Education

• 1995-1998 Residency in Clinical Pathology, Department of Pathology, Washington University School of Medicine, St. Louis, MO
• 1991-1995 Postdoctoral Fellow and Research Associate: Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO
• 1986-1991 PhD in Immunology, University of Texas Southwestern Medical Center, Dallas, TX
• 1983-1985 MS in Immunology, Fudan University Shanghai Medical School, Shanghai, China
• 1978-1982 MD, Fudan University Shanghai Medical School, Shanghai, China

Biography

Appointment and Position

1997-1998 Instructor, Department of Medicine, Washington University School of Medicine, St. Louis, MO

1998-2010 Assistant, Associate, Full Professor, Associated Director, Division of Molecular Diagnostics, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA

2010-2020 Louis Y. Mazzini Professor of Pathology, Vice Chair for Clinical Pathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

2010-2020 Director, Indiana University Health Pathology Laboratory, Indianapolis, IN

2020-Present  Professor and Chair, Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA

 

Publications

(Last 5 years)

Articles

1. Li, M., Z. Yang, L.L. Vollmer, Y. Gao, Y. Fu, C. Liu, Xiaoyun Chen, P. Liu, A. Vogt, X.-M. Yin.  AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition.  PLoS One 10 (3): e0122083, April 20, 2015 (doi: 10.1371/journal.pone.0122083).
2. Bronner, D.N., B.H. Abuaita, X. Chen, K.A. Fitzgerald, G. Nuñez, Y. He, X.M. Yin, M.X. O'Riordan. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.  Immunity. 43:451-462, 2015
3. Livingston, M.J., H.-F. Ding, S. Huang, J. A. Hill, X.-M. Yin and Z. Dong. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction.  Autophagy 12(6):976-98, 2016 (doi: 10.1080/15548627.2016.1166317)
4. Yu, C., S. Yan, B. Khambu, Xiaoyun Chen, Z. Dong, J. Luo, G. K. Michalopoulus, S. Wu, and X.-M. Yin.  Gene expression analysis indicates divergent mechanisms in DEN-induced carcinogenesis in wild type and Bid-deficient livers.  PLoS ONE 11(5): e0155211, 2016. Doi: 10.1371/journal.pone.0155211
5. Gao, Y., Y. Liu, X. Cai, Z. Yang, Xiaoyun Chen, Y. Fu, Y. Lin, W. Wen, S. Li, X. Liu, H. Huang, A. Vogt, P. Liu, X.-M. Yin* and M. Li*.  Golgi-associated LC3 lipidation requires V-ATPase in non-canonical autophagy.  (*co-corresponding).  Cell Death Dis.;7(8):e2330, 2016. (doi: 10.1038/cddis.2016.236)
6. Kwon, J.J. J.A. Willy, R.C. Wek, M. Korc, X.-M. Yin and J. Kota. Novel role of miR-29 in pancreatic cancer autophagy and its therapeutic potential.  Oncotarget. 7(44): 71635-71650, 2016 (doi: 10.18632/oncotarget.11928)
7. Wang, Y., Y. Zhang, L. Chen, Q. Liang, X.-M. Yin, L. Miao, B.-H. Kang and D. Xue. Kinetics and specificity of paternal mitochondrial elimination in Caenorhabitis elegans.  Nature Commun. 7:12569. 2016 (doi: 10.1038/ncomms12569).
8. Zhang, D., J. Pan, X. Xiang, Y. Liu, G. Dong, M.J. Livingston, J-K. Chen, X.-M. Yin and Z. Dong. Protein kinase Cδ suppresses autophagy to induce kidney cell apoptosis in cisplatin nephrotoxicity.  J. Am Soc Nephrol.  28:1131-1144, 2017 (published online on Oct 31, 2016, (doi: 10.1681/ASN.2016030337)
9. Wang, L., J. Zhou, S. Yan, G. Lei, C-H. Lee, and X.-Ming Yin.  Ethanol-triggered lipophagy requires SQSTM1 in AML12 cells.  Science Reports, 7(1):12307. doi: 10.1038/s41598-017-12485-2.Sept 26, 2017
10. Tang, C., H. Han, M. Yan, S. Zhu, J. Liu, Z. Liu, L. He, J. Tan, Y. Liu, H. Liu, L. Sun, S. Duan, Y. Peng, F. Liu, X-M. Yin, Z. Zhang and Z. Dong.  PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.  Autophagy.  Published on Nov 26, 2017. https://doi.org/10.1080/15548627.2017.1405880
11. Huang, T., C.K. Kim, A.A. Alvarez, R.P. Pangeni, X. Wan, X. Song, T. Shi, Y. Yang, N. Sastry, C.M. Horbinski, S. Lu, R. Stupp, J. A. Kessler, R. Nishikawa, I. Nakano, E.P. Sulman, X. Lu, C.D. James, X-M. Yin, B Hu, and S-Y. Cheng.  MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma.  Cancer Cell, 32: 840-855.e8, 2017. Doi: 10.1016/j.ccell.2017.11.005
