Giovane Tortelote, M.Sc., Ph.D.
Assistant Professor of Pediatrics, Section of Nephrology
Education & Affiliations
Research
Developmental Biology, Stem Cells, Kidney Development, Single Cell Sequencing, Single Cell RNA/ATAC, Proteomics and Metabolomics.
Publications
1. Comparisons of Single-Cell/Nucleus Techniques Show capture of large transcripts is favored in
single-nucleus RNA sequencing. Silva RRP., Diniz F., El-Dahr S. and Tortelote GG. (submitted).
2. Acetate acts as Metabolic Checkpoint and Shapes the Fate of Nephron Progenitor Cells Diniz F; Ngo
NYM.; Colon-Leyva M.; Edington-Giordano F; Hilliard H; Zwezdaryk K; Liu J, El-Dahr S and Tortelote GG.
(submitted).
3. Comprehensive characterization of nephron deficit in the low protein diet mouse model Short K.,
Tortelote GG. E-Dahr S., Smith I. (in preparation)
4. A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence. Toraih EA., Fawzy MS.,
Zerfaoui BNM., Errami Y., Ruiz EM., Hussein MH., Haidari M., Bratton M., Tortelote GG., et al. Cancers
2022, 14, 4128.
5. Single-Cell Transcriptome Analysis of the Circle of Willis in a Mouse Cerebral Aneurysm Model. Lege
AM, Tortelote GG, Pascale C, McCormack I, Nordham K, Suder N, Couldwell M, and Dumont A.
STROKE: 2022; 53:2647–2657.
6. Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors. Hilliard S,
Tortelote GG, Liu H, Chen CH, El-Dahr S. J Am Soc Nephrol 2022 Apr 5:ASN.2021091213.
7. Metabolic programming of nephron progenitor cell fate. Tortelote GG, Colón-Lyeva M, Saifudeen Z,
Pediatr Nephrol Aug.2021
8. Extracellular Vesicles Derived from Induced Pluripotent Stem Cells Promote Renoprotection in Acute
Kidney Injury Model. Collino F, Lopes JA, Tapparo M, Tortelote GG, et al., Cells 2020:17;9(2):453.
9. Complexity of the Wnt/β-catenin pathway: Searching for an activation model.
Tortelote GG, Reis RR, de Almeida Mendes F, Abreu JG. Cell Signal 2017;40:30-43.
10. Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice. Yoon Y, Huang T,
Tortelote G, et al., Dev. Biology 2015: 403(1):80-8
11. Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in
mice. Giovane Tortelote, José Manuel Hernández, et al., Dev. Biology 2012: 374(1):164-73
12. Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: cross talk between
glyceroand sphingolipids in the kidney. Lemos T, Verdoorn KS, Nogaroli L, Brito-Borges T, Bonilha TA,
Moreno PA, Silva OS, Tortelote GG, Einicker-Lamas M. Biochim Biophy Acta 2014 1838(3):1003-9
Awards & Accomplishments
Celso Lisboa Education Award - Brazil 2015-2019
Travel Award, Society for Developmental Biology - USA 2011
Presentation Award, Society for Developmental Biology- NESDB - USA 2011
GDE Fellowship National Counsel of Tech and Sci Development - Brazil 2008 – 2012
MSc Fellowship, CAPES - Brazil 2002 - 2004