Shengmin Yan, Ph.D.

Assistant Professor

Office Address
1430 Tulane Avenue, Rm 6710, New Orleans, LA 70112
School of Medicine

Education & Affiliations

2015-2020 Postdoctoral training in liver pathology Indiana University School of Medicine, Indianapolis, IN
2011-2015 Doctor of Philosophy in Biochemistry and Molecular Biology Institute of Zoology, CAS, Beijing, P.R. China
2008-2011 Master of Science in Biochemistry and Molecular Biology Fuzhou University, Fuzhou, P.R. China
204-2008 Bachelor of engineering in Bioengineering Fuzhou University, Fuzhou, P.R. China

Biography

I have a broad background in liver diseases, with specific training and expertise in hepatotoxicity, fatty liver diseases, gut-liver interaction, and laboratory medicine. My research includes basic and translational research in alcoholic fatty liver diseases, non-alcoholic fatty liver diseases, drug-induced liver injury, obesity, and environmental hepatotoxicity. I laid the groundwork for the proposed research by developing effective in vivo animal models and in vitro models, and by applying novel techniques including single-cell RNA sequencing, bulk RNA sequencing, metabolome analysis, miRNA array, proteomic analysis, 16S sequencing analysis, and other molecular biology technologies. 

Positions and Employment

2020-present    Instructor, Tulane University School of Medicine, New Orleans, LA
2015-2020    Postdoctoral appointee, Indiana University School of Medicine, Indianapolis, IN
2011-2015    Doctoral student, Institute of Zoology, CAS, Beijing, P.R. China
2008-2011    Master student, Fuzhou University, Fuzhou, P.R. China
 

Research

Research Support

Active

LA CaTS Pilot Grant Round 9           Yan, Shengmin (PI)               10/01/2020-03/31/2022

The role of BID in NAFLD-related metabolic changes of hepatic macrophages

The major goal of this project is to study the role of BID in diet-induced obesity and hepatic steatosis.

Role: PI                                                           Direct cost: $33,000

Publications

Research Articles

  1. Yan, S., B. Khambu, X. Chen, Z. Dong, G. Guo and X.-M. Yin (2021). "Hepatic autophagy deficiency remodels gut microbiota for an adaptive protection via FGF15-FGFR4 signaling." Cell Mol Gastroenterol Hepatol 11(4): 973-997.
  2. Yan, S., J. Zhou, X. Chen, Z. Dong and X.-M. Yin (2019). "Diverse Consequences in Liver Injury in Mice with Different Autophagy Functional Status Treated with Alcohol." Am J Pathol 189(9): 1744-1762.
  3. Zhang, H.#, S. Yan#, B. Khambu, F. Ma, Y. Li, X. Chen, J. A. Martina, R. Puertollano, Y. Li, N. Chalasani and X.-M. Yin (2018). "Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply." Autophagy 14(10): 1779-1795. (# co-first author)
  4. Yan, S., H. Zhang, X. Guo, J. Wang and J. Dai (2017). "High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver." Arch Toxicol 91(1): 247-258.
  5. Yan, S., H. Zhang, J. Wang, F. Zheng and J. Dai (2015). "Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate." Free Radic Biol Med 87: 300-311.
  6. Yan, S.#, H. Zhang#, F. Zheng, N. Sheng, X. Guo and J. Dai (2015). "Perfluorooctanoic acid exposure for 28 days affects glucose homeostasis and induces insulin hypersensitivity in mice." Sci Rep 5: 11029. (# co-first author)
  7. Yan, S., J. Wang and J. Dai (2015). "Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days." Arch Toxicol 89(9): 1569-1578.
  8. Yan, S., J. Wang, W. Zhang and J. Dai (2014). "Circulating microRNA profiles altered in mice after 28 days exposure to perfluorooctanoic acid." Toxicol Lett 224(1): 24-31.
  9. Khambu, B., T. Li, S. Yan, C. Yu, X. Chen, M. Goheen, Y. Li, J. Lin, O. W. Cummings, Y. A. Lee, S. Friedman, Z. Dong, G. S. Feng, S. Wu and X.-M. Yin (2019). "Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury." Hepatology 69(5): 2196-2213.
  10. Wang, L., J. Zhou, S. Yan, G. Lei, C. H. Lee and X.-M. Yin (2017). "Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells." Sci Rep 7(1): 12307.
  11. Zheng, F., N. Sheng, H. Zhang, S. Yan, J. Zhang and J. Wang (2017). "Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver." Toxicol Appl Pharmacol 335: 41-48.
  12. Lu, Y., J. Wang, X. Guo, S. Yan and J. Dai (2017). "Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes." Toxicol Appl Pharmacol 318: 41-48.
  13. Yu, C., S. Yan, B. Khambu, X. Chen, Z. Dong, J. Luo, G. K. Michalopoulos, S. Wu and X.-M. Yin (2016). "Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers." PLoS One 11(5): e0155211.
  14. Wang, J., S. Yan, W. Zhang, H. Zhang and J. Dai (2015). "Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice." J Proteome Res 14(1): 330-341.
  15. Zhang, H., Y. Lu, B. Luo, S. Yan, X. Guo and J. Dai (2014). "Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery." J Proteome Res 13(7): 3370-3385.
  16. Li, H., S. Yan, Z. Wang, X. Shen and P. Rao (2011). "In vivo and in vitro effect of peptide HP-6 derived from donkey serum albumin on hematopoietic system." China Journal of Chinese Materia Medica 36(16): 2259-2264. (in Chinese)
  17. Li, H., H. Weng, Q. Huang, X. Shen, X. Gao, S. Yan, Z. Zhang, Z. Wang and P. Rao (2011). "The preparation and purification of specific polyclonal antibody against melamine and detection by ELISA." Journal of Chinese Institute of Food Science and Technology 11(5): 169-175. (in Chinese)
  18. Li, H., T. Luo, S. Yan, X. Gao, X. Shen, Z. Zhang, and P. Rao (2010). "Study on the proliferation of bone marrow hematopoietic cells promoted by peptide from donkey serum albumin." Journal of Chinese Institute of Food Science and Technology 10(2): 12-19. (in Chinese)
  19. Li, H., H. Weng, Y. Zheng, X. Shen, X. Gao, Z. Zhang, S. Yan and P. Rao (2010). "Preparation and identification of polyclonal antibody against melamine." Journal of Fuzhou University 38(5): 763-766. (in Chinese)

