Anil Mishra, PhD

Professor of Medicine, Director Eosinophilic Disorder Center

Tulane Cancer Center Member - Genes X Environment Research Program
School of Medicine
Department
Pulmonary Diseases Critical Care Environmental Medicine Research
Tulane Cancer Center
Pulmonary Diseases Critical Care Environmental Medicine Clinical
TIPS Mentor
CV

Education & Affiliations

Phd, Kanpur University, Kanput, India
MS, Kanpur University, Kanput, India
BS, Zoology, Botany, Chemistry, Rajasthan University, Jaipur, India

Biography

Dr. Anil Mishra, PhD., is Professor of Medicine and Endowed Chair, Edward G. Schlieder Educational Foundation and the Director of Tulane Eosinophilic Disorder Center at the Section of Pulmonary Diseases, Tulane School of Medicine, New Orleans, LA. Earlier, Dr. Mishra served as a faculty member at Allergy and Immunology Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH and Professor Medicine, Case Western Reserve University Medical College, Cleveland, OH before joining the Tulane University School of Medicine, New Orleans, LA.

Dr. Mishra's most important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract (Mishra et al. J. Clin. Invest. 1999, 103, 1719-27) and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin-1(an eosinophil selective chemoattractant). Dr. Mishra developed a first murine model of asthma associated eosinophilic esophagitis (Mishra et al. J. Clin. Invest. 2001, 107, 83-90). His findings implicated aeroallergen in the etiology of EoE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation (Mishra et al. J. Immunology 2002, 168, 2464-69 and Gastroenterology, 2003, 125. 1419-27).His research implicated iNKT cells to the food and indoor insect allergens induce EoE and iNKT cell neutralization as a possible future therapy of EoE (Clinical and Translational Immunology, 2013). He patents IL-15 responsive T cell associated molecules as a non-invasive biographers for EoE that differentiate EoE from GERD. Current interest is on the role of IL-15 and IL-18 in pulmonary , pancreatitic and gastrointestinal eosinophilic inflammation. Most recently Dr. Mishra's laboratory showed the significance of IL-15 in recovering allergen-induced airway obstruction (J. Allergy Clin Immunology 2017) and reported a critical role of eosinophils biology.. Dr. Mishra showed that apart from IL-5, Il-18 also differentiate eosinophils and transform IL-5 generated naïve eosinophils to CD101+CD274+ pathogenic eosinophils (J. Allergy Clin Immunology 2018). Earlier, he also reported that CD274 expressed eosinophils are possible non-invasive biomarkers of EoE (Case Report in Gastroenterology, 2017). Dr. Mishra’s current research is focused on the role neuropeptide (VIP) in esophageal motility in EoE and GERD. VIP role in eosinophils and mast cell trafficking in EoE is shown via binding to its receptor CRTH2 present on both eosinophils and mast cells (Cell Mol Gastro Hepatol (JCMGH) 2017). In addition, Dr. Mishra showed the preventive role of rIL-15 in pulmonary and pancreatic fibrosis (AJP-Gastroenterology 2019 and Am. J Res. Mol. Cell Biol. 2019). Furthermore, Dr. Mishra’s laboratory developed first chemical-induced mouse model of pancreatic cancer that also metastasize into lung. The model is now leaded to testing several drugs to treat pancreatic and lung cancer.

Dr. Mishra is an elected fellow of the American Academy of Allergy Asthma Immunology (FAAAAI), and American Gastrointestinal Association (FAGA). He has over 100 peer-reviewed articles, book chapters and reviews on molecular mechanisms of the pulmonary and gastrointestinal toxicity and allergic responses in high impact factor journals. His publications are cited by ~ 7500. Some of his publications are cited more than 6 to 700 till 2018. Dr. Mishra's research has been supported by the 2-different institutes of National Institutes of Health (NIDDK and NIAID) He is serving in a number of study sections as member in NIH.

If interested in his research publications, grants, awards and honors go to his Publication list and visit the Tulane Eosinophilic Disorder Center website to learn more about Dr. Mishra's research.

Research

 

Research Support

Present

  1. National Institute of Health (NIH/NIAID)
    Anil Mishra, Principal Investigator
    R01 AI080851 5/2013-8/2019
    Role of IL-15 in the pathogenesis of eosinophilic esophagitis
    $250,000 (annual direct cost)
     
  2. National Institute of Health (NIH/NIAID)
    2R01AI080581-09A1 2018-2023
    Immune signaling molecules involved in promoting the pathogenesis of eosinophilic esophagitis.
    $300,000 (annual direct cost)

Pending

  1. National Institute of Health (NIH/NIAID)
    Anil Mishra, Principal Investigator
    R01 AI144614-01
    Title: The significance of neuroimmune axis in promoting esophageal functional abnormalities in human EoE
    $328,000 (annual direct cost)

