S. Michal Jazwinski, PhD

John W. Deming, MD Regents Chair in Aging

Director, Tulane Center for Aging, Professor of Medicine and Biochemistry
Office Address
Tulane Center for Aging, General Internal Medicine & Geriatrics 1430 Tulane Avenue, SL-12 New Orleans, LA 70112
School of Medicine

Education & Affiliations

PhD, Stanford University, 1975
Helen Hay Whitney Foundation Postdoctoral Research Fellow at The Rockefeller University, New York, New York


Dr. S. Michal Jazwinski received his doctoral degree from Stanford University.  He completed postdoctoral training at The Rockefeller University where he stayed on as assistant professor.  He moved to Louisiana State University Health Sciences Center in New Orleans as associate professor, where he achieved the rank of professor.  He is currently professor of medicine and professor of biochemistry at Tulane University.  He also directs the Tulane Center for Aging.  Dr. Jazwinski is active in research and education with a focus on aging and especially the genetics of aging.  His research interests are in the areas of genetics of aging, molecular genetics, and population genetics.


His research interests are in the areas of genetics of aging, molecular genetics, and population genetics.

  • Genetics of aging in yeast and humans
  • Molecular and cell biology of aging
  • Human aging
  • Population genetics


Tanes C, Walker EM, Slisarenko N, Gerrets GL, Grasperge BF, Qin X, Jazwinski SM, Bushman FD, Bittinger K, Rout N. Gut Microbiome Changes Associated with Epithelial Barrier Damage and Systemic Inflammation during Antiretroviral Therapy of Chronic SIV Infection. Viruses 13, 1567 (2021). PMCID: PMC8402875


Ji J, Jazwinski SM, Kim S.  Frailty and Biological Age. Ann. Geriatr. Med. Res. 25, 141-149 (2021). PMCID: PMC8497950

Merino KM, Jazwinski SM, Rout N.  Th17-Type Immunity and Inflammation of Aging.  Aging 13, 13378-13379 (2021). PMCID: PMC8202903

Liu S, Zhang B, Rowan BG, Jazwinski SM, Abdel-Mageed AB, Steele C, Wang AR, Sartor O, Niu T, Zhang Q. A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study.  Front. Mol. Biosci. 8, 696537 (2021). PMCID: PMC8211560

Kim S, Fuselier, J, Welsh DA, Cherry KE, Myers L, Jazwinski SM.  Feature Selection Algorithms Enhance the Accuracy of Frailty Indexes as Measures of Biological Age. J Gerontol A Biol Sci Med Sci. 76, 1347-1355 (2021).  PMCID: PMC277082

Walker E, Slisarenko N, Gerrets G, Grasperge B, Mattison J, Kissinger P, Welsh D, Veazey R, Jazwinski SM, Rout N.  Dysregulation of IL-17/IL-22 Effector Functions in Blood and Gut Mucosal Gamma Delta T cells Correlates with Increase in Circulating Leaky Gut and Inflammatory Markers during cART-Treated Chronic SIV Infection in Macaques.  Front Immunol. 12, 647398 (2021). doi: 10.3389/fimmu.2021.647398  PMCID: PMC7946846


Cherry KE, Elliott EM, Golob EJ, Silva Brown J, Kim S, Jazwinski SM, Strategic Encoding and Retrieval Processes in Verbal Recall among Middle-Aged and Older Adults.  Brit J Dev Psych, 39, 252-268 (2021). doi: 10.1111/bjdp.12349.  PMID: 33001487


Liu S, Liu F, Zhang B, Yan P, Rowan BG, Abdel-Mageed AB, Steele CH, Jazwinski SM, Moroz K, Norton EB, Wang A, Myers, L, Sartor AO, Zhang Q.  CD4+ T Helper 17 Cell Response of Aged Mice Promotes Prostate Cancer Cell Migration and Invasion.  The Prostate 80, 764-776 (2020).  PMCID: PMC7310589


