Aiguo Tian, PhD
Assistant Professor
Education & Affiliations
Biography
Research Support
NIH/NIGMS P20GM103629 The COBRE Grant in Aging, 01/01/2021-05/31/2022
Role: PI
Bridge Research Fund at Tulane University, 2022
Role: PI
Carol Lavin Bernick Foundation Faculty Grant, 07/01/2020-6/30/2021
Role: PI
NIH/NIGMS P20GM103629 The COBRE Pilot Grant in Aging, 06/01/2020-12/31/2020
Role: PI
Research
Dr. Tian’s laboratory is interested in the cancer research with the Drosophila model. Current research projects focus on:
- Determining how intestinal dysplasia is regulated by the intrinsic signaling pathways in response to tissue injury or aging.
- Determining how cell growth directions are regulated by intrinsic signaling pathways and tissue microenvironment.
Current Lab Members
Virginia Morejon
Sarah Kohoutek
Contributions
Tian A1,2, *, Morejon V1, Kohoutek S1, Huang Y-C1, Deng W-M1& Jiang J3. Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut. The EMBO Journal: (2022) e110834. *Corresponding authors
Tian A1*, Morejon V1, Kohoutek S1, Huang Y1, Deng W1, Jiang J2. Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in Drosophila midguts. bioRxiv 2021.11.22.469515. *Corresponding authors
Li S*, Tian A*, Li S*, Han Y, Wang B, Jiang J. Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut. J Cell Biol. 2020 Apr 6;219(4) PubMed Central PMCID: PMC7147094. * Co-first authors
Tian A, Wang B, Jiang J. Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration. Proc Natl Acad Sci USA. 2017 Mar 28;114(13):E2699-E2708. PubMed Central PMCID: PMC5380042.
Tian A*, Shi Q*, Jiang A, Li S, Wang B, Jiang J. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol. 2015 Mar 16;208(6):807-19. PubMed Central PMCID: PMC4362464. * Co-first authors
Tian A, Jiang J. Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. Elife. 2014 Mar 11;3:e01857. PubMed Central PMCID: PMC3948108.
Tian AG, Tamori Y, Huang YC, Melendez NT, Deng WM. Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking. Dev Biol. 2013 Jan 15;373(2):349-58. PubMed Central PMCID: PMC3650911.
Tian AG, Deng WM. Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. Dev Biol. 2009 Mar 15;327(2):458-64. PubMed Central PMCID: PMC2730513.
Tian AG, Deng WM. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 2008 Feb;135(3):463-71. PubMed Central PMCID: PMC2753475.
Zhou QY*, Tian AG*, Zou HF*, Xie ZM, Lei G, Huang J, Wang CM, Wang HW, Zhang JS, Chen SY. Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants. Plant Biotechnol J. 2008 Jun;6(5):486-503. PubMed PMID: 18384508. * Co-first authors
Tian AG, Wang J, Cui P, Han YJ, Xu H, Cong LJ, Huang XG, Wang XL, Jiao YZ, Wang BJ, Wang YJ, Zhang JS, Chen SY. Characterization of soybean genomic features by analysis of its expressed sequence tags. Theor Appl Genet. 2004 Mar;108(5):903-13. PubMed PMID: 14624337.
Tian AG, Zhao JY, Zhang JS, Gai JY, Chen SY. Genomic characterization of the S-adenosylmethionine decarboxylase genes from soybean. Theor Appl Genet. 2004 Mar;108(5):842-50. PubMed PMID: 14618239.
The full list of Dr. Tian's publication can be found at:
https://www.ncbi.nlm.nih.gov/myncbi/aiguo.tian.1/bibliography/public/