12. Liu, J., M. Livingston, G. Dong, C. Tang, Y. Su, G. Wu, X-M. Yin and Z. Dong.  Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells.  Cell Death Dis. 9(3): 322, 2018.  Doi: 10.1038/s41419-018-0374-7
13. Khambu, B., N. Huda, X. Chen, Y. Li, G. Dai, Z. Dong, W-X Zong, S. Waguri, U.A. Kohler, S. Werner, T.D. Oury, X.-M. Yin. HMGB1 promotes ductular reaction and tumorigenesis in autophagy deficient livers.  J. Clin. Invest.  128(6): 2419-2435, 2018 (doi: 10.1172/JCI91814. Epub 2018 May 7). (Correction: J Clin Invest. 129(5):2163. 2019; doi: 10.1172/JCI129234. Epub 2019 May 1) PMID: 31042163
14. Sethunath, D., S. Morusu, M. Tuceryan, O.W. Cummings, H. Zhang, X-M. Yin, S. Vanderbeck, N. Chalasani, S. Gawrieh.  Automated assessment of steatosis in murine fatty liver.  PLOS One, 13(5):e0197242, 2018 (doi: 10.1371/journal.pone.0197242). 
15. Zhang, H., S. Yan, B. Khambu, F. Ma, Y. Li, X. Chen, J. A. Martina, R. Puertollano, Y. Li, N. Chalasani, X.-M. Yin.  Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in ling-term nutrient oversupply.  Autophagy, 14:10, 1779-1795, 2018 (doi: 10.1080/15548627.2018.1490850). PMID: 30044707
16. Liao, Y., M. Li, X. Chen, Y. Jiang, X-M. Yin.  Interaction of TBC1D9B with mammalian ATG8 homologues regulates autophagic flux.  Scientific Reports. 8: 13496, 2018 (doi: 10.1038/s41598-018-32003-2). PMID: 30202024
17. Fu Y, L. Hong, J. Xu, G. Zhong, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.-M. Yin, P. Liu, M. Li. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 3. doi: 10.1080/15548627.2018.1517073. [Epub ahead of print]  PMID: 30176161
18. Lee, Y-M, L. A Noon, K. Akat, M. Ybanez, T.-F. Lee, M.-L. Berres, N. Fujiwara, N. Goossens, H.-I. Chou, F. Parvin-Nejad, B. Khambu, E. Kramer, R. Gordon, C. Pfleger, D. Germain, G. John, K. Campbell, Z. Yue, X.-M. Yin, A. M. Cuervo, M. Czaja, M. Fiel, Y. Hoshida, and S. Friedman. Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.  Nature Commun. 9(1): 4962, 2018, PMID: 30470740
19. Khambu, B., T. Li, S. Yan, C. Yu, X. Chen, M. Goheen, Y. Li, J. Lin, O.W. Cummings, Y. A. Lee, S. Friedman, Z. Dong, G-S. Feng, S. Wu and X.-M. Yin.  Hepatic autophagy deficiency compromises FXR functionality and causes cholestatic injury.  Hepatology, 69: 2196-2213, 2019, PMID: 30520052
20. Liu Y, X. Luo, H. Shan, Y. Fu, Q. Gu X. Zheng, Q. Dai, F. Xia F, Z. Zheng, P. Liu, X.-M Yin, L. Hong, M. Li. Niclosamide Triggers Non-Canonical LC3 Lipidation.  Cells. 2019 Mar 15; 8(3). pii: E248. doi: 10.3390/cells8030248. PMID: 30875964
21. Cho, S-G, X. Xiao, S. Wang, H. Gao, R. Rafikov, S. Black, S. Huang, H-F Ding, Y. Yoon, R. A. Kirken, X-M. Yin, H-G. Wang, Z. Dong. Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis. J. Amer. Soc. Neph.  30: 1174-1191, 2019. PMID: 31126972
22. Yan, S., J Zhou, X. Chen, Z. Dong and X.-M. Yin.  Diverse Consequences in liver injury in mice with different autophagy functional status treated with alcohol.  Am. J. Pathol. 189: 1744-1762, 2019  PMID: 31199920
23. Livingston M. J., J. Wang, J. Zhou, G. Wu, I.G. Ganley, J. A. Jill, X-M. Yin, Z. Dong.  Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidney.  Autophagy, 15: 2142-2162, 2019. PMID: 31066324
24. Tang, C., H. Han, Z. Liu, Y. Liu, L. Yin, J. Cai, L. He. Y. Liu, G. Chen, Z. Zhang. X-M. Yin, and Z. Dong. Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury. Cell Death Dis. 10: 677, 2019,  PMID: 31515472
25.  Zheng, X., Z. Yang, Q. Gu, F. Xia, Y. Fu, P. Liu, X-M. Yin, M. Li.  The protease activity of human ATG4B is regulated by reversible oxidative modification.  Autophagy. 2020 Jan 3: 1-13, doi: 1080/15548627.2019.1709763. PMID: 31880198