Walker EM, Slisarenko N, Gerrets GL, Kissinger PJ, Didier ES, Kuroda MJ, Veazey RS, Jazwinski SM, Rout N.  Inflammaging Phenotype in Rhesus Macaques Is Associated with a Decline in Epithelial Barrier-Protective Functions and Increased Pro-Inflammatory Function in CD161-Expressing Cells.  GeroScience 41, 739-757 (2019).  PMCID: PMC6925095

Patel TH, Norman L, Chang S, Abedi S, Liu C, Chwa M, Atilano SR, Thaker K, Lu S, Jazwinski SM, Miceli MV, Udar N, Bota D, Kenney MC.  European mtDNA Variants Are Associated with Differential Responses to Cisplatin, an Anticancer Drug:  Implications for Drug Resistance and Side Effects.  Front. Oncol. 9, 640 (2019).  PMCID: PMC6659439


Jazwinski SM, Kim S.  Examination of the Dimensions of Biological Age.  Front. Genet. 10, 263 (2019).  PMCID: PMC6445152


Cherry KE, Lyon BA, Boudreaux EO, Blanchard AB, Hicks JL, Elliott EM, Myers L, Kim S, Jazwinski SM.  Memory Self-Efficacy and Beliefs about Memory and Aging in Oldest-Old Adults in the Louisiana Healthy Aging Study (LHAS).  Exp. Aging Res. 45, 28-40 (2019).  PMCID: PMC6375752


Dasa V, Eastwood JRB, Podgorski M, Park H, Blackstock C, Antoshchenko T, Rogala P, Bieganski T, Jazwinski SM, Czarny-Ratajczak M.  Exome Sequencing Reveals a Novel COL2A1 Mutation Implicated in Multiple Epiphyseal Dysplasia.  Amer. J. Med. Genet. Part A 179, 534-541 (2019).  PMCID: PMC6424334


Jiang JC, Stumpferl SW, Jazwinski SM.  Dual roles of mitochondrial fusion gene FZO1 in yeast age asymmetry and in longevity mediated by a novel ATG32-dependent retrograde response.  Biogerontology 20, 93-107 (2019).  PMID: 30298458


Poggiogalle E, Cherry KE, Su LJ, Kim S, Myers L, Welsh DA, Jazwinski SM, Ravussin E.  Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia.  J. Amer. Med. Dir. Assoc. 20, 70-75.e2 (2019).  PMCID: PMC7001873


Schneider K, Chwa M, Atilano SR, Nashine S, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn, AB, Kuppermann BD, Kenney MC.  Role of STING Complex in Differential Retrograde Signaling in Cybrids with K versus H Haplogroup Mitochondrial DNA.  bioRxiv 2018 doi: https://doi.org/10.1101/402495


Kim S, Wyckoff J, Morris AT, Succop A, Avery A, Duncan GE, Jazwinski SM.  DNA Methylation Associated with Healthy Aging of Elderly Twins.  GeroScience 40, 469-484 (2018).  PMCID: 6294724


Kim S, Jazwinski SM.  The gut microbiota and healthy aging.  Gerontology 64, 513-520 (2018).  PMCID: PMC6191326

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Tetsuhiro Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Bo Kim K, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J.  cGAS drives non-canonical NLRP3 inflammasome in age-related macular degeneration.  Nature Medicine 24, 50-61 (2018).  PMID: 29176737

Jazwinski, SM, Hill SM, Belancio VP.  Introduction in Circadian Rhythms and Their Impact on Aging, Springer International Publishing AG, Cham, Switzerland, 2017.  ISBN 978-3-319-64542-1.  DOI: 10.1007/978-3-319-64543-8, p. vii-xi.

Jazwinski SM, Belancio VP, Hill SM.  (eds.) Circadian Rhythms and Their Impact on Aging, Springer International Publishing AG, Cham, Switzerland, 2017.  ISBN 978-3-319-64542-1.  DOI: 10.1007/978-3-319-64543-8.

