Welcome to the Wimley Lab at Tulane University School of Medicine! Our lab explores how proteins are structured, folded, and designed within membranes. By using peptide models of membrane proteins, the team develops new ways to understand and engineer these essential biological systems.
Approaches
The lab combines traditional methods with combinatorial chemistry and high-throughput screening to design and test peptide models. These peptides can self-assemble into membrane proteins or interact with existing ones, opening the door to innovative applications.
Current Projects
Learn about TuCeptin: Broad-Spectrum, Resistance-Proof Antimicrobial Peptides developed in the Wimley Lab.
Peptide pores: Designing membrane-spanning peptide pores for use in antibiotic development, targeted drug delivery, and biosensor engineering.
Cancer-targeting peptides: Creating peptides that bind specifically to receptors overexpressed in cancer cells, such as G-protein-coupled receptors and receptor tyrosine kinases. These molecules can modulate receptor activity or direct drugs and cytotoxic agents precisely to tumor cells.
Genomic and proteomic analysis: Developing tools to better identify membrane proteins within genome databases and improve predictions of their structure and function.
Contact Information:
Tulane University School of Medicine
Dept. of Biochemistry and Molecular Biology, 8643
1430 Tulane Avenue
New Orleans, LA 70112-2699
Lab Room Numbers: 6011, 6015, 6018, 6158
Office Room Number: 6032
Phone: 504-988-7076
Fax: 504-977-2739
Email: wwimley@tulane.edu
