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Minolfa C Prieto, MD, PhD
Minolfa Prieto, MD, PhD

Education

  • MD: Universidad del Zulia, Venezuela (1985)
  • MS: Clinical Genetics, Universidad del Zulia, Venezuela (1996)
  • PhD: Tulane University, New Orleans, LA (2004)
  • Postdoctoral Fellowship: Department of Clinical Gentics, Tulane University, New Orleans, LA
  • Postdoctoral Fellowship: Department of Physiology, Tulane University, New Orleans, LA

Research

  • Research in my lab is focused on the intrarenal regulation of the RAS in hypertension. My training in molecular genetics and renal physiology with emphasis on experimental hypertension has allowed focusing my efforts on investigating the functional role and the regulation of intrarenal RAS genes in the pathophysiology of hypertension and related renal morphological changes. In particular, investigating the role of prorenin and renin from collecting duct cells origin and their interaction with the prorenin receptor in the pathogenesis of high blood pressure. Other research includes the importance of elucidating the fundamental basis of the sex dependent differences in the intrarenal RAS that likely explain sex disparities in hypertension. I have pioneered the studies on the activation of collecting duct renin and prorenin during Ang II-dependent hypertension including cell-type localization and regulation of synthesis and secretion in rodent models.

    Laboratory Members:

    • Bruna Visniauskas, PhD – Postdoctoral Fellow
    • Michelle Galeas - PhD Student
    • Justine Jorgensen - Undergraduate Student
    • Andrew Curnow, BS - Medical Student (T3), Current DeBakey Scholar
    • Thomas John, BS - Medical Student (T2), Current DeBakey Scholar
    •

    Publications

    PubMed listing for Minolfa Prieto

    Areas of Expertise

    Research

  • Research in my lab is focused on the intrarenal regulation of the RAS in hypertension. My training in molecular genetics and renal physiology with emphasis on experimental hypertension has allowed focusing my efforts on investigating the functional role and the regulation of intrarenal RAS genes in the pathophysiology of hypertension and related renal morphological changes. In particular, investigating the role of prorenin and renin from collecting duct cells origin and their interaction with the prorenin receptor in the pathogenesis of high blood pressure. Other research includes the importance of elucidating the fundamental basis of the sex dependent differences in the intrarenal RAS that likely explain sex disparities in hypertension. I have pioneered the studies on the activation of collecting duct renin and prorenin during Ang II-dependent hypertension including cell-type localization and regulation of synthesis and secretion in rodent models.

    Laboratory Members:

    • Bruna Visniauskas, PhD – Postdoctoral Fellow
    • Michelle Galeas - PhD Student
    • Justine Jorgensen - Undergraduate Student
    • Andrew Curnow, BS - Medical Student (T3), Current DeBakey Scholar
    • Thomas John, BS - Medical Student (T2), Current DeBakey Scholar
    •