2023 ATC (Healthy/Px Anticoagulants)

This study is testing a new method of measuring blood clotting using small samples from finger pricks. Researchers want to compare these results with traditional lab tests to see if the new method is accurate for both healthy people and those on blood thinners.

Enrollment Period

Eligibility Criteria

Age

Adult (18 - 64)

Older adult (65+)

Accepts Healthy Volunteers

Yes

Gender

Any

Contact Information

Tulane Center for Clinical Research

504-988-0200

tccr@tulane.edu

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Who Qualifies for this Study?

Title

Comparative analysis of peripheral venous and capillary blood by acoustic tweezing coagulometry in healthy participants and participants treated with oral anticoagulants.

This study aims to correlate clinical laboratory coagulation tests (PT, APTT, TT, Fibrinogen, D-Dimer) with coagulation tests performed by the ATC of whole blood [and platelet poor plasma] collected by venipuncture. Aim 1b: To correlate ATC coagulation tests of whole blood [and platelet poor plasma] collected by venipuncture with ATC coagulation tests of whole blood collected by finger prick. Aim 2a: To standardize the ATC for coagulation measurements of capillary blood. Normal reference values for ATC coagulation parameters will be obtained from measurements of capillary blood samples collected from healthy volunteers. Capillary blood samples collected from patients on anticoagulant therapy will be used to test the validity of the normal reference values (in the limit of the hypo-coagulable state). Capillary blood samples from healthy volunteers will also be spiked with different concentration of fibrinogen and tissue plasminogen activator (tPA) to test the normal reference range validity in the limit of hyper-coagulable state. Two groups of participants are needed for this study: 1) a group of healthy subjects, 18 to 85 years old, 100 participants, and 2) a group of anticoagulant subjects with oral blood thinners such as Vitamin K antagonists, low molecular weight heparin (LMWH), and direct-acting oral anticoagulants (DOACs), 18 to 85 years old, 50 participants.

Study Overview

This research study is exploring whether a quicker, simpler method of checking how well blood clots—using finger-prick samples—can provide results as accurate as traditional lab tests. Researchers will compare finger-prick and regular blood draw results in both healthy people and those taking blood thinners. They’ll also test how well the new method works by adjusting certain blood components to mimic people who form too many or too few clots. The goal is to create reliable clotting test standards using this faster, less invasive method.

Conditions / Diseases

Blood clotting

Department / Organizations

Tulane Center for Clinical Research

Principal Investigator

ClinicalTrials.gov

Frequently Asked Questions

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By joining a clinical trial, you can gain access to new treatments before they’re widely available and help advance medical knowledge that could benefit others in the future.

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