R. Osvaldo Navia, MD, MBA

Ubolrat Piamjariyakul, Stephanie Young, Angel Smothers, Sijin Wen, R. Osvaldo Navia, George Sokos, Ann E. Hendrickson, Peggy Fink, Diana Niland, Matthew Hottle, Angelo C. Giolzetti & Carol E. Smith. Study protocol of sustaining home palliative care for patients with Heart Failure (HF) and their family caregivers in rural Appalachia: a mixed methods randomized clinical trial. BMC Palliat Care 24, 56 (2025). https://doi.org/10.1186/s12904-025-01680-y

Teixeira CVDL, Keith CM, Haut MW, Mehta R, Phelps H, Ward M, Miller M, Navia RO, Coleman MM, Marano GD, Wang X, Pockl S, Rajabalee N, McCuddy WT, D’Haese PF, Rezai AR, Wilhelmson K. Memory Consolidation, Brain Atrophy, and Metabolism in Amyloid Positive and Negative Amnestic Mild Cognitive Impairment. Alzheimer’s & Dementia. 2025 Jan 9;20(Suppl 2):e089852. doi: 10.1002/alz.089852. PMCID: PMC11714650.

Michelle M Coleman, Marc W Haut, Camila Vieira de Ligo Teixeira, Cierra M Keith1 Rashi Mehta, Holly Phelps, Melanie Ward, Mark Miller, R. Osvaldo Navia, Gary D Marano, Xiaofei Wang, Stephanie Pockl, Nafiisah Rajabalee, William T McCuddy, Pierre-Francois D’Haese, Kirk Wilhelmson. The role of the insula predicting memory performance in Alzheimer’s disease amyloid positive and negative: a clinical cohort study. January 2025. Alzheimer's & Dementia 20(S2). DOI: 10.1002/alz.087942

Rashi I Mehta, Cierra M Keith, Camila Vieira Ligo Teixeira, Patrick D Worhunsky, Holly E Phelps, Melanie Ward, Mark Miller, R Osvaldo Navia, Stephanie Pockl, Nafiisah Rajabalee, Michelle M Coleman, Pierre-François D’Haese, Ali R Rezai, Kirk C Wilhelmsen, Marc W Haut, The early-onset Alzheimer’s disease MRI signature: a replication and extension analysis in early-stage AD, Cerebral Cortex, Volume 34, Issue 12, December 2024, bhae475, https://doi.org/10.1093/cercor/bhae475

Keith CM, Haut MW, Vieira Ligo Teixeira C, Mehta RI, Phelps H, Ward M, Miller M, Navia RO, Coleman MM, Marano G, Wang X, Pockl S, Rajabalee N, Scarisbrick DM, McCuddy WT, D'Haese PF, Rezai A, Wilhelmsen K. Memory consolidation, temporal and parietal atrophy, and metabolism in amyloid-β positive and negative mild cognitive impairment. J Alzheimers Dis. 2024 Dec;102(3):778-791. doi: 10.1177/13872877241291223. Epub 2024 Oct 29. PMID: 39670736.

Piamjariyakul U, Young S, Hendrickson AE, Navia RO, Wang K, Smith CE. Palliative Home Care Based on Clinically Relevant Scientific Measures: A Cross-Sectional Study. American Journal of Hospice and Palliative Medicine®. 2024;0(0). doi:10.1177/10499091241304728

Theeke, L.A.; Liu, Y.; Wang, S.; Luo, X.; Navia, R.O.; Xiao, D.; Xu, C.; Wang, K.; The Alzheimer and Disease Neuroimaging Initiative. Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study. Int. J. Mol. Sci. 2024, 25, 10751. https://doi.org/10.3390/ijms251910751

David M. Scarisbrick, Cierra M. Keith, Camila Vieira Ligo Teixeira, Rashi I. Mehta, Holly E. Phelps, Michelle M. Coleman, Melanie Ward, Mark Miller, Osvaldo Navia, Stephanie Pockl, Nafiisah Rajabalee, Gary Marano, Joseph Malone, Pierre F. D’Haese, Ali R. Rezai, Kirk Wilhelmsen & Marc W. Haut (14 Aug 2024): Executive function and cortical thickness in biomarker aMCI, Applied Neuropsychology: Adult, DOI: 10.1080/23279095.2024.2389255

