Nakanjako D, Njoroge A, Otedo A, Page S, Farquhar C, Prevalence and factors associated with hypertension among adults with and without HIV in Western Kenya, PLoS ONE 17(1): e0262400 [Original work] PMID: 35007291
5. Zifodya JS, Ferguson TF, Siggins RW, Brashear MM, Kantrow SP, Nelson S, Shellito JE, Molina PE, Welsh DA, Cross Sectional Analysis of the Effect of Alcohol on Pulmonary Function in a Cohort of Men and Women Living with HIV. Alcohol. 2022 Mar 16: S0741-8329(22)00018-0. doi: 10.1016/j.alcohol.2022.03.001. Epub ahead of print. PMID: 35306109.
6. Zifodya JS, Crothers K. Tuberculosis, Chronic Obstructive Lung Disease, and Lung Cancer: The Holey Upper Lobe Trinity? Ann Am Thorac Soc. 2022 Apr;19(4):540-

Section of Pulmonary Diseases, Critical Care
and Environmental Medicine

July 1, 2020 - June 30, 2021

RAMSY ABDELGHANI, MD

1. Majid A, Ayala A, Uribe JP, Abdelghani R, Patel P, Chee A, Parikh M, Kheir F. Protective Strategies in a Simulated
Model When Performing Percutaneous Tracheostomies in the COVID-19 Era. Ann Am Thoracic Soc. 2020 Nov
17(11):1486-1488. PMID: 32609553.
2. Using Bronchoscopic Lung Cryobiopsy and a Genomic Classifier in the Multidisciplinary Diagnosis of Diffuse
Interstitial Lung Diseases. Kheir F, Alkhatib A, Berry GJ, Daroca P, Diethelm L, Rampolla R, Saito S, Smith DL, Weill D,
Bateman M, Abdelghani R, Lasky JA.Chest. 2020 Nov;158(5):2015-2025. doi: 10.1016/j.chest.2020.05.532. Epub
2020 May 25.PMID: 32464189
3. Becnel D, Abdelghani R, Nanbo A, Avilala J, Li L, Lin Z. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses.
2021. May 11;13(5): 877. PMID: 34064727.
4. Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z. Role of Virally Encoded Circular RNAs in the
Pathogenicity of Human Oncogenic Viruses. Frontiers in Microbiology. 2021 Apr 20;12:PMID: 33959113.
5. Cone-Beam Computed Tomography-Guided Electromagnetic Navigation for Peripheral Lung Nodules. Fayez Kheir,
Sanket R Thakore, Juan Pablo Uribe Becerra, Mohammad Tahboub, Rahul Kamat, Ramsy Abdelghani, Sebastian
Fernandez-Bussy, Upendra R Kaphle, AdnanMajid. Respiration. 2021; 100(1):44-51. Epub 2021 Jan 5. PMID:
33401270.

DAVID BECNEL, MD

1. Becnel D, Abdelghani R, Nanbo A, Avilala J, Li L, Lin Z. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses.
2021, 13(5): 877.
2. Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z. Role of Virally Encoded Circular RNAs in the
Pathogenicity of Human Oncogenic Viruses. Frontiers in Microbiology. 2021;12:668.
3. Zhao M, Nanbo A, Becnel D, Qin Z, Morris GF, Li L, Lin Z. Ubiquitin Modification of the Epstein-Barr Virus Immediate
Early Transactivator Zta. Journal of Virology. 2020 Aug 26. PMID: 32847852.

CHRISTINE BOJANOWSKI,MD

1. Ning B, Xiao Y, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin X, Cao J,
Lyon CJ, Li C, Roy CJ, Hu TY. Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in
plasma. Nature Nanotechnology. 2021. In Press
2. Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J,
Nilaad S, Ding J, NajhawanM, Watrous JD, Bojanowski CM, Jain M, Christiani DC, and Crotty Alexander LE. Vaping
induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and
sex. European Respiratory Journal Open Research. Accepted on April 24, 2021
3. Chopyk J, Bojanowski CM, Shin J, Moshensky A, Fuentes AL, Bonde SS, Chuki D, Pride DT, Crotty Alexander LE.
Compositional differences in the oral microbiome of e-cigarette users. Front Microbiol. 2021 May 31; 12:599664.doi:
10.3389/fmicb.2021.599664. eCollection 2021. PMID 34135868.
4. Masso-Silva J, Moshensky A, Shin J, Olay J, Nilaad S, Advani I, Bojanowski CM, Crotty S, Li WT, Ongkeko WM, Singla
S, Crotty Alexander LE. Chronic e-cigarette aerosol inhalation alters the immune state of the lungs and increases
ACE2 expression, raising concern for altered response and susceptibility to SARS-CoV-2. Front Physiol. 2021May 31;
12:649604. Doi:10.3389/fphys.2021.649604. eCollection 2021. PMID: 34122126
5. Cypro A, McGuire C, Rolfsen M, Jones N, Shah N, Cribbs SK, Kaul V, Bojanowski CM, Pedraza I, Lynch L, Guzman L,
Larsson E, Crotty Alexander LE. Creation of a Virtual Critical Care Training Forum for International and Local
HealthcareWorkers Taking Care of Patients with COVID-19. ATS Scholar. 2021 Accepted February 28, 2021
6. Bojanowski CM, Wilson S, Klingsberg RC. CFTR Modulator Therapy Improves Cystic Fibrosis-Related Diabetes. But
How? J Diabetes Complications. 2021 Feb 25; 107887. doi: 10.1016/j.jdiacomp.2021.107887. Epub ahead of print.
PMID: 33775536. (Invited)
7. Ween MP, Moshensky A, Thredgold L, Bastian N, Hamon R, Badiei A, Nguyen PT, Herewane K, JErsmann, Bojanowski
CM, Shin J, Reynolds PN, Crotty Alexander LE, Hodge SJ. E-cigarettes and health risks: more to the flavour than just
the name. Am J Physiol Lung Cell Mol Physiol. 2021; 320 (4): L600-L614. PMID: 33295836
8. Xie J, Zu Y, Alkhatib A, Pham TT, Gill F, Jang A, Radosta S, Chaaya G, Myers L, Zifodya JS, Bojanowski CM, Marrouche
NF, Mauvais-Jarvis F, Denon JLMetabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New
Orleans. Diabetes Care. 2020 Aug 25; 44 (1): 188-193. dc20-1714. PMID: 32843337; PMCID: PMC7783937
9. Alkhatib AL, Kreniske J, Zifodya JS, Fonseca V, Tahboub M, Khatib J, Denson JL, Lasky JA, Lefante JJ, Bojanowski CM.
Body Mass Index is Associated with COVID-19 Intensive Care Unit Admission in African Americans. Obesity. 2020
Oct; 28 (10): 1798-1801. Epub 2020 Aug 4. PMID: 32748568; PMCID: PMC7436599