 

Review

1. L. Wang, B. Khambu, H. Zhang and X-M. Yin.  Autophagy in alcoholic liver disease, self-eating triggered by drinking.  Clinics and Research in Hepatology and Gastroenterology, 2015 Sep;39 Suppl 1:S2-6. doi: 10.1016/j.clinre.2015.05.023
2. Klionsky, D, ……….X.-M. Yin et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (3^rd edition).  Autophagy 12(1):1-222, 2016
3. Li, M., Y. Fu, Z. Yang, and X.-M. Yin.  Analysis of the ATG4 cysteine proteases.  Methods in Enzymology, 587:207-225, 2017
4. Khambu, B, L. Wang, H. Zhang, and X.-M. Yin, The activation and function of autophagy in alcoholic liver disease.  Current Molecular Pharmacology (special issue on “New Insights on Mechanisms of Alcohol-induced Fatty Liver”), 10(3): 165-171, 2017. (doi: 10.2174/1874467208666150817112654)
5. Yan, S., N. Huda, B. Khambu and X-M. Yin. Relevance of autophagy to fatty liver diseases and potential therapeutic applications.  Amino Acids.  49: 1965-1979, 2017 (doi: 10.1007/s00726-017-2429-y)
6. Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin. Homeostatic role of autophagy in hepatocytes. Seminar in Liver Research.  38:308-319, 2018. PMID: 30357768
7. Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin. Autophagy in nonalcoholic fatty liver disease and alcoholic liver disease.  Liver Research.  2: 112-119, 2018
8. Huda, N., S. Yan, B. Khambu, H. Zou and X-M. Yin.  Analysis of autophagy in fatty liver diseases.  Methods in Molecular Biology 1880: 481-489, 2019 (ed. By O. Florey and N. Ktistakis).  (PMID: 30610716)
9. Fu, Y., Z. Huang, L. Hong, J.H. Lu, D. Feng, X-M. Yin, M. Li.  Targeting ATG4 in cancer therapy.  Cancers (Basel), 2019 May 10;11(5). pii: E649. doi: 10.3390/cancers11050649, PMID: 31083460
10. Huda, N. G. Liu, H. Hong, S. Yan, B. Khambu and X.-M. Yin. Hepatic senescence, the good and the bad.  World Journal of Gastroenterology. 25: 5069-5081, 2019. doi: 10.3748/wjg.v25.i34.5069. PMID: 31558857, PMID: 31558857
11. Yan, S., B. Khambu, H. Hong, G. Liu, N. Huda and X-M. Yin. Autophagy, metabolism, and alcohol-related liver disease: Novel modulators and functions. International Journal of Molecular Sciences. 20: E5029, doi: 10.3390/ijms20205029, PMID: 31614437
12. Khambu, B., S. Yan, N. Huda, and X-M. Yin. Role of High-Mobility Group Box-1 in liver pathogenesis.  International Journal of Molecular Sciences. 20: E5314, 2019, doi: 10.3390/ijms20215514, PMID: 31731454

 

Comments and Book Chapters

1. Zhang, H., B. Khambu, and X.-M. Yin.  Chapter 11. Autophagy.  In “Signaling Pathways in Liver Diseases” (3rd edition, by J. F. Dufour and P.A. Clavien), Wiley, 2015
2. Khambu, B., H. Zhang, and X.-M. Yin.  Chapter 9, Role of autophagy and mitophagy in liver disease.  In “Mitochondria in Liver Disease” (ed. By D. Han and N. Kaplowitz, a book of “Oxidative Stress and Disease” series), CRC Press, 2015
3. Khambu, B; N. Huda, J. Zhou, S. Yan, and X.-M. Yin. Chapter 8, Autophagy in liver homeostasis.  In “Cell Death in Liver Injury” (ed. by W.-X. Ding and X-M. Yin, a book of the “Cell death in Biology and Disease” series. Springer, 2017)
4. Yin, X.-M.  Autophagy in liver diseases: a matter of what to remove and whether to keep.  Liver Research. 2:109-111, 2018