Publications

Directed point mutation of human interferon-β structural gene
Chinese Journal of Biotechnology

Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms
Molecular Endocrinology

Expression of Human TGF-α/β-galactosidase Fusion Gene in Insect Cells with a Baculovirus Vector
Acta Biochimica et Biophysica Sinica

Proinflammatory Cytokines Tumor Necrosis Factor-(Y AND IL-6, but not IL-1, Down-Regulate The Ostecalcin Gene Promoter
The Journal of Immunology

Characterization of a Tumor Necrosis Factor-Responsive Element Which Down-Regulates the Human Osteocalcin Gene
Molecular and Cellular Biology

Expression of 92 kD Type IV Collagenase/Gelatinase B in Human Osteoclasts
Journal of Bone and Mineral Research

Characterization of a silencer element in the first exon of the human osteocalcin gene
Nucleic Acids Research

Cloning and Complete Coding Sequence of a Novel Human Cathepsin Expressed in Giant Cells of Osteoclastomas
Journal of Bone and Mineral Science

Molecular Cloning and Characterization of a Putative Novel Human Osteoclast-Specific 116-kDa Vacuolar Proton Pump Subunit
Biochemical and Biophysical Research Communications

Generation of Mouse Osteoclastogenic Cell Lines Immortalized with SV40 Large T Antigen
Journal of Bone and Mineral Research.

Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
Nature Genetics

Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression
Journal of Bone and Mineral Research.

Characterization of Mouse Atp6i Gene, the Gene Promoter, and Gene Expression
Journal of Bone and Mineral Research

Interferon-γ Down-regulates Gene Expression of Cathepsin K in Osteoclasts and Inhibits Osteoclast Formation
Journal of Dental Research.

Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene
GENE

The zinc-finger protein CNBP is required for forebrain formation in the mouse
Development

IL-1α Stimulates Cathepsin K Expression in Osteoclasts via the Tyrosine Kinase-NF-κB Pathway
Journal of Dental Research

Cloning and Characterization of a Novel Human ceg1 Gene cDNA
Acta Biologiae Experimentalis Sinica

In Silicon Cloning of TFL76, A novel Human Gene Encoding a Zinc Finger Protein
Chinese Journal of Applied & Environmental Biology

Cloning and characterization of a novel mouse gene BS G5 cDNA specifically expressed in early embryo brain
Acta Zoologica Sinica

Cloning and Characterization of a Novel Mouse Gene BSG1 cDNA Specifically Expressed in Brain
Acta Anatomica Sinica

Structural Characteristic and Special Expression Pattern During Development of a Novel Gene Bsg2 Containing BTB and Zinc Finger Domain
Chinese Journal of Biochemistry and Molecular Biology

Cloning and Characterization of a Novel Mouse Gene bsg3 cDNA Specifically Expressed in Brain
Journal of Beijing Normal University (Natural Science)

Mouse brain-specific gene bsg4 Cloning and expression
Progress in Natural Science

Detection of Transgenic Mice Line of Cathepsin K by PCR
Chinese Journal of Comparative Medicine

Human osteopetroses and the osteoclast V-H+-ATPase enzyme system
Frontiers in Bioscience

The Clone of Human Novel Gene WD R 70 and Its Tentative Study
Journal of Microbiology

Cloning and Characterization of a Novel Human Gene ACB P5 cDNA
Chinese Journal of Biochemistry and Molecular Biology

Molecular Cloning and Expression Analysis of a Novel Human Gene ZN F18
HEREDITAS (Beijing)

Identification of Transgenic Mice of Cathepsin- K by Southern Blot Hybridization
Chinese Journal of Comparative Medicine

B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease
The American Journal of Pathology

CNBP regulates forebrain formation at organogenesis stage in chick embryos
Developmental Biology

Cloning and Expression Analysis of a Novel Mouse Gene BTB/Zinc Finger Gene Bsg6
Chinese Journal of Biochemistry and Molecular Biology

Molecular Cloning and Expression Analysis of a Novel E1 Like Gene UBAL in Mouse and Chicken
Progress in Biochemistry and Biophysics

Cloning and Expression Analysis of Human N-Acetyltransferase Domain Containing gene hNATL
Journal of Molecular Cell Biology

Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophy
Journal of Molecular Biology

Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence
Human Molecular Genetics

RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation
Genes & Development

RGS12 Is Essential for RANKL-Evoked Signaling for Terminal Differentiation of Osteoclasts In Vitro
Journal of Bone and Mineral Research

Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation
Journal of Cell Science

Osteoclast differentiation and gene regulation
Frontiers in Bioscience

Signaling and transcriptional regulation in osteoblast commitment and differentiation
Frontiers in Bioscience

Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption
Journal of Bone and Mineral Research

Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts
Biochemistry Journal

Targeted Overexpression of BSP in Osteoclasts Promotes Bone Metastasis of Breast Cancer Cells
Journal of Cellular Physiology

Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews in Eukaryotic Gene Expression

Requirement of the Epithelium-specific Ets Transcription Factor Spdef for Mucous Gland Cell Function in the Gastric Antrum
Journal of Biological Chemistry

Mutant (CCTG)n expansion causes abnormal expression of zinc finger protein 9 (ZNF9) in myotonic dystrophy type 2
The American Journal of Pathology

Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice
International Journal of Biological Sciences

G protein and its signaling pathway in bone development and disease
Frontiers in Bioscience

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function
International Journal of Biological Sciences

V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption
Journal of Bone and Mineral Research

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
International Journal of Biological Sciences

C/EBPα regulates osteoclast lineage commitment
Proceedings of the National Academy of Sciences of the United States of America

Inhibiting Periapical Lesions through AAV-RNAi Silencing of Cathepsin K
Journal of Dental Research

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction
Bone Research

RNA Interference-Mediated Silencing of Atp6i Prevents Both Periapical Bone Erosion and Inflammation in the Mouse Model of Endodontic Disease
Infection and Immunity

RNAi-Mediated Silencing of Atp6i and Atp6i Haploinsufficiency Prevents Both Bone Loss and Inflammation in a Mouse Model of Periodontal Disease
PLOS One

Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis
International Journal of Biological Sciences

Cbfβ deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfβ required for skeletal development
Proceedings of the National Academy of Sciences of the United States of America

Chondrocyte-specific Knockout of Cbfβ Reveals the Indispensable Function of Cbfβ in Chondrocyte Maturation, Growth Plate Development and Trabecular Bone Formation in Mice
International Journal of Biological Sciences

Core Binding Factor Beta (Cbfb) Controls the Balance of Chondrocyte Proliferation and Differentiation by Upregulating Indian hedgehog (Ihh) Expression and Inhibiting Parathyroid Hormone‐Related Protein Receptor (PPR) Expression in Postnatal Cartilage and Bone Formation
Journal of Bone and Mineral Research

Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells provides new insights into Cbfβ/Runxs complex function in cartilage and bone development
Bone

Wnt and the Wnt signaling pathway in bone development and disease
Frontiers in Bioscience

A small molecule, odanacatib, inhibits inflammation and bone loss caused by endodontic disease
Infection and Immunity

Ac45 silencing mediated by AAV-sh-Ac45-RNAi prevents both bone loss and inflammation caused by periodontitis
Journal of Clinical Periodontology

Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role
Federation of European Biochemical Societies Letters

Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases
Journal of Periodontology

The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation
Journal of Periodontal Research

CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity
Journal of Biological Chemistry

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Bone Research

Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression
Proceedings of the National Academy of Sciences of the United States of America

Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway
Nature Communications

Monocyte-Specific Knockout of C/ebpα Results in Osteopetrosis Phenotype, Blocks Bone Loss in Ovariectomized Mice, and Reveals an Important Function of C/ebpα in Osteoclast Differentiation and Function
Journal of Bone and Mineral Research

The Triple Functions of D2 Silencing in Treatment of Periapical Disease
Journal of Endodontics

Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity
Oncotarget

Bone resorption deficiency affects tooth root development in RANKL mutant mice due to attenuated IGF-1 signaling in radicular odontoblasts
Bone

C/ebpα controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1
Journal of Pathology

C/EBPα and PU.1 exhibit different responses to RANK signaling for osteoclastogenesis
Bone

C/EBPα transcription factor is regulated by the RANK cytoplasmic 535 IVVY 538 motif and stimulates osteoclastogenesis more strongly than c-Fos
Journal of Biological Chemistry

GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1
Cell Death and Differentiation

Monocyte-Specific Knockout of C/ebpα Results in Osteopetrosis Phenotype, Blocks Bone Loss in Ovariectomized Mice, and Reveals an Important Function of C/ebpα in Osteoclast Differentiation and Function
Journal of Bone and Mineral Research

Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling
Journal of Bone and Mineral Research

C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption in Endodontic Disease
Journal of Endodontics

Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis
Biochemical Journal

Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation
Journal of Biological Chemistry

F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFκB signaling pathways
International Journal of Biological Sciences

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
PLOS Genetics

GPR125 positively regulates osteoclastogenesis potentially through AKT-NF-κB and MAPK signaling pathways.
Int J Biol Sci

IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation. 
PNAS

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Int J Biol Sci

Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis.
Bone Research

Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation.
Int J Oral Sci

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease.
Cell Research

Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways.
Int J Biol Sci.

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis.
Elife

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis. 
Cell Discovery

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease. 
Bone Research