JOSHUA DENSON, MD

1. Hardeman A,* Wong T,* Denson JL, Postelnicu R, Rojas JC. U.S. National Evaluation of Health Equity in COVID-19
Vaccine Distribution Plans. JAMA Netw Open. 2021 (Accepted, In Press).
2. Heath JK, Wang T, Santhosh L, Denson JL, Holmboe E, Yamakazi K, Clay AS, Carlos WG. Longitudinal Milestone
Assessment Extending through Subspecialty Training: The Relationship between ACGME Internal Medicine
Residency Milestones and Subsequent Pulmonary and Critical Care Fellowship Milestones. Academic Medicine 2021
May 18. doi: 10.1097/ACM.0000000000004165. PMID: 34010863
3. Dagher L, Shi H, Zhao Y, Wetherbie A, Johnsen E, Sangani D, Nedunchezhian S, Brown M, Miller P, Denson J,
Schieffelin J, Marrouche N. New-Onset Atrial Arrhythmias Associated WithMortality in Black and White Patients
Hospitalized with COVID-19. Pacing Clin Electrophysiol. 2021 Mar 20. doi: 10.1111/pace.14226. Epub ahead of print.
PMID: 33742724.
4. Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, HarhayMO, Garcia MA, KaufmanM,
Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin
GS, Gajic O, Walkey AJ, Kashyap R. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support
Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Jan
28. doi: 10.1097/CCM.0000000000004879. Epub ahead of print. PMID: 33555777.
5. Manka L, Guntur VP, Denson JL, Dunn RM, Dollin YT, Strand M, Wechsler ME. Efficacy and Safety of Reslizumab in
the Treatment of Eosinophilic Granulomatosis with Polyangiitis (EGPA). Ann Allergy Asthma Immunol. 2021 Feb
3:S1081-1206(21)00097-1. doi: 10.1016/j.anai.2021.01.035. Epub ahead of print. PMID: 33548468.
6. Yoshida Y, Gillet SA, BrownMI, Zu Y, Wilson SM, Ahmed SJ, Tirumalasetty S, Lovre D, Krousel-WoodM, Denson JL,
Mauvais-Jarvis F. Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019
in New Orleans. Biol Sex Differ. 2021 Feb 5;12(1):20. doi: 10.1186/s13293-021-00359-2. PMID: 33546750; PMCID:
PMC7863061.
7. Bateman ME, Hammer R, Byrne A, Ravindran N, Chiurco J, Lasky S, Denson R, Brown M, Myers L, Zu Y, Denson JL.
Death Cafes for Prevention of Burnout in Intensive Care Unit Employees: Study Protocol for a Randomized
Controlled Trial (STOPTHEBURN). Trials. 2020 Dec 11;21(1):1019. doi: 10.1186/s13063-020-04929-4. PMID:
33308290.
8. Guntur VP, Manka L, Denson JL, Dunn RM, Dollin YT, Gill M, Kolakowski C, Strand M, Wechsler ME. Benralizumab as
a steroid-sparing treatment option in eosinophilic granulomatosis with polyangiitis. J Allergy Clin Immunol Pract.
2020 Oct 13:S2213-2198(20)31104-1. doi: 10.1016/j.jaip.2020.09.054. Epub ahead of print. PMID: 33065367.
9. Pal P, Ibrahim M, Niu A, Zwezdaryk KJ, Tatje E, Robinson WR, Ko L, Satyavarapu I, Jones WE, Nachabe A, Luk A,
Mushatt DM, Halvorson K, Denson JL, Smith CC, Simeone F, Davis G, Gill SK, McDougal A, Vigh AS, Peterson TG, Ning
B, Hu T, Socola F, Robinson J, Safah H, Saba NS. Safety and efficacy of COVID-19 convalescent plasma in severe
pulmonary disease: A report of 17 patients. Transfusion Medicine. 2020 Oct 19. doi: 10.1111/tme.12729. Epub
ahead of print. PMID: 33073895.
10. Brady AK, Brown W, Denson JL, Winter G, Niroula A, Santhosh L, Carlos WG. Variation in Intensive Care Unit
Intubation Practices in Pulmonary Critical Care Medicine Fellowship. ATS Sch. 2020 Dec;1(4):395-405. doi:
10.34197/ats-scholar.2020-0004OC. Epub 2020 Oct 21. PMID: 33728421; PMCID: PMC7959255.
11. Xie J, Zu Y, Alkhatib A, Pham TT, Gill F, Jang A, Radosta S, Chaaya G, Myers L, Zifodya JS, Bojanowski CM, Marrouche
NF, Mauvais-Jarvis F, Denson JL. Metabolic Syndrome and COVID-19 Mortality among Adult Black Patients in New
Orleans. [published online ahead of print, 2020 Aug 25]. Diabetes Care. 2020;dc201714. doi:10.2337/dc20-1714.
PMID: 32843337.
12. Brown W, Santhosh L, Brady AK, Denson JL, Niroula A, Pugh ME, Self WH, Joffe AM, O'Neal Maynord P, Carlos WG. A
call for collaboration and consensus on training for endotracheal intubation in the medical intensive care unit. Crit
Care. 2020 Oct 22;24(1):621. doi: 10.1186/s13054-020-03317-3. PMID: 33092615; PMCID: PMC7583182.
13. Alkhatib AL, Kreniske J, Zifodya JS, Fonseca V, TahboubM, Khatib J, Denson JL, Lasky JA, Lefante J, Bojanowski CM.
Body Mass Index is Associated with COVID-19 Intensive Care Unit Admission in African Americans. [published online
ahead of print, 2020 Aug 4]. Obesity (Silver Spring). 2020;10.1002/oby.22937. doi:10.1002/oby.22937. PMID:
32748568.

FRANCESCO SIMEONE, MD

1. Pal P, Ibrahim M, Niu A, Zwezdaryk KJ, Tatje E, Robinson WR, Ko L, Satyavarapu I, Jones WE, Nachabe A, Luk A,
Mushatt DM, Halvorson K, Denson JL, Smith CC, Simeone F, Davis G, Gill SK, McDougal A, Vigh AS, Peterson TG, Ning
B, Hu T, Socola F, Robinson J, Safah H, Saba NS. Safety and efficacy of COVID-19 convalescent plasma in severe
pulmonary disease: A report of 17 patients. Transfusion Medicine. 2020 Oct 19. doi: 10.1111/tme.12729. Epub
ahead of print. PMID: 33073895.

