Education
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1995-1998 Residency in Clinical Pathology, Department of Pathology, Washington University School of Medicine, St. Louis, MO
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1991-1995 Postdoctoral Fellow and Research Associate: Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO
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1986-1991 PhD in Immunology, University of Texas Southwestern Medical Center, Dallas, TX
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1983-1985 MS in Immunology, Fudan University Shanghai Medical School, Shanghai, China
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1978-1982 MD, Fudan University Shanghai Medical School, Shanghai, China
Biography
Appointment and Position
1997-1998 Instructor, Department of Medicine, Washington University School of Medicine, St. Louis, MO
1998-2010 Assistant, Associate, Full Professor, Associated Director, Division of Molecular Diagnostics, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
2010-2020 Louis Y. Mazzini Professor of Pathology, Vice Chair for Clinical Pathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN
2010-2020 Director, Indiana University Health Pathology Laboratory, Indianapolis, IN
2020-Present Professor and Chair, Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
Research
Current Research Interests
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Publications
(Last 5 years)
Articles
- Li, M., Z. Yang, L.L. Vollmer, Y. Gao, Y. Fu, C. Liu, Xiaoyun Chen, P. Liu, A. Vogt, X.-M. Yin. AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition. PLoS One 10 (3): e0122083, April 20, 2015 (doi: 10.1371/journal.pone.0122083).
- Bronner, D.N., B.H. Abuaita, X. Chen, K.A. Fitzgerald, G. Nuñez, Y. He, X.M. Yin, M.X. O'Riordan. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity. 43:451-462, 2015
- Livingston, M.J., H.-F. Ding, S. Huang, J. A. Hill, X.-M. Yin and Z. Dong. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy 12(6):976-98, 2016 (doi: 10.1080/15548627.2016.1166317)
- Yu, C., S. Yan, B. Khambu, Xiaoyun Chen, Z. Dong, J. Luo, G. K. Michalopoulus, S. Wu, and X.-M. Yin. Gene expression analysis indicates divergent mechanisms in DEN-induced carcinogenesis in wild type and Bid-deficient livers. PLoS ONE 11(5): e0155211, 2016. Doi: 10.1371/journal.pone.0155211
- Gao, Y., Y. Liu, X. Cai, Z. Yang, Xiaoyun Chen, Y. Fu, Y. Lin, W. Wen, S. Li, X. Liu, H. Huang, A. Vogt, P. Liu, X.-M. Yin* and M. Li*. Golgi-associated LC3 lipidation requires V-ATPase in non-canonical autophagy. (*co-corresponding). Cell Death Dis.;7(8):e2330, 2016. (doi: 10.1038/cddis.2016.236)
- Kwon, J.J. J.A. Willy, R.C. Wek, M. Korc, X.-M. Yin and J. Kota. Novel role of miR-29 in pancreatic cancer autophagy and its therapeutic potential. Oncotarget. 7(44): 71635-71650, 2016 (doi: 10.18632/oncotarget.11928)
- Wang, Y., Y. Zhang, L. Chen, Q. Liang, X.-M. Yin, L. Miao, B.-H. Kang and D. Xue. Kinetics and specificity of paternal mitochondrial elimination in Caenorhabitis elegans. Nature Commun. 7:12569. 2016 (doi: 10.1038/ncomms12569).