Keith CM, Lindberg KE, Wilhelmsen K, Mehta RI, Vieira Ligo Teixeira C, Miller M, Ward M, Navia RO, McCuddy WT, Miller L, Bryant K, Coleman M, D'Haese PF, Haut MW. Cortical Thickness Correlates of Go/No-go and Motor Sequencing in Mild Cognitive Impairment and Suspected Alzheimer Disease Dementia. Cogn Behav Neurol. 2024 Jul 29. doi: 10.1097/WNN.0000000000000376. PMID: 39069962.

Kirk C. Wilhelmsen, Pierre-François D’Haese, Marc W. Haut, Gary D. Marano, Rashi I. Mehta, Xiaofei Wang, Melanie Ward, Mark Miller, Umer Najib, R.Osvaldo Navia, Cierra M. Keith, Ali Rezai. Metabolism as a biomarker for treatment success in anti-amyloid therapy: A case report, Neuroimage: Reports, Volume 4, Issue 2, 2024, 100203, ISSN 2666-9560ISSN 2666-9560, https://doi.org/10.1016/j.ynirp.2024.100203.

Mark Miller MD, Melanie Ward MD, Cierra Keith PhD , Vishal Patel DO , Marc Haut PhD , Kirk Wilhelmsen MD, PhD , Osvaldo Navia MD , Rashi Mehta MD , Gary Marano MD , Andriana Kiddy CNP. Managing Neurocognitive Disorders in the Real World: Optimizing Collaboration between Primary Care Providers and Dementia Specialists, The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice (April, 2024), doi: https://doi.org/10.1016/j.osep.2024.04.001

Piamjariyakul U, Wang K, Smith M, Young S, Shafique S, Navia RO, Williams K. Family Caregiving of Patients with Heart Failure and Vascular Dementia in Rural Appalachia: A Mixed-Methods Study. Western Journal of Nursing Research. 2024;0(0). doi:10.1177/01939459241242536

Keith, C. Haut, M. D’Hase, P. Mehta, R. Vieira, C. Coleman M, Navia, RO. Marano, G. Linberg, K. Wilhelmsen, K. ‘More Similar Than Different: Memory, Executive Functions, Cortical Thickness, and Glucose Metabolism in Biomarker-Positive Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia’. Journal of Alzheimer’s Disease Reports. Vol 8, No 1, pp. 57-73, 2024. DOI: 10.3233/ADR-230049

Piamjariyakul U, McKenrick SR, Smothers A, Giolzetti A, Melnick H, Beaver M, Shafique S, Wang K, Carte KJ, Grimes B, Haut MW, Navia RO, Patrick JH, Wilhelmsen K. Developing, implementing, and evaluating the visiting Neighbors' program in rural Appalachia: A quality improvement protocol. PLoS One. 2024 Jan 2;19(1):e0296438. doi: 10.1371/journal.pone.0296438. PMID: 38166130; PMCID: PMC10760886

Theeke L, Liu Y, Wang S, Navia RO, Xiao D, Xu C, Wang K. Longitudinal changes in proteomic biomarkers in Alzheimer's disease and cardiovascular disease.  Innov Aging. 2023 Dec 21;7(Suppl 1):1158. doi: 10.1093/geroni/igad104.3715. PMCID: PMC10738482

Xu C, Acevedo P, Lu Y, Su BB, Ozuna K, Padilla V, Karithara A, Mao C, Navia RO, Piamjariyakul U, Wang K; Alzheimer's Disease Neuroimaging Initiative. Racial differences in the effect of APOE-ε4 genotypes on trail making test B in Alzheimer's disease: A longitudinal study. Int J Geriatr Psychiatry. 2023 Dec; 38(12):e6037. doi: 10.1002/gps.6037. PMID: 38100638.