JAY KOLLS, MD

1. Hoffmann JP, Kolls JK, McCombs JE. Regulation and Function of ILC3s in Pulmonary Infections. Front Immunol. 2021
Apr 23;12:672523.
2. Schieffelin JS, Norton EB, Kolls JK. What should define a SARS-CoV-2 "breakthrough" infection? J Clin Invest. 2021
Jun 15;131(12):e151186. doi: 10.1172/JCI151186.
3. Das S, St Croix C, Good M, Chen J, Zhao J, Hu S, Ross M, Myerburg MM, Pilewski JM, Williams J, Wenzel SE, Kolls JK,
Ray A, Ray P. Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of
Cellular Autophagy. iScience. 2020 Jul 24;23(7):101256.
4. Han K, Blair RV, Iwanaga N, Liu F, Russell-Lodrigue KE, Qin Z, Midkiff CC, Golden NA, Doyle-Meyers LA, Kabir ME,
Chandler KE, Cutrera KL, Ren M, Monjure CJ, Lehmicke G, Fischer T, Beddingfield B, Wanek AG, Birnbaum A,Maness
NJ, Roy CJ, Datta PK, Rappaport J, Kolls JK, Qin X. Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-
2 Infection. Am J Respir Cell Mol Biol. 2020 Sep 29. doi: 10.1165/rcmb.2020-0354OC
5. Aarts J, Roeleveld DM, Helsen MM, Walgreen B, Vitters EL, Kolls J, van de Loo FA, van Lent PL, van der Kraan PM,
Koenders MI. Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently
reduces experimental arthritis in mice. Rheumatology (Oxford). 2020 Nov 16
6. Beddingfield BJ, Iwanaga N, Chapagain PP, Zheng W, Roy CJ, Hu TY, Kolls JK, Bix GJ. The Integrin Binding Peptide,
ATN-161, as a Novel Therapy for SARS-CoV-2 Infection. JACC Basic Transl Sci. 2020 Oct 16.
7. Henkel M, Dutta JA, Partyka J, Eddens T, Hirsch R, Kolls JK, Campfield BT. Regulation of Pulmonary Bacterial
Immunity by Follistatin-like 1. Infect Immun. 2020 Oct 19:IAI.00298-20.
8. Matsunaga Y, Clark T, Wanek AG, Bitoun JP, Gong Q, GoodM, Kolls JK. Intestinal IL-17R Signaling Controls Secretory
IgA and Oxidase Balance in Citrobacter rodentium Infection. J Immunol. 2021 Jan 11:ji2000591.
9. Dai G, Wanek A, Eddens T, Volden P, Kolls JK. Toward a humanized mouse model of Pneumocystis pneumonia. JCI
Insight. 2021 Jan 25;6(2):139573.
10. Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial
glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345.
11. Lin X, Tawch S, Wong HT, Roy S, Gaudino S, Castillo P, Elsegeiny W, Wakabayashi N, Oury TD, Pociask D, Chen K,
McLinskey N, Melville P, Syritsyna O, Coyle P, Good M, Awasthi A, Kolls JK, Kumar P. Nrf2 through Aryl Hydrocarbon
Receptor Regulates IL-22 Response in CD4+ T Cells. J Immunol. 2021 Apr 1;206(7):1540-1548.
12. Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C, Kolls J.
A Comparison of Growth Factors and Cytokines in Fresh Frozen Plasma and Never Frozen Plasma. J Surg Res. 2021
Mar 24;264:51-57.
13. Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina
P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. SARS-CoV-2 infection of primary
human lung epithelium for COVID-19 modeling and drug discovery. Cell Rep. 2021 Apr 13:109055.
14. Camiolo MJ, Zhou X, Oriss TB, Yan Q, Gorry M, Horne W, Trudeau JB, Scholl K, Chen W, Kolls JK, Ray P, Weisel FJ,
Weisel NM, Aghaeepour N, Nadeau K, Wenzel SE, Ray A. High-dimensional profiling clusters asthma severity by
lymphoid and non-lymphoid status. Cell Rep. 2021 Apr 13;35(2):108974.
15. Dai G, Noell K, Weckbecker G, Kolls JK Effect of Subcutaneous Anti-CD20. Antibody-Mediated B Cell Depletion on
Susceptibility to Pneumocystis Infection inMice. mSphere. 2021 May 5;6(3):e01144-20. doi:
10.1128/mSphere.01144-20.

ROSS KLINGSBERG, MD

1. Bojanowski CM, Wilson SM, Klingsberg RC. CFTR modulator therapy improves cystic fibrosis-related diabetes. But
how? J Diabetes Complications. 2021 Jun;35(6):107887. doi: 10.1016/j.jdiacomp.2021.107887. Epub 2021 Feb 25.
PMID: 33775536.

JOSEPH LASKY, MD

1. Raahe F, Belperio JA, Fitzgerald J, Gulati M, Hallowell R, Highland KB, Huie TJ, Kim HJ, KolbM, Lasky JA, Southern
BD, Swigris JJ, de Andrade JA. Delphi Consensus Recommendations on Management of Dosing, Adverse Events,
and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib. Clin Med Insights Circ
Respir Pulm Med. 2021 Mar 30;15:11795484211006050. doi: 10.1177/11795484211006050. eCollection 2021.
PMID: 33854398.
2. Podolanczuk AJ, Wong AW, Saito S, Lasky JA, Ryerson CJ, Eickelberg O.Am J Respir Crit Care Med. Update in
Interstitial Lung Disease 2020. 2021 Jun 1;203(11):1343-1352. doi: 10.1164/rccm.202103-0559UP.PMID:
33835899. No abstract available.
3. Lasky JA, Fuloria J, Morrison ME, Lanier R, Naderer O, Brundage T, Melemed A.Adv Ther. Design and Rationale of
a Randomized, Double-Blind, Placebo-Controlled, Phase 2/3 Study Evaluating Dociparstat in Acute Lung Injury
Associated with Severe COVID-19. 2021 Jan;38(1):782-791. doi: 10.1007/s12325-020-01539-z. Epub 2020 Oct 27.
PMID: 33108622 Free PMC article. Clinical Trial.
4. Long SA, Tahboub MY, Palomino J, Alkhatib AL, Kennedy TP, Caridi J, Lasky JA. Hypercoagulability in ICU Patients
With Coronavirus Disease 2019 With Respiratory Failure Results in Increased Prevalence of Venous
Thromboembolic Disease. Chest. 2021 Mar;159(3):1208-1211. doi: 10.1016/j.chest.2020.09.081. Epub 2020 Sep
14.PMID: 32941863 Free PMC article. No abstract available.
5. Cosgrove GP, Lasky JA. A New Piece to Help Solve the Interstitial Lung Disease Diagnostic Puzzle. Am J Respir Crit
Care Med. 2021 Jan 15;203(2):158-160. doi: 10.1164/rccm.202008-3189ED.PMID: 32926641 Free PMC article.
No abstract available.
6. Lasky JA, Criner GJ, Lazarus HM, Kohlbrenner V, Bender S, Richeldi L. Safety of Nintedanib in Patients with
Idiopathic Pulmonary Fibrosis: Global Pharmacovigilance Data. Adv Ther. 2020 Oct;37(10):4209-4219. doi:
10.1007/s12325-020-01452-5. Epub 2020 Aug 7.PMID: 32767182
7. Alkhatib AL, Kreniske J, Zifodya JS, Fonseca V, Tahboub M, Khatib J, Denson JL, Lasky JA, Lefante JJ, Bojanowski
CM. BMI is Associated with Coronavirus Disease 2019 Intensive Care Unit Admission in African Americans.
Obesity. (Silver Spring). 2020 Oct;28(10):1798-1801. doi: 10.1002/oby.22937. Epub 2020 Aug 4.PMID: 32748568
Free PMC article.
8. Salisbury ML, Conoscenti CS, Culver DA, Yow E, Neely ML, Bender S, Hartmann N, Palmer SM, Leonard TB; IPFPRO
Registry principal investigators as follows. Antifibrotic Drug Use in Patients with Idiopathic Pulmonary
Fibrosis. Data from the IPF-PRO Registry. Ann Am Thorac Soc. 2020 Nov;17(11):1413-1423. doi:
10.1513/AnnalsATS.201912-880OC.PMID: 32574517 Free PMC article.
9. Kheir F, Alkhatib A, Berry GJ, Daroca P, Diethelm L, Rampolla R, Saito S, Smith DL, Weill D, BatemanM,
Abdelghani R, Lasky JA. Using Bronchoscopic Lung Cryobiopsy and a Genomic Classifier in the Multidisciplinary
Diagnosis of Diffuse Interstitial Lung Diseases. Chest. 2020 Nov;158(5):2015-2025. doi:
10.1016/j.chest.2020.05.532. Epub 2020 May 25.PMID: 32464189

