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Core Facilities

Molecular, Imaging & Analytical

The Molecular, Imaging, and Analytical Core facility contributes greatly to the research projects conducted by the THRCE & COBRE investigators and provides a comprehensive service for molecular biology, imaging and biochemistry support. This facility serves as the resource to instruments and equipment needed to perform advanced molecular biology, semi-quantitative immuno-histochemistry and bio-analytical experiments, and support training of junior faculty, postdoctoral fellows, graduate and medical students in the areas of physiology, hypertension and cardiovascular and renal diseases.

Phenotype Core

The Mouse Phenotyping Core Facility offers:

  • 24-hour hemodynamic and activity monitoring by radio telemetry system.
  • Blood pressure determinations by plethysmography.
  • Single-mouse metabolic cages study.
  • Renal functional experiments (clearance experiments)
  • Renal Nerve activity recording
  • Echocardiography

Animal & Gene Targeted Core Facility

Animal and Gene-Targeted Core supports the study of genetic traits in intact animals has transgenic and gene-targeting experiments in which desired genetic changes are made in the germ-line. The facility maintains and generates new breeding pairs, genotyping, and colonies of genetically manipulated mouse and rat. These genetically engineered mouse and rat models and gene-targeted mouse strains are made available to COBRE investigators and others for hypertension, cardiovascular and renal research.

Clinical & Translational Core Facility

Clinical and Translational Core promote and facilitate clinical and translational studies in hypertension, kidney disorders, and related cardiovascular diseases. The goal is to facilitate and foster the translation of basic insights into clinical and population studies. This core will extend the existing synergies which have been developed in COBRE phases I and II.

COBRE III Pilot Projects & Investigators

Each year, 3 investigators are awarded a one year $45,000 grant to support their research. Applications are subjected to a rigorous review process to ensure that funds are provided to only the most highly meritorious projects that are likely to lead to extramural research support and will stimulate multidisciplinary collaborative interactions. The following are names of Pilot Project award recipients and information on their pilot project