Jazwinski, SM.  Your opportunity for digital health engagement and behavior change.  E-Journal of Age Management Medicine 12 (9), (2017)

Jazwinski SM, Jiang JC, Kim S.  Adaptation to metabolic dysfunction during aging: Making the best of a bad situation.  Exp. Gerontol. 2017.  DOI: 10.1016/j.exger.2017.07.013.  PMID: 28760705

Jazwinski SM, Kim S.  Metabolic and genetic markers of biological age. Front. Genet., 64 (2017).  PMCID: PMC5440459

Maffei VJ, Kim S, Blanchard IV E, Luo M, Jazwinski SM, Taylor CM, Welsh DA. Biological Aging and the Human Gut Microbiota. J. Gerontol. A Biol. Sci. Med. Sci. 72, 1474-1482 (2017). doi: 10.1093/gerona/glx042. PMID: 28444190

Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A. A review of the biomedical innovations for healthy aging.  Aging, 7-25 (2017).  PMCID: PMC5310653

Kim S, Myers L, Wyckoff J, Cherry KE, Jazwinski SM.  The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age.  GeroScience 39, 83-92 (2017).  PMCID: PMC5352589>

Jiang JC, Stumpferl SW, Tiwari A, Qin Q, Rodriguez-Quiñones JF, Jazwinski SM.  Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae. Genetics 204, 659-673 (2016).  [Highlighted Article] PMCID: PMC5068853

Thaker K, Chwa M, Atilano SR, Coskun P, Cáceres-Del-Carpio J, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn AB, Kuppermann BD, Kenney MC.  Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA.  Neurobiol Dis. 93, 64-77 (2016).  PMID: 27109188

Zaman S, Choudhury M, Jiang JC, Srivastava P, Mohanty BK, Danielson C, Humphrey SJ, Jazwinski SM, Bastia D. Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. Mol. Cell. Biol. 36, 1451-1463 (2016).  PMCID: PMC4859694

Calamia M, Reese-Melancon C, Cherry KE, Hawley KS, Jazwinski SM.  The Knowledge of Memory Aging Questionnaire: Factor Structure and Correlates in Lifespan Sample.  Yale J. Biol. Med. 89, 91-96 (2016).  PMCID: PMC4797842

Cherry KE, Silva Brown J, Kim S, Jazwinski SM.  Social factors and healthy aging: Findings from the Louisiana Healthy Aging Study (LHAS). Kinesiology Rev. 5, 50-56 (2016).  PMCID: PMC4811626

Jazwinski, S.M. (2016), "Yeast studies on ageing", in The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at https://hstalks.com/bs/3289/)

Kim S, Myers L, Ravussin E, Cherry KE, Jazwinski SM.  Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians.  Biogerontology 17, 725-736 (2016) PMCID: PMC4935613

Kim S, Simon E, Myers L, Hamm LL, Jazwinski SM. Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians. Gerontology 62, 519-529 (2016).  [Editor’s Choice – Free Article] PMCID: PMC4993668

Svenkrtova A, Belicova L, Volejnikova A, Sigler K, Jazwinski SM, Pichova A. Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17, 395-408 (2016). PMCID: PMC4808460

Neltner JH, Abner EL, Jicha GA, Schmitt FA, Patel E, Poon LW, Marla G, Green RC, Davey A, Johnson MA, Jazwinski SM, Kim S, Davis D, Woodard JL, Kryscio RJ, Van Eldik LJ, Nelson PT. Brain pathologies in extreme old age. Neurobiol. Aging 37, 1-11 (2016). PMCID: PMC4688098

Stanko KE, Cherry KE, Ryker KS, Mughal F, Marks LD, Silva Brown J, Gendusa PF, Sullivan MC, Bruner J, Welsh DA, Su LJ, Jazwinski SM, for the Louisiana Healthy Aging Study.  Looking for the silver lining: benefit finding after Hurricanes Katrina and Rita in middle-aged, older, and oldest-old adults.  Current Psychology 34, 564-575 (2015).  PMCID: PMC4948298