Review and book chapters

  1. Yan, S., B. Khambu, H. Hong, G. Liu, N. Huda and X.-M. Yin (2019). "Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions." Int J Mol Sci 20(20): 5029. (co-responding author)
  2. Yan, S., N. Huda, B. Khambu and X.-M. Yin (2017). "Relevance of autophagy to fatty liver diseases and potential therapeutic applications." Amino Acids 49(12): 1965-1979.
  3. Khambu, B., S. Yan, N. Huda and X.-M. Yin (2019). "Role of High-Mobility Group Box-1 in Liver Pathogenesis." Int J Mol Sci 20(21): 5314.
  4. Huda, N., G. Liu, H. Hong, S. Yan, B. Khambu and X.-M. Yin (2019). "Hepatic senescence, the good and the bad." World J Gastroentero 25(34): 5069-5081.
  5. Huda, N., H. Zou, S. Yan, B. Khambu and X.-M. Yin (2019). "Analysis of Autophagy for Liver Pathogenesis." Autophagy. Methods in Molecular Biology, N. Ktistakis and O. Florey, Humana Press, 1880: 481-489. (Book chapter)
  6. Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin (2018). "Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease." Liver Res 2(3): 112-119.
  7. Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin (2018). "Homeostatic Role of Autophagy in Hepatocytes." Semin Liver Dis 38(04): 308-319.
  8. Khambu, B., N. Huda, J. Zhou, S. Yan and X.-M. Yin (2017). “Autophagy in Liver Homeostasis.” Cellular Injury in Liver Diseases. W.-X. Ding and X.-M. Yin. Cham, Springer International Publishing: 195-217. (Book chapter)

Oral Presentation

  1. Yan, S. (2020, Oct.), Microbiome and cholestatic liver disease. Invited speaker presented at SCBA-Hepatology Division Third CALS Annual Symposium (Virtual).
  2. Yan, S., B. Khambu, X. Chen and X.-M. Yin (2019, Apr.), Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota. Abstract-Driven Short Talk presented at ASIP 2019 Annual Meeting, in Orlando, Florida.
  3. Yan, S., X. Chen, and X.-M. Yin (2018, Oct.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster Blitz presented at PISA 2018 Meeting (ASIP), Ann Arbor, MI, United States.
  4. Yan, S., L. Wang, J. Zhou, X. Chen, B. Khambu, and X.-M. Yin (2017, March), Establishment of a cellular model to study ethanol-induced lipophagy. Short talk presented at Gordon Research Conference on Alcohol-Induced End Organ Diseases, Ventura, CA, United States.