ANIL MISHRA, PhD & Sathisha Upparahalli Venkateshaiah, PhD & Hemanth Kumar Kandikattu PhD

1. Hemanth Kumar Kandikattu, Murli Manohar, Sathisha Upparahalli Venkateshaiah, Chandrasekhar Yadavalli,
Anil Mishra. Chronic inflammation promotes epithelial-mesenchymal transition-mediated malignant
phenotypes and lung injury in experimentally induced pancreatitis. Life Sciences, 278, 2021, 119640. PMID:
34048812
2. Sathisha Upparahalli Venkateshaiah, Madhavi Rayapudi, Hemanth Kumar Kandikattu, Chandra Sekhar
Yadavalli, Anil Mishra. Blood mRNA levels of T cells and IgE receptors are novel non-invasive biomarkers for
eosinophilic esophagitis (EoE). Clinical Immunology, 227, 2021, 108752 PMID: 33945873
3. Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Alok Kumar Verma, Anil Mishra. Tacrolimus
(FK506) treatment protects allergen, IL-5, and IL-13-induced mucosal eosinophilia. Immunology,
2021;163(2):220-235. PMID: 33512727
4. Sathisha Upparahalli Venkateshaiah, Hemanth Kumar Kandikattu, Anil Mishra. Possible novel non-invasive
biomarker for inflammation mediated pancreatic malignancy. Int. J. Basic Clin. Immonol. 2020: 3 (1-4), 1-8.
PMID: 34136883
5. Murli Manohar, Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli &
Anil Mishra. Eosinophils in the pathogenesis of pancreatic disorders. Seminars in Semin Immunopathol, 1-12,
(2021). PMID: 33783592
6. Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Anil Mishra. IL-15
immunotherapy is a viable strategy for COVID-19. Cytokine and Growth Factor Reviews 54 (2020) 24–31. PMID:
32536564
7. Anil Mishra, Interleukin (IL)-15 significance in aging associated asthma pathogenesis. Int. J cell Biol. Physiol. 3, 1-
3, 2020. PMID: 34027517
8. Anil Mishra, Prevalence of food allergen-induced diseases in developing countries. Int. J Pub. Health Awa. 2020:
3 (1-2),16-34
9. Anil Mishra, Hemanth Kumar Kandikattu, Sandeep Kumar, Sathisha Upparahalli Venkateshaiah. An update on
available traditional and convalescent plasma (CP) therapies for COVID-19. Int J. Pub. Health Awa. 2021: 4 (1-2)
1-6.
Chapter:
Sathisha Upparahalli Venkateshaiah, MurliManohar, Hemanth Kumar Kandikattu, Anil Mishra. Experimental
Modeling of Eosinophil-Associated Diseases. Methods Mol Biol. 2021;2241:275-291. PMID: 33486743

JAIME PALOMINO, MD

1. Bateman M, Kaphle U, Palomino J, Falk N, Kheir F. 54-Year-OldMan With Cough, Chest Pain, and Dyspnea on
Exertion. Chest. 2020 Dec;158(6):e299-e303. Doi 10.1016/j.chest.2020.07.047.
PMID: 33280773
2. Long SA, TahboubMY, Palomino J, Alkhatib AL, Kennedy TP, Caridi J, Lasky JA. Hypercoagulability in ICU Patients
With Coronavirus Disease 2019 With Respiratory Failure Results in Increased Prevalence of Venous
Thromboembolic Disease.
Chest. 2021 Mar;159(3):1208-1211. doi: 10.1016/j.chest.2020.09.081. Epub 2020 Sep 14. PMID: 32941863

NEREIDA PARADA, MD

Manuscript:
1. Moore, M *, Duncan, CD *, Gonis, A *, Chaiklin, C*, Eckles, D*, Parada NA. Uncontrolled Asthma is Associated with
Comorbid Stress and Somatoform Symptoms Annals of Pulmonology 2020. 4(1):45-49.
Chapter:
1. Parada NA, Hollingsworth H, Crolomes in Asthma UpToDate 2021

DEREK POCIASK, PhD

1. Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina
P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. SARS-CoV-2 infection of primary
human lung epithelium for COVID-19 modeling and drug discovery. Cell Rep. 2021 May 4;35(5):109055. doi:
10.1016/j.celrep.2021.109055. Epub 2021 Apr
13.https://www.sciencedirect.com/science/article/pii/S2211124721003715?via…
2. Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C, Kolls J.
A Comparison of Growth Factors and Cytokines in Fresh Frozen Plasma and Never Frozen Plasma. J Surg Res. 2021
Aug;264:51-57. doi: 10.1016/j.jss.2021.02.002. Epub 2021 Mar 24.
https://www.sciencedirect.com/science/article/pii/S0022480421000871?via…
3. Lin X, Tawch S, Wong HT, Roy S, Gaudino S, Castillo P, Elsegeiny W, Wakabayashi N, Oury TD, Pociask D, Chen K,
McLinskey N, Melville P, Syritsyna O, Coyle P, GoodM, Awasthi A, Kolls JK, Kumar P. Nrf2 through Aryl Hydrocarbon
Receptor Regulates IL-22 Response in CD4+ T Cells. J Immunol. 2021 Apr 1;206(7):1540-1548. doi:
10.4049/jimmunol.1900656. Epub 2021 Mar 1.https://www.jimmunol.org/content/206/7/1540.long
4. Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial
glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345. doi:
10.1097/TA.0000000000003019.
https://journals.lww.com/jtrauma/Fulltext/2021/02000/Interleukin_22_mit…

