Franck Mauvais-Jarvis, MD, PhD

Professor of Medicine, Price-Goldsmith Professor of Nutrition

Tulane Cancer Center Member - Cancer Biology Research Program
Phone
(504)-988-5990
School of Medicine
Department
Endocrinology Metabolism & Diabetes
Diabetes Research
Tulane Center Aging
TIPS Mentor
Tulane Cancer Center
Franck Mauvais-Jarvis

Education & Affiliations

Postdoctoral, Joslin Diabetes Center, Harvard Medical School
PhD, Biochemistry & Molecular Biology, Paris XI School of Medicine, Paris, France
MD, Paris V School of Medicine, Paris, France
BS, Paris V School of Medicine, Paris, France

Biography

Dr. Mauvais-Jarvis is a physician-scientist with dual clinical training in Internal Medicine and Endocrinology from the University of Paris School of Medicine and teaching hospitals in Paris, France. He also holds a PhD in Biochemistry and Molecular Biology from the University of Paris School of Medicine. Dr. Mauvais-Jarvis was a Post-Doctoral Fellow in the laboratory of Dr. C. Ronald Kahn at the Joslin Diabetes Center and Harvard Medical School in Boston. He was an Assistant Professor of Medicine in the Division of Endocrinology at Baylor College of Medicine, an attending physician at Ben Taub General Hospital in Houston, and an Associate Professor of Medicine in the Division of Endocrinology and Molecular Medicine at Northwestern University, Feinberg School of Medicine in Chicago. In 2013, he joined Tulane University School of Medicine as a Professor of Medicine in the Section of Endocrinology and Metabolism. He holds the Price-Goldsmith Endowed Professorship and is Director of the Tulane Center of Excellence in Sex-Based Biology & Medicine. He is also staff physician in the Endocrine service and Director of the Hormone Therapy Clinic at the Southeast Louisiana New Orleans VA Medical Center.

Research

Dr. Mauvais-Jarvis has directed well-funded research laboratories for the past 20 years. He is currently the Director of the Hormones & Metabolism Discovery Research Laboratory. His research program ranges from basic research to translational approaches and clinical studies to better understand the role of biological sex (chromosomes) and sex hormones (estrogens, androgens, and progestogens) in metabolism and metabolic disease. Dr. Mauvais-Jarvis is the principal investigator (PI) of grants from the National Institutes of Health (NIH) and the Veterans Administration and has received awards from the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, the March of Dimes Research Foundation, the French Diabetes Society, Pfizer, and Boehringer-Ingelhein Pharmaceuticals for a total cost of $25 million. He is the founding PI of the NIH-supported COBRE in Sex-Based Precision Medicine. Dr. Mauvais-Jarvis has authored over 200 publications and was invited to give over 180 national and international lectures. He was elected to the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP). 

 

Team and Lab members

Fahd Quadir, PhD, Post-Doctoral Research Fellow

Nazmul Haque, PhD, Post-Doctoral Research Fellow

Joubert B. Kharlyngdoh, PhD, Research Scientist

Weiwei Xu, PhD, Research Scientist

Dragana Lovre, MD, Associate Professor of Medicine

Yilin Yoshida, PhD, Assistant Professor of Medicine

Contributions

  1. Le May C, Chu K, Hu, M, Ortega CS, Simpson ER, Korach KS, Tsai MJ, Mauvais-Jarvis F*. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A. 2006. Jun 13;103(24):9232-7. PMID: 16754860; PMCID: PMC1482595
  2. Wong PS, Tiano J , Liu S, Hewitt SC, Le May C,  Dalle S, KatzenellenbogenJA,  Katzenellenbogen BS, Korach KS, Mauvais-Jarvis F*. The extranuclear estrogen receptor-a stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci USA. 2010 Jul 20;107(29):13057-62. Epub 2010 Jun 29.
  3. Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Latour MG, Fernstrom M, Bhatt SB, Najjar SM, Korach KS, Prentki M, Mauvais-Jarvis F*. Estrogen receptor activation reduces pancreatic islet lipogenesis and prevents b-cell failure in rodent model of type-2 diabetes. J Clin Invest. 2011 Aug 1;121(8):3331-42. Epub 2011 July 11. PMID: 21747171
  4. Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F*. Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab. 2016 May 10;23(5):837-51. Epub 2016 Apr 28. PMID: 27133133; PMCID: PMC4864089.
  5. Mauvais-Jarvis F*, Arnold A, Reue K. A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism. Cell Metab. 2017 Jun 6;25(6):1216-1230. Review. PMID: 28591630; PMCID: PMC5516948.
  6. Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NHF, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam  PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F*. Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes. JCI Insight. 2018 Jun 21;3(12). PMID: 29925687; PMCID: PMC6124401.
  7. Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F*. Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes. Cell Rep. 2018 Jul 3;24(1):181-196. PMID: 29972779; PMCID: PMC6092934.
  8. Mauvais-Jarvis F*, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough, LD Regitz-Zagrosek V, Regensteiner JD, Rubin J, Sandberg K, Suzuki A. Sex and gender: Modifiers of health, disease and medicine. Lancet. 2020. Vol 396 August 22, 2020: 565-582. PMID: 32828189.
  9. Fuselier T, Mota de Sa P, Qadir MMF, Xu B, Allard C, Meyers MM, Tiano JP, Yang BS, Gelfanov V, Lindsey, SL, Dimarchi RD, Mauvais-Jarvis F*. Efficacy of a glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and pre-clinical models of insulin-deficient diabetes. Cell Rep Med. 2022. Apr 7;3(4):100598. PMID: 35492248.

  10. Xu W, Qadir MMF, Nasteska D, Mota de Sa P, Gorvin CM, Blandino-Rosano M, Evans CR, Ho T, Potapenko E, Veluthakal R, Ashford FB, Bitsi S, Fan J, Bhondeley M, Song K, Sure VN, Sakamuri SSVP, Schiffer L, Beatty W, Wyatt R, Frigo DE, Liu X, Katakam PV, Arlt W, Buck J, Levin LR, Hu T, Kolls J, Burant CF, Tomas A, Merrins MJ, Thurmond DC, Bernal-Mizrachi E, Hodson DJ, Mauvais-Jarvis F*. Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells. Cell Rep. 2023 May 17;42(5):112529. PMID: 37200193.

     

    Full list of publications in PubMed