Choudhury M, Zaman S, Jiang JC, Jazwinski SM, Bastia D.  Mechanism of regulation of ‘chromosome kissing’ induced by Fob1 and its physiological relevance.  Genes Dev. 29, 1188-1201 (2015).  PMCID: PMC4470286

Kim S, Jazwinski SM.  Quantitative measures of healthy aging and biological age.  Healthy Aging Res.  4:26 (2015).  doi:10.12715/har.2015.4.26 PMCID: PMC4440677

Atilano SR, Malik D, Chwa M, Caceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC.  Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes.  Hum. Mol. Genet. 24, 4491-4503 (2015). PMCID: PMC4512622

Belancio VP, Blask DE, Deininger P, Hill SM, Jazwinski SM.  The aging clock and circadian control of metabolism and genome stability.  Front Genet. 5, 455 (2015). doi: 10.3389/fgene.2014.00455  PMCID: PMC4294216

Kim S, Welsh DA, Myers L, Cherry KE, Wyckoff J, Jazwinski SM.  Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival.  Oncotarget 6, 3600-3612 (2015).  PMCID: PMC4414140

Jazwinski SM.  Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging.  Ageing Res. Rev. 23, 67-74 (2015). PMCID: PMC4480153

Jazwinski SM, Yashin AI.  Introduction in Aging and Health: A Systems Biology Perspective, Karger, Basel, 2015, p. vii-xii.  PMID: 25509217

Yashin AI, Jazwinski SM (ed.) Aging and Health: A Systems Biology Perspective, Karger, Basel, 2015, pp. 194

Case ME, Griffith J, Dong W, Tigner IL, Gaines K, Jiang JC, Jazwinski SM, Arnold J for the Georgia Centenarian Study.  The aging biological clock in Neurospora crassa.  Ecol. Evol. 4, 3494-3507 (2014).  PMCID: PMC4228622

Patwardhan GA, Hosain SB, Liu DX, Khiste SK, Zhao Y, Bielawski J, Jazwinski SM, Liu YY.  Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.  Biochim. Biophys. Acta 1841, 1571-1580 (2014).  PMCID: PMC4188706

Jazwinski, SM.  The retrograde response: a conserved compensatory reaction to damage from within and from without.  Prog. Mol. Biol. Transl. Sci. 127, 133-154 (2014).  PMCID: PMC4271643

Ayyadevara, S, Tazearslan, C, Alla, R, Jiang, JC, Jazwinski, SM, Shmookler Reis, RJ.  Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondysjunction in C. elegans and replicative lifespan in S. cerevisiae.  Front. Genet. 5, 211 (2014). doi:10.3389/fgene.2014.00211 PMCID: PMC4120681

Malik D, Hsu T, Falatoonzadeh P, Cáceres-Del-Carpio J, Tarek M, Chwa M, Atilano SR, Ramirez C, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC.Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases. PLoS One. 2014 Jun 11;9(2):e99003. doi: 10.1371/journal.pone.0099003. eCollection 2014. PMCID: PMC4053329

Kenney, MC, Chwa, M, Atilano, SR, Falatoonzadeh, P, Ramirez, C, Malik, D, Tarek, M, Caceres-del-Carpio, J, Nesburn, AB, Boyer, DS, Kuppermann, BD, Vawter, M, Jazwinski, SM, Miceli, M, Wallace, DC, Udar, N.  Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial–nuclear interactions.  Hum. Mol. Genet. 23, 3537-3551 (2014).  PMCID: PMC4049308

Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, Tarek M, Del Carpio JC, Nesburn AB, Boyer DS, Kuppermann BD, Vawter MP, Jazwinski SM, Miceli MV, Wallace DC, Udar N. Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibilities to diseases. Biochim. Biophys. Acta 1842, 208-219 (2014).  PMCID: PMC4326177

Kim S, Welsh DA, Ravussin E, Welsch MA, Cherry KE, Myers L, Jazwinski SM. An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively.  J. Gerontol. A Biol. Sci. Med. Sci. 69, 650-656 (2014).  PMID: 24162336 PMCID: PMC4022095