SHIGEKI SAITO, MD

1. Liu YZ, Miller CA, Zhuang Y, Mukhopadhyay SS, Saito S, Overton EB, Morris GF. The impact of the Deepwater
Horizon oil spill upon lung health –mouse model-based RNA-seq analyses. Int. J. Environ. Res. Public Health..
2020 Jul 29;17(15). PubMed PMID: 32751227; PubMed Central PMCID: PMC7432840
2. Kheir F, Alkhatib A, Berry G, Daroca P, Diethelm N, Rampolla R, Saito S, Smith D, Weill D, Bateman M, Abdelghani
R, Lasky JA. Employing bronchoscopic lung cryobiopsy and a genomic classifier in the multidisciplinary diagnosis
of diffuse interstitial lung diseases. Chest. 2020 Nov;158(5):2015-2025. PubMed PMID: 32464189.
3. Podolanczuk AJ, Wong AW, Saito S, Lasky JA, Ryerson CJ, Eickelberg O. Update in Interstitial Lung Disease 2020.
Am J Respir Crit Care Med. 2021 Apr 9;. doi: 10.1164/rccm.202103-0559UP. [Epub ahead of print] PubMed
PMID: 33835899.
4. Samant S, Tran H, Uddo R, deBoisblanc BP, Saketkoo LA, Saito S, Helmcke FR, Lammi MR. Right atrial pressure by
handheld ultrasound: Incorporation into pulmonary hypertension management. Annals ATS (just accepted)

CHAD STEELE, PhD

1. Liu S, F. Liu, B. Zhang, P. Yan, B.G. Rowan, A.B. Abdel-Mageed, C. Steele, S.M. Jazwinski, K. Moroz, E.B. Norton, A.
Wang, L. Myers, O. Sartor and Q. Zhang. CD4+ T helper 17 cell response of aged mice promotes prostate cancer
cell migration and invasion. Prostate 80(10):764-776 (2020).
2. Marks, M., C. Steele, W. Moore, D.A. Meyers, B. Rector, E. Ampleford, E.R Bleecker and A.T. Hastie. Tumor
Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and receptors in Type 1, Type 2 and Type 17
Inflammation in Cross-sectional Asthma Study. Thorax. 75:808-811 (2020).
3. Godwin, M.S., K.M. Reeder, J.P. Blackburn, Z. Yu, S. Matalon, A.T. Hastie, D.A.Meyers and C. Steele. The
chemokine CX3CL1/fractalkine plays a protective role in the severity of fungal asthma. American Journal of
Physiology Lung Cellular and Molecular Physiology 320:L393-L404 (2021).
4. Mackel, J.J., J.M. Garth, M. Jones, D.A. Ellis, J.P. Blackburn, Z. Yu, S. Matalon, M. Curtiss, F.E. Lund, A. Hastie, D.
Meyers and C. Steele. Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during
fungal-associated allergic airway inflammation. American Journal of Physiology Lung Cellular and Molecular
Physiology 320:L615-L626 (2021).
5. Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C,
Kolls J. A comparison of growth factors and cytokines in fresh frozen plasma and never frozen plasma. Journal of
Surgical Research 264:51-57 (2021).
6. Liu S, Zhang B, Rowan BG, Jazwinski SM, Abdel-Mageed AB, Steele C, Wang AR, Sartor O, Niu T, Zhang Q. A Novel
Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study. Front Mol Biosci. 2021 Jun 3;8:696537

VICTOR THANNICKAL, MD

1. Bone NB, Becker EJ Jr, Husain M, Jiang S, Zmijewska AA, Park DW, Chacko B, Darley-Usmar V, Grégoire M, Tadie
JM, Thannickal VJ, Zmijewski JW. AMPK activates Parkin independent autophagy and improves post sepsis
immune defense against secondary bacterial lung infections. Sci Rep. 2021 Jun 11;11(1):12387. doi:
10.1038/s41598-021-90573-0. PMID: 34117280
2. Thannickal VJ. Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction. Methods Mol
Biol.2021;2299:9-15. doi: 10.1007/978-1-0716-1382-5_2.PMID: 34028732
3. Goliwas KF, Ashraf HM,Wood AM, Wang Y, Hough KP, Bodduluri S, Athar M, Berry JL, Ponnazhagan S,
Thannickal VJ, Deshane JS. Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung
Cancer Model. Front Oncol. 2021 Apr 23;11:654922. doi: 10.3389/fonc.2021.654922. eCollection 2021.PMID:
33968758
4. Jiang C, Liu G, Cai L, Deshane J, Antony V, Thannickal VJ, Liu RM. Divergent Regulation of Alveolar Type 2 Cell
and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. Am J Pathol. 2021
Jul;191(7):1227-1239. doi: 10.1016/j.ajpath.2021.04.003. Epub 2021 Apr 20.PMID: 33887217
5. Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA,
Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates
development and progression of lung fibrosis. Sci Transl Med. 2021 Mar 17;13(585):eaba2927. doi:
10.1126/scitranslmed.aba2927.PMID: 33731433
6. Qu J, Yang SZ, Zhu Y, Guo T, Thannickal VJ, Zhou Y. Targeting mechanosensitive MDM4 promotes lung fibrosis
resolution in aged mice. J Exp Med. 2021 May 3;218(5):e20202033.
doi: 10.1084/jem.20202033.PMID: 33688918
7. Locy ML, Rangarajan S, Yang S, Johnson MR, Bernard K, Kurundkar A, Bone NB, Zmijewski JW, Byun J, Pennathur
S, Zhou Y, Thannickal VJ. Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular
migration. Sci Signal. 2020 Aug 11;13(644):eaau2803.
doi: 10.1126/scisignal.aau2803.PMID: 32788339
8. Thannickal VJ. ENERGY SENSING PATHWAYS IN AGING AND CHRONIC LUNG DISEASE. Trans Am Clin Climatol
Assoc. 2020;131:286-293.PMID: 32675866
9. Thannickal VJ. Elixir of Youth: Lipid Signaling Chaperones Synthesized in the Liver. Dev Cell. 2020 Jun
22;53(6):625-626. doi: 10.1016/j.devcel.2020.06.001.PMID: 32574591
10. Migaud M, Gandotra S, Chand HS, Gillespie MN, Thannickal VJ, Langley RJ. Metabolomics to Predict Antiviral
Drug Efficacy in COVID-19. Am J Respir Cell Mol Biol. 2020 Sep;63(3):396-398.
doi: 10.1165/rcmb.2020-0206LE.PMID: 32574504
11. Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, Thannickal VJ, Liu G. ATF4 Mediates Mitochondrial Unfolded
Protein Response in Alveolar Epithelial Cells. Am J Respir Cell Mol Biol. 2020 Oct;63(4):478-489. doi:
10.1165/rcmb.2020-0107OC.PMID: 32551949
12. Sanders YY, Lyv X, Zhou QJ, Xiang Z, Stanford D, Bodduluri S, Rowe SM, Thannickal VJ. Brd4-p300 inhibition
downregulates Nox4 and accelerates lung fibrosis resolution in aged mice. JCI Insight. 2020 Jul
23;5(14):e137127. doi: 10.1172/jci.insight.137127.PMID: 32544088
13. Hough KP, Curtiss ML, Blain TJ, Liu RM, Trevor J, Deshane JS, Thannickal VJ. Airway Remodeling in Asthma. Front
Med (Lausanne). 2020 May 21;7:191. doi: 10.3389/fmed.2020.00191. eCollection 2020.PMID: 32509793

