Aiguo Tian, PhD

Assistant Professor

Tulane Cancer Center Member - Cancer Biology Research Program
Office Address
Room 713, Louisiana Cancer Research Center, 1700 Tulane Avenue, New Orleans, LA 70112
School of Medicine
Department
Biochemistry Molecular Biology
Tulane Center Aging
Tulane Cancer Center
Aiguo Tian, PhD

Education & Affiliations

PhD, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
BS, China Agricultural University

Biography

Research Support

Carol Lavin Bernick Foundation Faculty Grant, 2020-2021, 2023-2024, 2024─2025

Role: PI

Tulane impactful publication fund, 2023

Tulane impactful publication fund, 2022

School of Medicine Bridge Research Fund, Tulane University, 2022-2023

Role: PI

Tulane University Bridge Research Fund, 2022─2023     

Role: PI

Full Project of the COBRE Grant in Aging and Regenerative Medicine in Tulane University, 2021─2022

Role: PI

The COBRE Pilot Grant in Aging and Regenerative Medicine in Tulane University, 2020

Role: PI
 

Research

Dr. Tian’s laboratory is interested in the cancer research with the Drosophila model. Current research projects focus on:

  1. Determining how intestinal dysplasia is regulated by the intrinsic signaling pathways in response to tissue injury or aging.
  2. Determining how cell growth directions are regulated by intrinsic signaling pathways and tissue microenvironment.

Current Lab Members
Virginia Morejon
Sarah Kohoutek

Contributions

Sun J, Hosen MB, Deng WM, Tian A. Epithelial Polarity Loss and Multilayer Formation: Insights into Tumor Growth and Regulatory Mechanisms. BioEssays. Accepted 2024

Trubin S, Patel DB, Tian A. Regulation of the Intestinal Stem Cell Pool and Proliferation in Drosophila. Cells. 2024 Nov 8;13(22). doi: 10.3390/cells13221856. Review. PubMed PMID: 39594605; PubMed Central PMCID: PMC11592481.

Li M, Tian A, Jiang J. Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut. bioRxiv. 2024 Nov 7;. doi: 10.1101/2024.11.06.622285. PubMed PMID: 39574645; PubMed Central PMCID: PMC11580950.

Teng Z, Yang L, Zhang Q, Chen Y, Wang X, Zheng Y, Tian A, Tian D, Lin Z, Deng WM, Liu H. Topoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription. Nat Commun. 2024 Jun 17;15(1):5151. doi: 10.1038/s41467-024-49567-5. PubMed PMID: 38886382; PubMed Central PMCID: PMC11183047.

Teng Z, Yang L, Zhang Q, Chen Y, Wang X, Zheng Y, Tian A, Tian D, Lin Z, Deng WM, Liu H. Topoisomerase I is an Evolutionarily Conserved Key Regulator for Satellite DNA Transcription. bioRxiv. 2024 May 5;. doi: 10.1101/2024.05.03.592391. PubMed PMID: 38746280; PubMed Central PMCID: PMC11092777.

Tian A*, Wang XF, Xu Y, Morejon V, Huang YC, Nwapuda C, Deng WM*. EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity. EMBO J. 2023 Nov 13; PubMed PMID: 37953688. * Corresponding author

Tian A1,2, *, Morejon V1, Kohoutek S1, Huang Y-C1, Deng W-M1& Jiang J3. Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut. The EMBO Journal: (2022) e110834. *Corresponding authors

Tian A1*, Morejon V1, Kohoutek S1, Huang Y1, Deng W1, Jiang J2. Re-entry into mitosis and regeneration of intestinal stem cells through enteroblast dedifferentiation in Drosophila midguts. bioRxiv 2021.11.22.469515. *Corresponding authors

Li S*, Tian A*, Li S*, Han Y, Wang B, Jiang J. Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut. J Cell Biol. 2020 Apr 6;219(4) PubMed Central PMCID: PMC7147094. * Co-first authors

Tian A, Wang B, Jiang J. Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration. Proc Natl Acad Sci USA. 2017 Mar 28;114(13):E2699-E2708. PubMed Central PMCID: PMC5380042.

Tian A*, Shi Q*, Jiang A, Li S, Wang B, Jiang J. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol. 2015 Mar 16;208(6):807-19. PubMed Central PMCID: PMC4362464. * Co-first authors

Tian A, Jiang J. Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. Elife. 2014 Mar 11;3:e01857. PubMed Central PMCID: PMC3948108.

Tian AG, Tamori Y, Huang YC, Melendez NT, Deng WM. Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking. Dev Biol. 2013 Jan 15;373(2):349-58. PubMed Central PMCID: PMC3650911.

Tian AG, Deng WM. Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. Dev Biol. 2009 Mar 15;327(2):458-64. PubMed Central PMCID: PMC2730513.

Tian AG, Deng WM. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 2008 Feb;135(3):463-71. PubMed Central PMCID: PMC2753475.

Zhou QY*, Tian AG*, Zou HF*, Xie ZM, Lei G, Huang J, Wang CM, Wang HW, Zhang JS, Chen SY. Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants. Plant Biotechnol J. 2008 Jun;6(5):486-503. PubMed PMID: 18384508. * Co-first authors

Tian AG, Wang J, Cui P, Han YJ, Xu H, Cong LJ, Huang XG, Wang XL, Jiao YZ, Wang BJ, Wang YJ, Zhang JS, Chen SY. Characterization of soybean genomic features by analysis of its expressed sequence tags. Theor Appl Genet. 2004 Mar;108(5):903-13. PubMed PMID: 14624337.

Tian AG, Zhao JY, Zhang JS, Gai JY, Chen SY. Genomic characterization of the S-adenosylmethionine decarboxylase genes from soybean. Theor Appl Genet. 2004 Mar;108(5):842-50. PubMed PMID: 14618239.

The full list of Dr. Tian's publication can be found at:

https://www.ncbi.nlm.nih.gov/myncbi/aiguo.tian.1/bibliography/public/