Shannon Esher Righi, PhD

The principal goal of my research program is to study the dynamic interactions between fungi and the immune system, with a particular focus on how fungi direct specific immune responses. Projects in the laboratory aim to combine fungal genetics and biology with fungal immunology to elucidate novel pathways by which fungi regulate the immune response. Specifically, we’ve identified a new paradigm for trained immunity and are investigating mechanisms that drive this immune response, as well as the long-term consequences of this immunity. Current areas of focus include characterizing the epigenetic and metabolic signatures associated with protective Candida dubliniensis induced trained immunity and defining PRR/fungal PAMP interactions that drive trained immunity in the bone marrow.

Research Interests

• Host-pathogen interactions
• Fungal pathogenesis
• Innate immunity