Education
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2011-2014 - Postdoctoral Research Fellow, Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, USA Research Focus: Autophagy, Liver Injury, Inflammation, Fibrosis, and cancer. Mentor: Prof. Xiao-Ming Yin
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2008-2011 - PhD in Medicine, Graduate School of Medicine Kyoto University, Japan. Laboratory: Chemical Biology, Mentor: Prof. Motonari Uesugi
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2007-2008 - Pre-doctoral Research student, Department of Biochemistry, Kyoto University, Japan
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2005 - MSc (Medical Biochemistry), B. P. Koirala Institute of Health Sciences, Nepal
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2001 - BSc (Major: Microbiology), Tribhuvan University, Nepal
Biography
Professional Positions and Working Experience
2005-2007 - Lecturer, Department of Biochemistry, Kathmandu University Medical School (KUMS), Dhulikhel, Nepal
2007-2008 - Predoctoral research student, Chemical Biology laboratory, Department of Biochemistry, School of medicine, Kyoto University. (Mentor: Prof. Motonari Uesugi)
2008-2011 - Doctoral student, Chemical Biology Laboratory, Department of Biochemistry, School of medicine, Kyoto University. (Mentor: Prof. Motonari Uesugi)
2011-2014 - Postdoctoral fellow, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine. (Mentor: Prof. Xiao-Ming Yin)
2014-2015 - Senior Research fellow, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine. (Mentor: Prof. Xiao-Ming Yin)
2015-2020 - Research Assistant Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine.
2020-Present - Assistant Professor (Tenure-Track), Department of Pathology and Laboratory Medicine, Tulane University School of Medicine.
Research
Original Research
- Khambu B*, Hong H, Liu S, Liu G, Chen X, Dong Z, Wan J, and Yin XM. The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors. Cell Death and Disease, 2020, In Press. * Corresponding author
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Publications
Review Articles
- Khambu B*., Yan S, Huda N, and Yin X-M. Role of high-mobility group box-1 in liver pathogenesis. International Journal of Molecular Sciences, 2019, Int J Mol Sci. 2019 (Accepted) . * Corresponding author
- Huda N, Liu G, Hong H, Yan S, Khambu B, Yin XM. Hepatic senescence, the good and the bad. World J Gastroenterol 2019; 25(34): 5069-5081.
- Yan S, Khambu B, Hong H, Liu G, Huda N, Yin XM. Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions. Int J Mol Sci. 2019 Oct 11; 20(20). pii: E5029.
- Khambu B*, Yan S, Huda N, Liu Gang, Yin XM. Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease. Liver Research, 2018; 2(3):112-119. * Corresponding author
- Khambu B, Yan S, Huda N, Gang Liu, Yin XM. Homeostatic Role of Autophagy in Hepatocytes. Seminars in Liver Disease. 2018; 38(04): 308-319.
- Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017; 16; 24(2):207-217.
- Yan S, Huda N, Khambu B, Yin XM. Relevance of autophagy to fatty liver diseases and potential therapeutic applications. Amino Acids. 2017 Dec;49(12):1965-1979.
- Khambu, B, L. Wang, H. Zhang, and X.-M. Yin, The activation and function of autophagy in alcoholic liver disease. Current Molecular Pharmacology 2017;10(3):165-171.
- Klionsky D J,….., Khambu B., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2016: 12(1): 1-222.
- Wang L, Khambu B, Zhang H, Yin XM. Autophagy in alcoholic liver disease, self-eating triggered by drinking. Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S2-6.
- Kuo TF., Mao D., Hirata N., Khambu B., Kimura Y.,Kawase E., Shimogawa H., Ojita M., Nakatsuji N, Ueda K., Uesugi M. Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative. Journal of the American Chemical Society, 2014; 136 (28): 9798-9801.
