Samuel X. Shi, MSc, PhD
Postdoctoral Fellow, Wang Lab, Clinical Neuroscience Research Center
Education & Affiliations
Biography
Dr. Samuel X. Shi is a neuroimmunologist focused on acute brain injuries, specifically, intracerebral hemorrhage and ischemic strokes. He completed his undergraduate degree in nutritional biochemistry at Case Western Reserve University and competed for their nationally ranked men’s tennis team. Following undergrad, Dr. Shi earned his master’s degree in Clinical Translational Science at the University of Arizona College of Medicine – Phoenix, conducting his thesis on stroke immunology under Dr. Rayna J. Gonzales. Continuing his work on stroke neuro-immunity during his doctoral studies in the Barrow Neurological Institute-ASU Interdisciplinary Neuroscience Program where the primary focus of Dr. Shi’s research investigated neuroimmune interactions in response to hemorrhagic brain injury. Samuel’s doctoral work produced two first author publications in Stroke and Science Translational Medicine, as well as a supporting authorship in the Journal of Experimental Medicine. Upon the successful defense of his dissertation, Dr. Shi joined Dr. Xiaoying Wang’s lab as a postdoctoral fellow at the CNRC to extend his expertise on molecular pathophysiologies following cerebrovascular diseases complimenting his background in immunology and neuropathology. Dr. Shi has been awarded an American Heart Association Postdoctoral Fellowship for his proposed work with T-cells in ICH pathology.
Contributions
Selected Publications:
1. Shi SX, Shi K, Liu Q. Brain injury instructs cellular lineage destination in bone marrow. Sci. Trans. Med. 4 April 2021, eabc7029 (2021). DOI: 10.1126/scitranslmed.abc7029
2. Shi K, Zou M, Jia DM, Shi SX, Yang X, Liu Q, Dong J, Sheth KN, Wang X, Shi FD. tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke. Circulation Res. (2020). PMID: 33070717
3. Li Z, Li M, Shi SX, Yao N, … Liu Q. Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J. Experimental Medicine (2020). PMID: 32870258
4. Shi SX, Li Y, Shi K, Wood K, Ducruet AF, Liu Q. Interleukin-15 bridges astrocyte-microglia crosstalk and exacerbates brain injury following intracerebral hemorrhage. Stroke (2020). PMID: 32019481
5. Li YJ, Shi SX, Liu Q, … Gonzales RJ. Targeted role for sphingosine-1-phosphate receptor 1 in cerebrovascular integrity and inflammation during acute ischemic stroke. Neurosci Lett. (2020). PMID: 32561451
6. Jin WN, Shi SX, Li M, Wood K, Gonzales RJ, and Liu Q. Depletion of microglia exacerbates post-ischemic inflammation and brain injury. J. Cerebral Blood Flow & Metabolism (2017). PMID: 28273719
7. Jin WN, Yang X, Li Z, Li M, Shi SX, Wood K, Liu Q, Fu Y, Han W, Xu Y, Liu Q. Non-invasive tracking of CD4+ T cells with a paramagnetic and fluorescent nanoparticle in brain ischemia. J. Cerebral Blood Flow & Metabolism (2016). PMID: 26661207
8. Jin W, Li Z, Li MS, Shi SX, Wood K, Liu QW, Fu Y, Han W, Xu Y, Liu Q. Non-invasive tracking of CD4+ T cells with a nanoparticle in brain ischemia. J. Cerebral Blood Flow & Metabolism (2015). PMID: 26661207
9. Liu L, Spangler C. L, Prager B, Benson B, Shi SX, Zhang CJ, Cotleur C. A, Ransohoff M. R. Spatiotemporal ablation of CXCR2 on oligodendrocyte lineage cells role in myelin repair. Neurol Neuroimmunol Neuroinflamm. (2015). PMID: 26668819
Published Abstracts & Presentations:
1. Shi SX, Li Y, Shi K, Wood K, Ducruet AF, Liu Q. Astrocyte-Microglia Crosstalk Exacerbates Acute Brain Injury. 1st International Stroke Immunology Meeting. Munich, Germany. Mar. 1-3, 2021. Research Presentation.
2. Shi SX, Shi K, Hendricks B, Liu Q, Ducruet AF. Brain injury instructs bone marrow cellular lineage destination that suppresses neuroinflammation. 6th Annual ABRC-Flinn Research Conference. Phoenix, AZ. Feb. 24, 2021. Grant Awardee Presentations.
3. Shi SX, Li Y, Shi K, Wood K, Ducruet AF, Liu Q. Interleukin-15 bridges astrocyte-microglia crosstalk and exacerbates brain injury following intracerebral hemorrhage. Immunology 2020. Honolulu, HI. May 8-12, 2020.
4. Shi SX, Mohamed A, Shi K, Rodriguez J, Liu Q, Gonzales RJ. Differential Sphingosine-1-Phosphate Receptor 1 Expression in the Heart and Brain Following Transient Middle Cerebral Artery Occlusion in Mouse Model. Experimental Biology 2018. San Diego, CA. Apr. 20-25, 2018. Graduate Student Physiology Research Presentations.
5. Shi SX, Liu Q, Gonzales RJ. Dihydrotestosterone Protects against Ischemia/Reperfusion in Adult Male Mice Involving Activation of Estrogen Receptor B. Experimental Biology 2017. Chicago IL, Apr. 22-26, 2017. APS Student Presentations.
