Prasun Datta, PhD

My research focuses on elucidating the role of metabolism in HIV-1 biogenesis and survival in latent CNS reservoirs, and the effects of HIV-1 induced neuro-inflammatory cytokines and small extracellular vesicles released from HIV-1 infected macrophage and microglia on the regulation of astrocyte glutamate transporter, EAAT2 and neurodegeneration. I am also interested in assessing the impact of substance of abuse such as opiate and cocaine on the cross-talk between cellular metabolism and epigenetics in HIV-1 biogenesis in macrophage and microglia, and astrocyte EAAT2 and non-coding RNA regulation. With emergence of SARS-CoV-2, I am interested in understanding how SARS-CoV-2 infection modulates lung cell metabolism and inflammation.