Santosh Yadav, Ph.D.

My research focuses on the role of DNA repair genes in the genomic instability associated with cancer and age-related diseases, such as lung fibrosis. Early in my career, I developed expertise in analyzing mutations within the DNA repair genome, including the biochemical characterization of mutations affecting DNA polymerase Kappa.

Currently, I am working on mechanism of immune surveillance, oxidative stress, and aging as they relate to chronic lung diseases, in particular idiopathic pulmonary fibrosis (IPF). I have also established a biorepository of IPF Bronchoalveolar Lavage Fluid (BALF) and have been acquiring lung tissues for spatial transcriptomics and proteomics. These resources are essential for investigating unique cellular populations in the lung through single-cell sequencing, enabling a deeper understanding of cellular diversity.

I recently received a COBRE NIIGMS Pilot Grant for my project “Immune Surveillance and T Cell Exhaustion in Fibrotic Disease” and serve as co-investigator on multiple other NIH supported projects.