Shengmin Yan, Ph.D.
Assistant Professor
Education & Affiliations
Biography
I have a broad background in liver diseases, with specific training and expertise in hepatotoxicity, fatty liver diseases, gut-liver interaction, and laboratory medicine. My research includes basic and translational research in alcoholic fatty liver diseases, non-alcoholic fatty liver diseases, drug-induced liver injury, obesity, and environmental hepatotoxicity. I laid the groundwork for the proposed research by developing effective in vivo animal models and in vitro models, and by applying novel techniques including single-cell RNA sequencing, bulk RNA sequencing, metabolome analysis, miRNA array, proteomic analysis, 16S sequencing analysis, and other molecular biology technologies.
Positions and Employment
2020-present Instructor, Tulane University School of Medicine, New Orleans, LA
2015-2020 Postdoctoral appointee, Indiana University School of Medicine, Indianapolis, IN
2011-2015 Doctoral student, Institute of Zoology, CAS, Beijing, P.R. China
2008-2011 Master student, Fuzhou University, Fuzhou, P.R. China
Research
Research Support
Active
LA CaTS Pilot Grant Round 9 Yan, Shengmin (PI) 10/01/2020-03/31/2022
The role of BID in NAFLD-related metabolic changes of hepatic macrophages
The major goal of this project is to study the role of BID in diet-induced obesity and hepatic steatosis.
Role: PI Direct cost: $33,000
Publications
Research Articles
- Yan, S., B. Khambu, X. Chen, Z. Dong, G. Guo and X.-M. Yin (2021). "Hepatic autophagy deficiency remodels gut microbiota for an adaptive protection via FGF15-FGFR4 signaling." Cell Mol Gastroenterol Hepatol 11(4): 973-997.
- Yan, S., J. Zhou, X. Chen, Z. Dong and X.-M. Yin (2019). "Diverse Consequences in Liver Injury in Mice with Different Autophagy Functional Status Treated with Alcohol." Am J Pathol 189(9): 1744-1762.
- Zhang, H.#, S. Yan#, B. Khambu, F. Ma, Y. Li, X. Chen, J. A. Martina, R. Puertollano, Y. Li, N. Chalasani and X.-M. Yin (2018). "Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply." Autophagy 14(10): 1779-1795. (# co-first author)
- Yan, S., H. Zhang, X. Guo, J. Wang and J. Dai (2017). "High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver." Arch Toxicol 91(1): 247-258.
- Yan, S., H. Zhang, J. Wang, F. Zheng and J. Dai (2015). "Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate." Free Radic Biol Med 87: 300-311.
- Yan, S.#, H. Zhang#, F. Zheng, N. Sheng, X. Guo and J. Dai (2015). "Perfluorooctanoic acid exposure for 28 days affects glucose homeostasis and induces insulin hypersensitivity in mice." Sci Rep 5: 11029. (# co-first author)
- Yan, S., J. Wang and J. Dai (2015). "Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days." Arch Toxicol 89(9): 1569-1578.
- Yan, S., J. Wang, W. Zhang and J. Dai (2014). "Circulating microRNA profiles altered in mice after 28 days exposure to perfluorooctanoic acid." Toxicol Lett 224(1): 24-31.
- Khambu, B., T. Li, S. Yan, C. Yu, X. Chen, M. Goheen, Y. Li, J. Lin, O. W. Cummings, Y. A. Lee, S. Friedman, Z. Dong, G. S. Feng, S. Wu and X.-M. Yin (2019). "Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury." Hepatology 69(5): 2196-2213.
- Wang, L., J. Zhou, S. Yan, G. Lei, C. H. Lee and X.-M. Yin (2017). "Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells." Sci Rep 7(1): 12307.
- Zheng, F., N. Sheng, H. Zhang, S. Yan, J. Zhang and J. Wang (2017). "Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver." Toxicol Appl Pharmacol 335: 41-48.
- Lu, Y., J. Wang, X. Guo, S. Yan and J. Dai (2017). "Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes." Toxicol Appl Pharmacol 318: 41-48.
- Yu, C., S. Yan, B. Khambu, X. Chen, Z. Dong, J. Luo, G. K. Michalopoulos, S. Wu and X.-M. Yin (2016). "Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers." PLoS One 11(5): e0155211.
