Samir El-Dahr, MD

Chair, Department of Pediatrics, Jane B. Aron Professor

Mentoring Faculty, Biochemisty & Molecular Biology, Tulane Cancer Center Member - Cancer Biology Research Program
Phone
504-988-6692
Office Address
1430 Tulane Avenue, New Orleans, LA 70112 Room 4536
School of Medicine
Department
Pediatrics
Biochemistry-Molecular-Biology-Adjunct
Tulane Cancer Center
Debakey
Diabetes Research
TIPS Mentor

Education & Affiliations

1982 Aleppo University School of Medicine, M.D
1983-84 Mercy Hospital, Baltimore, MD, Intern, Pediatrics
1984-86 Medical Center of Delaware, Wilmington, DE, Resident, Pediatrics
1986-90 University of Virginia, Charlottesville, VA, Fellow, Pediatric Nephrology

Areas of Expertise

Pediatric Nephrology; Hypertension
Dialysis & Transplantation

Biography

Research

Epigenetic Control of Kidney Development and Disease

Clinical Research Interests:

1.  Pediatric hypertension (high blood pressure)
2.  Nephrotic syndrome (swelling due to loss of protein in the urine)
3.  Hematuria (blood in the urine)
4.  Chronic kidney disease (abnormal kidney function) and kidney failure
5.  Dialysis
6.  Kidney transplantation

Contributions

1.  El-Dahr SS, Li Y, Liu J, Gutierrez E, Herring-Smith KS, Signoretti S, Pignon J-C, Sinha S, Saifudeen Z.  P63+ ureteric bud tip cells are progenitors of intercalated cells.  JCI Insight.  2(9). Pii: 89996. [Epub ahead of print] 2017

2.  Lara LS, Bourgeois CR, El-Dahr SS, Prieto MC.  Bradykinin/B2 receptor activation regulates renin in M-1 cells via protein kinase C and nitric oxide.  Physiol. Rep. 5(7): e13211.  2017

3.  Hilliard SA, and El-Dahr SS.  Epigenetics of renal development and disease.  Yale J. Biol. Med. 89 (4): 565-573, 2016  Review.  PMID: 28018145

4.  Hilliard S, and El-Dahr SS.  Epigenetic mechanisms in renal development. Pediatr. Nephrol. 31: 1055-1060, 2016.   PMID 26493068

5.  Kopkan L, Huskova Z, Jichova S, Cervenkova L, Cervenka L, Saifudeen Z, El-Dahr SS.  Conditional Knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake.  Clin. Exp. Hypertens. 38: 1-9, 2016. PMID: 26151827

6. Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS.  Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 15;142(6):1180-92, 2015. PMID: 25758227

7.  Adli M1, Parlak M, Li Y, El-Dahr S. (2015) Epigenetic States of Nephron Progenitors and Epithelial Differentiation. J Cell Biochem doi: 10.1002/jcb.25048.

8. Yan, L., Yao, X., Bachvarov, D., Saifudeen, Z., and El-Dahr, S. S. (2014) Genome-wide analysis of gestational gene-environment interactions in the developing kidney. Physiological genomics 46, 655-670.

9. Hilliard, S. A., Yao, X., and El-Dahr, S. S. (2014) Mdm2 is required for maintenance of the nephrogenic niche. Developmental biology 387, 1-14.

10. El-Dahr, S., Hilliard, S., Aboudehen, K., and Saifudeen, Z. (2014) The MDM2-p53 pathway: multiple roles in kidney development. Pediatr Nephrol 29, 621-627.

11. McLaughlin, N., Yao, X., Li, Y., Saifudeen, Z., and El-Dahr, S. S. (2013) Histone signature of metanephric mesenchyme cell lines. Epigenetics 8, 970-978.

12. Li, Y., Liu, J., McLaughlin, N., Bachvarov, D., Saifudeen, Z., and El-Dahr, S. S. (2013) Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiological genomics 45, 948-964.

13. El-Dahr, S. S., and Saifudeen, Z. (2013) Interactions between BdkrB2 and p53 genes in the developing kidney. Biological chemistry 394, 347-351.

14. Chen, S., and El-Dahr, S. S. (2013) Histone deacetylases in kidney development: implications for disease and therapy. Pediatr Nephrol 28, 689-698.

15. Saifudeen, Z., Liu, J., Dipp, S., Yao, X., Li, Y., McLaughlin, N., Aboudehen, K., and El-Dahr, S. S. (2012) A p53-Pax2 pathway in kidney development: implications for nephrogenesis. PloS one 7, e44869.

16. Aboudehen, K., Hilliard, S., Saifudeen, Z., and El-Dahr, S. S. (2012) Mechanisms of p53 activation and physiological relevance in the developing kidney. Am J Physiol Renal Physiol 302, F928-940.

17.Rosenberg, S. L., Chen, S., McLaughlin, N., and El-Dahr, S. S. (2011) Regulation of kidney development by histone deacetylases. Pediatr Nephrol 26, 1445-1452.

18. Hilliard, S., Aboudehen, K., Yao, X., and El-Dahr, S. S. (2011) Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Developmental biology 353, 354-366.

Pubmed listing of research publications:
https://www.ncbi.nlm.nih.gov/pubmed/?term=El-Dahr+S