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2017
Wiedman G, Kim SY, Zapata-Mercado E, Wimley WC, Hristova K. pH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides. J Am Chem Soc. 2017 139(2):937-945. doi PubMed
2016
Starr CG, He J, Wimley WC. Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics. ACS Chem Biol. 2016 Dec 16;11(12):3391-3399. doi PubMed
Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium.. An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. doi PubMed PMC
2015
Krauson AJ, Hall OM, Fuselier T, Starr CG, Kauffman WB, Wimley WC. Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity. J Am Chem Soc. 2015 Dec 30;137(51):16144-52. doi PubMed PMC
Kauffman WB, Fuselier T, He J, Wimley WC. Mechanism Matters: A Taxonomy of Cell Penetrating Peptides. Trends Biochem Sci. 2015 Dec;40(12):749-64. doi PubMed PMC
Wimley WC. Determining the Effects of Membrane-Interacting Peptides on Membrane Integrity. Methods Mol Biol. 2015;1324:89-106. doi: 10.1007/978-1-4939-2806-4_6. doi PubMed
Wiedman G, Wimley WC, Hristova K. Testing the limits of rational design by engineering pH sensitivity into membrane-active peptides. Biochim Biophys Acta. 2015 Apr;1848(4):951-7.doi PubMed PMC
2014
He J, Starr CG, Wimley WC. A lack of synergy between membrane-permeabilizing cationic antimicrobial peptides and conventional antibiotics. Biochim Biophys Acta. 2015 Jan;1848(1 Pt A):8-15. doi PubMed PMC
Badani H, Garry RF, Wimley WC. Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity. Biochim Biophys Acta. 2014 Sep;1838(9):2180-97. doi PubMed PDF
Wiedman G, Fuselier T, He J, Searson PC, Hristova K, Wimley WC. Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide. J Am Chem Soc. 2014 Mar 26;136(12):4724-31. doi. PubMed PMC.
2013
Krauson AJ, He J, Wimley AW, Hoffmann AR, Wimley WC. Synthetic molecular evolution of pore-forming peptides by iterative combinatorial library screening. ACS Chem Biol. 2013, 8(4):823-31. doi PubMed PMC
He J, Kauffman WB, Fuselier T, Naveen SK, Voss TG, Hristova K, Wimley WC. Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides. J Biol Chem. 2013 Oct 11;288(41):29974-86. doi PubMed PMC.
He J, Krauson AJ, Wimley WC. Toward the de novo design of antimicrobial peptides: Lack of correlation between peptide permeabilization of lipid vesicles and antimicrobial, cytolytic, or cytotoxic activity in living cells. Biopolymers. 2014 Jan;102(1):1-6. doi. PubMed PMC
Cruz J, Mihailescu M, Wiedman G, Herman K, Searson PC, Wimley WC, Hristova K. A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbations. Biophys J. 2013 Jun 4;104(11):2419-28. doi PubMed PMC
Walkenhorst WF, Klein JW, Vo P, Wimley WC. pH Dependence of microbe sterilization by cationic antimicrobial peptides. Antimicrob Agents Chemother. 2013 Jul;57(7):3312-20. doi PubMed PMC.
Wiedman G, Herman K, Searson P, Wimley WC, Hristova K. The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization. Biochim Biophys Acta. 2013 May;1828(5):1357-64. doi PubMed PMC.
2012
Krauson AJ, He J, Wimley WC. Gain-of-function analogues of the pore-forming peptide melittin selected by orthogonal high-throughput screening. J Am Chem Soc. 2012 Aug 1;134(30):12732-41. doi PubMed PMC
Lok SM, Costin JM, Hrobowski YM, Hoffmann AR, Rowe DK, Kukkaro P, Holdaway H, Chipman P, Fontaine KA, Holbrook MR, Garry RF, Kostyuchenko V, Wimley WC, Isern S, Rossmann MG, Michael SF. Release of dengue virus genome induced by a peptide inhibitor. PLoS One. 2012;7(11):e50995. doi PubMed PMC
Freeman TC Jr, Wimley WC. TMBB-DB: a transmembrane β-barrel proteome database. Bioinformatics. 2012 Oct 1;28(19):2425-30. doi PubMed PMC
He J, Hristova K, Wimley WC. A highly charged voltage-sensor helix spontaneously translocates across membranes. Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7150-3. doi. PubMed PMC
Lin J, Motylinski J, Krauson AJ, Wimley WC, Searson PC, Hristova K. Interactions of membrane active peptides with planar supported bilayers: an impedance spectroscopy study. Langmuir. 2012 Apr 10;28(14):6088-96. doi PubMed
Krauson AJ, He J, Wimley WC. Determining the mechanism of membrane permeabilizing peptides: identification of potent, equilibrium pore-formers. Biochim Biophys Acta. 2012 Jul;1818(7):1625-32. doi PubMed PMC
2011
Marks JR, Placone J, Hristova K, Wimley WC. Spontaneous membrane-translocating peptides by orthogonal high-throughput screening. J Am Chem Soc. 2011 Jun 15;133(23):8995-9004. doi PubMed PMC
He L, Hoffmann AR, Serrano C, Hristova K, Wimley WC. High-throughput selection of transmembrane sequences that enhance receptor tyrosine kinase activation. J Mol Biol. 2011 412(1):43-54. doi PubMed PMC
Li E, Wimley WC, Hristova K. Transmembrane helix dimerization: beyond the search for sequence motifs. Biochim Biophys Acta. 2012 Feb;1818(2):183-93. doi PubMed PMC.
Bishop CM, Wimley WC. Structural plasticity in self-assembling transmembrane β-sheets. Biophys J. 2011 Aug 17;101(4):828-36. doi PubMed PMC.
