Biography

I joined Tulane University as a tenure-tracked Assistant Professor in September 2019, where I am continuing to focus my research efforts on developing and validating integrated nanotechnique-based strategies for biomarker discovery and the development diagnostic approaches that use blood or urine. My goal is to provide novel solutions for early disease diagnosis to improve patient outcomes. I have a strong background in biochemistry, analytical chemistry and translational medicine and have published 29 peer-reviewed papers, filed three patents, wrote one book chapter, and received awards and recognition from several scientific societies, including the US Human Proteome Organization and The Association for Mass Spectrometry: Applications to the Clinical Laboratory. I am the Director of a newly established Proteomics Core at Tulane University and have access to and expertise with the instruments required to perform these biomarker discovery studies.
One notable achievement (BMC Med. 2017) has been the development of a method to diagnosis active tuberculosis cases earlier and with greater sensitivity than the current clinical gold-standard method. This method was verified in a cohort from the Houston Tuberculosis Initiative, a population-based retrospective case-control study. More recently, my research (Sci Adv. 2020) identified an extracellular vesicle protein, Tspan8, that can predict distant metastasis in lung cancer. This biomarker was evaluated for its ability to predict the future distant metastasis in samples obtained from a prospective randomized clinical trial.

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Publications

1. Liu, Y., Fan, J., Xu, T., Ahmadinejad, N., Hess, K., Lin, S.H., Zhang, J., Liu, X., Liu, L., Ning, B., Liao, Z., Hu, T.Y., 2020. Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non–small cell lung cancer after concurrent chemoradiation. Science Advances, 6: eaaz6162.
2. Fan, J., Wei, Q., Koay, E.J., Liu, Y., Ning, B., Bernard, P.W., Zhang, N., Han, H., Katz, M.H., Zhao, Z. and Hu, Y., 2018. Chemoresistance Transmission via Exosome-Mediated EphA2 Transfer in Pancreatic Cancer. Theranostics, 8(21), p.5986. (Cover Story)
3. Liang, K., Liu, F., Fan, J., Sun, D., Liu, C., Lyon, C.J., Bernard, D.W., Li, Y., Yokoi, K., Katz, M.H. and Koay, E.J., Zhao, Z., Hu, Y., 2017. Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring. Nature Biomedical Engineering, 1, p.0021. (Reported by Nat Rev Gastroenterol Hepatol, Chemical&Engineering News, Nature Asia).
4. Sun, D., Fan, J., Liu, C., Liu, Y., Bu, Y., Lyon, C.J. and Hu, Y., 2016. Noise Reduction Method for Quantifying Nanoparticle Light Scattering in Low Magnification Dark-Field Microscope Far-Field Images. Analytical Chemistry, 88(24), 12001-12005.
5. Zhang, F., Lyon, C.J., Walls, R.J. Ning, B. Fan, J.*, Hu, T.Y., 2019. Cathepsin B Dependent Cleavage Product of Serum Amyloid A1 Identifies Patients with Chemotherapy-Related Cardiotoxicity. ACS Pharmacology & Translational Science, 2 (5), 333-341. (co-corresponding author, Cover Story in this issue).
6. Fan, J., Tea, M.K.M., Yang, C., Ma, L., Meng, Q.H., Hu, T.Y., Singer, C.F. and Ferrari, M., 2016. Profiling of cross-functional peptidases regulated circulating peptides in BRCA1 mutant breast cancer. Journal of proteome research, 15(5), pp.1534-1545.
7. Fan, J., Niu, S., Dong, A., Shi, J., Wu, H.J., Fine, D.H., Tian, Y., Zhou, C., Liu, X., Sun, T., Anderson, G.J., Ferrari, M., Nie, G., Hu, Y., Zhao, Y., 2014. Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids. Nanomedicine: nanotechnology, biology, and medicine. 10(5):879-888. (Cover Story and Feature Article in this issue, and cited as Editors' Choice in Science Translational Medicine 23 APRIL 2014, VOL. 6, #233).  
8. Fan, J., Huang, Y., Finoulst, I., Wu, H.J., Deng, Z., Xu, R., Xia, X., Ferrari, M., Shen, H., Hu, Y., 2013. Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer letters. 334(2):202-10
9. Fan, J., Zhang, H., Nguyen, D.T., Lyon, C.J., Mitchell, C.D., Zhao, Z., Graviss, E.A. and Hu, Y., 2017. Rapid diagnosis of new and relapse tuberculosis by quantification of a circulating antigen in HIV-infected adults in the Greater Houston metropolitan area. BMC medicine, 15(1), p.188.
10. Liu, C., Zhao, Z., Fan, J., Zelazny, A.M., Olivier, K.N., Cazares, L., Holland, S.M., Graviss, E. A., Hu, Y., 2017. Quantification of circulating M. tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment responses, Proceedings of the National Academy of Sciences, 114(15), 3969-3974.
11. Wu, H.J., Li, Y., Fan, J., Deng, Z., Hu, Z., Liu, X., Graviss, E.A., Ferrari, M., Ma, X., Hu, Y., 2014. Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps. Analytical chemistry, 86(4):1988-96. (Reported by Chemical & Engineering News).
12. Hu, Y., Ma, X., Wu, H.-J., Fan, J., Sun, T., “Methods and compositions for detecting tuberculosis”, Publication No: US9196465 B2.