Xu C, Xiao D, Su BB, Saveron JM, Gamez D, Navia RO, Wang N, Roy U, Adjeroh DA, Wang K; Alzheimer and Disease Neuroimaging Initiative. Association of APOE gene with longitudinal changes of CSF amyloid beta and tau level Alzheimer's disease: racial differences. Neurol Sci. 2023 Sep 28. doi: 10.1007/s10072-023-07076-1. Epub ahead of print. PMID: 37759100.

Coleman MM, Keith CM, Wilhemsen K, Mehta RI, Vieira Ligo Texeira C, Miller M Navia RO, McCuddy WT, D’Haese P-F and Haut MW (2023) Surface-based correlates of cognition along the Alzheimer’s continuum in a memory clinic population. Front. Neurol. 14:1214083. doi:10.3389/fneuro. 2023.1214083.

Keith CM, McCuddy WT, Lindberg K, Miller LE, Bryant K, Mehta RI, Wilhelmsen K, Miller M, Navia RO, Ward M, Deib G, D'Haese PF, Haut MW. Procedural learning and retention relative to explicit learning and retention in mild cognitive impairment and Alzheimer's disease using a modification of the trail making test. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2023 Sep-Nov;30(5):669-686. doi: 10.1080/13825585.2022.2077297. Epub 2022 May 22. PubMed PMID: 35603568.

Constantine L, DeCicco D, Carpenter RD, Pockl S, Seachrist KB, Navia RO. Healthcare Providers' Experiences of Caring for Patients With COVID-19 Requiring Extracorporeal Membrane Oxygenation Support. Am J Hosp Palliat Care. 2023 May 22:10499091231178503. doi: 10.1177/10499091231178503. Epub ahead of print. PMID: 37218036; PMCID: PMC10203850.

Keith CM, Haut MW, Wilhelmsen K, Mehta RI, Miller M, Navia RO, Ward M, Lindberg K, Coleman M, McCuddy WT, Deib G, Giolzetti A, D'Haese PF. Frontal and temporal lobe correlates of verbal learning and memory in aMCI and suspected Alzheimer's disease dementia. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2022 Nov 11:1-17. doi: 10.1080/13825585.2022.2144618. Epub ahead of print. PMID: 36367308.

Navia, RO. MD; Constantine, Lori Anne DNP, FNP-BC, ACHPN Palliative care for patients with advanced dementia, Nursing: March 2022 - Volume 52 - Issue 3 - p 19-26 doi: 10.1097/01.NURSE.0000820024.83629.ee. PMID: 35196277

Baker Rogers JE, Thompson JM, Mupamombe CT, Vanin JM, Navia RO. Hospice Emergency Planning and COVID-19. J Palliat Care. 2021 Aug 19:8258597211037428. doi: 10.1177/08258597211037428. Epub ahead of print. PMID: 34410180.

Wang K, Xu C, Smith A, Xiao D, Navia RO, Lu Y, Xie C, Piamjariyakul U; Alzheimer's Disease Neuroimaging Initiative. Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jul 2:110393. doi: 10.1016/j.pnpbp.2021.110393. PMID: 34224794.

Shannon B, Rhomika D, Minta B, Haghnazar H, Navia RO.  Anticholinergic Burden and Hospital Delirium in an Appalachian University Hospital. J Aging Geriatr. 2021 May; Med 5:4.

Moss AH, Navia RO. Should we recommend dialysis for older patients with kidney failure and dementia? J Am Geriatr Soc. 2021 Apr;69(4):1105-1107. doi: 10.1111/jgs.17076. Epub 2021 Mar 5. PMID: 33666942

Rogers JEB, Constantine LA, Thompson JM, Mupamombe CT, Vanin JM, Navia RO. COVID-19 Pandemic Impacts on U.S. Hospice Agencies: A National Survey of Hospice Nurses and Physicians. Am J Hosp Palliat Care. 2021 May;38(5):521-527. doi: 10.1177/1049909121989987. Epub 2021 Jan 27. PMID: 33499673