Wimley WC, Hristova K. Antimicrobial peptides: successes, challenges and unanswered questions. J Membr Biol. 2011 Jan;239(1-2):27-34. doi. PubMed PMC
2010
Hristova K, Wimley WC. (2010) A look at arginine in membranes. J Membr Biol. 2011 Jan;239(1-2):49-56. PDF
Freeman TC Jr, Landry SJ, Wimley WC. (2010) The prediction and characterization of YshA, an unknown outer-membrane protein from Salmonella typhimurium. Biochim Biophys Acta. 2011 Jan;1808(1):287-97.
Wimley WC. (2010) Describing the mechanism of antimicrobial peptide action with the interfacial activity model.ACS Chem Biol. 2010 Oct 15;5(10):905-17. PDF
Wimley WC. (2010) Energetics of peptide and protein binding to lipid membranes.Adv Exp Med Biol. 2010;677:14-23.
Freeman TC Jr, Wimley WC.(2010) A highly accurate statistical approach for the prediction of transmembrane beta-barrels. Bioinformatics. 2010 Aug 15;26(16):1965-74. PDF
Rathinakumar R, Wimley WC. (2010) High-throughput discovery of broad-spectrum peptide antibiotics. FASEB J. 2010 Sep;24(9):3232-8. PDF
Rathinakumar R, Walkenhorst WF, Wimley WC. (2009) Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc. 2009 Jun 10;131(22):7609-17. PDF
Walkenhorst WF, Merzlyakov M, Hristova K, Wimley WC. (2009) Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta. 2009 Jun;1788(6):1321-31. doi PubMed PMC
Chang WK, Wimley WC, Searson PC, Hristova K, Merzlyakov M. (2008) Characterization of antimicrobial peptide activity by electrochemical impedance spectroscopy. Biochim Biophys Acta. 2008 Oct;1778(10):2430-6. doi PubMed PMC
Rathinakumar R, Wimley WC. (2008) Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes. J Am Chem Soc. 2008 Jul 30;130(30):9849-58. PDF
Han X, Hristova K, Wimley WC. (2008) Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomer. Biophys J. 2008 Jan 15;94(2):492-505. PDF
Costin JM, Rausch JM, Garry RF, Wimley WC. (2007) Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein. Virol J. 2007 Nov 20;4:123. PDF
Cynthia Paul, Jianping Wang, William C. Wimley, Robin M. Hochstrasser, and Paul H. Axelsen (2004) Vibrational Coupling, Isotopic Editing, and B-Sheet Structure in a Membrane-Bound Polypeptide (2004) J. Am. Chem. Soc.; 2004;126(18) pp 5843 - 5850. doi PubMed PMC
Wimley WC; (2003) The Versitile beta-Barrel Membrane Protein. Current Opinion in Structural Biology. 13(4):401-411. PDF
Mohanty AK, Bishop CM, Bishop TC, Wimley WC, Wiener MC. (2003) Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffold. J Biol Chem. 2003 Oct 17;278(42):40953-8. doi PubMed
Wimley, WC; (2002) Toward Genomic Identification of beta-barrel Membrane Proteins: Composition and Architecture of Known Structures.Protein Sci. 11:301-12. PDF
Bishop CM; Walkenhorst WF; and Wimley WC; (2001) Folding of beta-sheets in membranes: Specificity and promiscuity in peptide model systems Journal of Molecular Biology, 309(4):975-88. PDF
Rausch JM; Wimley WC; (2001) A high-throughput screen for transmembrane pore-forming peptides. Analytical Biochemistry, 293(2):258-63. PDF
Wimley WC; White, SH; (2000) Designing transmembrane alpha-helices that insert spontaneously. Biochemistry, 39(15):4432-42. PubMed
Wimley, WC; White, SH (2000) Determining the membrane topology of peptides by fluorescence quenching. Biochemistry, 39(1):161-70. PubMed
White SH; Wimley WC; (1999) Membrane Protein Folding and Stability:Physical Principles. Annual Reviews of Biophysics and Biomolecular Structure 28:319-65. PDF
Yau, Y-M.; Wimley, WC; Gawrisch, K; White, SH (1998) The Preference of Tryptophan for Membrane Interfaces. Biochemistry, 37(42):14713-8. PDF
Wimley, WC; Hristova, K; Ladokhin, AS; White, SH (1998) Protein Folding in Membranes: Determining the Energetics of Peptide-Bilayer Interactions. Methods Enzymol., 295:62-87. PDF
Wimley,WC; Hristova, K., Silvestri, L., Axelsen, P.H., Ladokhin, AS; White, SH. (1998) Folding of beta-sheet Membrane Proteins: A Hydrophobic Hexapeptide Model. Journal of Molecular Biology, 277:1091-1110. PDF
Ladokhin AS; Wimley WC; Hristova, K; White SH. (1997) Mechanism of Leakage of Contents of Membrane Vesicles Determined by Fluorescence Requenching. Methods in Enzymology 278:474-86. doi PubMed PMC
Wimley WC; White SH. (1996) Experimentally-Determined Interfacial Hydrophobicity Scale for Proteins in Membranes. Nature Structural Biology, 3, 842-848. PDF
Wimley WC; Gawrisch K; Creamer TP; White SH. A (1996) Direct Measurement of Salt-Bridge Solvation Energies Using A Peptide Model System: Implications for Protein Stability. Proceedings of the National Academy of Sciences, 93, 2985-2990. PDF
Wimley WC; Creamer TP; White SH. (1996) Solvation Energies of Amino Acid Residues and Backbone in a Family of Host Guest Pentapeptides. Biochemistry, 35, 5109-5124. PDF
