CHAP Maternal Follow-Up Study
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The CHAP Maternal follow-up study is a follow-up to the previous Chronic Hypertension and Pregnancy (CHAP) Project trial (2015-2021), which evaluated the safety and benefits of treating chronic hypertension (CHTN), or high blood pressure during pregnancy, and showed that treatment improved outcomes for mother and baby.
 

Study Status

Recruiting by invitation only

Enrollment Period

-

Eligibility Criteria

Age
Adult (18 - 64)
Accepts Healthy Volunteers
No
Gender
Female

Contact Information

Shae Williams
504-988-0200

Select a tab above for more information.

 

Who Qualifies for this Study?

  • Must have participated in the original CHAP Trial during pregnancy.
  • Must have had a diagnosis of mild chronic hypertension during that pregnancy.
  • Eligible participants may be between 0–6 years to 10 years postpartum from the time of CHAP trial participation.
  • Women with or without a history of superimposed preeclampsia during their CHAP trial pregnancy are eligible.
Funded by the National Institutes of Health & National Heart Lung and Blood Institute

 

Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension- Chronic Hypertension and Pregnancy (CHAP) Trial Maternal Follow-up Study

 

Protocol: 2R01HL120338-07

 

Sponsor: Funded by the National Institutes of Health, National Heart Lung and Blood Institute

The Chronic Hypertension and Pregnancy (CHAP) Project randomized pregnant women with mild chronic hypertension (CHTN) to usual care (i.e. antihypertensive therapy only if the patient experienced severe hypertension defined as systolic blood pressure (SBP) ≥160 mmHg or diastolic blood pressure (DBP) ≥105 mmHg) or to intervention (i.e. antihypertensive therapy to goal BP < 140/90 mmHg). The current protocol describes long-term follow up of these women during a 5-year window starting between 0 – 6 years until 5 – 10 years after their participation in the original CHAP trial. The goal is to determine whether treatment of mild chronic hypertension in pregnancy influences maternal risk of cardiovascular disease (CVD) and to evaluate the long-term effect of superimposed preeclampsia on CVD outcomes in women who had CHTN. 

Study Overview

The CHAP Maternal follow-up study will follow mothers who participated in the CHAP study. It will determine whether treatment of mild chronic hypertension (CHTN) in pregnancy affects the maternal risk of cardiovascular disease (CVD) 5-10 years after pregnancy. It will also evaluate the long-term effect on CVD outcomes of women who have CHTN but also developed preeclampsia (high blood pressure or worsening blood pressure in the second half of pregnancy) during pregnancy.

Conditions / Diseases

Hypertension (High blood pressure)

Department / Organizations

Tulane Center for Clinical Research (TCCR)

Principal Investigator

Dr. Gabriella Pridjian, MD

ClinicalTrials.gov

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