Published abstracts

  1. Yan, S., X. Chen, M. Ma and X.-M. Yin (2021). "BID-deficiency leads to resistance to diet-induced obesity and hepatic steatosis and reduced expression of fatty acid receptor, CD36." FASEB J 35(S1).
  2. Yan, S., B. Khambu, X. Chen and X.-M. Yin (2020). "Gut Microbiota Protect Against Liver Injury in Autophagy Deficient Mice by FXR-FGF15 Feedback Signaling." Am J Pathol 190(12): S27-S27.
  3. Yan, S., X. Chen and X.-M. Yin (2019). " Gut Microbiota Participate in the Resistance of Bid-Deficient Mice to Diet-Induced Hepatic Steatosis and Obesity." Hepatology 70: 1155a-1155a.
  4. Yan, S., B. Khambu, X. Chen, and X.-M. Yin (2019). “Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota.” FASEB J 33 (1_supplement): 126.5-126.5.
  5. Yan, S., X. Chen and X.-M. Yin (2018). "Autophagy Regulation of Ethanol-Induced Liver Injury Is Affected By Multiple Factors." Am J Pathol 188(10): 2434-2435.
  6. Yan, S., X. Chen and X.-M. Yin (2018). "Autophagy Regulation of Ethanol-Induced Liver Injury Is Affected By Multiple Factors." Hepatology 68: 802a-802a.
  7. Khambu, B., S. Yan, N. Huda, G. Liu, H. Hong, X. Chen and X.-M. Yin (2019). "Autophagy Regulates Bile Acid Metabolism via a NRF2-FXR Signaling Axis." The FASEB Journal 33(1_supplement): 126.123-126.123.
  8. Yin, X.-M., L. Wang, S. Yan, J. Zhou, X. Chen and B. Khambu (2018). “SQSTM1 is Important for Ethanol-Induced Lipophagy in Hepatic Cells.” Alcoholism-Clinical and Experimental Research, Wiley 111 River St, Hoboken 07030-5774, NJ USA.

Poster presentation

  1. Yan, S, X. Chen, M. Ma and X.-M. Yin (2021, Apr). "BID-deficiency leads to resistance to diet-induced obesity and hepatic steatosis and reduced expression of fatty acid receptor, CD36." ePoster session presented at ASIP 2021 Annual Meeting, Virtual.
  2. Yan, S, B. Khambu, X. Chen and X.-M. Yin (2020, Nov.), Gut Microbiota Protect Against Liver Injury in Autophagy Deficient Mice by FXR FGF15 Feedback Signaling. ePoster session presented at PISA 2020 Meeting (ASIP), Virtual.
  3. Yan, S, X. Chen, and X.-M. Yin (2019, Nov.), Gut Microbiota Participate in the Resistance of Bid-Deficient Mice to Diet-Induced Hepatic Steatosis and Obesity. Poster session presented at The Liver Meeting 2019 (AASLD), Boston, MA, United States.
  4. Yan, S, B. Khambu, X. Chen and X.-M. Yin (2019, Apr.), Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota. ASIP Highlights Session: I Am An ASIP Member and This is My Science presented at ASIP 2019 Annual Meeting, Orlando, Florida.
  5. Yan, S, X. Chen, and X.-M. Yin (2018, Oct.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster session presented at PISA 2018 Meeting (ASIP), Ann Arbor, MI, United States.
  6. Yan, S, X. Chen, and X.-M. Yin (2018, Nov.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster session presented at The Liver Meeting 2018 (AASLD), San Francisco, CA, United States.
  7. Yan, S, L. Wang, J. Zhou, X. Chen, B. Khambu, and X.-M. Yin (2017, Mar.), Establishment of a cellular model to study ethanol-induced lipophagy. Poster session presented at Gordon Research Conference on Alcohol-Induced End Organ Diseases, Ventura, CA, United States.

My current research interests include 1) cholestasis and alcohol-associated liver disease; 2) the role of autophagy in liver pathophysiology; 3) the formation and physiological functions of protein condensates in liver diseaeses; and 4) the impact of immunometabolism on the progression of NAFLD/NASH.