Education

• 1982 Aleppo University School of Medicine, M.D
• 1983-84 Mercy Hospital, Baltimore, MD, Intern, Pediatrics
• 1984-86 Medical Center of Delaware, Wilmington, DE, Resident, Pediatrics
• 1986-90 University of Virginia, Charlottesville, VA, Fellow, Pediatric Nephrology

Biography

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Publications

1.  El-Dahr SS, Li Y, Liu J, Gutierrez E, Herring-Smith KS, Signoretti S, Pignon J-C, Sinha S, Saifudeen Z.  P63+ ureteric bud tip cells are progenitors of intercalated cells.  JCI Insight.  2(9). Pii: 89996. [Epub ahead of print] 2017

2.  Lara LS, Bourgeois CR, El-Dahr SS, Prieto MC.  Bradykinin/B2 receptor activation regulates renin in M-1 cells via protein kinase C and nitric oxide.  Physiol. Rep. 5(7): e13211.  2017

3.  Hilliard SA, and El-Dahr SS.  Epigenetics of renal development and disease.  Yale J. Biol. Med. 89 (4): 565-573, 2016  Review.  PMID: 28018145

4.  Hilliard S, and El-Dahr SS.  Epigenetic mechanisms in renal development. Pediatr. Nephrol. 31: 1055-1060, 2016.   PMID 26493068

5.  Kopkan L, Huskova Z, Jichova S, Cervenkova L, Cervenka L, Saifudeen Z, El-Dahr SS.  Conditional Knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake.  Clin. Exp. Hypertens. 38: 1-9, 2016. PMID: 26151827

6. Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS.  Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 15;142(6):1180-92, 2015. PMID: 25758227

7.  Adli M1, Parlak M, Li Y, El-Dahr S. (2015) Epigenetic States of Nephron Progenitors and Epithelial Differentiation. J Cell Biochem doi: 10.1002/jcb.25048.

8. Yan, L., Yao, X., Bachvarov, D., Saifudeen, Z., and El-Dahr, S. S. (2014) Genome-wide analysis of gestational gene-environment interactions in the developing kidney. Physiological genomics 46, 655-670.

9. Hilliard, S. A., Yao, X., and El-Dahr, S. S. (2014) Mdm2 is required for maintenance of the nephrogenic niche. Developmental biology 387, 1-14.

10. El-Dahr, S., Hilliard, S., Aboudehen, K., and Saifudeen, Z. (2014) The MDM2-p53 pathway: multiple roles in kidney development. Pediatr Nephrol 29, 621-627.

11. McLaughlin, N., Yao, X., Li, Y., Saifudeen, Z., and El-Dahr, S. S. (2013) Histone signature of metanephric mesenchyme cell lines. Epigenetics 8, 970-978.

12. Li, Y., Liu, J., McLaughlin, N., Bachvarov, D., Saifudeen, Z., and El-Dahr, S. S. (2013) Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiological genomics 45, 948-964.

13. El-Dahr, S. S., and Saifudeen, Z. (2013) Interactions between BdkrB2 and p53 genes in the developing kidney. Biological chemistry 394, 347-351.

14. Chen, S., and El-Dahr, S. S. (2013) Histone deacetylases in kidney development: implications for disease and therapy. Pediatr Nephrol 28, 689-698.

15. Saifudeen, Z., Liu, J., Dipp, S., Yao, X., Li, Y., McLaughlin, N., Aboudehen, K., and El-Dahr, S. S. (2012) A p53-Pax2 pathway in kidney development: implications for nephrogenesis. PloS one 7, e44869.

16. Aboudehen, K., Hilliard, S., Saifudeen, Z., and El-Dahr, S. S. (2012) Mechanisms of p53 activation and physiological relevance in the developing kidney. Am J Physiol Renal Physiol 302, F928-940.

17.Rosenberg, S. L., Chen, S., McLaughlin, N., and El-Dahr, S. S. (2011) Regulation of kidney development by histone deacetylases. Pediatr Nephrol 26, 1445-1452.

18. Hilliard, S., Aboudehen, K., Yao, X., and El-Dahr, S. S. (2011) Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Developmental biology 353, 354-366.

Pubmed listing of research publications:
https://www.ncbi.nlm.nih.gov/pubmed/?term=El-Dahr+S