- Zhang, D., J. Pan, X. Xiang, Y. Liu, G. Dong, M.J. Livingston, J-K. Chen, X.-M. Yin and Z. Dong. Protein kinase Cδ suppresses autophagy to induce kidney cell apoptosis in cisplatin nephrotoxicity. J. Am Soc Nephrol. 28:1131-1144, 2017 (published online on Oct 31, 2016, (doi: 10.1681/ASN.2016030337)
- Wang, L., J. Zhou, S. Yan, G. Lei, C-H. Lee, and X.-Ming Yin. Ethanol-triggered lipophagy requires SQSTM1 in AML12 cells. Science Reports, 7(1):12307. doi: 10.1038/s41598-017-12485-2.Sept 26, 2017
- Tang, C., H. Han, M. Yan, S. Zhu, J. Liu, Z. Liu, L. He, J. Tan, Y. Liu, H. Liu, L. Sun, S. Duan, Y. Peng, F. Liu, X-M. Yin, Z. Zhang and Z. Dong. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury. Autophagy. Published on Nov 26, 2017. https://doi.org/10.1080/15548627.2017.1405880
- Huang, T., C.K. Kim, A.A. Alvarez, R.P. Pangeni, X. Wan, X. Song, T. Shi, Y. Yang, N. Sastry, C.M. Horbinski, S. Lu, R. Stupp, J. A. Kessler, R. Nishikawa, I. Nakano, E.P. Sulman, X. Lu, C.D. James, X-M. Yin, B Hu, and S-Y. Cheng. MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma. Cancer Cell, 32: 840-855.e8, 2017. Doi: 10.1016/j.ccell.2017.11.005
- Liu, J., M. Livingston, G. Dong, C. Tang, Y. Su, G. Wu, X-M. Yin and Z. Dong. Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells. Cell Death Dis. 9(3): 322, 2018. Doi: 10.1038/s41419-018-0374-7
- Khambu, B., N. Huda, X. Chen, Y. Li, G. Dai, Z. Dong, W-X Zong, S. Waguri, U.A. Kohler, S. Werner, T.D. Oury, X.-M. Yin. HMGB1 promotes ductular reaction and tumorigenesis in autophagy deficient livers. J. Clin. Invest. 128(6): 2419-2435, 2018 (doi: 10.1172/JCI91814. Epub 2018 May 7). (Correction: J Clin Invest. 129(5):2163. 2019; doi: 10.1172/JCI129234. Epub 2019 May 1) PMID: 31042163
- Sethunath, D., S. Morusu, M. Tuceryan, O.W. Cummings, H. Zhang, X-M. Yin, S. Vanderbeck, N. Chalasani, S. Gawrieh. Automated assessment of steatosis in murine fatty liver. PLOS One, 13(5):e0197242, 2018 (doi: 10.1371/journal.pone.0197242).
- Zhang, H., S. Yan, B. Khambu, F. Ma, Y. Li, X. Chen, J. A. Martina, R. Puertollano, Y. Li, N. Chalasani, X.-M. Yin. Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in ling-term nutrient oversupply. Autophagy, 14:10, 1779-1795, 2018 (doi: 10.1080/15548627.2018.1490850). PMID: 30044707
- Liao, Y., M. Li, X. Chen, Y. Jiang, X-M. Yin. Interaction of TBC1D9B with mammalian ATG8 homologues regulates autophagic flux. Scientific Reports. 8: 13496, 2018 (doi: 10.1038/s41598-018-32003-2). PMID: 30202024
- Fu Y, L. Hong, J. Xu, G. Zhong, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.-M. Yin, P. Liu, M. Li. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 3. doi: 10.1080/15548627.2018.1517073. [Epub ahead of print] PMID: 30176161
- Lee, Y-M, L. A Noon, K. Akat, M. Ybanez, T.-F. Lee, M.-L. Berres, N. Fujiwara, N. Goossens, H.-I. Chou, F. Parvin-Nejad, B. Khambu, E. Kramer, R. Gordon, C. Pfleger, D. Germain, G. John, K. Campbell, Z. Yue, X.-M. Yin, A. M. Cuervo, M. Czaja, M. Fiel, Y. Hoshida, and S. Friedman. Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap. Nature Commun. 9(1): 4962, 2018, PMID: 30470740
- Khambu, B., T. Li, S. Yan, C. Yu, X. Chen, M. Goheen, Y. Li, J. Lin, O.W. Cummings, Y. A. Lee, S. Friedman, Z. Dong, G-S. Feng, S. Wu and X.-M. Yin. Hepatic autophagy deficiency compromises FXR functionality and causes cholestatic injury. Hepatology, 69: 2196-2213, 2019, PMID: 30520052
- Liu Y, X. Luo, H. Shan, Y. Fu, Q. Gu X. Zheng, Q. Dai, F. Xia F, Z. Zheng, P. Liu, X.-M Yin, L. Hong, M. Li. Niclosamide Triggers Non-Canonical LC3 Lipidation. Cells. 2019 Mar 15; 8(3). pii: E248. doi: 10.3390/cells8030248. PMID: 30875964
- Cho, S-G, X. Xiao, S. Wang, H. Gao, R. Rafikov, S. Black, S. Huang, H-F Ding, Y. Yoon, R. A. Kirken, X-M. Yin, H-G. Wang, Z. Dong. Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis. J. Amer. Soc. Neph. 30: 1174-1191, 2019. PMID: 31126972