- Wang, J., S. Yan, W. Zhang, H. Zhang and J. Dai (2015). "Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice." J Proteome Res 14(1): 330-341.
- Zhang, H., Y. Lu, B. Luo, S. Yan, X. Guo and J. Dai (2014). "Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery." J Proteome Res 13(7): 3370-3385.
- Li, H., S. Yan, Z. Wang, X. Shen and P. Rao (2011). "In vivo and in vitro effect of peptide HP-6 derived from donkey serum albumin on hematopoietic system." China Journal of Chinese Materia Medica 36(16): 2259-2264. (in Chinese)
- Li, H., H. Weng, Q. Huang, X. Shen, X. Gao, S. Yan, Z. Zhang, Z. Wang and P. Rao (2011). "The preparation and purification of specific polyclonal antibody against melamine and detection by ELISA." Journal of Chinese Institute of Food Science and Technology 11(5): 169-175. (in Chinese)
- Li, H., T. Luo, S. Yan, X. Gao, X. Shen, Z. Zhang, and P. Rao (2010). "Study on the proliferation of bone marrow hematopoietic cells promoted by peptide from donkey serum albumin." Journal of Chinese Institute of Food Science and Technology 10(2): 12-19. (in Chinese)
- Li, H., H. Weng, Y. Zheng, X. Shen, X. Gao, Z. Zhang, S. Yan and P. Rao (2010). "Preparation and identification of polyclonal antibody against melamine." Journal of Fuzhou University 38(5): 763-766. (in Chinese)
Review and book chapters
- Yan, S., B. Khambu, H. Hong, G. Liu, N. Huda and X.-M. Yin (2019). "Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions." Int J Mol Sci 20(20): 5029. (co-responding author)
- Yan, S., N. Huda, B. Khambu and X.-M. Yin (2017). "Relevance of autophagy to fatty liver diseases and potential therapeutic applications." Amino Acids 49(12): 1965-1979.
- Khambu, B., S. Yan, N. Huda and X.-M. Yin (2019). "Role of High-Mobility Group Box-1 in Liver Pathogenesis." Int J Mol Sci 20(21): 5314.
- Huda, N., G. Liu, H. Hong, S. Yan, B. Khambu and X.-M. Yin (2019). "Hepatic senescence, the good and the bad." World J Gastroentero 25(34): 5069-5081.
- Huda, N., H. Zou, S. Yan, B. Khambu and X.-M. Yin (2019). "Analysis of Autophagy for Liver Pathogenesis." Autophagy. Methods in Molecular Biology, N. Ktistakis and O. Florey, Humana Press, 1880: 481-489. (Book chapter)
- Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin (2018). "Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease." Liver Res 2(3): 112-119.
- Khambu, B., S. Yan, N. Huda, G. Liu and X.-M. Yin (2018). "Homeostatic Role of Autophagy in Hepatocytes." Semin Liver Dis 38(04): 308-319.
- Khambu, B., N. Huda, J. Zhou, S. Yan and X.-M. Yin (2017). “Autophagy in Liver Homeostasis.” Cellular Injury in Liver Diseases. W.-X. Ding and X.-M. Yin. Cham, Springer International Publishing: 195-217. (Book chapter)
Oral Presentation
- Yan, S. (2020, Oct.), Microbiome and cholestatic liver disease. Invited speaker presented at SCBA-Hepatology Division Third CALS Annual Symposium (Virtual).
- Yan, S., B. Khambu, X. Chen and X.-M. Yin (2019, Apr.), Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota. Abstract-Driven Short Talk presented at ASIP 2019 Annual Meeting, in Orlando, Florida.
- Yan, S., X. Chen, and X.-M. Yin (2018, Oct.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster Blitz presented at PISA 2018 Meeting (ASIP), Ann Arbor, MI, United States.
- Yan, S., L. Wang, J. Zhou, X. Chen, B. Khambu, and X.-M. Yin (2017, March), Establishment of a cellular model to study ethanol-induced lipophagy. Short talk presented at Gordon Research Conference on Alcohol-Induced End Organ Diseases, Ventura, CA, United States.