JERRY ZIFODYA, MD

1. Masyuko SJ, Page ST, Kinuthia J, Osoti AO, Polyak SJ, Otieno FC, Kibachio JM, Mogaka JN, Temu TM, Zifodya JS,
Otedo A, Nakanjako D, Hughes JP, Farquhar C. Metabolic syndrome and 10-year cardiovascular risk among HIVpositive
and HIV negative adults: a cross-sectional study. Medicine 2020; 99:27(e20845) PMID: 32629671
2. Alkhatib AL, Kreniske J, Zifodya JS, Fonseca V, Tahboub M, Khatib J, Denson JL, Lasky JA, Bojanowski CM, BMI is
Associated with Coronavirus Disease 2019 Intensive Care Unit Admission in African Americans, Journal of
Obesity 2020, 28 (10): 1798-1801 PMID: 32748568
3. Xie J, Zu Y, Alkhatib A, Pham TT, Gill F, Jang A, Radosta S, Chaaya G, Myers L, Zifodya JS, Bojanowski CM,
Marrouche NF, Mauvais-Jarvis F, Denson JL, Metabolic Syndrome and COVID-19 Mortality Among Adult Black
Patients in New Orleans, Diabetes Care 2020, dc201714 DOI: 10.2337/dc20-1714. PMID: 32843337
4. Wenger DS, Triplette M, Shahrir S, Akgun KM, Wongtrakool C, Brown ST, Kim JW, Soo Hoo GW, Rodriguez-
Barradas MC, Huang L, Feemster LC, Zifodya J, Crothers K, Associations of marijuana with markers of chronic
lung disease in people living with HIV, HIVMedicine 2021; 22(2):92-101. doi: 10.1111/hiv.12966. Epub 2020
PMID: 33022830
5. Temu TM, Polyak S, Zifodya JS, Wanjalla C, Koethe JR, Masyuko S, Kinuthia J, Oyugi J, Page S, Farquhar C,
Endothelial Dysfunction is Related to Monocyte/Macrophage Activation in Antiretroviral Treated People Living
with HIV and HIV-negative Adults in Kenya, Open Forum Infectious Diseases 2020, 7 (10), ofaa425,
https://doi.org/10.1093/ofid/ofaa425 PMID: 33094120
6. Temu TM, Zifodya JS, Polyak SJ, Wagoner J, Wanjalla CN, Masyuko S, Nyabiage J, Kinuthia J, Bloomfield GS, Page
S, Farquhar C, Antiretroviral therapy reduces but does not normalize immune and vascular inflammatory
markers in adults with chronic HIV infection in Kenya, AIDS 2021; 35(1):45-51. doi:
10.1097/QAD.0000000000002729 PMID: 33055570
7. Zifodya JS, Duncan MS, So-Armah K, Attia E, Akgun KM, Rodriguez-Barradas M, Marconi V, Budoff M, Bedimo R,
Soo Hoo GW, Tate J, Justice A, Butt A, Kim JW, Sico J, Tindle H, FreibergM, Crothers KA, Community Acquired
Pneumonia and Risk of Cardiovascular Events in HIV-infected Compared to Uninfected Patients, Journal of the
American Heart Association, 2020; 9(23):e017645. doi: 10.1161/JAHA.120.017645. Epub 2020 Nov 23 PMID:
33222591
8. Masyuko SJ, Page ST, Polyak SJ, Kinuthia J, Osoti AO, Otieno FC, Kibachio JM, Mogaka JN, Chohan B, Wogner J,
Temu TM, Zifodya JS, Otedo A, Nakanjako D, Hughes JP, Farquhar C, HIV Is Associated with Higher Levels of
Systemic Inflammation among Kenyan Adults despite Viral Suppression, Clinical Infectious Diseases ciaa1650,
DOI: 10.1093/cid/ciaa1650 PMID: 33313687
9. Zifodya JS, Kreniske J, Schiller I, Kohli M, Dendukuri N, Schumacher SG, Ochodo EA, Haraka F, Pai M, Steingart
KR, Horne DJ, Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults
with presumptive pulmonary tuberculosis, Cochrane Database of Systematic Reviews 2021, Issue 2. Art. No.:
CD009593. PMID: 33616229
10. Temu TM, Wagoner J, Masyuko S, O'Connor A, Zifodya JS, Macharia P, Wanjalla CN, Mogaka JN, Chohan B,
Omodi VM, Gervassi AL, Oyugi J, Page ST, Farquhar C, Polyak SJ, Central Obesity is a Contributor to Systemic
Inflammation and Monocyte Activation in Virally Suppressed Adults with Chronic HIV in Kenya, AIDS, 2021 Jun 3.
doi: 10.1097/QAD.0000000000002956. Online ahead of print. PMID: 34033591, Accepted
11. Zifodya JS, Temu TM, Masyuko S, Nyale G, Nyabiage JM, Nyale G, Kinuthia J, Page S, LaCourse S, Kolls J, Farquhar
C, Crothers K, HIV, Pulmonary Infections, and Risk of Chronic Lung Disease among Kenyan Adults, Annals of the
American Thoracic Society, Accepted

Section of Pulmonary Diseases, Critical Care and Environmental Medicine

July 1, 2019 - June 30, 2020

Nancy; Zhou, Tong; Gonzalez-Garay, Manuel; Rosas, Ivan; Goldberg, Hilary; Ryter, Stefan; Collard, Harold; El-Chemaly, Souheil; Flaherty, Kevin; Hunninghake, Gary; Lasky, Joseph; Lederer, David; Machado, Roberto; Martinez, Fernando; Noth, Imre; Peters, Elizabeth; Raghu, Ganesh; Choi, Augustine; Garcia, Joe. Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes, Sci Rep. 2019 Oct 15;9(1):14802.
 