- Yan, S., J Zhou, X. Chen, Z. Dong and X.-M. Yin. Diverse Consequences in liver injury in mice with different autophagy functional status treated with alcohol. Am. J. Pathol. 189: 1744-1762, 2019 PMID: 31199920
- Livingston M. J., J. Wang, J. Zhou, G. Wu, I.G. Ganley, J. A. Jill, X-M. Yin, Z. Dong. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidney. Autophagy, 15: 2142-2162, 2019. PMID: 31066324
- Tang, C., H. Han, Z. Liu, Y. Liu, L. Yin, J. Cai, L. He. Y. Liu, G. Chen, Z. Zhang. X-M. Yin, and Z. Dong. Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury. Cell Death Dis. 10: 677, 2019, PMID: 31515472
- Zheng, X., Z. Yang, Q. Gu, F. Xia, Y. Fu, P. Liu, X-M. Yin, M. Li. The protease activity of human ATG4B is regulated by reversible oxidative modification. Autophagy. 2020 Jan 3: 1-13, doi: 1080/15548627.2019.1709763. PMID: 31880198
Review
- L. Wang, B. Khambu, H. Zhang and X-M. Yin. Autophagy in alcoholic liver disease, self-eating triggered by drinking. Clinics and Research in Hepatology and Gastroenterology, 2015 Sep;39 Suppl 1:S2-6. doi: 10.1016/j.clinre.2015.05.023
- Klionsky, D, ……….X.-M. Yin et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016
- Li, M., Y. Fu, Z. Yang, and X.-M. Yin. Analysis of the ATG4 cysteine proteases. Methods in Enzymology, 587:207-225, 2017
- Khambu, B, L. Wang, H. Zhang, and X.-M. Yin, The activation and function of autophagy in alcoholic liver disease. Current Molecular Pharmacology (special issue on “New Insights on Mechanisms of Alcohol-induced Fatty Liver”), 10(3): 165-171, 2017. (doi: 10.2174/1874467208666150817112654)
- Yan, S., N. Huda, B. Khambu and X-M. Yin. Relevance of autophagy to fatty liver diseases and potential therapeutic applications. Amino Acids. 49: 1965-1979, 2017 (doi: 10.1007/s00726-017-2429-y)
- Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin. Homeostatic role of autophagy in hepatocytes. Seminar in Liver Research. 38:308-319, 2018. PMID: 30357768
- Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin. Autophagy in nonalcoholic fatty liver disease and alcoholic liver disease. Liver Research. 2: 112-119, 2018
- Huda, N., S. Yan, B. Khambu, H. Zou and X-M. Yin. Analysis of autophagy in fatty liver diseases. Methods in Molecular Biology 1880: 481-489, 2019 (ed. By O. Florey and N. Ktistakis). (PMID: 30610716)
- Fu, Y., Z. Huang, L. Hong, J.H. Lu, D. Feng, X-M. Yin, M. Li. Targeting ATG4 in cancer therapy. Cancers (Basel), 2019 May 10;11(5). pii: E649. doi: 10.3390/cancers11050649, PMID: 31083460
- Huda, N. G. Liu, H. Hong, S. Yan, B. Khambu and X.-M. Yin. Hepatic senescence, the good and the bad. World Journal of Gastroenterology. 25: 5069-5081, 2019. doi: 10.3748/wjg.v25.i34.5069. PMID: 31558857, PMID: 31558857
- Yan, S., B. Khambu, H. Hong, G. Liu, N. Huda and X-M. Yin. Autophagy, metabolism, and alcohol-related liver disease: Novel modulators and functions. International Journal of Molecular Sciences. 20: E5029, doi: 10.3390/ijms20205029, PMID: 31614437
- Khambu, B., S. Yan, N. Huda, and X-M. Yin. Role of High-Mobility Group Box-1 in liver pathogenesis. International Journal of Molecular Sciences. 20: E5314, 2019, doi: 10.3390/ijms20215514, PMID: 31731454
Comments and Book Chapters
- Zhang, H., B. Khambu, and X.-M. Yin. Chapter 11. Autophagy. In “Signaling Pathways in Liver Diseases” (3rd edition, by J. F. Dufour and P.A. Clavien), Wiley, 2015
- Khambu, B., H. Zhang, and X.-M. Yin. Chapter 9, Role of autophagy and mitophagy in liver disease. In “Mitochondria in Liver Disease” (ed. By D. Han and N. Kaplowitz, a book of “Oxidative Stress and Disease” series), CRC Press, 2015
- Khambu, B; N. Huda, J. Zhou, S. Yan, and X.-M. Yin. Chapter 8, Autophagy in liver homeostasis. In “Cell Death in Liver Injury” (ed. by W.-X. Ding and X-M. Yin, a book of the “Cell death in Biology and Disease” series. Springer, 2017)
- Yin, X.-M. Autophagy in liver diseases: a matter of what to remove and whether to keep. Liver Research. 2:109-111, 2018