Contributions

  1. Mishra A, Hogan SP, Lee, JJ, and Rothenberg ME Fundamental signals regulating eosinophil homing Into the gastrointestinal tract. J Clin Invest 1999; 103:1719-1727. PMID: 11134183
  2. Mishra A, Hogan SP, Brandt E, Rothenberg ME. An etiological role for aeroallergens in experimental esophagitis, J Clin Invest, 2001; 107:83-90. PMCID: PMC198543.
  3. Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, Foster PS, Rothenberg ME. 2001. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nature Immunol 2(4): 353-360 PMID: 11276207
  4. Mishra A, Hogan,SP, Brandt,E and Rothenberg ME. 2002. Interleukin-5 promotes eosinophil trafficking to the esophagus. J Immunol, 168(5): 2464-2469 PMID: 11859139
  5. Mishra A*, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, Abonia JP, Blanchard C, Putnam PE, Rothenberg ME. 2008. Esophageal remodeling develops as a consequence of tissue specific IL-5 induced eosinophilia. Gastroenterology 134(1);204-14. PMCID: PMC2654267.
  6. Mishra A, Rothenberg ME. 2003. Intratracheal IL-13 induces eosinophil esophagitis by an IL-5, eotaxin-1 and STAT6-dependent mechanism. Gastroenterology. 125(5):1419-27 PMID:14598258
  7. Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. 2010. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukocyte Biol. 88(2);337-346. PMCID: PMC2908938.
  8. Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. 2010. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 139(1);182-193. PMID:20381491 PMCID:, PMC4116278
  9. Parm Mav, Priya Rajavelu, Madhavi Rayapudi, Richard Paul and Mishra A. 2012. Esophageal functional impairment in experimental eosinophilic esophagitis. AJP Gastroenterology & Liver Physiol 302, G1347-1355, PMCID: PMC3378164
  10. Mishra A Significance of mouse models in dissecting the mechanism of human eosinophilic gastrointestinal diseases (EGID). J Gastroenterology and Hepatology. 2013; 2(11), 845-853.
  11. Mavi P, Crump CH, Niranjan R, Dutt P, Zaidi A, Shukla JS, and Korfhagen T and Mishra A. Resistin-like molecule (Relm)-a induction in eosinophilic esophagitis promotes esophageal epithelial cell hyperplasia. AJP-Gastroentrology. 2014, 302;G499-508
  12. Madhavi, R, Rajavelu P. Zhu X, , Kaul A, Niranjan R, Dynda S, Mishra A, Mattner J, Zaidi A, Dutt P Mishra A. Invariant natural killer T cells neutralization is a possible novel therapy for human eosinophilic esophagitis. Clinical and Translational Immunology, 2014:3, 1-11 PMID: 25505954
  13. Rituraj Niranjan, Priya Rajavelu, Jai Shankar Shukla,1 Asifa Zaidi, Siddesha Jalahalli Mariswamy, Jochen Mattner, Ilana Fortgang, Monika Kowalczyk, Luis Balart, Anshi Shukla, and Anil Mishra. Involvement of Interleukin-18 in the pathogenesis of human eosinophilic esophagitis. Clinical Immunology, 2015. 157:103-113 PMID:25638412
  14. Parmesh Dutt, Jai Shankar Shukla, Sathisha Upparahalli Ventateshaiah, Siddesha Jalahalli. Mariswamy, Jochen Mattner, Anshi Shukla and Anil Mishra. Allergen-induced Interleukin-18 promotes experimental eosinophilic esophagitis in mice. Immunology and Cell Biology 2015.157(2):103-13 PMID:2659707
  15. Ventateshaiah SU, Zhu X, Rajavelu P, Niranjan R, Manohar M, Verma AK, Lasky JA, Mishra A. Regulatory effects of Interleukin (IL)-15 on allergen-induced airway obstruction. Journal of Allergy and Clinical Immunology 2017. pii: S0091-6749(17)30926-0. DOI: 10.1016/j.jaci.2017.05.025.
  16. Sanders, Nathan and Anil Mishra. Role of interleukin-18 in the pathophysiology of allergic diseases. Cytokine and Growth Factor. 2016, 32 (2016) 31–39 PMID: 2749675
  17. Mussarat A, Manohar M, Verma AK , Ventateshaiah SU, Zaidi A, Zhu X, Sanders NL, Mishra A. Intestinal overexpression of Interleukin (IL)-15 promotes tissue eosinophilia and goblet cell hyperplasia. Immunology & Cell Biology, 2017;96 ((3), 273-283 DOI: 10.1111/imcb.1036. PMID:29363170
  18. Verma AK, Manohar M, Ventateshaiah SU, Blecker U, Collins M, Mishra A. Vasoactive intestinal peptide role in promoting pathogenesis of eosinophilic esophagitis (EoE). Cellular and Molecular Gastroenterology and Hepatology (JCMGH), 2017; 5(1):99-100.e7 PMID:29276755
  19. Venkateshaiah SU, Mishra A, Manohar M, Verma AK, Rajavelu P, Niranjan R, Wild LG, Parada NA, Blecker B, Lasky JA and Mishra A. Role of IL-18 in differentiation, maturation, activation and transformation of pathogenic eosinophils. J Allergy. Clin. Immunol 2018. Published Online: 27 Feb 2018; DOI: https://doi.org/10.1016/j.jaci.2018.02.011 PMID: 29499224

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