DEPTH 
This is an image of liquid being dropped into a test tube

This study is exploring whether doxycycline, a common antibiotic, can help slow down lung damage from emphysema in people living with HIV. While doxycycline is FDA-approved for other conditions, its use in treating emphysema in this population is investigational. The trial also examines how safe and well-tolerated the drug is over time.

Study Status

Enrollment Period

Eligibility Criteria

Age
Adult (18 - 64)
Accepts Healthy Volunteers
No
Gender
Any

Contact Information

Tulane Center for Clinical Research
504-988-0200

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Who Qualifies for this Study?

  • Must be living with HIV.
  • Must have a diagnosis or evidence of emphysema or chronic lung damage.
  • Must be willing to take an investigational use of doxycycline.
  • Additional eligibility criteria may include specific lung function measurements, age requirements, and medical history review, as determined by the study team.
NHLBI (National Heart Lung and Blood Institute)

Doxycycline for Emphysema in People Living with HIV (The DEPTH Trial)

Protocol: DEPTH-001

This is a research study to evaluate if doxycycline can slow the damage to lungs caused by emphysema in people who also have HIV. It will also evaluate the safety and tolerability of the doxycycline. Doxycycline is an antibiotic that was originally approved by the Food and Drug Administration (FDA) in 1967 to treat or prevent a variety of infections and conditions including bronchitis, pneumonia, certain genital infections, Lyme disease, and malaria. Because doxycycline has not been approved by the Food and Drug Administration (FDA) to treat emphysema in people living with HIV, the use of this drug is considered investigational.

Study Overview

The DEPTH Trial (Doxycycline for Emphysema in People Living with HIV) is a clinical research study sponsored by the National Heart, Lung, and Blood Institute. Its goal is to determine whether doxycycline can slow the progression of emphysema—a chronic lung condition—in individuals who are also living with HIV. While doxycycline is an FDA-approved antibiotic commonly used to treat infections like pneumonia, bronchitis, and Lyme disease, its use for emphysema in people with HIV is considered investigational and is not currently FDA-approved for this purpose.

In addition to evaluating whether doxycycline is effective in slowing lung damage, the study also looks at the drug’s safety and how well participants tolerate it. The hope is that this research will provide a new therapeutic option for managing chronic lung disease in people with HIV, who may be at higher risk for emphysema-related complications.

Conditions / Diseases

HIV/AIDS

Department / Organizations

Tulane Center for Clinical Research (TCCR)

Principal Investigator

ClinicalTrials.gov

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What is a clinical trial?

A clinical trial is a research study that tests how new medical approaches work in people. It helps doctors find better ways to prevent, detect, or treat diseases.

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By joining a clinical trial, you can gain access to new treatments before they’re widely available and help advance medical knowledge that could benefit others in the future.

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