New Tulane University study reveals heart abnormalities in retired NFL players

A new, first-time study by Tulane University has revealed that former National Football League (NFL) players, particularly those with larger body sizes, were found to have heart abnormalities specifically associated with high blood pressure. Dr. Genevieve Smith, a faculty instructor at the Tulane University School of Medicine, is the lead author and Dr. Gregory Stewart, co-director of the Tulane Sports Medicine Program, is the senior author.

The study is the first to examine how an athlete’s body type and training style (strength versus endurance-based training) may influence changes in the shape of the heart years later. It’s also the first to attempt to distinguish changes that result from the intense nature of athletic training, which are likely harmless, from changes resulting from uncontrolled high blood pressure, which could be a warning sign for cardiovascular problems. 

“Because of their years of athletic training at the most elite level, there tends to be an expectation that former professional players would have fewer cardiovascular issues, but there’s a growing body of research that suggests that’s not the case,” said Smith. “Our study suggests we need to be vigilant in monitoring players’ cardiovascular health because we don’t yet truly understand the long-term consequences of high-performance athletics.”

“Our study suggests we need to be vigilant in monitoring players’ cardiovascular health because we don’t yet truly understand the long-term consequences of high-performance athletics.”

- Dr. Genevieve Smith

Elite athletes commonly show changes in the shape and size of their hearts in response to the advanced level of athletic training they receive, which are referred to as “athlete’s heart.” One component of an athlete’s heart is left ventricular hypertrophy (LVH), an increase in the thickness of the wall of the heart’s left ventricle. LVH is not thought to be harmful when it develops as a result of athletic training. However, in the general population LVH can develop as a consequence of uncontrolled high blood pressure, or hypertension, and is linked with an increased risk of heart disease. 

The new research is part of an ongoing study of the health of professional football players supported by the NFL Player Care Foundation. Researchers examined echocardiograms and images of the heart, along with blood pressure measurements and demographic factors, in a sample of 1,172 former players. 

Overall, about 12 percent of players in the sample had LVH, a rate comparable to that found in the general public. The condition appeared to be linked with an increased rate of hypertension, a key risk factor for cardiovascular disease. Former players with severe LVH had significantly higher blood pressure than those without LVH. Those former players with hypertension were also 1.5 times more likely to have LVH than those without hypertension.

In addition, the researchers found the likelihood of LVH tracked closely with the player’s position. LVH was most prevalent in positions that emphasize strength-based training and large body size, including linemen, fullbacks, running backs, linebackers, quarterbacks and tight ends. The condition was least prevalent among players in skill and speed-based positions such as cornerbacks, safeties, wide receivers, returners, kickers and punters. Those in positions emphasizing strength-based training were equally likely to have eccentric LVH, in which there is both thickening of the walls of the left ventricle and the left ventricle chamber volume is enlarged, or concentric LVH, in which only the walls of the left ventricle are thickened. Those in skill-based positions were more likely to have concentric LVH.

The findings underscore the need for former players and their doctors to keep an eye on any cardiovascular risk factors and work to keep blood pressure in a healthy range, Smith said.

Another early warning sign for heart problems is obstructive sleep apnea, a common sleep disorder. In a separate study, Smith and her colleagues found that a simple eight-question questionnaire administered during a check-up is a useful low-cost method to flag potential sleep apnea among former NFL players. Sleep apnea has increasingly been linked to cardiovascular disease.

In this study, former players who reported symptoms of sleep apnea on the questionnaire were more likely to have hypertension and LVH than those reporting few or no sleep apnea symptoms. While an overnight sleep test is required to definitively diagnose sleep apnea, the questionnaire can be used as a screening tool to identify patients who may need to be tested, Smith said. 

Both studies were funded by the NFL Player Care Foundation and will be presented at the American College of Cardiology’s 68th Annual Scientific Session, March 16-18, in New Orleans.