Book Chapters
- Khambu B, Zhang H, Yin XM. Role of autophagy and mitophagy in liver disease. In “Mitochondria in Liver Disease” (ed. By D. Han and N. Kaplowitz, a book of “Oxidative Stress and Disease” series), CRC Press, 2015.
- Zhang H, Khambu B, Yin XM. Chapter 12. Autophagy. In “Signaling Pathways in Liver Diseases” (3rd edition, by J. F. Dufour and P.A. Clavien), Springer, 2015
- Khambu B, Huda N, Zou H, Yan S, Yin XM (2017). Autophagy in Liver Homeostasis. In: Ding WX., Yin XM. (eds) Cellular Injury in Liver Diseases. Cell Death in Biology and Diseases. Springer, Cham.
- Huda N, Zou H, Yan S, Khambu B, Yin XM (2019) Analysis of Autophagy for Liver Pathogenesis. In: Ktistakis N., Florey O. (eds) Autophagy. Methods in Molecular Biology, vol 1880. Humana Press, New York, NY.
Published Abstracts
- Khambu B, Hong H, Liu G, Chen X, Wan J, and Yin XM. Role of HMGB1 in hepatic tumorigenesis caused by autophagy-deficiency. Hepatology 2019; 70,S1:0270-9139.
- Huda N, Khambu B, Chen X, and Yin XM. Senescence contributes to inflammation in autophagy-deficient livers. Hepatology 2019; 70,S1:0270-9139.
- Khambu B, Yan S, Huda N, Liu G, Hong H, Chen X and Yin XM. Autophagy Regulates Bile Acid Metabolism via a NRF2-FXR Signaling Axis. The FASEB Journal 2019; 33(1), 126.3-126.3.
- Yan S, Khambu B, Chen X and Yin XM. Autophagy Deficiency in the Liver Altered Pathogenesis of Alcoholic Liver Disease and Profile of Gut Microbiota. The FASEB Journal 2019; 33(1)126.5-126.5.
- Khambu B, Huda N, Chen X and Yin XM. A Critical Role of HMGB1 in Liver Pathology Caused By Autophagy Deficiency. Hepatology 2018; 68, 40A-41A.
- Huda N, Khambu B, Chen X and Yin XM. Autophagy Orchestrates Senescence in the Liver. Hepatology 2018; 68, 881A-882A.
- Yin XM, Khambu B, Huda N. A critical role of HMGB1 in liver tumor development under autophagy deficiency. Cancer Biology & Medicine 2018; 15(1).4.
- Yin XM, Wang L, Yan S, Zhou J, X Chen J, Khambu B. SQSTM1 is important for ethanol-induced lipophagy in hepatic cells. Alcoholism-Clinical And Experimental Research, 2018, 42, 91A-91A.
- Huda N, Khambu B, Chen X and Yin XM. Autophagy regulates hepatocellular senescence. The FASEB Journal 2017; 31(1), 470.1-470.1
- Wang L, Zhou J, Chen X, Khambu B, Yin XM. Establishment of a cellular model to study ethanol-induced lipophagy. Hepatology 2016; 64, 615A-615A.
- Khambu B., Zhang, H. XY Chen, Y. Li and Yin XM. Mechanism of Liver Injury caused by autophagy deficiency. The FASEB Journal; 29, 2015.
- Yang Z., Guo N., Khambu B., Zhang H., Liu P., Yin XM., Li M. Impaired lysosome function can induce autophagy via suppression of mTOR activity. The FASEB Journal 2014; 28 (S1), 738.1.
- Li, M, Khambu B, Zhang H, Vogt A..Liu P. and Yin XM. Suppression of Lysosome Function Induces Autophagy via a Feedback Downregulation of MTORC1 Activity. 2014 Keystone Meeting on Autophagy.
- Zhang H., Khambu B., Chen X., Yin XM. Modulation of Autophagy Affects the Hepatic Pathology in Alcoholic and Non-alcoholic Liver Diseases. The FASEB Journal 2013; 27, 1086.2.