Biochemical & Molecular Pharmacology, Structural Biology
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate (Pan) in the biosynthetic pathway of coenzyme A (CoA), a metabolic cofactor essential in multiple physiological processes including the citric acid cycle and fatty acid synthesis. Thus, PanK represents an important drug target for the design of antimicrobial agents, much needed for the treatment of multidrug-resistant bacterial strains that include E. coli, K. pneumoniae, P....
Strushkevich N, Mackenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci USA. 2011; 108(25):10139-43.
Wang H, Hota PK, Tong Y, Li B, Shen L, Nedyalkova L, Borthakur S, Kim S, Tempel W, Buck M, Park HW. Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs). J Biol Chem. 2011; 286(29):26093-106.
Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.Proc Natl Acad Sci USA. 2010; 107(47):20346-51.
Hong BS, Allali-Hassani A, Tempel W, Finerty PJ Jr, Mackenzie F, Dimov S, Vedadi M, Park HW. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J Biol Chem. 2010; 285(21):16330-40.
Wiens CJ, Tong Y, Esmail MA, Oh E, Gerdes JM, Wang J, Tempel W, Rattner JB, Katsanis N, Park HW, Leroux MR. Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem. 2010; 285(21):16218-30.
Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol.2010; 397(4):1067-78.
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. J Biol Chem. 2010; 285(3):1773-80.
Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park, HW. Structural analysis of CYP2R1 in complex with vitamin D3. J Mol Biol. 2008; 380:95-106.