Published abstracts
- Yan, S., X. Chen, M. Ma and X.-M. Yin (2021). "BID-deficiency leads to resistance to diet-induced obesity and hepatic steatosis and reduced expression of fatty acid receptor, CD36." FASEB J 35(S1).
- Yan, S., B. Khambu, X. Chen and X.-M. Yin (2020). "Gut Microbiota Protect Against Liver Injury in Autophagy Deficient Mice by FXR-FGF15 Feedback Signaling." Am J Pathol 190(12): S27-S27.
- Yan, S., X. Chen and X.-M. Yin (2019). " Gut Microbiota Participate in the Resistance of Bid-Deficient Mice to Diet-Induced Hepatic Steatosis and Obesity." Hepatology 70: 1155a-1155a.
- Yan, S., B. Khambu, X. Chen, and X.-M. Yin (2019). “Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota.” FASEB J 33 (1_supplement): 126.5-126.5.
- Yan, S., X. Chen and X.-M. Yin (2018). "Autophagy Regulation of Ethanol-Induced Liver Injury Is Affected By Multiple Factors." Am J Pathol 188(10): 2434-2435.
- Yan, S., X. Chen and X.-M. Yin (2018). "Autophagy Regulation of Ethanol-Induced Liver Injury Is Affected By Multiple Factors." Hepatology 68: 802a-802a.
- Khambu, B., S. Yan, N. Huda, G. Liu, H. Hong, X. Chen and X.-M. Yin (2019). "Autophagy Regulates Bile Acid Metabolism via a NRF2-FXR Signaling Axis." The FASEB Journal 33(1_supplement): 126.123-126.123.
- Yin, X.-M., L. Wang, S. Yan, J. Zhou, X. Chen and B. Khambu (2018). “SQSTM1 is Important for Ethanol-Induced Lipophagy in Hepatic Cells.” Alcoholism-Clinical and Experimental Research, Wiley 111 River St, Hoboken 07030-5774, NJ USA.
Poster presentation
- Yan, S, X. Chen, M. Ma and X.-M. Yin (2021, Apr). "BID-deficiency leads to resistance to diet-induced obesity and hepatic steatosis and reduced expression of fatty acid receptor, CD36." ePoster session presented at ASIP 2021 Annual Meeting, Virtual.
- Yan, S, B. Khambu, X. Chen and X.-M. Yin (2020, Nov.), Gut Microbiota Protect Against Liver Injury in Autophagy Deficient Mice by FXR FGF15 Feedback Signaling. ePoster session presented at PISA 2020 Meeting (ASIP), Virtual.
- Yan, S, X. Chen, and X.-M. Yin (2019, Nov.), Gut Microbiota Participate in the Resistance of Bid-Deficient Mice to Diet-Induced Hepatic Steatosis and Obesity. Poster session presented at The Liver Meeting 2019 (AASLD), Boston, MA, United States.
- Yan, S, B. Khambu, X. Chen and X.-M. Yin (2019, Apr.), Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota. ASIP Highlights Session: I Am An ASIP Member and This is My Science presented at ASIP 2019 Annual Meeting, Orlando, Florida.
- Yan, S, X. Chen, and X.-M. Yin (2018, Oct.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster session presented at PISA 2018 Meeting (ASIP), Ann Arbor, MI, United States.
- Yan, S, X. Chen, and X.-M. Yin (2018, Nov.), Autophagy regulation of ethanol-induced liver injury is affected by multiple factors. Poster session presented at The Liver Meeting 2018 (AASLD), San Francisco, CA, United States.
- Yan, S, L. Wang, J. Zhou, X. Chen, B. Khambu, and X.-M. Yin (2017, Mar.), Establishment of a cellular model to study ethanol-induced lipophagy. Poster session presented at Gordon Research Conference on Alcohol-Induced End Organ Diseases, Ventura, CA, United States.
My current research interests include 1) cholestasis and alcohol-associated liver disease; 2) the role of autophagy in liver pathophysiology; 3) the formation and physiological functions of protein condensates in liver diseaeses; and 4) the impact of immunometabolism on the progression of NAFLD/NASH.