PhD: Jawaharlal Nehru University, School of Biotechnology, New Delhi, India, 2004
Postdoctoral Training: Dept. of Physiology, Tulane University, New Orleans, LA
My major research interest is to understand the molecular mechanisms governing the regulation of natriuretic peptide (NP) receptor expression. Natriuretic peptides and their receptors have physiological and pathophysiological importance including cardiovascular, renal, and immunological aspect in normal and disease conditions. Atrial natriuretic peptide (ANP) and brain NP (BNP) binds to NP receptor-A (NPRA), C-type NP (CNP) binds to NP receptor-B (NPRB), and all three NP binds to NP receptor-C (NPRC) which mediates their biological functions. The focus of my research is to elucidate interactive roles of DNA binding proteins involved in regulation of natriuretic peptide receptors. Ongoing studies involve identification of epigenetic signaling and role of transcription factors in regulating NP receptor expression and function by utilizing molecular biology techniques and cell culture system.
- Kumar P, Periyasamy R, Das S, Neerukonda S, Mani I, Pandey KN. All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification. Mol Pharmacol. 2014 Jun;85(6):946-57.
- Kumar P, Tripathi S, Pandey KN. Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. J Biol Chem. 2014 Mar 7;289(10):6991-7002.
- Kumar P, Garg R, Bolden G, Pandey KN. Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription. J Biol Chem. 2010 Nov 26;285(48):37521-30.
PubMed listing for Prerna Kumar, Ph.D.