Deskin B, Yin Q, Zhuang Y, Saito S, Shan B, Lasky JA. Inhibition of HDAC6 attenuates tumor growth of Non-Small Cell Lung Cancer. Transl Oncol. 2019 Dec 19;13(2):135-145. PMID: 31865176; PMCID: PMC6926313.

Jamie L Todd, Richard Vinisko, Katey Durham, Yi Liu, Megan L Neely, Robert Overton, Kevin R Flaherty, Imre Noth, L Kristin Newby, Joseph Lasky, Mitchell A Olman, Christian Hesslinger, Thomas Leonard, Scott M Palmer, John A Belperio on behalf of the IPF-PRO Registry investigators. Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort, BMC Pulm Med. 2020 Mar 14;20(1):64.
 
Qinyan Yin, Nan Deng, Erik Flemington, Joao DeAndrade, Joseph A. Lasky
Assessment of viral RNA in idiopathic pulmonary fibrosis by RNA-seq. BMC Pulm Med. 2020 Apr 3;20(1):81.
 
Fayez Kheir, Ala Alkahtab, Phillip Daroca, Shigeki Saito, Reynaldo Rampolla, David Weill, Lisa Deithelm, and Joseph A. Lasky. Employing Bronchoscopic Lung Cryobiopsy and a Genomic Classifier in the Multidisciplinary Diagnosis of Diffuse Interstitial Lung Diseases, Chest. 2020 May 25:S0012-3692(20)31499-9.

Ala L. Alkhatib , Jonah Kreniske, Jerry S. Zifodya, Vivian Fonseca, Mohammad Tahboub , Joanna Khatib, Joshua L. Denson, Joseph A. Lasky, Christine M. Bojanowski. Clinical Determinants of Severe CoVID-19 Infections in African Americans, in press, Obesity.

Mackel, J.J. and C. Steele. Host defense mechanisms against Aspergillus fumigatus colonization and invasion and in the lung. Current Opinion in Microbiology 52:14-19 (2019).

Godwin, M.S., K.M. Reeder, J.M. Garth, J.J. Mackel, J.P. Blackburn, Z. Yu, S. Matalon, A.T. Hastie, D.A. Meyers and C. Steele. IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation.  JCI Insight 4 pii: 129055 (2019).

Mackel J.J., J.M. Garth, J.P. Blackburn, M. Jones and C. Steele. 12/15-lipoxygenase deficiency impairs neutrophil granulopoiesis and lung pro-inflammatory responses to Aspergillus fumigatus. Journal of Immunology 204:1849-1858 (2020).

Marks, M., C. Steele, W. Moore, D.A. Meyers, B. Rector, E. Ampleford, E.R Bleecker and A.T. Hastie. Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and receptors in Type 1, Type 2 and Type 17 Inflammation in Cross-sectional Asthma Study. Thorax 2020 Jun 1 2019-214496 (2020).

Abood RN, McHugh KJ, Rich HE, Ortiz MA, Tobin JM, Ramanan K, Robinson KM, Bomberger JM, Kolls JK, Manni ML, Pociask DA, Alcorn JF.  IL-22-binding protein exacerbates influenza, bacterial super-infection. Mucosal Immunol. 2019 July doi: 10.1038/s41385-019-0188-7.

Eddens T, Elsegeiny W, Ricks D, Goodwin M, Horne WT, Zheng M, Kolls JK. Transcriptomic and Proteomic Approaches to Finding Novel Diagnostic and Immunogenic Candidates in Pneumocystis. mSphere. 2019 Sep 4;4(5). pii: e00488-19. doi: 10.1128/mSphere.00488-19.

Martinu T, McManigle WC, Kelly FL, Nelson ME, Sun J, Zhang HL, Kolls JK, Gowdy KM, Palmer SM. IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease. Transplantation. 2019 Nov;103(11):2264-2274.

Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL. Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia. Infect Immun. 2019 Oct 18;87(11).

Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK.  Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products.  Cell Rep. 2019 Nov 19;29(8):2270-2283.

Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Shapiro SD, Kolls JK, Campfield BT. Follistatin-like 1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2019.

Shaikh N, Martin JM, Hoberman A, Skae M, Milkovich L, McElheny C, Hickey RW, Gabriel LV, Kearney DH, Majd M, Shalaby-Rana E, Tseng G, Kolls J, Horne W, Huo Z, Shope TR. Biomarkers that differentiate false positive urinalyses from true urinary tract infection. Pediatr Nephrol. 2020 Feb;35(2):321-329

Hebert KD, Mclaughlin N, Galeas-Pena M, Zhang Z, Eddens T, Govero A, Pilewski JM, Kolls JK, Pociask DA.  Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection. Mucosal Immunol. Mucosal Immunol. 2020 Jan;13(1):64-74.

Iwanaga N, Sandquist I, Wanek A, McCombs J, Song K, Kolls JK. Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infection.  JCI Insight. 2020 Apr 23;5(8):e135591.

Kolls JK, Ray A, Wenzel S. High-Dose Vitamin D3 for Critically Ill Vitamin D-Deficient Patients.  N Engl J Med. 2020 Apr 23;382(17):1669-1670.

Watanabe T, Guan Z, Horie M, Joe B, Juan MU, Buhari H, Hwang D, Kolls JK, Liu M, Keshavjee S, Juvet S, Martinu T. IL-17 Receptor on Donor Cells Regulates Acute and Chronic Lung Allograft Rejection Potentiated by Repeated Endotoxin Inhalations.  J Heart Lung Transplant. 2020 Apr;39(4S):S196

Carsten Schwarz, MD; Sivagurunathan Sutharsan; Ralph Epaud; Ross C Klingsberg; Rainald Fischer; Steven M Rowe; Paul K Audhya; Neil Ahluwalia; Xiaojun You; Thomas J Ferro; Margaret E Duncan; Bote G Bruinsma Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events. Journal of Cystic Fibrosis, in press.

Heijerman HGM, McKone EF, Downey DG, Van Braeckel E, Rowe SM, Tullis E, Mall MA, Welter JJ, Ramsey BW, McKee CM, Marigowda G, Moskowitz SM, Waltz D, Sosnay PR, Simard C, Ahluwalia N, Xuan F, Zhang Y, Taylor-Cousar JL, McCoy KS; VX17-445-103 Trial Group (Klingsberg). Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.Lancet. 2019 Nov 23;394(10212):1940-1948. doi: 10.1016/S0140-6736(19)32597-8. Epub 2019 Oct 31.

Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group (Klingsberg). Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31.

