Clinical Trials Directory

This study is testing a new method of measuring blood clotting using small samples from finger pricks. Researchers want to compare these results with traditional lab tests to see if the new method is accurate for both healthy people and those on blood thinners.

This clinical trial is testing pritelivir, a new antiviral medication, in people with weakened immune systems who have herpes simplex virus (HSV) infections that no longer respond to standard treatment with acyclovir. The study compares pritelivir to other treatments to evaluate its effectiveness and safety in managing these drug-resistant infections.

This NIH-funded study tests whether inhaled budesonide and formoterol can prevent acute respiratory failure (ARF). Though FDA-approved for asthma and COPD, their use for ARF is investigational. The drugs are considered safe, but their effectiveness for ARF prevention is unknown.

This study follows women who participated in the original CHAP trial during pregnancy, which compared different ways of managing mild chronic high blood pressure. Researchers are now tracking these women over time to see whether treating high blood pressure during pregnancy has long-term effects on their heart health. The goal is to better understand how pregnancy complications like preeclampsia may affect future cardiovascular disease risk.

This study is exploring whether doxycycline, a common antibiotic, can help slow down lung damage from emphysema in people living with HIV. While doxycycline is FDA-approved for other conditions, its use in treating emphysema in this population is investigational. The trial also examines how safe and well-tolerated the drug is over time.

This study looks at how the immune system reacts to common food allergens like peanuts, tree nuts, milk, and eggs. By analyzing blood samples from people with and without food allergies, researchers hope to understand why some people have severe reactions and how food processing affects those responses. The goal is to improve allergy diagnosis and treatment.

This study explores how diabetes affects the body’s mineral balance—something that hasn’t been well understood. Researchers are especially focused on a type of diabetes drug (SGLT2 inhibitors) that helps with blood sugar and heart health but may cause unusual side effects.

This study is testing whether using a special surgical mesh called Phasix™ can help prevent hernias after abdominal surgery. Patients who have open abdominal surgery (a midline laparotomy) are randomly assigned to receive either the mesh or the standard method of closing the incision with stitches. The goal is to see if the mesh provides better support and reduces the chances of a hernia forming after surgery.

This study is for people with chronic kidney disease who may have a genetic variation called APOL1, which can increase the risk of kidney problems. If you haven’t been tested before, you’ll get a blood test to check for this gene—if you have it, you may be able to join the full study to test a new treatment.