Lammi MR, Saketkoo LA, Okpechi SC, Ghonim MA, Wyczechowska D, Bauer N, Pyakurel K, Saito S, deBoisblanc BP, Boulares AH. Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers. Respirology. 2019 Jul;24(7):675-683. PubMed PMID: 30747487; PubMed Central PMCID: PMC6579687.

Saito S, Alkhatib A^, Kolls JK, Kondoh Y, Lasky JA. Pharmacotherapy and Adjunctive Treatment for IPF J Thorac Dis. 2019 Sep;11(Suppl 14):S1740-S1754. PMID: 31632751

Bateman ME*, Oakland H*, Oral E, Fisher P, Udemgba, C, Walker, C, Nuss H, Parada NA. Evaluation of a Multidisciplinary Disease Management Program to Improve Asthma Control in an Underserved Patient Population in Louisiana. Population Health Management Jan 2020 PMID32096685

Pritesh, P, Hansen, G, Daignault, S, Kasper, B, Parada, NA Adaptive High Frequency Chest Wall Oscillation (HFCWO) Therapy for Maximum Patient Adherence: A Patient-Centered Approach. Respiratory Therapy 2019; 14: 76-79

Becnel, D. M., Jantz, M. A., & Mehta, H. J. (2020). Endobronchial Valves Are Radiographically Protective during Interstitial Lung Disease Exacerbation. American Journal of Respiratory and Critical Care Medicine, 201(4), e10-e11.

Omballi, M., Fernandez-Bussy, S., Patel, P. P., Jantz, M. A., Becnel, D., Patel, N. M., & Mehta, H. J. (2020, January). Surveillance Imaging After Curative Intent Therapy for Lung Cancer. In Seminars in roentgenology (Vol. 55, No. 1, p. 60).

Liu, Y. Z., S. Saito, G. F. Morris, C. A. Miller, 3rd, J. Li and J. J. Lefante (2019). "Proportions of resting memory T cells and monocytes in blood have prognostic significance in idiopathic pulmonary fibrosis." Genomics 111(6): 1343-1350.

Saito, S., Y. Zhuang, T. Suzuki, Y. Ota, M. Bateman, A. Alkhatib, G.F. Morris, J. Lasky. HDAC8 inhibition ameliorates pulmonary fibrosis. American Journal of Physiology, Lung Cellular and Molecular Physiology 316(1):L175-L186 (2019).

Corriden R, Moshensky A, Bojanowski CM, Meier A, Chien J, Nelson R, Crotty Alexander LE. E-cigarette Use Increases Susceptibility to Bacterial Infection by Impairment of Human Neutrophil Chemotaxis, Phagocytosis and NET Formation. Am J Physiol Cell Physio. 2020. Jan1; 318 (1):C205-214. Epub 2019 Oct 30. PMID: 31664858.

Alasmari F, Crotty Alexander LE, Hammad A, Bojanowski CM, Moshenksy A, Sari Y. Effects of chronic inhalation of electronic cigarette vapor containing nicotine on neurotransmitters in the frontal cortex and striatum of C57BL/6 mice. Front Pharmacol. 2019 Aug 12; 10:885. PMID:31456684

Boddu SA, Bojanowski CM, Lam MT, Advani IN, Scholten EL, Sun Z, Montgrain P, Malhotra A, Jain S, Crotty Alexander LE. Use of E-cigarettes with Conventional Tobacco is Associated with Decreased Sleep Quality in Women. Am J Resp Crit Care. 2019 Dec 1: 200 (11): 1431-1434. PMID: 31314572

Kandikattu, H.K., Venkateshaiah, S.U., Kumar, S. and Mishra, A., 2020. IL-15 immunotherapy is a viable strategy for COVID-19. Cytokine & Growth Factor Reviews. 2020 Jun 6; S1359-6101(20)30098-8.

Kandikattu HK, Venkateshaiah SU, Mishra A. Chronic Pancreatitis and the Development of Pancreatic Cancer. Endocrine, Metabolic & Immune Disorders Drug Targets. 2020 Apr 22. DOI: 10.2174/1871530320666200423095700

Venkateshaiah, S.U., Niranjan, R., Manohar, M., Verma, A.K., Kandikattu, H.K., Lasky, J.A. and Mishra, A. Attenuation of Allergen-, IL-13–, and TGF-α–induced Lung Fibrosis after the Treatment of rIL-15 in Mice. American Journal of Respiratory Cell and Molecular Biology, 2019. 61(1), p.97.

Venkateshaiah SU, Kandikattu HK, Mishra A. Significance of Interleukin (IL)-15 in IgE associated eosinophilic Esophagitis (EoE). International journal of basic and clinical immunology. 2019 Dec 16;2:1.

Manohar, M., Verma, A.K., Singh, G. and Mishra, A., 2020. Eosinophilic pancreatitis: a rare or unexplored disease entity?. Przeglad Gastroenterologiczny, 15(1), p.34.

Masyuko SJ, Page ST, Kinuthia J, Osoti AO, Polyak SJ, Otieno FC, Kibachio JM, Mogaka JN, Temu TM, Zifodya JS, Otedo A, Nakanjako D, Hughes JP, Farquhar C. Metabolic syndrome and 10-year cardiovascular risk among HIV-positive and HIV-negative adults: a cross-sectional study. Medicine 2020; 99:27(e20845)

Choate R, Pasquale CB, Parada NA, Prieto-Centurion V, Mularski RA, Yawn BP. The burden of cough and phlegm in people with COPD: a COPD Patient-Powered Research Network study. Chronic Obstr Pulm Dis. 2020; 7(1): 49-59. doi: http://doi.org/10.15326/jcopdf.7.1.2019.0146

Adnan Majid, MD1, Alvaro Ayala, MD1, Juan Pablo Uribe, MD1, Ramsy Abdelghani, MD1, Priya Patel, MD1, Alex Chee, MD1, Mihir Parikh, MD1, Fayez Kheir MS, MD1. "Protective Strategies in a Simulated Model When Performing Percutaneous Tracheostomies in the COVID-19 Era." Annals of the American Thoracic Society, 0(ja), pp. – 2020.

Listed as a Collaborator on Pubmed

Todd JL, Neely ML, Overton R, Durham K, Gulati M, Huang H, Roman J, Newby LK, Flaherty KR, Vinisko R, Liu Y, Roy J, Schmid R, Strobel B, Hesslinger C, Leonard TB, Noth I, Belperio JA, Palmer SM; IPF-PRO Registry investigators (Lasky JA). Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry. Respir Res. 2019 Oct 22;20(1):227.

O'Brien EC, Hellkamp AS, Neely ML, Swaminathan A, Bender S, Snyder LD, Culver DA, Conoscenti CS, Todd JL, Palmer SM, Leonard TB; IPF-PRO Registry investigators. Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry (Lasky JA). Chest. 2020 May;157(5):1188-1198.